Search Results (66)

Background: Accurate early identification of sepsis remains a major clinical challenge due to its heterogeneous presentation and overlap of clinical signs with the non-infectious systemic inflammatory response syndrome (SIRS). Timely differentiation is crucial for improving patient outcomes, meeting sepsis bundle requirements and reducing inappropriate antimicrobial use. We hypothesized that clinical–laboratory data available within the first three hours of patient presentation could be used to identify patients with sepsis at a clinically useful level of diagnostic accuracy, in lieu of traditional microbiology results which would not become available until at least 12–24 h. Data from two independent studies were used to quantify the diagnostic value of demographic, vital, clinical–laboratory, and microbiological data available at three time points for distinguishing retrospectively diagnosed critically ill patients with either sepsis or non-infectious SIRS. A particular focus of this work was an assessment of the utility of SeptiCyte RAPID (Immunexpress Inc., Seattle, WA, USA) as an aid to sepsis diagnosis, producing actionable data within one hour. Methods: Data from two independent study cohorts were analyzed. The “510(k) cohort” consisted of 419 adult patients in intensive care (ICU) (MARS, VENUS, and NEPTUNE studies). The “Andalusian cohort” consisted of 353 ICU patients from the PANGEA study. Logistic regression models, selected by a greedy search algorithm and validated by repeated cross-validation, were used to determine the contributions of different variables to diagnostic accuracy. Diagnostic performance was quantified by the area under the receiver operating characteristic curve (AUC). Results: For the 510(k) cohort, a baseline AUC of 0.69–0.73 was observed using five to seven vital and demographic variables assessed immediately upon presentation (time T1). The addition of clinical–laboratory variables, in particular SeptiCyte RAPID, within one to three hours post-presentation (time T2) increased the AUC to 0.85–0.86. Finally, the addition of microbiological data 12–24 h post-presentation (time T3) further improved the AUC to 0.90–0.91. Similar results were obtained for the Andalusian cohort. AUC values at the three time points were as follows: At time T1, AUC = 0.67 based solely on vital signs and demographics; at time T2, AUC = 0.87 based on vitals + demographics + SeptiCyte RAPID ± other clinical–laboratory data; at time T3, AUC = 0.93 based on vitals + demographics + SeptiCyte RAPID ± other clinical–laboratory data + microbiology results. For both cohorts, the most significant variables included temperature, mean arterial pressure, respiratory rate, suspected infection site, SeptiCyte RAPID, procalcitonin, confirmed bacterial infection and positive blood culture confirmation. In summary, the AUC for diagnosing sepsis rose progressively from T1 (510(k) 0.69–0.73; Andalusian 0.67) to T2 (510(k) 0.85–0.86; Andalusian 0.87) with the addition of SeptiCyte RAPID to T3 (510(k) 0.90–0.91; Andalusian 0.93) as more clinical information became available over time. Conclusions: The accuracy of identification of sepsis increases markedly as demographics and vital signs are supplemented with clinical–laboratory information, and ultimately with microbiological culture results. The AUC improves in the shortest time within the first three hours when laboratory data, and particularly SeptiCyte RAPID results, become available. Integrating rapid host response testing with SeptiCyte RAPID into time-based diagnostic frameworks may enhance early sepsis recognition, improve antimicrobial stewardship, and support guideline-driven clinical decisions. Full article

This paper presents the results of apatite fission-track (AFT) and zircon fission-track (ZFT) analysis (dating) on samples collected from the surface exposures of six Precambrian intrusions in the southeastern Fennoscandian Shield: the Avdeevo and Shala dykes, the Valaam sill, the Salmi and Wiborg batholiths, and the Kuznechenskii massif. The short mean track lengths in apatite (10.7–13.5 μm) indicate that the studied rocks resided for a prolonged period within the apatite partial annealing zone (APAZ, 60–120 °C). We suggest that the AFT ages obtained from two of the granitic intrusions—the Salmi batholith and the Kuznechenskii massif—are apparent due to α-radiation-enhanced annealing (REA), as evidenced by an inverse correlation between single-grain AFT age and effective uranium (eU) concentration, and high dispersion and a negative chi-square test. An attempt to minimize the contribution of the REA effect to the AFT data for the Salmi batholith allowed its AFT age to be estimated as 1251 ± 125 (2σ) Ma, but the same approach was unsuccessful for the Kuznechenskii massif. In contrast, the mafic intrusions show no such correlation and yield reliable AFT ages: the Avdeevo dyke, 1040 ± 104 Ma; the Shala dyke, 1145 ± 89 Ma; and the Valaam sill, 1184 ± 78 Ma. The AFT data from the Wiborg batholith can be regarded as preliminary only. The most reliable AFT ages and thermal evolution models for the studied intrusions are similar and indicate prolonged exhumation of the intrusions to the surface over more than 1 billion years, with a marked increase in cooling rates around 300 Ma, which possibly has far-field causes, such as mantle dynamics related to the initial fragmentation of Pangea. Our data, as a first approximation, suggest a similar tectono–thermal evolution for intrusions located both within the northeastern margin of the Svecofennian orogen and on the Archean Karelian craton. Full article

