Most Cited

The aim of this study was to evaluate the efficiency of successive extraction (using solvents of increasing polarity, namely hexane, ethyl acetate, acetone, ethanol, and water) of polyphenols from Cistus creticus L. The results were compared with the...

Mitochondrial oxidative stress has been implicated in various forms of brain injury, both traumatic and non-traumatic. Due to its oxidative demand, the brain is intimately dependent on its mitochondrial functioning. However, there remains appreciable...

A member of the Verbenaceae family, Aloysia citrodora, or lemon verbena, is a medicinal herb with antioxidant compounds. The aim of this study was to develop a green, optimized method for the bioactive compound (carotenoids, ascorbic acid, and polyph...

Over 2000 publications including more than 100 human studies seem to indicate that humans have only recently benefited from or known about the medical effects of H₂ within the past 15 years. However, we have unknowingly benefited from H₂ since the da...

Wheat-flour crackers represent a staple snack option, although they lack nutritional value. Agricultural by-products such as olive and grape seeds, cereals such as barley and legumes such as lupine and chickpea are rich in bioactive compounds; theref...

The pathogenesis of various gastrointestinal (GI) disorders, including gastritis, ulcers, inflammatory bowel disease (IBD) and cancer, can be linked to oxidative stress. It is known that reactive species carry out a crucial role in the genesis and pr...

Marine fungal metabolites often exhibit antioxidant activity, but their effects on the Keap1/Nrf2 cellular system are rarely studied, possibly due to insufficient isolated amounts. In this work, we used a bioinformatics approach to evaluate the abili...

Oxidative stress, characterized by an imbalance between the production of reactive oxygen species and the body’s antioxidant defenses, plays an important role in the pathogenesis of various health conditions, including cancer and neurological d...

Blood flow restriction (BFR) may become ineffective or potentially dangerous without sufficient standardization. The purpose of this investigation was therefore to (1) assess the viability of multiple sizes of a novel BFR cuff to determine arterial o...

Reactive oxygen species (ROS) are unstable and highly reactive molecular forms that play physiological roles in cell signaling and immune defense. However, when ROS generation is not properly balanced by antioxidant defenses, a pathological condition...

In 2007 a paper in Nature Medicine sparked a new wave of interest in the use of molecular hydrogen (H₂) for medical treatments. Since then there has been a flurry of papers looking at a range of medical aspects, from neurodegenerative disease to spor...

Liquid organic hydrogen carriers (LOHCs) are aromatic molecules that are being considered for the safe storage and release of hydrogen. The thermodynamic properties of a range of aromatic ethers were investigated using various experimental and theore...

This review explores the unique structural and functional characteristics of natural products featuring highly oxygenated cyclobutane rings, with a specific focus on oxetane and 1,2-dioxetane motifs. It presents the structures and biological activiti...

This study explored the use of mandarin peels as an important source of health-promoting compounds by utilizing green methods (i.e., pulsed electric field and ultrasound-assisted extraction), along with conventional stirring. The impact of several ex...

Halophyte plants and seaweed are described in the literature as rich sources of antioxidant compounds that can be used in the pharmaceutical and food industries. In this work, we studied the antioxidant composition of five species of halophytic plant...

Skin grafting is a critical procedure for treating skin defects from burns, trauma, and surgical interventions, yet complications such as ischemia, necrosis, and infection can limit graft success. Hyperbaric Oxygen Therapy (HBOT) has emerged as a pro...

The generation of energy within cells is a fundamental process enabling cell survival, and as such it represents a potential target in cancer therapy. In this article, we therefore review the relative contributions of glycolysis and oxidative phospho...

Mitochondrial dysfunction significantly contributes to the pathogenesis and progression of chronic obstructive pulmonary disease (COPD). To treat mitochondrial dysfunction in COPD, novel drug delivery systems (DDS) are needed. In this review, we prov...

Red spinach extract is high in inorganic nitrate/nitrite (NO₃/NO₂) which has been shown to enhance vascular function, cognition, and physical performance. To date, there have been no investigations as to whether red spinach extract serves as an effec...

In this review, in addition to the potential cardiovascular applications of β-blockers and, more specifically, propranolol, we wanted to list the more recent applications in psychiatry as well as current knowledge on the impact of oxidative stre...

Background: In otorhinolaryngology and head and neck surgery, oxygen is a therapeutic tool used for various pathologies. Oxidative stress is the imbalance between the production of free radicals (ROS) and the antioxidant capacity of the body, which c...

Atmospheric oxygen is produced and consumed by life on Earth, and the ozone layer protects life on Earth from harmful solar UV radiation. The research on oxygen in the Earth system is of interest to many different geoscientific communities, from pale...

Chronic kidney disease (CKD) affects 10% of the population. Fibrosis is the hallmark of CKD, which is marked by the deposit of extracellular matrix (ECM). This response is the final outcome of an unbalanced reaction to inflammation and wound healing...

Oxygen binds to hemoglobin cooperatively, and a correct description of this binding is relevant not only for understanding the mechanisms of involved molecular processes but also for clinical purposes. Hill’s equation, derived over a hundred ye...

Globally, among different types of cancers, breast cancer is identified as the chief cause of mortality among females, and it is a challenge to find new effective treatment strategies with minimal side effects and increased efficacy. Plants are an in...

