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  • Article
  • Open Access
9 Citations
3,756 Views
12 Pages

Decomposition of Glucose-Sensitive Layer-by-Layer Films Using Hemin, DNA, and Glucose Oxidase

  • Kentaro Yoshida,
  • Yu Kashimura,
  • Toshio Kamijo,
  • Tetsuya Ono,
  • Takenori Dairaku,
  • Takaya Sato,
  • Yoshitomo Kashiwagi and
  • Katsuhiko Sato

4 February 2020

Glucose-sensitive films were prepared through the layer-by-layer (LbL) deposition of hemin-modified poly(ethyleneimine) (H-PEI) solution and DNA solution (containing glucose oxidase (GOx)). H-PEI/DNA + GOx multilayer films were constructed using elec...

  • Article
  • Open Access
29 Citations
13,636 Views
15 Pages

Theoretical Analysis of the Performance of Glucose Sensors with Layer-by-Layer Assembled Outer Membranes

  • Robert A. Croce,
  • Santhisagar Vaddiraju,
  • Fotios Papadimitrakopoulos and
  • Faquir C. Jain

1 October 2012

The performance of implantable electrochemical glucose sensors is highly dependent on the flux-limiting (glucose, H2O2, O2) properties of their outer membranes. A careful understanding of the diffusion profiles of the participating species throughout...

  • Article
  • Open Access
3 Citations
4,760 Views
17 Pages

The Impact of the Functional Layer Composition of Glucose Test-Strips on the Stability of Electrochemical Response

  • Ekaterina V. Zolotukhina,
  • Ekaterina V. Gerasimova,
  • Vladislav V. Sorokin,
  • Maria G. Levchenko,
  • Alisa S. Freiman and
  • Yuliya E. Silina

Herein, the impact of the chemical stability of RedOx mediator ferricyanide, K3[Fe(CN)6] (FC), a type of buffer solution used for bioreceptor preparation, gel composition (carboxymethylcellulose, CMC, Aerosile, AS, and alginate, ALG) on the long term...

  • Article
  • Open Access
20 Citations
2,409 Views
14 Pages

5 August 2024

This paper presents a new biosensor design based on the Kretschmann configuration, for the detection of analytes at different refractive indices. Our studied design consists of a TiO2/SiO2 bi-layer sandwiched between a BK7 prism and a bimetallic laye...

  • Communication
  • Open Access
9 Citations
7,619 Views
7 Pages

24 September 2016

The incidence of diabetes is continually increasing, and by 2030, it is expected to have increased by 69% and 20% in underdeveloped and developed countries, respectively. Therefore, glucose sensors are likely to remain in high demand in medical devic...

  • Article
  • Open Access
5,787 Views
7 Pages

The effects of 5, 25, and 40 Echinostoma caproni miracidia on the sugar content of young adult and mature adult Biomphalaria glabrata were studied using high performance thin layer chromatography (HPTLC)-densitometry. Analysis was done on the snail’s...

  • Article
  • Open Access
15 Citations
2,346 Views
13 Pages

Layer-by-Layer Films of Silsesquioxane and Nickel(II) Tetrasulphophthalocyanine as Glucose Oxidase Platform Immobilization: Amperometric Determination of Glucose in Kombucha Beverages

  • João Paulo Winiarski,
  • Douglas José de Melo,
  • Edson Roberto Santana,
  • Cleverson Siqueira Santos,
  • Cliciane Guadalupe de Jesus,
  • Sérgio Toshio Fujiwara,
  • Karen Wohnrath and
  • Christiana Andrade Pessôa

This paper describes the development of a novel glucose biosensor through the layer-by-layer technique (LbL). The self-assembled architectures were composed of a positive-charged silsesquioxane polyelectrolyte, 3-n-propylpyridinium silsesquioxane chl...

  • Article
  • Open Access
1 Citations
2,572 Views
12 Pages

Evaluation of Mesoporous TiO2 Layers as Glucose Optical Sensors

  • David Ortiz de Zárate,
  • Sara Serna,
  • Salvador Ponce-Alcántara and
  • Jaime García-Rupérez

20 July 2022

Porous materials are currently the basis of many optical sensors because of their ability to provide a higher interaction between the light and the analyte, directly within the optical structure. In this study, mesoporous TiO2 layers were fabricated...