Investigation of deposystems, sediment routing, and basin architecture during Gondwana breakup refines understanding of Permian–Cretaceous landscape evolution in the central Andes. New chronostratigraphic and provenance constraints from the Eastern Cordillera and Subandean Zone of Bolivia (19–22°S) are based on U-Pb geochronology of detrital and volcanic zircons and ⁴⁰Ar/³⁹Ar dating of interbedded basalts. A discontinuous <2 km-thick Permian–Cretaceous succession records deposition in fluvial, lacustrine, alluvial fan, eolian, and shallow marine environments. Stratigraphic correlations indicate alternations between isolated half-graben subbasins and regional, non-compartmentalized basins. Detrital zircon age spectra from 18 sandstones document sediment recycling from western orogenic and magmatic arc sources and eastern cratonic basement. Synextensional successions of Early Triassic, Early Jurassic, and mid-Cretaceous age were sourced mainly from the west, including Carboniferous and Devonian rocks, while post-extensional fluvial and eolian systems were derived chiefly from the eastern craton. Variations in thickness, facies, and mafic magmatism reflect alternating extensional and neutral tectonic regimes, with localized synextensional subsidence potentially linked to extensional collapse, mantle plume activity, and South Atlantic opening. Comparison with Andean regions in Peru and Argentina indicates that episodic extension and post-extensional thermal subsidence accompanied subduction along the western margin of South America during Gondwana-Pangea breakup. Full article

This article presents a gamified digital twin in Minecraft designed to support practical exercises in digital logic in the Computer Engineering I course at the University of Salamanca. Implemented as a Spigot/Paper server plugin based on the Platform for Automatic coNstruction of orGanizations of intElligent Agents (PANGEA) multi-agent architecture, the system orchestrates four virtual organizations and employs a world cloning strategy (via Multiverse and WorldGuard) to ensure individual and isolated workspaces, while also enabling collaborative work. The central contribution is a multi-agent system with an integrated ‘black box’ verification engine that mitigates redstone asynchrony and latency through controlled signal injection and software clock synchronization, enabling real-time deterministic validation of both basic logic gates and more complex sequential circuits. Additionally, the ecosystem includes a specialized suite of logic scenarios and a web-based dashboard for real-time teacher monitoring. In a pilot study ($N=30$), the system achieved an average task completion rate of 89.1%, and an adapted Unified Theory of Acceptance and Use of Technology (UTAUT) analysis indicated that technical stability is positively associated with student performance. Full article

During the course of the Carboniferous to Permian, large parts of eastern Laurentia and northern Gondwana were affected by the Variscan Orogeny accompanying the assembly of Pangea. Here, we concentrate on the Appalachian belt of eastern Laurentia and the Mauritanide of western Gondwana. Owing to the irregular shapes of the craton margins, the collision between Laurentia and the West African Craton provides several conjugate promontories and embayments alongside both cratons. Among others, the coupled pair formed by the African Reguibat promontory and its counterpart in North America, the Pennsylvania embayment, is the principal subject of this study. The western movement of the Reguibat Shield had initially imprinted the West African belts but finally also affected the Appalachians. Acting as a “hallmark”, it produced two specific lobes (stacks of nappes) on both sides of the promontory. The southern NW-SW lobe (Akjoujt nappes) is long known. However, the northern lobe of the “Adrar Souttouf Massif” has not been identified previously, owing to being partially covered and also to its N-S alignment instead of an expected symmetrical SW-NE direction. Furthermore, the Adrar Souttouf Massif is partially covered by allochthonous terranes (Western Thrust Belt, TB, or Appalachians). This new discovery supports a classical impingement model for the deformation of the North American and African belts by westward displacement of the Reguibat Shield. Full article

