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6,050 Results Found

  • Review
  • Open Access
18 Citations
5,933 Views
21 Pages

Research Progress of Protein-Based Bioactive Substance Nanoparticles

  • Mengqing Han,
  • Kunlun Liu,
  • Xin Liu,
  • Muhammad Tayyab Rashid,
  • Huiyan Zhang and
  • Meiyue Wang

9 August 2023

Bioactive substances exhibit various physiological activities—such as antimicrobial, antioxidant, and anticancer activities—and have great potential for application in food, pharmaceuticals, and nutraceuticals. However, the low solubility...

  • Proceeding Paper
  • Open Access
3 Citations
1,746 Views
9 Pages

Edible Films with Protein and Bioactive Compounds from Arthrospira sp.

  • Valter F. R. Martins,
  • Fátima Poças,
  • Manuela Pintado,
  • Rui M. S. C. Morais and
  • Alcina M. M. B. Morais

Arthrospira sp. is an alternative source of protein in the food chain, but it may also be considered a source of phenolic compounds with interesting properties, such as antioxidant and antimicrobial properties. In active packaging, these two properti...

  • Review
  • Open Access
3 Citations
3,022 Views
24 Pages

Bioactive Food Proteins: Bridging Nutritional and Functional Benefits with Sustainable Protein Sources

  • Manuela Machado,
  • Israel Bautista-Hérnandez,
  • Ricardo Gómez-García,
  • Sara Silva and
  • Eduardo M. Costa

29 August 2025

Bioactive food proteins play multifunctional roles in human health and functional food development. Beyond their nutritional value, these proteins contain peptide sequences capable of exerting physiological effects, such as antioxidant, anti-hyperten...

  • Article
  • Open Access
9 Citations
2,717 Views
13 Pages

Bioactive Compounds and Their Impact on Protein Modification in Human Cells

  • Ankush Prasad,
  • Claudio Rossi,
  • Renuka Ramalingam Manoharan,
  • Michaela Sedlářová,
  • Lorenzo Cangeloni,
  • Deepak Rathi,
  • Gabriella Tamasi,
  • Pavel Pospíšil and
  • Marco Consumi

Reactive oxygen species (ROS) represent a group of molecules with a signaling role that are involved in regulating human cell proliferation and differentiation. Increased ROS concentrations are often associated with the local nonspecific oxidation of...

  • Review
  • Open Access
38 Citations
6,070 Views
20 Pages

Preparation, Characteristics, and Advantages of Plant Protein-Based Bioactive Molecule Delivery Systems

  • Tongwei Guan,
  • Zhiheng Zhang,
  • Xiaojing Li,
  • Shaoning Cui,
  • David Julian McClements,
  • Xiaotian Wu,
  • Long Chen,
  • Jie Long,
  • Aiquan Jiao and
  • Chao Qiu
  • + 1 author

26 May 2022

As a renewable resource, the market trend of plant protein has increased significantly in recent years. Compared with animal protein, plant protein production has strong sustainability factors and a lower environmental impact. Many bioactive substanc...

  • Feature Paper
  • Review
  • Open Access
48 Citations
11,811 Views
20 Pages

Extraction of Novel Bioactive Peptides from Fish Protein Hydrolysates by Enzymatic Reactions

  • Rhessa Grace Guanga Ortizo,
  • Vishal Sharma,
  • Mei-Ling Tsai,
  • Jia-Xiang Wang,
  • Pei-Pei Sun,
  • Parushi Nargotra,
  • Chia-Hung Kuo,
  • Chiu-Wen Chen and
  • Cheng-Di Dong

7 May 2023

Bioactive peptides derived from fish the byproduct protein hydrolysate have wide potential as functional food ingredients. The preparation of bioactive peptides is commonly achieved via enzymatic hydrolysis; this is the most preferred method because...

  • Review
  • Open Access
36 Citations
3,947 Views
13 Pages

9 June 2022

The health effects of bioactive substances in the human body are affected by several factors, including food processing conditions, storage conditions, light and heat, among others. These factors greatly limit the stability and bioavailability of bio...