  • Article
  • Open Access
67 Citations
7,211 Views
15 Pages

Layered Double Hydroxide-Modified Organic Electrochemical Transistor for Glucose and Lactate Biosensing

  • Isacco Gualandi,
  • Marta Tessarolo,
  • Federica Mariani,
  • Danilo Arcangeli,
  • Luca Possanzini,
  • Domenica Tonelli,
  • Beatrice Fraboni and
  • Erika Scavetta

18 June 2020

Biosensors based on Organic Electrochemical Transistors (OECTs) are developed for the selective detection of glucose and lactate. The transistor architecture provides signal amplification (gain) with respect to the simple amperometric response. The b...

  • Article
  • Open Access
26 Citations
7,307 Views
12 Pages

18 September 2015

A novel amperometric glucose biosensor was fabricated by layer-by-layer self-assembly of gold nanorods (AuNRs) and glucose oxidase (GOD) onto single-walled carbon nanotubes (SWCNTs)-functionalized three-dimensional sol-gel matrix. A thiolated aqueou...

  • Article
  • Open Access
76 Citations
17,271 Views
10 Pages

Planar Amperometric Glucose Sensor Based on Glucose Oxidase Immobilized by Chitosan Film on Prussian Blue Layer

  • Jianzhong Zhu,
  • Ziqiang Zhu,
  • Zongsheng Lai,
  • Rong Wang,
  • Xiaoming Guo,
  • Xiaqin Wu,
  • Guoxiong Zhang,
  • Zongrang Zhang,
  • Yiting Wang and
  • Zongyou Chen

23 April 2002

A planar amperometric glucose microsensor based on glucose oxidase immobilized by chitosan film on Prussian Blue layer has been developed. The experimental results show that the optimum detection potential is 50 mV (versus Ag/AgCl) and the optimum pH...

  • Article
  • Open Access
1 Citations
864 Views
10 Pages

30 July 2025

Films of a Ni/Al-layered double hydroxide intercalated with reduced graphene oxide were deposited, by means of a simple and rapid electrochemical synthesis, on Pt electrodes previously submitted to a special cleaning procedure. The aim of the researc...

  • Article
  • Open Access
17 Citations
7,127 Views
13 Pages

20 April 2016

The research on intelligent bioelectrocatalysis based on stimuli-responsive materials or interfaces is of great significance for biosensors and other bioelectronic devices. In the present work, lectin protein concanavalin A (Con A) and glycoenzyme gl...

  • Article
  • Open Access
2 Citations
1,305 Views
15 Pages

12 April 2025

Background/Objectives: In this study, AuDNs/EPLE composite electrodes with hierarchical dendritic nanogold structures were fabricated using the in situ electrodeposition of gold nanoparticles through the i-t method. Methods: A conductive polymer comp...

  • Article
  • Open Access
12 Citations
3,461 Views
13 Pages

4 March 2024

Two types of low-cost reagentless electrochemical glucose biosensors based on graphite rod (GR) electrodes were developed. The electrodes modified with electrochemically synthesized platinum nanostructures (PtNS), 1,10-phenanthroline-5,6-dione (PD),...

  • Article
  • Open Access
906 Views
19 Pages

22 October 2025

Diabetes is a metabolic disorder characterized by persistent hyperglycemia, with its incidence steadily rising worldwide. Blood glucose monitoring is a core measure in diabetes management, and continuous glucose monitoring provides more comprehensive...

  • Article
  • Open Access
2 Citations
1,564 Views
13 Pages

Exploring the Photocatalytic Efficiency of Gold Nanoparticles Deposited on Ni-Al-Zr-Layered Double Hydroxides for Selective Glucose Oxidation

  • Nihel Dib,
  • Frédéric Sauvage,
  • Lucie Quéhon,
  • Khadidja Khaldi,
  • Sumeya Bedrane,
  • José Juan Calvino,
  • Redouane Bachir,
  • Ginesa Blanco and
  • Gwladys Pourceau

24 December 2024

Confronting escalating challenges in energy security and environmental sustainability has intensified interest in renewable sources for fuels and chemicals. Among the most promising alternatives, sugars derived from biomass are emerging as a cornerst...