Due to the recent improvement in the additive manufacturing field, aerospike engines have been reconsidered as a possible alternative to the traditional bell-shaped nozzles. The former offer higher thrust and specific impulse during the launcher ascension phase because they are theoretically able to adapt the gas expansion ratio, reaching the optimal condition for a wide range of ambient pressure values, while bell-shaped nozzles can achieve the optimal expansion condition only at the design altitude. This capability has been proved for full-length plug nozzles, which, however, have some drawbacks, like a low thrust-to-weight ratio and challenging design of the cooling system at the spike tip. Therefore, research is moving towards truncated spike geometries, which allow the previously mentioned issues to be overcome. The aim of this work is to verify the expansion adaptation ability of a specific truncated aerospike geometry at different ambient pressures and to develop a simplified theory to estimate the upper bound of the base thrust coefficient. The analysis has been addressed by running numerical fluid dynamics simulations performed with an OpenFOAM solver. Full article

Studying Geography and Geology in formal education involves learning about landforms, landscapes, and the importance of preserving Natural Heritage. Geomorphosites are valuable resources with significant educational potential, as they can help students understand Earth’s history, appreciate Natural Heritage, and recognize their cultural and historical connections to the territory. By analyzing the curricular contents of the educational systems in Spain and Italy, this research proposes a novel method, focused on formal education, to assess the didactic potential of geomorphosites. The assessment is based on (i) how representative geomorphosites are of physical processes, (ii) their potential to support interdisciplinary learning, (iii) the availability of didactic materials, and (iv) the possibility of applying field techniques. The results revealed varying levels of didactic suitability among the analyzed geomorphosites, with Ulaca Hill (Spain) and Nirano mud volcanoes (Italy) having the highest didactic potential, also allowing evaluation of their relevance across different educational stages. The application of the methodology in both the Spanish and Italian contexts, with minor adjustments, showed that this approach is readily adaptable to other educational systems. Overall, this study provides a transferable framework for integrating geomorphological heritage into formal teaching, promoting place-based learning and fostering awareness and conservation of Natural Heritage. Full article

Fluvio-lacustrine systems are highly dynamic continental environments, often developing in tectonically controlled, endorheic basins where sedimentation reflects the interplay of fluvial processes, lake-level fluctuations, climate, and subsidence. The main aim of this paper is to reconstruct the depositional architecture and paleogeographic evolution of the Ludwikowice Formation (Intra-Sudetic Basin, NE Bohemian Massif), which preserves a high-resolution record of a late Carboniferous (late Gzhelian) fluvio-lacustrine system. The formation developed as a fining-upward megacyclothem documenting the transition from proximal alluvial and fluvial fan deposits to distal, organic-rich lacustrine facies referred to as the Lower Anthracosia Shale (LAS). This study integrates lithological data from 92 archival boreholes with high-resolution sedimentological, geochemical, petrological, palynological, and magnetic susceptibility analyses from two fully cored reference sections (Ścinawka Średnia PIG-1 and Rybnica Leśna PIG-1) and selected exposures. Nine facies associations (FA1–FA9) have been identified within the formation, including fluvial, sandy to muddy floodplain, aeolian, playa lake margin/coastal mudflat, nearshore, delta plain, subaqueous delta front and subaqueous fan, prodelta, and open lake. The succession shows progressive thickening into narrow, NW–SE-trending depocenters associated with possible strike-slip faulting. Geochemical and isotopic data indicate alternating hydrologically open and closed lake conditions, while magnetic susceptibility reflects climatically driven variations in detrital influx and microbial activity. Organic petrography and palynofacies analyses reveal redox-controlled maceral associations. The Ludwikowice Formation constitutes a detailed archive of Late Paleozoic environmental change and provides new insights into sedimentation and organic matter preservation in intramontane endorheic basins. Our results highlight the response of fluvio-lacustrine systems to climatic and tectonic factors and provide a framework for interpreting analogous successions throughout the stratigraphic record. Full article

