Nanoparticle (NP)-mediated drug delivery (NMDD) for active targeting of diseases is a primary goal of nanomedicine. NPs have much to offer in overcoming the limitations of traditional drug delivery approaches, including off-target drug toxicity and t...
Active cancer targeting consists of the selective recognition of overexpressed biomarkers on cancer cell surfaces or within the tumor microenvironment, enabled by ligands conjugated to drug carriers. Nanoparticle (NP)-based systems are highly relevan...
Targeting nanoparticle (NP) carriers to sites of disease is critical for their successful use as drug delivery systems. Along with optimization of physicochemical properties, researchers have focused on surface modification of NPs with biological lig...
Purpose: To assess the transretinal penetration of intravitreally injected retinal multicell-derived exosomes and to develop exosome-based active targeting of choroidal neovascularization (CNV) by bioengineering with ASL, which is composed of a membr...
We present here an innovative modular and outsourced model of drug research and development for microRNA oligonucleotide therapeutics (miRNA ONTs). This model is being implemented by a biotechnology company, namely AptamiR Therapeutics, in collaborat...
Arg-Gly-Asp (RGD)-based cyclopentapeptides (cRGDs) have a high affinity towards integrin αvβ3 and αvβ5, which are overexpressed by many tumor cells. Here, curcumin-loaded silk fibroin nanoparticles (SFNs) have been functionalized on the surface with...
Effective drug delivery in oncology is challenged by a hierarchy of biological barriers—from abnormal vasculature and dense stroma to cellular immunosuppression and specialized interfaces like the blood–brain barrier. This review provides...
Breast cancer in women is one of the most common life-threatening malignancies. Despite of the development for the improved treatment, there are still many limitations to overcome. Among them, cancer stem cells (CSCs) are well known for tumor formati...
Over the past few decades, finding more efficient and selective administration routes has gained significant attention due to its crucial role in the bioavailability, absorption rate and pharmacokinetics of therapeutic substances. The pulmonary deliv...
Chromatin regulators of the Polycomb group of genes are well-known by their activities as transcriptional repressors. Characteristically, their presence at genomic sites occurs with specific histone modifications and sometimes high-order chromatin st...
High accuracy target recognition and tracking systems using a single sensor or a passive multisensor set are susceptible to external interferences and exhibit environmental dependencies. These difficulties stem mainly from limitations to the availabl...
Compounds with multitarget activity are of high interest for polypharmacological drug discovery. Such promiscuous compounds might be active against closely related target proteins from the same family or against distantly related or unrelated targets...
Due to the silent operation of the receiver station in a multistatic radar system, it is difficult for the jammer to generate the cooperative active deception target for the multistatic radar system. Making use of the spatial diversity property, a da...
Chemical probes are of central relevance for chemical biology. To unambiguously explore the role of target proteins in triggering or mediating biological functions, small molecules used as probes should ideally be target-specific; at least, they shou...
Drug nanocrystals, which are comprised of active pharmaceutical ingredients and only a small amount of essential stabilizers, have the ability to improve the solubility, dissolution and bioavailability of poorly water-soluble drugs; in turn, drug nan...
Fucoidan—a marine natural active polysaccharide derived from brown algae with a variety of medicinal activities and low toxicity—has been used as clinical drug for renal diseases for nearly 20 years. The pharmacological mechanism of fucoi...
Underwater vision research is the foundation of marine-related disciplines. The target contour extraction is significant for target tracking and visual information mining. Aiming to resolve the problem that conventional active contour models cannot e...
The task of detecting and classifying highly maneuverable and unidentified underwater targets in complex environments is significant in active sonar systems. Previous studies have applied many detection schemes to this task using signals above a pres...
Active sonar can usually only directly measure the distance and bearing information of underwater targets, and cannot directly obtain target velocity, acceleration and other information. Therefore, the amount of information is relatively small, makin...
Active targeting is a valuable and promising approach with which to enhance the therapeutic efficacy of nanodelivery systems, and the development of tumor-targeted nanoparticles has therefore attracted much research attention. In this field, the rese...
Breast cancer is one of the most frequently diagnosed tumors and the second leading cause of cancer death in women worldwide. The use of nanosystems specifically targeted to tumor cells (active targeting) can be an excellent therapeutic tool to impro...
This paper proposes a sensor node activation method using the nature-inspired algorithm (NIA) for the target coverage problem. The NIAs have been used to solve various optimization problems. This paper formulates the sensor target coverage problem in...
The active tracking technology of underwater acoustic targets is an important research direction in the field of underwater acoustic signal processing and sonar, and it has always been issued that draws researchers’ attention. The commonly used Kalma...
Proline rich 11 (PRR11), initially renowned for its relevance with cell-cycle progression, is a proline-rich protein coding gene in chromosome 17q22-23. Currently, accumulating studies have demonstrated that PRR11 plays a critical role in cellular pr...
A lot of solid tumors are characterized by uncontrolled signal transduction triggered by receptors related to cellular growth. The targeting of these cell receptors with antitumor drugs is essential to improve chemotherapy efficacy. This can be achie...
