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  • Article
  • Open Access
60 Views
19 Pages

31 October 2026

Background/Objectives: High in-domain accuracy of diabetic retinopathy (DR) grading models does not guarantee a similar performance for a new population. We quantify how an APTOS-trained grader degrades on an independent cohort and examine why. Metho...

(This article belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)
  • Article
  • Open Access
237 Views
20 Pages

Cross-Dataset Generalization of Deep Learning for Retinal Vessel Segmentation in Fundus Images: External Evaluation from DRIVE to CHASE_DB1

  • Rashid Abbasi,
  • Oyewale Ibrahim Abdulrasheed,
  • Madiha Jabeen Abbasi,
  • Md Belal Bin Heyat and ,
  • Farhan Amin,
  • Isabel de la Torre,
  • Mirtha Silvana Garat de Marin and
  • Eduardo Silva Alvarado
  • + 3 authors+ 0 author

Automated retinal vessel segmentation can support quantitative analysis of fundus photographs and facilitate measurement of vascular characteristics associated with ocular and systemic disease. Although deep-learning methods achieve high segmentation...

(This article belongs to the Special Issue Deep Learning in Medical Applications: Challenges and Opportunities)
  • Article
  • Open Access
1,137 Views
22 Pages

Background: Artificial intelligence (AI) has shown promise in breast ultrasound image analysis, but most evidence still comes from single-dataset studies. Clinical translation requires evaluation under heterogeneous acquisition and curation condition...

(This article belongs to the Special Issue AI‑Driven Innovations in Medical Imaging)
  • Article
  • Open Access
639 Views
35 Pages

16 September 2026

Breast cancer remains a major global health concern, making accurate lesion assessment essential for effective clinical decision making. Deep learning has shown promising performance in breast ultrasound analysis, yet models evaluated on data from th...

  • Article
  • Open Access
665 Views
41 Pages

19 August 2026

Background/Objectives: Artificial intelligence (AI) models for glaucoma screening using colour fundus photography have shown strong internal performance; however, their external validity and calibration reliability remain uncertain. This study develo...

(This article belongs to the Special Issue Glaucoma: Advances in Diagnosis, Management, and Vision Preservation)
  • Article
  • Open Access
203 Views
26 Pages

17 October 2026

Background/Objectives: Automated phonocardiogram (PCG) analysis is a candidate tool for scaling up cardiac auscultation, but the internal accuracy reported in many studies may not reflect performance when a model is applied to recordings from a diffe...

(This article belongs to the Special Issue Artificial Intelligence and Machine Learning in Cardiovascular Disease: Diagnosis, Risk Stratification, and Prognosis)
  • Systematic Review
  • Open Access
948 Views
48 Pages

Background/Objectives: Artificial intelligence is increasingly applied to dental imaging, yet favorable internal performance does not necessarily indicate clinical transferability. This systematic review evaluated whether imaging-based dental artific...

  • Article
  • Open Access
2 Citations
957 Views
31 Pages

With the large-scale deployment of Internet of Things (IoT) devices in smart homes, smart healthcare, and industrial internet scenarios, network attacks against IoT environments have become increasingly sophisticated, making reliable intrusion detect...

(This article belongs to the Section Computer Science & Engineering)
  • Article
  • Open Access
287 Views
32 Pages

11 October 2026

Breast cancer remains one of the most serious diseases threatening human health globally. To address diagnostic subjectivity and insufficient classification granularity in pathological screening, this study proposes a lightweight complementary convol...

(This article belongs to the Section Computing and Artificial Intelligence)
  • Article
  • Open Access
495 Views
36 Pages

BHM-IDS: Behavior-Driven Hierarchy and Multi-Dataset Training for Cross-Dataset Generalization

  • Mounira Zekiouk,
  • Madjed Bencheikh Lehocine,
  • Yehya Bouzeraa,
  • Ahlam Bouanane and ,
  • Georgi Hristov and
  • Plamen Zahariev
  • + 1 author+ 0 author

7 August 2026

Digital infrastructures are increasingly exposed to diverse and evolving cyber threats, highlighting the need for robust intrusion detection systems (IDSs). Although machine learning (ML)-based IDSs have achieved strong performance, most existing fra...

