The subcooling potential of a novel R717-based waste heat-driven multi-ejector chiller (HEC) integrated with an R744 refrigeration system was evaluated for use in supermarkets. The performance was compared with an R744 refrigeration system coupled to...
The R744/R404A cascade refrigeration system (CRS) has been widely used in supermarkets and hypermarkets, but due to the refrigerant regulation of R404A, research on alternative refrigerants is necessary. In addition, although there have been quite a...
This paper studies the evaporative heat transfer characteristics of R744 at low temperatures in a horizontal smooth tube as a cascade refrigeration system (CRS) among hybrid cascade refrigeration systems (HCRSs). There is a lack of research on the lo...
The cascade refrigeration systems (CRS) used in hypermarkets and supermarkets, which are used by many people, have been employing R744 for the low-temperature cycle (LTC) and R404A for the high-temperature cycle (HTC) due to environmental and public...
In the last century, the refrigerant R744 (carbon dioxide) has become an environmentally friendly solution in commercial refrigeration despite its particular issues related to the low critical temperature. The use of transcritical cycles in warm and...
The energy-saving potential of heat pump technology is widely recognized in the building sector. In retrofit applications, especially in old and historic buildings, it may be difficult to replace the existing distribution and high-temperature emissio...
In this study, the evaporation heat transfer characteristics of an intermediate temperature of R744 in a smooth horizontal tube, when operating as an indirect refrigeration system (IRS) among hybrid cascade refrigeration systems (HCRSs), are evaluate...
Plate heat exchangers (PHE) are used for a wide range of applications, thus utilizing new and unique heat sources is of crucial importance. R744 has a low critical temperature, which makes its thermophysical properties variation smoother than other s...
This paper examines the exergy efficiency and exergy destruction rate of the R744/R404A cascade refrigeration system (CRS) using an internal heat exchanger in supermarkets according to various conditions affecting the system. A refrigerant of a low-t...
This study evaluates the performance of an R744/R404A cascade refrigeration system (CRS) with internal heat exchangers (IHE) in supermarkets. R744 is used as the refrigerant in a low-temperature cycle, and R404A is used as the refrigerant in a high-t...
The heat transfer characteristics of evaporative condensers in an R744 air conditioning system were evaluated using the numerical and the experimental methods. Two configurations of condensers were studied: Case 1 with five layers of tubes and Case 2...
The object-oriented two-phase ejector hybrid reduced-order model (ROM) was developed for dynamic simulation of the R744 refrigeration system. OpenModelica software was used to evaluate the system’s performance. Moreover, the hybrid ROM results...
The cooling systems of the future tracking detectors of the ATLAS and CMS experiments at the Large Hadron Collider (LHC) at CERN will be entirely based on CO2 refrigeration technology. The system is a booster refrigeration system, composed of a two s...
In the naval sector, hydrofluorocarbons (HFCs) are the primary refrigerants in use. To face global environmental challenges, international treaties have established stringent regulations aimed at transitioning towards more sustainable alternatives. N...
R744 is the most competitive and ideal natural refrigerant when flammability and toxicity are strictly limited. However, there are still some problems when it is applied to a heating system. For example, the discharge pressure of the system exceeds 1...
The objective of this study was to investigate the cooling performance characteristics of an electrical air conditioning system using R744 as an alternative of R-134a for a fuel cell electric vehicle. In order to analyze the cooling performance chara...
Replacing electric water heaters with heat pumps significantly lowers energy consumption and greenhouse gas emissions. Among the refrigerants considered, carbon dioxide (CO2 or R744) has attracted considerable attention from refrigeration specialists...
Conventional Heating, Ventilation, and Air Conditioning (HVAC) systems in electric vehicles significantly penalize the driving range due to high power consumption, particularly during heating operation. While R744 heat pump systems are gaining tracti...
Background: Myelodysplastic syndromes (MDSs) and acute myeloid leukemia (AML) are clonal hematological disorders that share molecular origins but present with distinct clinical features. MicroRNAs (miRNAs) are key post-transcriptional regulators, and...
Specific gene and miRNA expression patterns are potential early biomarkers of harmful environmental carcinogen exposures. The aim of our research was to develop an assay panel by using several miRNAs for the rapid screening of potential carcinogens....
Glioblastoma (GBM), the most common primary brain tumor, is a complex and extremely aggressive disease. Despite recent advances in molecular biology, there is a lack of biomarkers, which would improve GBM’s diagnosis, prognosis, and therapy. He...
Background/Objectives: This study aimed to determine the potential roles of miR-4295, miR-4720-5p, miR-4773, miR-6831-5p, and miR-7161-5p in colorectal cancer by evaluating their expression levels in matched tumor and adjacent non-tumor tissues from...
It has been reported that in an oxidative environment, the flavonoid 2R,3R-dihydroquercetin (2R,3R-DHQ) oxidizes into a product that rearranges to form quercetin. As quercetin is a very potent antioxidant, much better than 2R,3R-DHQ, this would be an...
R is one of the most powerful programming languages for conducting data analysis, modeling, and visualization. Although it is widely utilized in biodiversity conservation research, the comprehensive trends in R and R package usage and patterns in the...
This paper presents the two-phase condensation heat transfer and pressure drop characteristics of R-513A as an alternative refrigerant to R-134a in a 9.52-mm OD horizontal microfin copper tube. The test facility had a straight, horizontal test sectio...
Background/Objectives: MicroRNAs (miRNAs) regulate gene expression and are proposed as biomarkers in colorectal cancer (CRC). This study evaluated miR-185-5p, miR-141-5p, and miR-21-5p expression in CRC tissues; their association with tumor location,...