  • Review
  • Open Access
67 Citations
8,134 Views
15 Pages

Protein Hydrolysis by Subcritical Water: A New Perspective on Obtaining Bioactive Peptides

  • Carlos I. Rivas-Vela,
  • Silvia L. Amaya-Llano,
  • Eduardo Castaño-Tostado and
  • Gustavo A. Castillo-Herrera

3 November 2021

The importance of bioactive peptides lies in their diverse applications in the pharmaceutical and food industries. In addition, they have been projected as allies in the control and prevention of certain diseases due to their associated antioxidant,...

  • Review
  • Open Access
54 Citations
12,552 Views
25 Pages

Protein-Stabilized Emulsion Gels with Improved Emulsifying and Gelling Properties for the Delivery of Bioactive Ingredients: A Review

  • Yuan Xu,
  • Liping Sun,
  • Yongliang Zhuang,
  • Ying Gu,
  • Guiguang Cheng,
  • Xuejing Fan,
  • Yangyue Ding and
  • Haotian Liu

14 July 2023

In today’s food industry, the potential of bioactive compounds in preventing many chronic diseases has garnered significant attention. Many delivery systems have been developed to encapsulate these unstable bioactive compounds. Emulsion gels, a...

  • Review
  • Open Access
114 Citations
15,733 Views
22 Pages

Seaweed Protein Hydrolysates and Bioactive Peptides: Extraction, Purification, and Applications

  • Javier Echave,
  • Maria Fraga-Corral,
  • Pascual Garcia-Perez,
  • Jelena Popović-Djordjević,
  • Edina H. Avdović,
  • Milanka Radulović,
  • Jianbo Xiao,
  • Miguel A. Prieto and
  • Jesus Simal-Gandara

31 August 2021

Seaweeds are industrially exploited for obtaining pigments, polysaccharides, or phenolic compounds with application in diverse fields. Nevertheless, their rich composition in fiber, minerals, and proteins, has pointed them as a useful source of these...

  • Article
  • Open Access
25 Citations
4,511 Views
26 Pages

20 March 2023

Hypercholesterolemia remains a serious global public health concern. Previously, synthetic anti-hypercholesterolemic drugs were used for ameliorating this condition; however, long-term usage presented several side-effects. In this regard, natural pro...

  • Review
  • Open Access
8 Citations
5,418 Views
20 Pages

6 December 2024

This review explores strategies for mitigating food allergies by treating foods with biopolymers, bioactive compounds, and food-grade enzymes. Biopolymers like chitosan, alginate, and pectin show potential in reducing the allergenic properties of foo...

  • Review
  • Open Access
27 Citations
8,621 Views
24 Pages

13 November 2024

Hydrogels have a unique three-dimensional network that can create a good environment for the loading of functional compounds; hence, they have considerable potential in the delivery of bioactive substances. Natural macromolecular substances (proteins...

  • Article
  • Open Access
6 Citations
3,507 Views
26 Pages

Whey is a by-product of the production of various types of cottage cheese and cheese, casein, and coprecipitates. Conditions of milk coagulation directly affect the physico-chemical properties of whey and the formation of its protein profile. This fa...

  • Review
  • Open Access
22 Citations
5,732 Views
31 Pages

A Review of Bioactive Compound Effects from Primary Legume Protein Sources in Human and Animal Health

  • Zachary Shea,
  • Matheus Ogando do Granja,
  • Elizabeth B. Fletcher,
  • Yaojie Zheng,
  • Patrick Bewick,
  • Zhibo Wang,
  • William M. Singer and
  • Bo Zhang

The global demand for sustainable and nutritious food sources has catalyzed interest in legumes, known for their rich repertoire of health-promoting compounds. This review delves into the diverse array of bioactive peptides, protein subunits, isoflav...

