Vav1 is normally and exclusively expressed in the hematopoietic system where it functions as a specific GDP/GTP nucleotide exchange factor (GEF), firmly regulated by tyrosine phosphorylation. Mutations and overexpression of Vav1 in hematopoietic mali...
5 May 2020
Introduction: Rheumatoid arthritis (RA) is an important public health problem because this disease often causes disability. RA is a chronic, destructive autoimmune disease that leads to joint destruction and the development of extraarticular manifest...
Pancreatic ductal adenocarcinoma (PDAC) is the most aggressive tumor malignancy worldwide, mainly due to uncontrolled metastasis. Among the numerous molecules deregulated in PDAC, different members of the Akt pathways are of great importance because...
Phosphatidylinositol–5 phosphate (PI5P) and other mono-phosphoinositides (mono-PIs) play second messenger roles in both physiological and pathological conditions. Despite this, their intracellular targets and mechanisms of action remain poorly...
Vav1 works both as a catalytic Rho GTPase activator and an adaptor molecule. These functions, which are critical for T cell development and antigenic responses, are tyrosine phosphorylation-dependent. However, it is not known whether other posttransl...
VAV1 is a hematopoietic signal transducer that possesses a GDP/GTP nucleotide exchange factor (GEF) that is tightly regulated by tyrosine phosphorylation, along with adapter protein domains, such as SH2 and SH3. Research on VAV1 has advanced over the...
The vascular response to hypoxia and ischemia is essential for maintaining homeostasis during stressful conditions and is particularly critical for vital organs such as the heart. Hypoxia-inducible factor-1 (HIF-1) is a central regulator of the respo...
Triple negative breast cancer (TNBC) represents the most aggressive breast tumor, showing a high intrinsic variability in terms of both histopathological features and response to therapies. Blocking the Akt signaling pathway is a well-studied approac...
Vav1 is a Rho/Rac (Ras-related C3 botulinum toxin substrate) guanine nucleotide exchange factor expressed in hematopoietic and endothelial cells that are involved in a wide range of cellular functions. It is also stabilized under hypoxic conditions w...
Renal cell carcinoma (RCC) is characterized by high mortality and morbidity rates. Vav guanine nucleotide exchange factors (VAVs), crucial for signal transduction between cell membrane receptors and intracellular mediators, have been implicated in ca...
Vav guanine nucleotide exchange factor 3 (Vav3), a Rho family GTPase, regulates multiple cell signaling pathways including those of T- and B-cell receptors in vertebrates through mediating the activities of the Rho family members. Whether the lamprey...
The objective of this study was to propose a control method with a ventilation requirement of variable air volume (VAV) system in multi-zone. In order to control the VAV system inmulti-zone, it is essential to control the terminal unit installed in e...
Zika virus (ZIKV) infection during pregnancy can result in a significant impact on the brain and eye of the developing fetus, termed congenital zika syndrome (CZS). At a morphological level, the main serious presentations of CZS are microcephaly and...
We have recently shown that VAV2, a guanosine nucleotide exchange factor that catalyzes the stimulation step of RHO GTPases, is involved in a stem cell-like (SCL) regenerative proliferation program that is important for the development and subsequent...
In this paper, a new calibration device for an air flow sensor of the VAV terminal unit is designed. Multi-aperture air outlets are designed to meet the calibration requirements of the air flow sensor in a variety of measurement range. The device can...
Vav proteins activate GTPases of the RhoA subfamily that regulate the cytoskeleton and are involved in adhesion, migration, differentiation, polarity and the cell cycle. While the importance of RhoA GTPases for neuronal morphology is undisputed, thei...
Buildings account for a large portion of the total energy use in the US; therefore, improving the operation of typical variable-air-volume (VAV) systems in buildings can provide a tremendous economic opportunity. ASHRAE Guideline 36 recommends a rese...
Guanosine nucleotide exchange factors (GEFs) are responsible for catalyzing the transition of small GTPases from the inactive (GDP-bound) to the active (GTP-bound) states. RHO GEFs, including VAV proteins, play essential signaling roles in a wide var...
As building systems account for almost half of the total energy consumed by the building sector to provide space heating, cooling, and ventilation, efficiently designing these systems can be the key to energy conservation in buildings. Dual VAV syste...
This study aimed to develop a new concept for an air terminal device for a VAV (variable air volume) ventilation system that would improve overall ventilation efficiency under a varying air supply volume. In VAV systems, air volume is modified accord...
Temperature measuring point is the key to room environment control. Temperature measuring points and climate changes are directly related to the room control effect. It is of great theoretical and practical significance to study the temperature measu...
To provide useful information concerning energy-conserving heating, ventilation, and air-conditioning (HVAC) systems, this study used EnergyPlus to analyze in detail their operational characteristics and energy performance. This study also aimed to u...
This study proposes an operational strategy to reduce building infiltration rates by predicting the infiltration rate in a variable air volume (VAV) system and implementing pressure control based on these predictions. To achieve this, a theoretical r...
Casein Kinase II (CK2) is a ubiquitously present serine/threonine kinase essential for mammalian development. CK2 holoenzyme is a tetramer with two highly related catalytic subunits (α or α’) and two regulatory ß subunits. Glo...