With the increasing global requirements for environmental protection, refrigerants with ODP of 0 and low GWP are widely concerned and applied. In this paper, the CFD numerical method simulates the R134a centrifugal compressor directly replaced by R12...
(R,R) ZX-5 has been proven to have positive effects on choroidal blood flow without affecting the sclera and ciliary bodies in New Zealand white rabbits. This study was designed to investigate the mechanisms of (R,R) ZX-5 on improving the choroidal b...
Glioma is the common highly malignant primary brain tumor. However, the molecular pathways that result in the pathogenesis of glioma remain elusive. In this study, we found that microRNA-103 (miR-103), microRNA-195 (miR-195), or microRNA-15b (miR-15b...
The fundamental function of ribonucleic acids is to transfer genetic information from DNA to protein during translation process, however, this is not the only way connecting active RNA sequences with essential biological processes. Up until now, many...
Colorectal cancer (CRC) is the third most diagnosed cancer and a leading cause of cancer-related mortality in Morocco, often detected at late stages. Circulating microRNAs (miRNAs) have emerged as promising non-invasive biomarkers for CRC detection,...
Background: MicroRNA-133 (miR-133) has been implicated in diverse cancers as a tumor suppressor, yet the isoform-specific contributions of miR-133A1, miR-133A2, and miR-133B in colorectal cancer (CRC) remain unclear. Methods: We established stable co...
HuR regulates cytoplasmic mRNA stability and translatability, with its expression correlating with adverse outcomes in various cancers. This study aimed to assess the prognostic value and pro-oncogenic properties of HuR and its post-translational iso...
In the presented article, we define the R-norm entropy and the conditional R-norm entropy of partitions of a given fuzzy probability space and study the properties of the suggested entropy measures. In addition, we introduce the concept of R-norm div...
miRNAs, a group of short noncoding RNAs, are key regulators of fundamental cellular processes and signaling pathways. Dysregulation of miRNA expression with known oncogenic or tumor suppressor functions has been associated with neoplastic transformat...
Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD), is a group of chronic inflammatory disorders characterized by alternating episodes of flares and clinical remission, often leading to intestinal fibro...
R2R3-MYB transcription factors (TFs) participate in the modulation of plant development, secondary metabolism, and responses to environmental stresses. Ammopiptanthus nanus, a leguminous dryland shrub, tolerates a high degree of environmental stress,...
As one of the most prominent gene families, R2R3-MYB transcription factors significantly regulate biochemical and physiological processes under salt stress. However, in Sophora alopecuroides, a perennial herb known for its exceptional saline alkali r...
Background/Objectives: We have previously identified let-7f-5p, miR-10b-5p, miR-34a-5p, miR-181b-5p, and miR-181d-5p as differentially expressed between uterine leiomyoma (LM) and leiomyosarcoma (LMS) tissue samples. The present study aimed to charac...
The R2R3-MYB genes in plants play an essential role in the drought-responsive signaling pathway. Plenty of R2R3-MYB S21 and S22 subgroup genes in Arabidopsis have been implicated in dehydration conditions, yet few have been covered in terms of the ro...
Early hepatocellular carcinoma (HCC) diagnosis is challenging. Moreover, for patients with alpha-fetoprotein (AFP)-negative HCC, this challenge is augmented. MicroRNAs (miRs) profiles may serve as potential HCC molecular markers. We aimed to assess p...
Inflammatory breast cancer (IBC) is a rare yet aggressive breast cancer variant, associated with a poor prognosis. The major challenge for IBC is misdiagnosis due to the lack of molecular biomarkers. We profiled dysregulated expression of microRNAs (...
R134a is currently the most widely used refrigerant, whose problem is the high value of the global warming potential, and which will have to be replaced in the near future. Thus far, R1234ze(E) has proven to be the most suitable alternative, but it i...
The popularity of vehicles and the increased time spent in cars with air conditioning systems has led to regulations in many countries that require the use of environmentally friendly refrigerants with minimal global warming and zero ozone depletion...
The gene encoding a (2R,3R)-2,3-butanediol dehydrogenase from Rhodococcus erythropolis WZ010 (ReBDH) was over-expressed in Escherichia coli and the resulting recombinant ReBDH was successfully purified by Ni-affinity chromatography. The purified ReBD...
Paulownia witches’ broom (PaWB), caused by phytoplasmas, is the most devastating infectious disease of Paulownia. R2R3-MYB transcription factors (TF) have been reported to be involved in the plant’s response to infections caused by these...
A comparative analysis of the flow boiling characteristics of R450A, R515B, and R1234ze(E) inside a 7.0 mm OD microfin tube was performed. The mass velocity was explored from low values, starting from 50 kg m−2 s−1, up to 400 kg m−2...
25 July 2022
This paper explores the interrelationship between R&D investment, financial leverage, and a firm’s R&D innovation success. Using a sample of UK and EU firms, we predict that changes in one-year-ahead R&D investment are negatively as...
(R,R)ZX-5 is a NO regulatory compound, which could significantly increase choroidal blood flow in New Zealand rabbit. The aim of this paper is to investigate the molecular mechanism of (R,R)ZX-5 promoting NO production. Besides this, we also investig...
The mainstays of lung cancer pathogenesis are cell cycle progression dysregulation, impaired apoptosis, and unregulated cell proliferation. While individual microRNA (miR) targeting or delivering is a promising approach that has been extensively stud...
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