  • Article
  • Open Access
17 Citations
3,792 Views
12 Pages

Protein Adsorption on SiO2-CaO Bioactive Glass Nanoparticles with Controllable Ca Content

  • Martin Kapp,
  • Chunde Li,
  • Zeqian Xu,
  • Aldo R. Boccaccini and
  • Kai Zheng

24 February 2021

Bioactive glass nanoparticles (BGNs) are emerging multifunctional building blocks for various biomedical applications. In this study, the primary aim was to develop monodispersed binary SiO2-CaO BGNs with controllable Ca content. We successfully synt...

  • Review
  • Open Access
21 Citations
7,631 Views
44 Pages

15 March 2023

This review article discusses advanced extraction methods to enhance the functionality of egg-derived peptides while reducing their allergenicity. While eggs are considered a nutrient-dense food, some proteins can cause allergic reactions in suscepti...

  • Article
  • Open Access
6 Citations
1,528 Views
16 Pages

6 December 2024

The purpose of this study was to evaluate the potential of alginate-based packaging materials with the incorporation of protein hydrolysates to improve the safety and quality of chicken meat during storage. Physicochemical parameters, microbiological...

  • Article
  • Open Access
246 Views
18 Pages

Bioactive Protein Profile and Compositional Evolution of Donkey Milk Across Lactation Reflecting Its Nutritional and Functional Food Value

  • Ana-Maria Plotuna,
  • Ionela Hotea,
  • Alexandra Ban-Cucerzan,
  • Kalman Imre,
  • Viorel Herman,
  • Ileana Nichita,
  • Ionela Popa and
  • Emil Tîrziu

12 December 2025

Donkey milk is increasingly recognized as a functional food due to its unique nutritional profile and richness in bioactive compounds. This longitudinal observational study investigated changes in both chemical composition (total solids, protein, fat...

  • Article
  • Open Access
34 Citations
5,495 Views
19 Pages

4 July 2020

Proteins from fresh New Zealand green-lipped mussels were hydrolyzed for 240 min using pepsin and alcalase. The extent of the hydrolysis, antioxidant, antimicrobial, and angiotensin-converting enzyme (ACE) inhibitory activities of each protein hydrol...

  • Article
  • Open Access
14 Citations
3,632 Views
18 Pages

Effectiveness of Sprayed Bioactive Fruit Extracts in Counteracting Protein Oxidation in Lamb Cutlets Subjected to a High-Oxygen MAP

  • D. Morcuende,
  • C. Vallejo-Torres,
  • S. Ventanas,
  • S. L. Martínez,
  • S. C. Ruiz and
  • M. Estévez

22 November 2020

High-oxygen packaging atmosphere (High-Ox-MAP) promotes meat protein oxidation and leads to texture deterioration. This study was conceived to assess the extent to which sprayed fruit extracts could inhibit the oxidative damage to proteins in lamb cu...

  • Article
  • Open Access
94 Views
15 Pages

22 December 2025

β-casein (β-CN) is the predominant casein fraction in breast milk, while current infant milk formula (IMF) contains substantially lower β-CN levels than breast milk. The impact of β-CN fortification on neonatal digestive character...

  • Article
  • Open Access
3 Citations
2,387 Views
14 Pages

Despite its increasing application in pursing potential ligands, the capacity of receptor affinity chromatography is greatly challenged as most current research studies lack a comprehensive characterization of the ligand–receptor interaction, p...

  • Review
  • Open Access
50 Citations
7,366 Views
22 Pages

Exploiting of Secondary Raw Materials from Fish Processing Industry as a Source of Bioactive Peptide-Rich Protein Hydrolysates

  • Girija Gajanan Phadke,
  • Nikheel Bhojraj Rathod,
  • Fatih Ozogul,
  • Krishnamoorthy Elavarasan,
  • Muthusamy Karthikeyan,
  • Kyung-Hoon Shin and
  • Se-Kwon Kim

25 August 2021

Developing peptide-based drugs are very promising to address many of the lifestyle mediated diseases which are prevalent in a major portion of the global population. As an alternative to synthetic peptide-based drugs, derived peptides from natural so...