Common energy management control systems (EMCS) in building HVAC systems could be made much more energy efficient without sacrificing comfort. Most researchers have focused on implementing optimal control algorithms in Variable Air Volume (VAV) syste...
Despite stricter global energy codes, performance standards, and advanced renewable technologies, the building sector must accelerate its transition to zero carbon emissions. Many studies show that new buildings, especially non-residential ones, ofte...
This study is aimed at developing a real-time optimal control strategy for variable air volume (VAV) air-conditioning in a heating, ventilation, and air-conditioning (HVAC) system using genetic algorithms and a simulated large-scale office building....
Vav proteins play roles as guanosine nucleotide exchange factors for Rho GTPases and signaling adaptors downstream of protein tyrosine kinases. The recent sequencing of the genomes of many species has revealed that this protein family originated in c...
Genetic evidence suggests that three members of the VAV family (VAV1, VAV2 and VAV3) of signal transduction proteins could play important roles in rheumatoid arthritis. However, it is not known currently whether the inhibition of these proteins prote...
Hematopoietic cells play a crucial role in the adult retina in health and disease. Monocytes, macrophages, microglia and myeloid angiogenic cells (MACs) have all been implicated in retinal pathology. However, the role that hematopoietic cells play in...
Vav proteins act as tyrosine phosphorylation-regulated guanosine nucleotide exchange factors for Rho GTPases and as molecular scaffolds. In mammals, this family of signaling proteins is composed of three members (Vav1, Vav2, Vav3) that work downstrea...
In large public facilities, such as airport terminals or open-plan office spaces, the HVAC system typically consumes substantial amounts of energy. However, individuals often gather at specific areas while other zones are occupied by transient or occ...
Myeloid phagocytes have evolved to rapidly recognize invading pathogens and clear them through opsonophagocytic killing. The adenylate cyclase toxin (CyaA) of Bordetella pertussis and the edema toxin (ET) of Bacillus anthracis are both calmodulin-act...
The purpose of this study was to determine the annual energy consumption that can be attributed to heating, ventilation, and air conditioning (HVAC) systems’ mixing temperature error. To develop a mixing temperature prediction model for a singl...
Variable air volume (VAV) is the most common installation among heating ventilating and air conditioning (HVAC) systems. To maintain the comfort level and lessen energy utilization, there is a pressing need for its effective control. In this study, a...
This study evaluates indoor thermal comfort and the energy performance of HVAC control strategies in the Congo Zone of a zoological facility located in Poland. The main objective in this zone is to maintain adequate relative humidity, which is more c...
Most of the energy consumed by the residential and commercial buildings in the U.S. is dedicated to space cooling and heating systems, according to the U.S. Energy Information Administration. Therefore, the need for better operation mechanisms of tho...
In this study, we developed a virtual air flow sensor using an in-situ damper performance curve to secure the stability of control of the variable air volume (VAV) terminal unit, and also established the in-situ measurement procedure. The minimum air...
This research presents the design and implementation of a cascade Proportional–Integral (PI) controller tailored for a Variable Air Volume (VAV) system that was specially created and executed particularly for hospital operating rooms. The main...
Control strategies for variable-air-volume (VAV) air conditioning significantly affect both the air quality within buildings and the consumption of building energy. Current control techniques effectively regulate room temperature using feedback on te...
According to EIA, the Heating Ventilation and Air Conditioning (HAVC) systems account for about 25% of the U.S.’s total commercial building’s energy use. Therefore, advanced modeling and optimization methods of the system components and operation off...
The pathogen Helicobacter pylori is the first reported bacterial type-1 carcinogen playing a role in the development of human malignancies, including gastric adenocarcinoma. Cancer cell motility is an important process in this scenario, however, the...
Accurate measurement of air flow rate is essential in automatic building control using the variable air volume (VAV) system. In order to solve the problems of the existing air flow measurement method and improve the accuracy of air flow control, this...
As global warming accelerates due to greenhouse gas emissions, more efforts are required to reduce greenhouse gas emissions. One of the methods used to save building energy is the efficient management of building mechanical systems. The economizer co...
Climate change and the need to reduce greenhouse gas emissions have made energy efficiency in modern building operations more critical than ever. This study presents an improved damper control strategy for VAV systems, combined with techniques like D...
Crop management should be determined to reintroduce ancient wheat. This study aimed to determine: i. the response of the yield of ancient wheat on sowing density; ii. the impact of sowing density on plant health, weed infestation and pest occurrence....
This study reviewed the existing studies on the types of variable air volume (VAV) terminal units, control and operation methods, prediction models, and sensor calibration methods. As a result of analyzing the existing research trends on the system t...
Patients with cardiopulmonary failure may not be fully supported with typical configurations of extracorporeal membrane oxygenation (ECMO), either veno-arterial (VA) or veno-venous (VV). Veno-arterial-venous (VAV)-ECMO is a technique used to support...
In a commercial building, a significant amount of energy is used by the ventilation systems to condition the air for the indoor environments to satisfy the required quantity (temperature and humidity) and quality (amount of fresh air). For many years...
Dysregulation of glucose homeostasis leading to metabolic syndrome and type 2 diabetes is the cause of an increasing world health crisis. New intriguing roles have emerged for Rho family GTPases and their Rho guanine nucleotide exchange factor (GEF)...
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