  • Article
  • Open Access
8 Citations
1,425 Views
33 Pages

28 January 2026

Epilepsy affects over 50 million people worldwide, yet automated seizure detection systems either achieve moderate sensitivity with excessive false alarms or rely on uninterpretable deep networks. This study presents a patient-independent EEG-based s...

(This article belongs to the Special Issue Multimodal Human Behavior Understanding in Human–AI Interaction: Sensor-Based Signal Processing and Interaction Techniques)
  • Article
  • Open Access
2 Citations
861 Views
32 Pages

Background: Diabetic cardiomyopathy (DCM) is characterized by metabolic dysfunction, inflammation, extracellular matrix (ECM) remodeling, and myocardial fibrosis. Increasing evidence suggests that ferroptosis-associated oxidative injury may contribut...

(This article belongs to the Section Drug Discovery, Development and Delivery)
  • Article
  • Open Access
2 Citations
786 Views
32 Pages

H-FuseNet: A Hybrid Multi-Representation Fusion Framework for Robust Misinformation Detection

  • Abdullah,
  • Muhammad Ateeb Ather,
  • Kinza Sardar,
  • Zulaikha Fatima and ,
  • Grigori Sidorov,
  • Carlos Guzmán Sánchez-Mejorada,
  • Rolando Quintero Téllez and
  • Miguel Jesús Torres Ruiz
  • + 3 authors+ 0 author

This study investigates automated fake news detection as a reliability-oriented text classification problem in dynamic digital information environments. We propose H-FuseNet, a hybrid multi-representation fusion framework that combines pretrained tra...

(This article belongs to the Special Issue Knowledge Discovery and Extraction with Large Language Models, Retrieval-Augmented Generation, and Autonomous Agents: Methods, Architectures, and Applications)
  • Article
  • Open Access
171 Views
22 Pages

10 October 2026

Cross-dataset nucleus instance segmentation requires robust separation of touching nuclei despite changes in tissue appearance. We introduce contact-aware multi-granular instance geometry prototypes (CA-MIGP), a training-time objective that assigns s...

(This article belongs to the Special Issue Advances in Data Security: Challenges, Technologies, and Applications)
  • Article
  • Open Access
1 Citations
552 Views
28 Pages

Breast cancer screening is a fundamentally probabilistic diagnostic task that requires precise identification of complex imaging characteristics from diverse patient cohorts. Despite improvements in deep learning techniques, current automatic tools a...

(This article belongs to the Special Issue Next-Generation Machine Learning and Deep Learning Models for Complex Data, Vision, and Intelligent Applications)
  • Article
  • Open Access
764 Views
21 Pages

Cross-Dataset Generalization of Deep Learning-Based Detectors for Intracranial Hemorrhage Subtype Localization on Noncontrast Head CT: A Comparative Study

  • Chiao-Hua Lee,
  • Hikam Muzakky,
  • Cheng-En Juan,
  • Chia-Ching Chang and ,
  • Ya-Hui Li,
  • Tung-Yang Lee,
  • Cheng-Hsuan Juan,
  • Ming-Ting Tsai and
  • Chun-Jung Juan
  • + 4 authors+ 0 author

Background/Objectives: To evaluate the effect of detector architecture and dataset characteristics on intracranial hemorrhage (ICH) subtype localization on noncontrast head CT, with emphasis on bidirectional cross-dataset generalization. Methods: Thi...

(This article belongs to the Special Issue Advanced Imaging and Theranostics in Neurological Diseases)
  • Article
  • Open Access
323 Views
26 Pages

30 August 2026

Pulmonary nodule malignancy classification requires effective integration of heterogeneous imaging features and contextual information among nodules. Existing models mainly analyze nodules independently and may overlook inter-nodule relationships. We...

(This article belongs to the Topic Applications of Image and Video Processing in Medical Imaging)
  • Article
  • Open Access
1 Citations
569 Views
32 Pages

Background: Rare neurological diseases are challenging to diagnose from brain MRI because of their low prevalence, heterogeneous imaging patterns, and limited annotated datasets. Deep learning may support image-level recognition, but results from cur...