  • Review
  • Open Access
29 Citations
6,304 Views
22 Pages

8 February 2022

Diet is an essential factor determining the ratio of pathogenic and beneficial gut microbiota. Hydrolysates and bioactive peptides have been described as crucial ingredients from food protein that potentially impact human health beyond their roles as...

  • Article
  • Open Access
3 Citations
3,029 Views
22 Pages

27 September 2024

Background/Objectives: Human milk is the optimal source of nutrition and protection against infection for infants. If breastfeeding is not possible, standard and hydrolyzed infant formulas (IF) are an alternative. Extensively hydrolyzed IFs (eHFs) co...

  • Article
  • Open Access
23 Citations
5,043 Views
12 Pages

27 January 2023

Bioactive peptides range in size from 2–30 amino acids and may be derived from any protein-containing biomass using hydrolysis, fermentation or high-pressure processing. Pro-peptides or cryptides result in shorter peptide sequences following di...

  • Review
  • Open Access
43 Citations
7,117 Views
20 Pages

23 August 2021

There are tens of thousands of scientific papers about flavonoids and their impacts on human health. However, despite the vast amount of energy that has been put toward studying these compounds, a unified molecular mechanism that explains their bioac...

  • Systematic Review
  • Open Access
8 Citations
5,488 Views
18 Pages

Protein Hydrolysates and Bioactive Peptides as Mediators of Blood Glucose—A Systematic Review and Meta-Analysis of Acute and Long-Term Studies

  • Arig Elbira,
  • Maryam Hafiz,
  • Alan Javier Hernández-Álvarez,
  • Michael A. Zulyniak and
  • Christine Boesch

22 January 2024

Type 2 diabetes mellitus (T2DM) is a major public health concern associated with high mortality and reduced life expectancy. Since diabetes is closely linked with lifestyle, not surprisingly, nutritional intervention and increased physical activity c...

  • Review
  • Open Access
26 Citations
8,737 Views
48 Pages

4 April 2025

The marine environment, covering over 70% of the Earth’s surface, serves as a reservoir of bioactive molecules, including peptides and proteins. Due to the unique and often extreme marine conditions, these molecules exhibit distinctive structur...

  • Review
  • Open Access
179 Citations
43,268 Views
26 Pages

5 November 2020

With the increased consumer demand for nutritional foods, it is important to develop value-added products, which will not only catch the attention of a wider consumer group but also provide greater benefits in terms of enhanced nutrition and function...

  • Review
  • Open Access
136 Citations
17,953 Views
27 Pages

Faba Bean: An Untapped Source of Quality Plant Proteins and Bioactives

  • Delphine Martineau-Côté,
  • Allaoua Achouri,
  • Salwa Karboune and
  • Lamia L’Hocine

7 April 2022

Faba beans are emerging as sustainable quality plant protein sources, with the potential to help meet the growing global demand for more nutritious and healthy foods. The faba bean, in addition to its high protein content and well-balanced amino acid...

  • Review
  • Open Access
103 Citations
10,536 Views
26 Pages

Seaweed-Derived Proteins and Peptides: Promising Marine Bioactives

  • Javier Echave,
  • Paz Otero,
  • Paula Garcia-Oliveira,
  • Paulo E. S. Munekata,
  • Mirian Pateiro,
  • Jose M. Lorenzo,
  • Jesus Simal-Gandara and
  • Miguel A. Prieto

17 January 2022

Seaweeds are a typical food of East-Asian cuisine, to which are alleged several beneficial health effects have been attributed. Their availability and their nutritional and chemical composition have favored the increase in its consumption worldwide,...

  • Review
  • Open Access
7 Citations
6,274 Views
36 Pages

Whey Proteins and Bioactive Peptides: Advances in Production, Selection and Bioactivity Profiling

  • Anna Luparelli,
  • Daniela Trisciuzzi,
  • William Matteo Schirinzi,
  • Leonardo Caputo,
  • Leonardo Smiriglia,
  • Laura Quintieri,
  • Orazio Nicolotti and
  • Linda Monaci

The whey protein (WP) fraction represents 18–20% of the total milk nitrogen content. It was originally considered a dairy industry waste, but upon its chemical characterization, it was found to be a precious source of bioactive components, grow...