Produced by photosynthesis, oxygen (O₂) is a fundamentally important gas in biological systems, playing roles as a terminal electron receptor in respiration and in host defence through the creation of reactive oxygen species (ROS). Hydrogen (H₂) play...

Addressing the global environmental problem of water splitting to produce hydrogen fuel by solar energy is receiving so much attention. In water splitting, the essential problem to solve is the development of efficient catalysts for oxygen production...

Flooding induces low-oxygen stress, which reduces plant growth. The activity of the γ-aminobutyric acid (GABA) shunt is crucial for plant stress adaptation, in which it acts by changing cytosolic pH, limiting reactive oxygen species production,...

Because soybean is sensitive to salt stress, it is necessary to improve their stress tolerance. Titanium-oxide nanoparticles (TiO₂ NPs) enhanced the growth of soybean under salt stress. To elucidate the promotive effects of TiO₂ NPs on soybean growth...

Evidence suggests that COVID-19 infection increases the risk of type 1 (T1D) and type 2 diabetes (T2D). Diabetes, in turn, increases COVID-19 susceptibility and contributes to increased COVID-19 morbidity and mortality. Oxidative stress has emerged a...

Molecular mechanisms based on photo-physical processes involving dietary carotenoids, their radicals, and the role of oxygen are discussed and used to suggest explanations of the poorly understood and often contradictory results related to mainly ski...

Rheumatoid arthritis (RA) is a well-known autoimmune inflammatory disease that affects the diarthrodial joints. Inflammation increases the production of reactive oxygen species (ROS), which may explain why RA is one of the diseases that induce oxidat...

Uterine fibroids are the most common tumors in females, affecting up to 70% of women worldwide, yet targeted therapeutic options are limited. Oxidative stress has recently surfaced as a key driver of fibroid pathogenesis and provides insights into hy...

On the thirty-fifth anniversary of the first description of O₂-sensitive K⁺ channels in the carotid body chemoreceptors O₂ sensing remains a salient issue in the literature. Whereas much has been learned about this subject, important questions such a...

The objective of this study was to determine the optimal conditions for the recovery of bioactive and antioxidant compounds in aqueous solutions of Cistus creticus leaves and then employ the optimal extract for the enrichment of yogurt samples. The o...

The success of heated tobacco products (HTPs) and electronic cigarettes (e-cigs) has been largely attributed to their ability to mimic the gestural experience of traditional cigarette smoking, while being perceived as a safer alternative due to the a...

In a previous Arabidopsis investigation, three ovule-specific cell-wall peroxidases decreased seed abortion rates. These peroxidases were expressed in soybean plants. Because cell wall peroxidases alter extensibility, possible effects on seed size an...

With humans living longer and the median age of the population increasing, there is an ever-increasing demand for better biomedical implants. Titanium implants have a long history of successful use, but their naturally forming amorphous oxide surface...

Compounds known as liquid organic hydrogen carriers (LOHCs) offer a promising pathway for storing hydrogen. Beyond the use of pure hydrocarbons, the incorporation of oxygen atoms offers a way to modify thermodynamic properties and potentially improve...

Background: Emerging evidence suggests that the outcomes of hypoxia training may be influenced by various factors, contingent upon the chosen method, such as chamber, tent, or mask. This study aimed to examine how different training methods influence...

Propolis is a natural honeybee product, which is known for its beneficial pharmacological effects and use in traditional medicine. This study aspired to investigate the chemical and antioxidant properties of five propolis specimens, followed by the a...

Amiodarone (AMD) is an effective antiarrhythmic drug whose long-term use is limited by multi-organ toxicities linked to oxidative stress. This review synthesizes current evidence on how AMD induces reactive oxygen species (ROS) generation in vitro an...

The purpose of this analysis is to report on the clinical efficacy of Continuous Diffusion of Oxygen (CDO) therapy in real-world clinical practice and compare those results to data published in controlled clinical studies. For the real-world clinical...

Noble gases are a valuable but overlooked source of effective and safe therapeutics. Being monoatomic and chemically inert, they nonetheless have a surprisingly wide range of biochemical and medically valuable properties. This mini review briefly sum...

Alterations in cellular energy metabolism are a hallmark of cancer and lactate dehydrogenase (LDH) enzymes are overexpressed in many cancers regardless of sufficient oxygen and functional mitochondria. Further, L-lactate plays signaling roles in mult...

Fibromyalgia is a syndrome that causes chronic musculoskeletal pain accompanied by symptoms such as fatigue, sleep disorders, headaches, anxiety, and depression. People diagnosed with fibromyalgia usually have higher levels of reactive oxygen species...

Platinum-based catalysts remain the benchmark for the oxygen reduction reaction (ORR) in fuel cells, owing to their exceptional catalytic activity in the harsh chemical environment. However, optimizing Pt utilization and improving performance through...

Seven lager beers and seven non-alcoholic counterparts, marketed by the same producers, were analyzed for their total phenolic content (TPC), radical scavenging activity (RSA) towards the DPPH radical and ThioBarbituric Index (TBI). All beers were al...

The mitochondrial electron transport chain (mETC) contains molecular targets of volatile general anesthetics (VGAs), which places individuals with mETC mutations at risk for anesthetic complications, as exemplified by patients with Leigh syndrome (LS...

Cancer remains one of the leading causes of death despite advancements in research and treatment, with traditional therapies often causing significant side effects and resistance. Oxyhydrogen gas, a mixture of 66% molecular hydrogen (H₂) and 33% mole...