(This article belongs to the Special Issue Advances in Diagnostic Imaging and Interpretation in Pediatric Radiology)
  • Article
  • Open Access
3 Citations
1,859 Views
26 Pages

Phishing URL Detection Using Transformer-Based Architecture and Contextual Content Features

  • Emad-ul-Haq Qazi,
  • Muhammad Hamza Faheem and
  • Abdulrazaq Almorjan

Phishing sites are increasingly causing harm to consumers, commercial enterprises, and the online infrastructure. Online safety is dependent on how well these evil sites can be detected in time and correctly. A number of solutions that exist are base...

(This article belongs to the Topic Artificial Intelligence Models, Tools and Applications: 2nd Edition)
  • Article
  • Open Access
1 Citations
906 Views
22 Pages

Background/Objectives: This study proposes CMT-BUSNet, a hybrid architecture integrating CNN, Mamba, and Transformer branches for breast ultrasound tumor segmentation with built-in explainability. Methods: CMT-BUSNet employs a CNN-anchored hierarchic...

(This article belongs to the Special Issue Artificial Intelligence in Medical Image Analysis and Clinical Decision Support)
  • Article
  • Open Access
598 Views
24 Pages

Gut microbiota dysbiosis has been associated with ischemic stroke (IS), myocardial infarction (MI), and aging, but whether these contexts share reproducible microbial features remains unclear. We conducted an exploratory and hypothesis-generating des...

(This article belongs to the Special Issue Gut Microbiota and Host Immune Interactions in Inflammatory Diseases)
  • Article
  • Open Access
243 Views
51 Pages

Melanoma accounts for a small fraction of skin cancer cases but for the majority of skin-cancer-related deaths, making accurate early detection essential. Although deep learning-based dermoscopic image analysis has shown strong diagnostic potential,...

(This article belongs to the Section Biological Optimisation and Management)
  • Article
  • Open Access
673 Views
23 Pages

NucFuseRank: Dataset Fusion and Performance Ranking for Nuclei Instance Segmentation

  • Nima Torbati,
  • Anastasia Meshcheryakova,
  • Ramona Woitek,
  • Sepideh Hatamikia and ,
  • Diana Mechtcheriakova and
  • Amirreza Mahbod
  • + 1 author+ 0 author

Nuclei instance segmentation in hematoxylin and eosin (H&E)-stained images plays an important role in automated histological image analysis, with various applications in downstream tasks. While several machine learning and deep learning approache...

(This article belongs to the Special Issue Machine Learning-Aided Medical Image Analysis: Second Edition)
  • Article
  • Open Access
1 Citations
1,814 Views
28 Pages

12 February 2026

Background/Objectives: The precise classification of non-small-cell lung cancer (NSCLC) into lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) has important role in treatment decisions and in prognosis. Proper subtyping ensures that...

(This article belongs to the Special Issue Artificial Intelligence and Machine Learning in Lung Cancer)
  • Systematic Review
  • Open Access
944 Views
18 Pages

Background: Artificial intelligence (AI)-driven gait analysis using plantar pressure and ground reaction force (GRF) signals may provide objective digital biomarkers for rehabilitation, but clinical translation remains uncertain. This scoping review...

(This article belongs to the Special Issue Artificial Intelligence in Gait Analysis and Rehabilitation)
  • Article
  • Open Access

DUET-Net: A Deformable CNN–Transformer with Calibrated Dual Uncertainty for Brain Tumor MRI Classification

  • Md Ariful Islam Mozumder,
  • Proloy Kumar Mondal,
  • Hee Cheol Kim and
  • Suliman Aladhadh

2 November 2026

Background: Magnetic resonance imaging (MRI) is a primary modality for brain tumor diagnosis and treatment planning, making accurate automated classification critically important. However, existing deep learning approaches face limitations in predict...

(This article belongs to the Special Issue Artificial Intelligence in Diagnostics: From Algorithms to Clinical Impact)
  • Article
  • Open Access
573 Views
27 Pages

28 July 2026

Cross-dataset pothole segmentation is difficult because illumination, camera characteristics, asphalt texture, and boundary quality vary between training and deployment environments. This study proposes PotholeBAF-Net, an EfficientNet-B3 encoder&ndas...