  • Article
  • Open Access
46 Citations
5,759 Views
15 Pages

Smart Microneedles with Porous Polymer Layer for Glucose-Responsive Insulin Delivery

  • Asad Ullah,
  • Hye Jin Choi,
  • Mijin Jang,
  • Sanghyun An and
  • Gyu Man Kim

A closed-loop system imitating the function of pancreatic cells, connected to microneedles (MNs) that automatically “release” insulin in response to the blood glucose (BG) levels would be highly satisfactory for improving the quality of l...

  • Article
  • Open Access
30 Citations
3,936 Views
17 Pages

2 April 2023

This study presents a glucose biosensor based on electrospun core–sheath nanofibers. Two types of film were fabricated using different electrospinning procedures. Film F1 was composed solely of core–sheath nanofibers fabricated using a mo...

  • Article
  • Open Access
16 Citations
3,079 Views
15 Pages

7 August 2022

Nowadays, the efficient conversion of plant biomass components (alcohols, carbohydrates, etc.) into more energy-intensive fuels, such as hydrogen, is one of the urgent scientific and technological problems. The present study is the first one focused...

  • Article
  • Open Access
2 Citations
2,069 Views
14 Pages

1 August 2023

High-performance non-enzymatic glucose sensor composite electrodes were prepared by loading Ni onto a boron-doped diamond (BDD) film surface through a thermal catalytic etching method. A carbon precipitate with a desired thickness could be formed on...

  • Article
  • Open Access
9 Citations
2,125 Views
14 Pages

Magnetic Nanoparticle Support with an Ultra-Thin Chitosan Layer Preserves the Catalytic Activity of the Immobilized Glucose Oxidase

  • Boris B. Tikhonov,
  • Daniil R. Lisichkin,
  • Alexandrina M. Sulman,
  • Alexander I. Sidorov,
  • Alexey V. Bykov,
  • Yury V. Lugovoy,
  • Alexey Y. Karpenkov,
  • Lyudmila M. Bronstein and
  • Valentina G. Matveeva

17 April 2024

Here, we developed magnetically recoverable biocatalysts based on magnetite nanoparticles coated with an ultra-thin layer (about 0.9 nm) of chitosan (CS) ionically cross-linked by sodium tripolyphosphate (TPP). Excessive CS amounts were removed by mu...

  • Article
  • Open Access
27 Citations
8,774 Views
8 Pages

Self-Assembled Films of Dendrimers and Metallophthalocyanines as FET-Based Glucose Biosensors

  • Nirton C.S. Vieira,
  • Alessandra Figueiredo,
  • Alvaro A.A. De Queiroz,
  • Valtencir Zucolotto and
  • Francisco E.G. Guimarães

3 October 2011

Separative extended gate field effect transistor (SEGFET) type devices have been used as an ion sensor or biosensor as an alternative to traditional ion sensitive field effect transistors (ISFETs) due to their robustness, ease of fabrication, low cos...

  • Article
  • Open Access
53 Citations
19,830 Views
14 Pages

Sensing of Salivary Glucose Using Nano-Structured Biosensors

  • Yunqing Du,
  • Wenjun Zhang and
  • Ming L. Wang

17 March 2016

The anxiety and pain associated with frequent finger pricking has always been troublesome for diabetics measuring blood glucose (BG) in their daily lives. For this reason, a reliable glucose monitoring system that allows noninvasive measurements is h...

  • Feature Paper
  • Article
  • Open Access
1,363 Views
12 Pages

Comparative Study on Structural Differences in Monosaccharide Layers Using PLD and PED Techniques

  • Agata Niemczyk,
  • Agata Goszczyńska,
  • Dariusz Moszyński,
  • Paweł Figiel,
  • Sebastian Fryska and
  • Jolanta Baranowska

28 October 2024

To demonstrate the feasibility of obtaining low-molecular-weight organic films (below 200 Da) using non-solvent PVD processes, glucose layers were produced via pulsed laser deposition (PLD) and pulsed electron beam deposition (PED) methods. Glucose w...

