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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Physical Therapy in Musculoskeletal Disorders: Prevention, Diagnosis, Clinical Management and Treatment submission deadline 30 Aug 2025 | 17 articles | Viewed by 21613 | Submission Open
Keywords: physical therapy; musculoskeletal disorders; prevention; diagnosis; clinical management; treatment
(This special issue belongs to the Section Clinical Rehabilitation)
Review Special Issue Series: Recent Advances in Cardiovascular Medicine, 2nd Edition
edited by
submission deadline 30 Aug 2025 | 2 articles | Viewed by 15073 | Submission Open
Keywords: cardiovascular medicine; recent advances; review articles; diagnostic techniques; therapeutic interventions; emerging trends; cardiovascular health; expert analysis; research
(This special issue belongs to the Section Cardiovascular Medicine)
Targeted Treatment in Head–Neck Cancer
edited by Jacopo Zocchi, and
submission deadline 30 Aug 2025 | 4 articles | Viewed by 7131 | Submission Open
Keywords: head and neck squamous cell carcinoma; precision medicine; targeted therapies; immunotherapy; tumor heterogeneity; treatment response monitoring
(This special issue belongs to the Section Otolaryngology)
New Progress and Challenges in Clinical Cardiac Surgery
edited by
submission deadline 30 Aug 2025 | 4 articles | Viewed by 6463 | Submission Open
Keywords: coronary artery bypass grafting (CABG); mitral valve repair; aortic valve replacement; percutaneous coronary intervention (PCI); heart transplantation; atrial fibrillation ablation; ventricular assist devices (vad); minimally invasive cardiac surgery
(This special issue belongs to the Section Cardiology)
Targeted Treatment of Hematological Malignancy
edited by , Chloe A.L. Thompson-Peach, Elyse C. Page and Deborah White
submission deadline 30 Aug 2025 | 4 articles | Viewed by 5763 | Submission Open
Keywords: leukemia; lymphoma; multiple myeloma; myelodysplastic syndromes; chronic myeloid leukemia; acute lymphoblastic leukemia; acute myeloid leukemia; non-Hodgkin lymphoma; Hodgkin lymphoma
(This special issue belongs to the Section Hematology)
Sexually Transmitted Infections as a Challenge of Modern Society: Old Problems and Modern Solutions
edited by Mauro Zaccarelli and
submission deadline 30 Aug 2025 | 4 articles | Viewed by 5559 | Submission Open
Keywords: sexually transmitted infections (STIs); human papilloma virus (HPV); syphilis; gonorrhea; chlamydia trachomatis; HIV infection; PrEP; chemsex
(This special issue belongs to the Section Infectious Diseases)
Current Trends and Future Directions in Prosthetic and Implant Dentistry in the Digital Era, 3rd Edition submission deadline 30 Aug 2025 | 4 articles | Viewed by 5537 | Submission Open
Keywords: 3D printing; additive manufacturing; milling technologies; CAD/CAM; digital implant planning; digital workflow; facial scanners; computer-guided implant surgery; intraoral scanners; digital design and fabrication of dental prostheses
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Cystic Fibrosis: Diagnosis and Treatment
edited by Corrado Tagliati and Gian Marco Giuseppetti
submission deadline 30 Aug 2025 | 4 articles | Viewed by 5483 | Submission Open
Keywords: cystic fibrosis; diagnosis; treatment; management
(This special issue belongs to the Section Respiratory Medicine)
Recent Advances in Neurorehabilitation: Emerging Techniques and Technologies submission deadline 30 Aug 2025 | 2 articles | Viewed by 3351 | Submission Open
Keywords: neurorehabilitation; neuroimaging; robotic rehabilitation; virtual reality therapy; neuroprosthetics; brain– computer interfaces; pharmacological interventions; functional recovery; neuroplasticity; cognitive rehabilitation
(This special issue belongs to the Section Clinical Neurology)
Targeted Treatment in Chronic Inflammatory Arthritis
edited by , and Simone Perniola
submission deadline 30 Aug 2025 | 3 articles | Viewed by 2581 | Submission Open
Keywords: rheumatoid arthritis; psoriatic arthritis; ankylosing spondylitis; spondyloarthritis; disease-modifying antirheumatic drugs (DMARDs); personalized medicine; immunomodulatory therapies; patient outcomes; combination therapies
(This special issue belongs to the Section Immunology)
Endocrine Surgery: Current Developments and Trends
edited by Leonardo Rossi and Gabriele Materazzi
submission deadline 30 Aug 2025 | 3 articles | Viewed by 2081 | Submission Open
Keywords: thyroid; parathyroid; adrenal gland; minimally invasive surgery; remote-access surgery; robotic surgery; parathyroid fluorescence; adrenal fluorescence
(This special issue belongs to the Section Endocrinology & Metabolism)
Pain Management: Current Challenges and Future Prospects
edited by Gian Marco Petroni
submission deadline 30 Aug 2025 | 2 articles | Viewed by 1598 | Submission Open
Keywords: chronic joint pain; radio frequency ablation; adipose-derived mesenchimal stem cells (ADMScs); intrarticular injection; facet joint injection with ADMScs
(This special issue belongs to the Section Anesthesiology)
Advancements in Cardiac Electrophysiology Through Biomedical Engineering for Abnormality Monitoring and Detection in Clinical Practice
edited by Ilaria Marcantoni and Michela Casella
submission deadline 30 Aug 2025 | 2 articles | Viewed by 1427 | Submission Open
Keywords: electrocardiogram; cardiac electrophysiology; cardiac risk index; cardiac arrhythmias; electrocardiographic alternans; long QT syndrome; heart electrical system anomalies; monitoring of heart electrical system; prevention; biomedical engineering in electrocardiology; cardiac signal processing; cardiac image processing