STEM (Science, Technology, Engineering, and Mathematics) education faces the challenge of incorporating advanced technologies that foster motivation, collaboration, and hands-on learning. This study proposes a portable system capable of transforming ordinary surfaces into interactive learning spaces through gamification and spatial perception. A prototype based on multi-agent architecture was developed on the PANGEA (Platform for automatic coNstruction of orGanizations of intElligent agents) platform, integrating LIDAR (Light Detection and Ranging) sensors for gesture detection, an ultra-short-throw projector for visual interaction and a web platform to manage educational content, organize activities and evaluate student performance. The data from the sensors is processed in real time using ROS (Robot Operating System), generating precise virtual interactions on the projected surface, while the web allows you to configure physical and pedagogical parameters. Preliminary tests show that the system accurately detects gestures, translates them into digital interactions, and maintains low latency in different classroom environments, demonstrating robustness, modularity, and portability. The results suggest that the combination of multi-agent architectures, LIDAR sensors, and gamified platforms offers an effective approach to promote active learning in STEM, facilitate the adoption of advanced technologies in diverse educational settings, and improve student engagement and experience. Full article

A significant wildfire event occurred in Korinthos, Greece, on 22 July 2020, releasing large amounts of smoke into the atmosphere. This episode provided the opportunity to develop and apply the methodology described in this work, where the synergistic use of ground data, satellite remote sensing data and dispersion modeling is utilized to demonstrate highly accurate source detection, emission transport, and dispersion of the smoke plumes. The Fire Radiative Power (FRP) data from SEVIRI, on board Meteosat Second Generation, are used to estimate hourly fire top-down emissions. These emissions are used as input for the FLEXPART Lagrangian particle dispersion model, driven by GFS meteorological data. Simulated smoke transport is compared with TROPOMI satellite CO observations and lidar profiles from the PANhellenic GEophysical observatory of Antikythera (PANGEA) station. The model includes key atmospheric processes such as advection and deposition, providing a framework for assessing wildfire impacts on air quality and transport. The results highlight the effectiveness of combining high temporal resolution FRP data with the WARM START configuration of FLEXPART versus the Standard FLEXPART Simulation. Full article

Ex situ conservation is a vital strategy of preserving plant species at risk, offering practical methods to obtain information regarding species-specific germination characteristics. Campanula pangea, a local endemic species of NE Greece, has been previously classified as vulnerable, partly due to the lack of knowledge about its biology. This study focused on the germination behaviour of C. pangea stored seeds by assessing their germination success under the effects of incubation temperature and gibberellic acid (GA₃). To contextualize the experimental conditions, a bioclimatic profile of the species was developed using open-access temperature and precipitation data that characterize its natural habitat. The results showed that the optimal germination temperature range for C. pangea is 15–20 °C. Pre-treatment of seeds with GA₃ solution (1000 mg L⁻¹) widened the germination range of the seeds only at the low temperature of 10 °C. The experimentation results showed that the seeds of C. pangea exhibit dormancy. These findings contribute to the development of a species-specific germination protocol for ex situ propagation and conservation, enhance understanding of the species’ germination requirements, and thus support future conservation efforts and assessments of extinction risk, or other ornamental applications and/or targeted medicinal research. Full article

The nocturnal, flightless camel crickets (Rhaphidophoridae) have a global distribution and are believed to have originated prior to the breakup of Pangea. We investigated the phylogeny and the timing of the radiation of East Asian species with mitogenomic data. Initially we analyzed a large taxon dataset (n = 117) using available partial mitochondrial and nuclear DNA sequences to confirm the monophyly of subfamilies and current taxonomy. Our findings support the monophyly of each genus within the subfamily Aemodogryllinae, with a minor inconsistency between taxonomy and phylogeny resolved by resurrection of the genus Gymnaeta Adelung. Fossil-calibrated molecular clock analysis used 11,124 bp alignment of 13 complete mitochondrial protein-coding genes for 20 species of Rhaphidophoridae, with a focus on the neglected Rhaphidophorinae and Aemodogryllinae lineages. Divergence time estimates suggest that the most recent common ancestor of the family lived during the Early Jurassic (189 Mya ± 23 Mya) before Pangea broke into the supercontinents or possibly during the early stage of breakup when Gondwana and Laurasia were still connected by land. The two subfamilies, Rhaphidophorinae and Aemodogryllinae, that overlap in Asia are estimated to have diverged 138 Mya ± 17 Mya, well before the Late Cretaceous northern connection between America and Asia (the Bering Land Bridge). Thus, our extended sampling of species from East Asia and Oceania refutes the importance of continental drift in the evolution of this wingless orthopteran family. Full article

