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The Vav GEF Family: An Evolutionary and Functional Perspective

1
Centro de Investigación del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC) and University of Salamanca, Campus Unamuno, E37007 Salamanca, Spain
2
Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC) and University of Salamanca, Campus Unamuno, E37007 Salamanca, Spain
3
Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Consejo Superior de Investigaciones Científicas (CSIC) and University of Salamanca, Campus Unamuno, E37007 Salamanca, Spain
*
Author to whom correspondence should be addressed.
Cells 2019, 8(5), 465; https://doi.org/10.3390/cells8050465
Received: 22 April 2019 / Revised: 10 May 2019 / Accepted: 15 May 2019 / Published: 16 May 2019
(This article belongs to the Special Issue Rho GTPases in Health and Disease)
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Abstract

Vav proteins play roles as guanosine nucleotide exchange factors for Rho GTPases and signaling adaptors downstream of protein tyrosine kinases. The recent sequencing of the genomes of many species has revealed that this protein family originated in choanozoans, a group of unicellular organisms from which animal metazoans are believed to have originated from. Since then, the Vav family underwent expansions and reductions in its members during the evolutionary transitions that originated the agnates, chondrichthyes, some teleost fish, and some neoaves. Exotic members of the family harboring atypical structural domains can be also found in some invertebrate species. In this review, we will provide a phylogenetic perspective of the evolution of the Vav family. We will also pay attention to the structure, signaling properties, regulatory layers, and functions of Vav proteins in both invertebrate and vertebrate species. View Full-Text
Keywords: Rho GTPases; Dbl-homology; guanosine diphosphate to guanosine triphosphate exchange factors; protein tyrosine kinases; signaling; evolution; phosphorylation; tyrosine; animal models Rho GTPases; Dbl-homology; guanosine diphosphate to guanosine triphosphate exchange factors; protein tyrosine kinases; signaling; evolution; phosphorylation; tyrosine; animal models
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Rodríguez-Fdez, S.; Bustelo, X.R. The Vav GEF Family: An Evolutionary and Functional Perspective. Cells 2019, 8, 465.

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