(This article belongs to the Special Issue AI and Fusion Methods for Urban and Medical Sensing)
  • Article
  • Open Access
2 Citations
641 Views
25 Pages

This study proposes TPA-ConvNeXt, a ConvNeXt-Small-based deep learning architecture for retinal image classification using a phase-based trigonometric attention mechanism. The proposed Trigonometric Phase Attention (TPA) block recalibrates feature ma...

(This article belongs to the Special Issue Machine Learning in Biomedical Research: Application, Innovation and Exploration)
  • Article
  • Open Access
285 Views
30 Pages

9 October 2026

Background: Deep learning approaches, especially convolutional neural networks (CNNs) and Vision Transformers (ViTs), have made substantial progress in breast cancer classification from histopathological images. Yet, previous CNN–ViT-based arch...

(This article belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)
  • Article
  • Open Access
1,095 Views
28 Pages

Objectives: Accurate severity classification is important for sensor-based assessment of Parkinson’s disease, but overlap between adjacent stages and class imbalance can reduce model robustness. This study aimed to develop and evaluate a dual-t...

(This article belongs to the Special Issue AI for Precision Diagnostics: Enhancing Accuracy, Accessibility, and Outcomes)
  • Article
  • Open Access
3 Citations
665 Views
30 Pages

23 April 2026

Accurate prediction of ultra-high-performance concrete (UHPC) compressive strength is essential for optimizing mixture design and reducing experimental iterations. Existing machine learning approaches suffer from limited algorithm diversity, insuffic...

(This article belongs to the Section B: Mathematics)
  • Article
  • Open Access
80 Views
32 Pages

FDNet: A Lightweight Feature-Dominated U-Net for Hippocampus Segmentation in Brain MRI

  • Mehmet Halis Korkmaz,
  • Özkan Bingöl and
  • the Alzheimer’s Disease Neuroimaging Initiative

29 October 2026

Background/Objectives: Hippocampus segmentation in brain MRI is challenging because the structure is small, irregularly shaped, and poorly contrasted against surrounding tissue. Increasingly complex U-Net variants improve accuracy at computational co...

(This article belongs to the Special Issue 4th Edition: AI/ML-Based Medical Image Processing and Analysis)
  • Systematic Review
  • Open Access
2 Citations
762 Views
16 Pages

Explainable Artificial Intelligence in Mammography: A Systematic Review of Methods, Evaluation Practices, and Clinical Readiness

  • Filippo Pesapane,
  • Anna Rotili,
  • Silvia Penco,
  • Valeria Dominelli and ,
  • Francesca Priolo,
  • Irene Marinucci,
  • Luca Nicosia,
  • Roberto Grasso,
  • Gabriella Pravettoni and
  • Enrico Cassano
  • + 5 authors+ 0 author

Background: Explainable artificial intelligence (XAI) is increasingly proposed to improve trust in mammography-based artificial-intelligence systems, but the validity and clinical readiness of published explanations remain unclear. We aim to systemat...

(This article belongs to the Special Issue Recent Advances in Diagnostic and Interventional Radiology)
  • Article
  • Open Access
770 Views
26 Pages

Wavelet-Enhanced CNN for Breast Ultrasound Classification Under Speckle Noise

  • Ratapong Onjun,
  • Tanakorn Sritarapipat and
  • Sayan Kaennakham

Background/Objectives: Ultrasound is widely used for breast cancer screening and diagnosis, particularly in low- and middle-income settings, but its diagnostic reliability is often compromised by speckle noise that degrades lesion margins and tissue...

(This article belongs to the Special Issue AI/Machine Learning-Driven Multi-Omics Research in Oncology)
  • Article
  • Open Access
2 Citations
1,050 Views
20 Pages

Pre-Existing Heterogeneity Predicts Rare Proteostasis-Stress Programs Across Diverse Perturbations

  • Zongnan Lyu,
  • Chunxue Shao,
  • Renyu Yang,
  • Qi Yu and ,
  • Guang Yang and
  • Ziheng Wang
  • + 1 author+ 0 author

23 July 2026

Stress-associated transcriptional programs are common in single-cell perturbation data, but they are often treated as technical or experimental nuisance signals. Whether rare high-stress populations arise stochastically after perturbation or reflect...