  • Editorial
  • Open Access
53 Citations
8,151 Views
3 Pages

14 March 2018

By 2050, the world population is estimated to reach 9.6 billion, and this growth continues to require more food, particularly proteins. Moreover, the Westernisation of society has led to consumer demand for protein products that taste good and are co...

  • Review
  • Open Access
5 Citations
2,350 Views
23 Pages

Challenges and Advances in the Encapsulation of Bioactive Ingredients Using Whey Proteins

  • Manuel Figueiredo,
  • Zsuzsa Sárkány,
  • Fernando Rocha and
  • Pedro M. Martins

17 February 2025

Functional foods represent an emerging trend in the food industry. Fortifying foods with bioactive ingredients results in health benefits and reduces the risk of disease. Encapsulation techniques protect sensitive ingredients from degradation due to...

  • Review
  • Open Access
97 Citations
13,302 Views
25 Pages

Microalgal Proteins and Bioactives for Food, Feed, and Other Applications

  • Simona Lucakova,
  • Irena Branyikova and
  • Maria Hayes

27 April 2022

Microalgae are a known source of proteins, prebiotics, lipids, small molecules, anti-oxidants and bioactives with health benefits that can be harnessed for the development of functional foods, feeds, cosmeceuticals and pharmaceuticals. This review co...

  • Feature Paper
  • Review
  • Open Access
71 Citations
9,228 Views
22 Pages

Macroalgae as Protein Sources—A Review on Protein Bioactivity, Extraction, Purification and Characterization

  • Mariana Gordalina,
  • Helena M. Pinheiro,
  • Marília Mateus,
  • M. Manuela R. da Fonseca and
  • M. Teresa Cesário

28 August 2021

The increased demand for protein sources combined with a decrease in the available land and water resources have led to a growing interest in macroalgae as alternative protein sources. This review focuses on strategies for macroalgae protein extracti...

  • Review
  • Open Access
63 Citations
11,023 Views
47 Pages

27 July 2020

The global demand for dietary proteins and protein-derived products are projected to dramatically increase which cannot be met using traditional protein sources. Seafood processing by-products (SPBs) and microalgae are promising resources that can fi...

  • Review
  • Open Access
23 Citations
4,756 Views
15 Pages

Bioactive Peptides from Lupinus spp. Seed Proteins-State-of-the-Art and Perspectives

  • Aleksandra Garmidolova,
  • Ivelina Desseva,
  • Dasha Mihaylova and
  • Anna Lante

8 April 2022

Nowadays, the search for food-suitable plant proteins is a great challenge. In addition to their sustainability and nutritional value, the focus is more and more on possible positive interactions with human health. To date, the presence of bioactive...

  • Review
  • Open Access
33 Citations
5,716 Views
14 Pages

Oceans abound in resources of various kinds for R&D and for commercial applications. Monitoring and bioprospecting allow the identification of an increasing number of key natural resources. Macroalgae are essential elements of marine ecosystems a...

  • Review
  • Open Access
72 Citations
7,307 Views
14 Pages

Bioactive Peptides from Walnut Residue Protein

  • Xiangyang Li,
  • Manli Guo,
  • Jingtian Chi and
  • Jiangang Ma

12 March 2020

Walnut residue is a kind of high-quality plant protein resource. The bioactive peptide prepared from walnut residue has excellent health care functions such as antioxidation and antihypertensive activity, but at present, walnut residue is often regar...

  • Article
  • Open Access
54 Citations
5,968 Views
14 Pages

Sequence Identification of Bioactive Peptides from Amaranth Seed Proteins (Amaranthus hypochondriacus spp.)

