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Polymers 2017, 9(7), 255;

Glucose Oxidase-Based Glucose-Sensitive Drug Delivery for Diabetes Treatment

Laboratory of Building Energy-Saving Technology Engineering, College of Material Science and Engineering, Jilin Jianzhu University, Changchun 130118, Jilin, China
Department of Endocrinology, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin, China
School of Phermaceuticel Science and Technology, Dalian University of Technology, Dalian 116024, Liaoning, China
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin, China
Authors to whom correspondence should be addressed.
Academic Editors: Chih-Feng Huang, Jinlian Hu and Rui Xiao
Received: 12 May 2017 / Revised: 19 June 2017 / Accepted: 25 June 2017 / Published: 29 June 2017
(This article belongs to the Special Issue Functionally Responsive Polymeric Materials)
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The glucose-sensitive drug delivery systems based on glucose oxidase (GOD), which exhibit highly promising applications in diabetes therapy, have attracted much more interest in recent years. The self-regulated drug delivery systems regulate drug release by glucose concentration automatically and continuously to control the blood glucose level (BGL) in normoglycemic state. This review covers the recent advances at the developments of GOD-based glucose-sensitive drug delivery systems and their in vivo applications for diabetes treatment. The applications of GOD-immobilized platforms, such as self-assembly layer-by-layer (LbL) films and polymer vesicles, cross-linking hydrogels and microgels, hybrid mesoporous silica nanoparticles, and microdevices fabricated with insulin reservoirs have been surveyed. The glucose-sensitive drug delivery systems based on GOD are expected to be a typical candidate for smart platforms for potential applications in diabetes therapy. View Full-Text
Keywords: glucose oxidase; glucose sensitivity; drug delivery; diabetes therapy glucose oxidase; glucose sensitivity; drug delivery; diabetes therapy

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Zhao, L.; Wang, L.; Zhang, Y.; Xiao, S.; Bi, F.; Zhao, J.; Gai, G.; Ding, J. Glucose Oxidase-Based Glucose-Sensitive Drug Delivery for Diabetes Treatment. Polymers 2017, 9, 255.

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