(This article belongs to the Section Bioinformatics)
  • Article
  • Open Access
1 Citations
527 Views
20 Pages

Immune–Inflammatory Hub Genes Intersecting with a Ferroptosis-Associated Gene Set in Active Tuberculosis: A Multi-Dataset Bioinformatics Study

  • Rasha Elsayim,
  • Monerah S. M. Alqahtani,
  • Malek Hassan Ibrahim Alaaullah,
  • Reem A. Bin Suaydan and ,
  • Esra’a Abudouleh,
  • Sami Habiballa Abdalla Mohamed and
  • Nihal Almuraikhi
  • + 2 authors+ 0 author

29 August 2026

The progression of tuberculosis (TB) from a latent infection to an active disease involves intricate modifications in host immune, inflammatory, oxidative, and metabolic pathways. Ferroptosis represents a distinct form of regulated cell death that re...

(This article belongs to the Special Issue 25th Anniversary of IJMS: Updates and Advances in Molecular Microbiology)
  • Article
  • Open Access
1 Citations
1,110 Views
25 Pages

7 January 2026

Weed competition represents a primary constraint in sesame production, causing substantial yield losses typically ranging from 18 to 68% under inadequate control measures. Precise crop–weed discrimination remains challenging due to morphologica...

(This article belongs to the Collection AI, Sensors and Robotics for Smart Agriculture)
  • Article
  • Open Access
9 Citations
2,288 Views
33 Pages

An Interpretable Ensemble Transformer Framework for Breast Cancer Detection in Ultrasound Images

  • Riyadh M. Al-Tam,
  • Aymen M. Al-Hejri,
  • Fatma A. Hashim,
  • Sachin M. Narangale and ,
  • Mugahed A. Al-Antari and
  • Sarah A. Alzakari
  • + 1 author+ 0 author

20 February 2026

Background/Objectives: Early and accurate detection of breast cancer is essential for reducing mortality and improving patient outcomes. However, the manual interpretation of breast ultrasound images is challenging due to image variability, noise, an...

(This article belongs to the Special Issue Artificial Intelligence in Biomedical Imaging and Signal Processing)
  • Article
  • Open Access
415 Views
24 Pages

3 September 2026

Background: Accurate white blood cell (WBC) segmentation is important for quantitative microscopic image analysis, but conventional supervised approaches depend on labor-intensive pixel-level annotations and may exhibit reduced robustness across data...

(This article belongs to the Section Machine Learning and Artificial Intelligence in Clinical Medicine)
  • Article
  • Open Access
1 Citations
866 Views
32 Pages

Background: Accurate segmentation of white blood cells (WBCs) in peripheral blood smear images is a fundamental step in computational hematology, enabling downstream tasks such as classification, morphological assessment, and quantitative analysis. H...

(This article belongs to the Special Issue AI and Digital Health for Disease Diagnosis and Monitoring, 2nd Edition)
  • Article
  • Open Access
17 Citations
4,118 Views
17 Pages

28 May 2022

Real-time monitoring of crop responses to environmental deviations represents a new avenue for applications of remote and proximal sensing. Combining the high-throughput devices with novel machine learning (ML) approaches shows promise in the monitor...

(This article belongs to the Special Issue Remote Sensing of Vegetation Function and Traits)
  • Article
  • Open Access
5 Citations
869 Views
34 Pages

Calibrated Deep-Learning Risk Indexing and Latent Behavioural Profiling for Occupational Mental-Health Risk Assessment

  • Abuzar Khan,
  • Khalid Rehman,
  • Ahmad Junaid,
  • Abid Iqbal and ,
  • Muhammad Farooq Siddique,
  • Muhammad Ismail Mohmand and
  • Ghassan Husnain
  • + 2 authors+ 0 author

Occupational mental-health risk in knowledge-work settings is an important public-health and psychosocial-support concern because workload demands, career insecurity, limited mentoring, uneven institutional support and barriers to care can increase p...