The rhodanine core is a well-known privileged heterocycle in medicinal chemistry. The rhodanines, as subtypes of thiazolidin-4-ones, show a broad spectrum of biological activity, including anticancer properties. This review aims to analyze the antica...
Antibody-cytokine fusion proteins (immunocytokines) are gaining importance for cancer therapy, but those products are often limited by systemic toxicity related to the activity of the cytokine payload in circulation and in secondary lymphoid organs....
Photodynamic therapy (PDT) is an alternative modality to conventional cancer treatment, whereby a specific wavelength of light is applied to a targeted tumor, which has either a photosensitizer or photochemotherapeutic agent localized within it. This...
Detection and classification of unidentified underwater targets maneuvering in complex underwater environments are critical for active sonar systems. In previous studies, many detection methods were applied to separate targets from the clutter using...
Predicting compounds with single- and multi-target activity and exploring origins of compound specificity and promiscuity is of high interest for chemical biology and drug discovery. We present a large-scale analysis of compound promiscuity including...
The marine environment is complex and changeable, and the interference of noise and reverberation seriously affects the classification performance of active sonar equipment. In particular, when the targets to be measured have similar characteristics,...
Precision medicine is based on innovative administration methods of active principles. Drug delivery on tissue of interest allows improving the therapeutic index and reducing the side effects. Active targeting by means of drug-encapsulated micelles d...
Cancer is the most common cause of death worldwide; therefore, there is a need to discover novel treatment modalities to combat it. One of the cancer treatments is nanoparticle technology. Currently, nanoparticles have been modified to have desirable...
Pancreatic cancer remains a recalcitrant neoplasm associated with chemoresistance and high fatality. Because it is frequently resistant to apoptosis, exploiting autophagic cell death could offer a new treatment approach. We repurpose echinomycin, an...
Deep representation learning has gained significant momentum in advancing text-dependent speaker verification (TD-SV) systems. When designing deep neural networks (DNN) for extracting bottleneck (BN) features, the key considerations include training...
Superparamagnetic iron oxide nanoparticles (SPIONs) have attracted great attention in many biomedical fields and are used in preclinical/experimental drug delivery, hyperthermia and medical imaging. In this study, biocompatible magnetite drug carrier...
O6-alkylguanine-DNA alkyltransferase (AGT) is the main cause of tumor cell resistance to DNA-alkylating agents, so it is valuable to design tumor-targeted AGT inhibitors with hypoxia activation. Based on the existing benchmark inhibitor O6-benzylguan...
Human T-cell leukemia virus type 1 (HTLV-1) is the causative agent of adult T-cell leukemia/lymphoma (ATL). The trans-activator protein Tax of HTLV-1 is thought to play a crucial role in the early-stage transformation of the virus-infected cells. Tax...
A new series of aryloxyacetic acids was prepared and tested as peroxisome proliferator-activated receptors (PPARs) agonists and fatty acid amide hydrolase (FAAH) inhibitors. Some compounds exhibited an interesting dual activity that has been recently...
Underwater target classification methods based on deep learning suffer from obvious model overfitting and low recognition accuracy in the case of small samples and complex underwater environments. This paper proposes a novel classification network (E...
During the production of 18F, as a result of the interaction of the beam of protons and secondary neutrons with the structural elements of the target body, many radionuclide impurities are created in the cyclotron. As part of this work, we theoretica...
Electric anomaly detection (EAD) has been widely used for target detection in underwater areas. However, due to the high path loss in the water, an electric anomaly is usually submerged in environmental noise and interference, which affects the detec...
Despite recent progressions in cancer genomic and immunotherapies, advanced melanoma still represents a life threat, pushing to optimise new targeted nanotechnology approaches for specific drug delivery to the tumour. To this aim, owing to their bioc...
As the performance of a convolutional neural network is logarithmically proportional to the amount of training data, data augmentation has attracted increasing attention in recent years. Although the current data augmentation methods are efficient be...
Background: The peptidyl–prolyl cis–trans isomerase PIN1 regulates multiple oncogenic and tumor-suppressive pathways and is frequently overexpressed in human cancers. Although pharmacological inhibition of PIN1 has shown antitumor potenti...
An active target is being developed to be used in low-energy nuclear astrophysics experiments. It is a position- and time-sensitive detector system based on the low-pressure Multi Wire Proportional Chamber (MWPC) technique. Methylal ((OCH3)2CH2), at...
Cancer is a complex disease affecting millions of people worldwide, with over a hundred clinically approved drugs available. In order to improve therapy, treatment, and response, it is essential to draw better maps of the targets of cancer drugs and...
This paper addresses the active target protection problem in a three-player (Target–Attacker–Defender, TAD) conflict by proposing a cooperative integrated guidance and control (IGC) strategy. Unlike previous studies that have designed gui...
Antimicrobial resistance (AMR) poses an increasing challenge to modern medicine, necessitating the search for novel therapeutic strategies. This study evaluates the synergistic antimicrobial activity of oregano essential oil (OEO) and thyme essential...
Cytochrome P450 1A is one of the vital subfamilies of heme-containing cytochrome P450 enzymes belonging to an important exogenous metabolizing CYP in human. The abnormal of endoplasmic reticulum (ER) may directly affect the functional activity of ER-...
of 1,002