  • Article
  • Open Access
3 Citations
4,662 Views
11 Pages

RETRACTED: Advanced Binder-Free Electrode Based on CuCo2O4 Nanowires Coated with Polypyrrole Layer as a High-Performance Nonenzymatic Glucose Sensing Platform

  • Mohammad Rafe Hatshan,
  • Sadia Aslam,
  • Dmitry Bokov,
  • Ahmed Jaber Ibrahim,
  • Yasser Fakri Mustafa,
  • Afshin Davarpanah,
  • Marischa Elveny and
  • Shafaqat Ali

28 November 2021

In this work, the CuCo2O4 nanowires (CuCo2O4 NWs) were grown on carbon cloth electrode (CCE) and then coated with polypyrrole (pPy) layer (CuCo2O4 NWs-pPy@CCE). The morphology and structure characterization of as-prepared CuCo2O4 NWs-pPy@CCE were car...

  • Article
  • Open Access
19 Citations
3,926 Views
14 Pages

Reusable TiN Substrate for Surface Plasmon Resonance Heterodyne Phase Interrogation Sensor

  • Ru-Jing Sun,
  • Hung Ji Huang,
  • Chien-Nan Hsiao,
  • Yu-Wei Lin,
  • Bo-Huei Liao,
  • Yuan-Fong Chou Chau and
  • Hai-Pang Chiang

A TiN-based substrate with high reusability presented high-sensitivity refractive index measurements in a home-built surface plasmon resonance (SPR) heterodyne phase interrogation system. TiN layers with and without additional inclined-deposited TiN...

  • Retraction
  • Open Access
1 Citations
1,363 Views
2 Pages

RETRACTED: Hatshan et al. Advanced Binder-Free Electrode Based on CuCo2O4 Nanowires Coated with Polypyrrole Layer as a High-Performance Nonenzymatic Glucose Sensing Platform. Coatings 2021, 11, 1462

  • Mohammad Rafe Hatshan,
  • Sadia Aslam,
  • Dmitry Bokov,
  • Ahmed Jaber Ibrahim,
  • Yasser Fakri Mustafa,
  • Afshin Davarpanah,
  • Marischa Elveny and
  • Shafaqat Ali

The Coatings Editorial Office retracts the article entitled “Advanced Binder-Free Electrode Based on CuCo2O4 Nanowires Coated with a Polypyrrole Layer as a High-Performance Nonenzymatic Glucose Sensing Platform” [...]

  • Article
  • Open Access
29 Citations
6,109 Views
16 Pages

28 December 2018

In this study, three-dimensional glucose/graphene-based aerogels (G/GAs) were synthesized using the hydrothermal reduction and CO2 activation method. Graphene oxide (GO) was used as a matrix, and glucose was used as a binder for the orientation of th...

  • Article
  • Open Access
20 Citations
5,758 Views
17 Pages

21 September 2019

A simple, low-cost technique has been developed for the rapid fabrication of single-layered paper-based microfluidic devices (μPADs). This technique, for the first time, made use of the deposition of patterned adhesive tape into the filter paper t...

  • Article
  • Open Access
3 Citations
2,407 Views
14 Pages

Glucose Sensor Using Sol–Gel Coating Layer Deposited on PMMA Optical Fiber: An Enzyme Activity Measurement System

  • Jorge-A. Ortega-Contreras,
  • Edgar Alvarado-Méndez,
  • Guillermo Almanza-Rodríguez,
  • María del Carmen Hernández and
  • Luis Celaya-García

27 July 2023

In the present work, a biocatalytic glucose optical sensor produced by immobilizing glucose oxidase (GOD) as a recognition molecule over a PMMA (polymethylmethacrylate) optical fiber is introduced. An enzymatic encapsulation process was carried out u...

  • Article
  • Open Access
1 Citations
912 Views
17 Pages

19 November 2025

To meet the demand for rapid and accurate glucose determination in clinical diagnostics, food testing, and related fields, this study developed a high-performance electrochemical glucose biosensor based on multi-walled carbon nanotubes/Prussian blue/...

