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Pharmaceutics 2018, 10(1), 2;

GE11 Peptide as an Active Targeting Agent in Antitumor Therapy: A Minireview

Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy
Author to whom correspondence should be addressed.
Received: 29 October 2017 / Revised: 6 December 2017 / Accepted: 11 December 2017 / Published: 22 December 2017
(This article belongs to the Special Issue Nanotechnology Advances in Cancer Treatment)
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A lot of solid tumors are characterized by uncontrolled signal transduction triggered by receptors related to cellular growth. The targeting of these cell receptors with antitumor drugs is essential to improve chemotherapy efficacy. This can be achieved by conjugation of an active targeting agent to the polymer portion of a colloidal drug delivery system loaded with an antitumor drug. The goal of this minireview is to report and discuss some recent results in epidermal growth factor receptor targeting by the GE11 peptide combined with colloidal drug delivery systems as smart carriers for antitumor drugs. The minireview chapters will focus on explaining and discussing: (i) Epidermal growth factor receptor (EGFR) structures and functions; (ii) GE11 structure and biologic activity; (iii) examples of GE11 conjugation and GE11-conjugated drug delivery systems. The rationale is to contribute in gathering information on the topic of active targeting to tumors. A case study is introduced, involving research on tumor cell targeting by the GE11 peptide combined with polymer nanoparticles. View Full-Text
Keywords: drug targeting; antitumor drug; GE11; EGFR; colloidal drug delivery systems; nanomedicine drug targeting; antitumor drug; GE11; EGFR; colloidal drug delivery systems; nanomedicine

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Genta, I.; Chiesa, E.; Colzani, B.; Modena, T.; Conti, B.; Dorati, R. GE11 Peptide as an Active Targeting Agent in Antitumor Therapy: A Minireview. Pharmaceutics 2018, 10, 2.

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