(This article belongs to the Special Issue Computational Intelligence for Healthcare)
  • Article
  • Open Access
466 Views
19 Pages

5 September 2026

Monocular 3D human pose estimation is sensitive to depth ambiguity and upstream 2D-detector error. We investigate a detector-conditioned virtual 2D pose as an auxiliary hypothesis rather than an independent physical measurement. Joint reliability com...

(This article belongs to the Special Issue Computer Vision Based on Artificial Intelligence: Methods and Applications)
  • Review
  • Open Access
1,225 Views
47 Pages

30 August 2026

Building facades are continually exposed to weathering, material aging, hygrothermal cycling, and service-related disturbances. Cracks, delamination, spalling, and seepage can compromise durability and safety, while associated thermal anomalies provi...

(This article belongs to the Special Issue Intelligent Remote Sensing for Urban Building Health Assessment)
  • Article
  • Open Access
1,357 Views
32 Pages

Explainable Breast Cancer Detection Using Hierarchical Multi-Scale and Edge-Aware Transformer Networks

  • Maria Altaib Badawi,
  • Ehtisham Arshad,
  • Armughan Ali,
  • Oumaima Saidani and ,
  • Taoufik Saidani,
  • Zepa Yang and
  • Yunyoung Nam
  • + 2 authors+ 0 author

Breast cancer remains the leading cause of cancer-related deaths among women globally. Early detection through mammography is vital for improving survival rates; however, the large volume of medical images and subtle variations in lesion characterist...

(This article belongs to the Special Issue Recent Advances in Machine Learning and Explainable Artificial Intelligence in Biomedical Data Mining, and Disease Diagnosis Frameworks—2nd Edition)
  • Article
  • Open Access
866 Views
25 Pages

Artificial intelligence (AI) has shown strong potential in dermoscopic image classification; however, reliable clinical deployment remains challenging due to limited generalizability across populations and institutions. This challenge is further comp...

(This article belongs to the Special Issue Feature Papers in Bioelectronics: 2025–2026 Edition)
  • Article
  • Open Access
514 Views
20 Pages

Single-cell RNA sequencing (scRNA-seq) studies increasingly combine expression-based and mutation-derived signals, but small-cohort designs with repeated runs from the same biological unit can make standard cross-validation overly optimistic. We rean...

(This article belongs to the Special Issue AI, ML and Bioinformatics in Molecular Mechanisms of Human Health and Disease)
  • Article
  • Open Access
12 Citations
3,021 Views
11 Pages

Automated Detection and Measurement of Dural Sack Cross-Sectional Area in Lumbar Spine MRI Using Deep Learning

  • Babak Saravi,
  • Alisia Zink,
  • Sara Ülkümen,
  • Sebastien Couillard-Despres and ,
  • Jakob Wollborn,
  • Gernot Lang and
  • Frank Hassel
  • + 2 authors+ 0 author

Lumbar spine magnetic resonance imaging (MRI) is a critical diagnostic tool for the assessment of various spinal pathologies, including degenerative disc disease, spinal stenosis, and spondylolisthesis. The accurate identification and quantification...

(This article belongs to the Section Regenerative Engineering)
  • Article
  • Open Access
2 Citations
704 Views
24 Pages

Concrete Compressive Strength Prediction, External Benchmark Validation, and Scenario-Based Candidate Mixture Screening Using TabPFN and NSGA-II

  • Wei Chen,
  • Yinggang Liu,
  • Liukui Zhu,
  • Yinbo Zhang and ,
  • Weifei Zhao,
  • Xiaofang Zhao and
  • Baoyu Dong
  • + 2 authors+ 0 author

24 June 2026

Public concrete datasets often contain duplicate records, coupled variables, and cross-source distribution shifts, which may lead to overly optimistic model evaluation. Based on a deduplicated UCI high-performance concrete dataset (1005 samples), thi...

(This article belongs to the Special Issue AI in Construction: Automation, Optimization, and Safety)
  • Article
  • Open Access
641 Views
28 Pages

3 July 2026

Background/Objectives: Osteoporosis is a major public health concern associated with increased fracture risk and reduced quality of life if not detected at an early stage. Automated analysis of knee X-ray images using artificial intelligence has show...

(This article belongs to the Special Issue Rebuilding the Knee: From Repair to Replacement and Recovery)

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