  • Article
  • Open Access
12 Citations
2,364 Views
11 Pages

Retinal Microvascular and Neuronal Changes Are Also Present, Even If Differently, in Adolescents with Type 1 Diabetes without Clinical Diabetic Retinopathy

  • Elisabetta Pilotto,
  • Tommaso Torresin,
  • Francesca Leonardi,
  • Joaquin Gutierrez De Rubalcava Doblas,
  • Giulia Midena,
  • Carlo Moretti and
  • Edoardo Midena

8 July 2022

The purpose of this study was to evaluate retinal changes in adolescents with childhood-onset, long-lasting type 1 diabetes mellitus (T1D). Patients and healthy controls (HC) underwent optical coherence tomography (OCT) and OCT-angiography (OCTA). In...

  • Article
  • Open Access
33 Citations
6,268 Views
18 Pages

29 July 2020

Glucose concentration is an important parameter in biomedicine since glucose is involved in many metabolic pathways in organisms. Many methods for glucose detection have been developed for use in various applications, particularly in the field of hea...

  • Article
  • Open Access
2,426 Views
18 Pages

Glucose Sensor Design Based on Monte Carlo Simulation

  • Gang Xue,
  • Ruiping Zhang,
  • Yihao Chen,
  • Wei Xu and
  • Changxing Zhang

4 January 2025

Continuous glucose monitoring based on the minimally invasive implantation of glucose sensor is characterized by high accuracy and good stability. At present, glucose concentration monitoring based on fluorescent glucose capsule sensor is a new devel...

  • Article
  • Open Access
39 Citations
6,634 Views
15 Pages

Developing an Individual Glucose Prediction Model Using Recurrent Neural Network

  • Dae-Yeon Kim,
  • Dong-Sik Choi,
  • Jaeyun Kim,
  • Sung Wan Chun,
  • Hyo-Wook Gil,
  • Nam-Jun Cho,
  • Ah Reum Kang and
  • Jiyoung Woo

12 November 2020

In this study, we propose a personalized glucose prediction model using deep learning for hospitalized patients who experience Type-2 diabetes. We aim for our model to assist the medical personnel who check the blood glucose and control the amount of...

  • Article
  • Open Access
34 Citations
10,306 Views
13 Pages

6 January 2018

A cuprous oxide (Cu2O) thin layer served as the base for a non-enzymatic glucose sensor in an alkaline medium, 0.1 NaOH solution, with a linear range of 50–200 mg/dL using differential pulse voltammetry (DPV) measurement. An X-ray photoelectron spect...

  • Article
  • Open Access
11 Citations
3,879 Views
14 Pages

29 August 2019

In the past, high-κ dielectrics gained much attention because of the constant demand for increasingly smaller semiconductors. At the same time, in the field of optical sensing, high-κ dielectrics are key materials. This study presents the experimenta...

  • Review
  • Open Access
92 Citations
17,180 Views
21 Pages

Glucose Oxidase-Based Glucose-Sensitive Drug Delivery for Diabetes Treatment

  • Li Zhao,
  • Liyan Wang,
  • Yuhan Zhang,
  • Shanshan Xiao,
  • Fei Bi,
  • Jianyu Zhao,
  • Guangqing Gai and
  • Jianxun Ding

29 June 2017

The glucose-sensitive drug delivery systems based on glucose oxidase (GOD), which exhibit highly promising applications in diabetes therapy, have attracted much more interest in recent years. The self-regulated drug delivery systems regulate drug rel...

  • Article
  • Open Access
4 Citations
3,050 Views
15 Pages

Cultivation of Saccharomyces cerevisiae with Feedback Regulation of Glucose Concentration Controlled by Optical Fiber Glucose Sensor

  • Lucie Koštejnová,
  • Jakub Ondráček,
  • Petra Majerová,
  • Martin Koštejn,
  • Gabriela Kuncová and
  • Josef Trögl

14 January 2021

Glucose belongs among the most important substances in both physiology and industry. Current food and biotechnology praxis emphasizes its on-line continuous monitoring and regulation. These provoke increasing demand for systems, which enable fast det...