Continental rifting is the process by which land masses separate and create new ocean basins. The emplacement of large igneous provinces (LIPs) is thought to have played a key role in (super) continental rifting; however, this relationship remains controversial due to the lack of a clearly established mechanism linking LIP emplacement to continental fragmentation. Here, we show that plume flow links LIP magmatism to continental rifting quantitatively. Our findings are further supported by the sedimentary record, as well as by the mineralogy and petrology of the rocks. This study analyzes the early Cretaceous separation of West Gondwana into South America and Africa. Prior to rifting, Jurassic hiatuses in the stratigraphic record of continental sediments from both continents indicate plume ascent and the resulting dynamic topography. Cretaceous mafic dyke swarms and sill intrusions are products of major magmatic events that coincided with continental rifting, leading to the formation of large igneous provinces in South America and Africa, including the Central Atlantic Magmatic Province, Equatorial Magmatic Province, Paraná–Etendeka, and Karoo. It has been suggested that dyke intrusions may weaken the lithosphere by reducing its mechanical strength, creating structural weaknesses that localize extensional deformation and facilitate rift initiation. The sedimentary analysis and petrological evidence from flood basalt magmas indicate that plumes may have migrated from the depths toward the surface during the Jurassic and erupted during the Cretaceous. It is thought that the resulting fast plume flow, induced by one or more mantle plumes, generated a dynamic force that, in combination with lithospheric weakening from dyke intrusion, eventually rifted the lithosphere of West Gondwana. Full article

Geomorphosites include all those places of abiotic heritage that are important for understanding the Earth’s history, with a landscape and territorial component. These places may not have high scientific value at an international, national, or regional scale, but they hold local value due to their connection to the territory, environmental and cultural legacy, and their link to the populations that inhabit them, especially in Natural Protected Areas (NPAs) where there is already recognition of natural heritage but not geomorphological heritage. The first objective of this work was the recognition of geomorphological heritage, for which an inventory of geomorphosites in the NPA Sierras de la Paramera and la Serrota was developed. The potential of these sites is currently diminished by the lack of recognition of geotourism, with no proper integration of geomorphosites in the planning of NPAs in Spain, particularly in Castilla y León, where the study area was located. This work proposes a methodology for evaluating the potential use of the inventoried geomorphosites, focused on their geotourism potential, to enable the development of a geotourism offering that promotes the dissemination of geomorphological heritage and the development of tourism infrastructure, benefiting the local population and ensuring the survival and use of this cultural service. In the Sierras de la Paramera and la Serrota, 12 geomorphosites were inventoried with medium to high value but lacking any tourism infrastructure. The next step is to evaluate their potential, study their geomorphological heritage, and carry out dissemination activities to enhance their value in this area. Full article

Background/Objectives: A Body Shape Index (ABSI), which accounts for waist circumference relative to mass and height, shows a robust association with mortality risk. The present study evaluates the effectiveness of ABSI as a predictor of 10-year all-cause mortality in physically active, non-obese elderly individuals. Methods: This prospective cohort study included 159 volunteers (94 women, aged 60–80 years), recruited in the frame of the “Physical Activity and Nutrition for Great Ageing” (PANGeA) Cross-border Cooperation Program Slovenia–Italy 2007–2013, and followed for 10 years. Baseline characteristics included anthropometric measurements, bioelectrical impedance analysis, and cardiovascular fitness tests (VO₂max). Statistical analyses (Cox regression, Kaplan–Meier survival) were conducted to examine the relationship between ABSI and mortality. Results: During the 10-year follow-up, 10 deaths (6.7%) were recorded. ABSI (adjusted for age, smoking, comorbidities, and therapy) was an independent predictor of mortality (hazard ratio = 4.65, p < 0.001). Higher ABSI scores were linked to reduced VO₂max (r = −0.190, p = 0.017) and increased systolic blood pressure (r = 0.262, p = 0.001). An ABSI-based predictive model showed strong discriminatory power (AUROC = 0.91). Conclusions: ABSI is a reliable predictor of 10-year mortality in active, non-obese elderly individuals and may improve risk stratification in clinical practice. Full article