  • Alexis Ayala-Niño,
  • Gabriela Mariana Rodríguez-Serrano,
  • Luis Guillermo González-Olivares,
  • Elizabeth Contreras-López,
  • Patricia Regal-López and
  • Alberto Cepeda-Saez

21 August 2019

Amaranthus hypochondriacus spp. is a commonly grown cereal in Latin America, known for its high protein content. The objective of this study was to separate and identify bioactive peptides found in amaranth seeds through enzymatically-assisted hydrol...

  • Review
  • Open Access
13 Citations
5,732 Views
21 Pages

Sustainable Isolation of Bioactive Compounds and Proteins from Plant-Based Food (and Byproducts)

  • Zakir Showkat Khan,
  • Saira Amir,
  • Tea Sokač Cvetnić,
  • Ana Jurinjak Tušek,
  • Maja Benković,
  • Tamara Jurina,
  • Davor Valinger and
  • Jasenka Gajdoš Kljusurić

9 August 2023

Plant-based food produces significantly less greenhouse gases, and due to its wealth of bioactive components and/or plant-based protein, it becomes an alternative in a sustainable food system. However, the processing and production of products from p...

  • Review
  • Open Access
2,522 Views
47 Pages

7 October 2025

The growing demand for sustainable and nutritionally balanced protein sources has intensified global interest in edible insects as an emerging alternative to conventional animal- and plant-based proteins. This review synthesizes current knowledge on...

  • Article
  • Open Access
6 Citations
3,034 Views
24 Pages

27 July 2024

Pinctada fucata meat is the main by-product of the pearl harvesting industry. It is rich in nutrition, containing a lot of protein and peptides, and holds significant value for both medicine and food. In this study, a new active protein was discovere...

  • Review
  • Open Access
62 Citations
25,370 Views
15 Pages

Cellular Disulfide Bond Formation in Bioactive Peptides and Proteins

  • Nitin A. Patil,
  • Julien Tailhades,
  • Richard Anthony Hughes,
  • Frances Separovic,
  • John D. Wade and
  • Mohammed Akhter Hossain

14 January 2015

Bioactive peptides play important roles in metabolic regulation and modulation and many are used as therapeutics. These peptides often possess disulfide bonds, which are important for their structure, function and stability. A systematic network of...

  • Article
  • Open Access
84 Citations
20,253 Views
19 Pages

25 February 2013

There has been an unprecedented demand for inexpensive plant-derived protein hydrolysates in recent years, owing to their potential nutritional applications. This review examines existing evidence regarding protein hydrolysates from agricultural crop...

  • Article
  • Open Access
3 Citations
1,475 Views
21 Pages

Biodegradable Films with Polysaccharides, Proteins, and Bioactive Compounds from Lobosphaera sp.: Antioxidant and Antimicrobial Activities

  • Valter F. R. Martins,
  • Ana I. Lopes,
  • Manuela Machado,
  • Eduardo M. Costa,
  • Tânia B. Ribeiro,
  • Fátima Poças,
  • Manuela Pintado,
  • Rui M. S. C. Morais and
  • Alcina M. M. B. Morais

11 April 2025

Microalgae are a sustainable source of bioactive compounds and nutrients that do not compete with crops for arable land. Lobosphaera sp. was used to produce biodegradable films. Bioactive compounds, polysaccharides, and proteins were extracted from t...

  • Article
  • Open Access
4 Citations
2,956 Views
9 Pages

Modification of Vegetable Proteins to Release Bioactive Peptides Able to Treat Metabolic Syndrome—In Silico Assessment

  • Diego Armando Maldonado-Torres,
  • D. Alejandro Fernández-Velasco,
  • Gema Morales-Olán,
  • Flor de Fátima Rosas-Cárdenas and
  • Silvia Luna-Suárez

10 April 2020

Metabolic syndrome comprises a cluster of diseases like hypertension, dyslipidemia, and insulin resistance, among others. Its treatment is based on lifestyle modification; however, this treatment often fails to improve metabolic syndrome indicators o...

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