  • Article
  • Open Access
12 Citations
4,039 Views
10 Pages

29 September 2022

Diabetes is a serious health condition that requires patients to regularly monitor their blood glucose level, making the development of practical, compact, and non-invasive techniques essential. Optical glucose sensors—and, specifically, NIR se...

  • Article
  • Open Access
3 Citations
1,940 Views
13 Pages

Study of a Sensitive and Selective Electrochemical Biosensor for Glucose Based on Bi2Ru2O7 Pyrochlore Clusters Combined with MWCNTs

  • Jelena Isailović,
  • Aleksandra Dapčević,
  • Milan Žunić,
  • Matjaž Finšgar,
  • Kristijan Vidović,
  • Nikola Tasić and
  • Samo B. Hočevar

The development of sensitive, selective, and reliable glucose biosensors remains a persistent challenge in clinical diagnostics. In this study, we exploited the advantageous (electro)catalytic properties of bismuth ruthenate (Bi2Ru2O7) pyrochlore clu...

  • Article
  • Open Access
36 Citations
4,441 Views
14 Pages

14 August 2022

In this study, graphite rod (GR) electrodes were electrochemically modified by dendritic gold nanostructures (DGNs) followed by immobilization of glucose oxidase (GOx) in the presence of mediator phenazine methosulfate (PMS). Modified with polyanilin...

  • Article
  • Open Access
10 Citations
2,572 Views
10 Pages

3 October 2022

Flexible enzyme-free glucose sensors have attracted widespread attention due to their importance and potential applications in clinical diagnosis, flexible wearable devices, and implanted devices in vivo. At present, there are still major problems in...

  • Article
  • Open Access
5 Citations
2,986 Views
15 Pages

Microwave Antenna Sensing for Glucose Monitoring in a Vein Model Mimicking Human Physiology

  • Youness Zaarour,
  • Fatimazahrae El Arroud,
  • Tomas Fernandez,
  • Juan Luis Cano,
  • Rafiq El Alami,
  • Otman El Mrabet,
  • Abdelouheb Benani,
  • Abdessamad Faik and
  • Hafid Griguer

30 April 2025

Non-invasive glucose monitoring has become a critical area of research for diabetes management, offering a less intrusive and more patient-friendly alternative to traditional methods such as finger-prick tests. This study presents a novel approach us...

  • Article
  • Open Access
11 Citations
2,652 Views
16 Pages

13 July 2023

Reagentless electrochemical glucose biosensors were developed and investigated. A graphite rod (GR) electrode modified with electrochemically synthesized dendritic gold nanostructures (DGNs) and redox mediators (Med) such as ferrocenecarboxylic acid...

  • Communication
  • Open Access
13 Citations
3,594 Views
11 Pages

Polyethylene Glycol Functionalized Silicon Nanowire Field-Effect Transistor Biosensor for Glucose Detection

  • Yan Zhu,
  • Qianhui Wei,
  • Qingxi Jin,
  • Gangrong Li,
  • Qingzhu Zhang,
  • Han Xiao,
  • Tengfei Li,
  • Feng Wei and
  • Yingchun Luo

2 February 2023

Accurate monitoring of blood glucose levels is crucial for the diagnosis of diabetes patients. In this paper, we proposed a simple “mixed-catalyzer layer” modified silicon nanowire field-effect transistor biosensor that enabled direct det...

  • Article
  • Open Access
2 Citations
2,410 Views
10 Pages

2 September 2023

Various generations of membrane vesicles (MV) have been observed in Escherichia coli in terms of triggering events and populations of single-layered (s)/multi-layered (m) forms. Previously, we proposed a novel mechanism for MV generation triggered by...

  • Article
  • Open Access
3 Citations
981 Views
19 Pages

The priming effect (PE), a microbially mediated process, critically regulates the balance between carbon sequestration and mineralization. This study used soils from different soil depths (0–20 cm, 20–40 cm, and 40–60 cm) under Pice...

  • Article
  • Open Access
9 Citations
2,631 Views
12 Pages

5 December 2023

A Ag@AuNP-functionalized capillary-based surface-enhanced Raman scattering (SERS) sensing platform for the interference-free detection of glucose using SERS tags with a built-in nitrile signal has been proposed in this work. Capillary-based SERS capt...

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