(This special issue belongs to the Section Cardiology)
Cardiopulmonary Resuscitation in Emergency Care Units submission deadline 30 Aug 2025 | 2 articles | Viewed by 1322 | Submission Open
Keywords: cardiopulmonary resuscitation; emergency care; cardiac arrest; CPR techniques; resuscitation devices; post-resuscitation care; survival outcomes
(This special issue belongs to the Section Emergency Medicine)
Pulmonary Hypertension: Advances in Clinical Diagnosis and Management
edited by Victor F. Tapson
submission deadline 30 Aug 2025 | 2 articles | Viewed by 1321 | Submission Open
Keywords: pulmonary arterial hypertension; pulmonary hypertension; pulmonary vascular disease; chronic thromboembolic pulmonary hypertension; lung disease; left heart disease; functional class; right heart catheterization; prostacyclins; endothelin receptor antagonists; phosphodiesterase inhibitor; soluble guanylate cyclase stimulators; sotatercept
(This special issue belongs to the Section Respiratory Medicine)
The Complex Interplay Between Physical Activity, Sleep, Diet, and Obesity: Clinical Insights for Treatment and Prevention submission deadline 30 Aug 2025 | 2 articles | Viewed by 1178 | Submission Open
Keywords: body mass; body composition; nutrition; sleep patterns; weight management; lifestyle interventions; sedentary behavior; adiposity; obesity prevention; dietary habits
(This special issue belongs to the Section Clinical Rehabilitation)
New Advances in Total Knee Arthroplasty
edited by
submission deadline 30 Aug 2025 | 1 articles | Viewed by 1131 | Submission Open
Keywords: artificial intelligence; bone tumors; knee joint; knee pain; knee replacement; knee surgery; orthopedic surgery; osteoarthritis; prognostic markers; radiological evaluation
(This special issue belongs to the Section Orthopedics)
Robotic Urological Surgery: Clinical Updates for Better Outcomes
edited by
submission deadline 30 Aug 2025 | 1 articles | Viewed by 955 | Submission Open
Keywords: robotic urological surgery; clinical outcomes; surgical techniques; surgical navigation; patient-reported outcomes; side effects; incident
(This special issue belongs to the Section Nephrology & Urology)
Orthopedic Trauma in Polytraumatized Patients: Current Management Concepts and Innovations submission deadline 30 Aug 2025 | 1 articles | Viewed by 635 | Submission Open
Keywords: polytrauma; geriatric polytrauma; fracture management; fracture stabilization; damage control orthopedics; early appropriate care; multidisciplinary approach; innovations; minimally invasive surgery
(This special issue belongs to the Section Orthopedics)
Orthopedic Trauma Surgery: Current Challenges and Future Perspectives
edited by Paolo Schiavi, Enrico Vaienti and Francesco Pogliacomi
submission deadline 30 Aug 2025 | Viewed by 545 | Submission Open
Keywords: trauma surgery; politrauma; osteosynthesis; arthroplasty; internal fixation; MIPO; outcome
(This special issue belongs to the Section Orthopedics)
New Clinical Insights into Exercise, Obesity, and Diabetes
edited by , , Ana Conceição and
submission deadline 30 Aug 2025 | Viewed by 475 | Submission Open
Keywords: diabetes; obesity; physical activity; exercise prescription; physically active learning; tissue oxidation; exercise physiology; physically active senior centres
(This special issue belongs to the Section Sports Medicine)
Thrombosis: Latest Advances and Prospects
edited by Manila Gaddh
submission deadline 30 Aug 2025 | Viewed by 319 | Submission Open
Keywords: thromboembolism; venous thrombosis; arterial thrombosis; anticoagulation
(This special issue belongs to the Section Hematology)
The Role of Bayesian Methods in Clinical Medicine
edited by Nicolas Meyer
submission deadline 30 Aug 2025 | Viewed by 310 | Submission Open
Keywords: bayesian statistics; clinical trials; epidemiology; clinical epidemiology; decision; diagnostic test; master protocol; review; statistical controversies; adaptive design
(This special issue belongs to the Section Clinical Research Methods)
Alcohol-Related Liver Disease: Diagnosis, Treatment, and Management submission deadline 30 Aug 2025 | Viewed by 223 | Submission Open
Keywords: alcohol-related liver disease; gut– liver axis; hepatic fibrosis; liver cirrhosis; micro-RNA; inflammatory pathways; liver transplantation; steatohepatitis; fecal microbiota transplantation in liver cirrhosis
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Current and Emerging Treatment Options in Atrial Fibrillation: 2nd Edition submission deadline 30 Aug 2025 | Viewed by 206 | Submission Open
Keywords: atrial fibrillation; left atrial appendage closure; ablation techniques; personalized medicine in AF treatment; cardioversion methods
(This special issue belongs to the Section Cardiology)
Cardiac Anesthesia: Current Research and Future Prospects
edited by and Lorenzo Stephan Cesare Grazioli
submission deadline 30 Aug 2025 | Viewed by 175 | Submission Open
Keywords: cardiac anesthesia; cardiac surgery; echocardiography; interventional cardiology; anesthesia; cardiology
(This special issue belongs to the Section Anesthesiology)
Recent Developments of Radiotherapy in Oncology
edited by Rosario Mazzola and
submission deadline 30 Aug 2025 | Viewed by 143 | Submission Open
Keywords: radiotherapy; image-guided radiotherapy; adaptive radiotherapy; treatment planning; radiation oncology; immunotherapy synergy
(This special issue belongs to the Section Oncology)
Kidney Failure: Diagnosis and Treatment of Acute and Chronic Conditions
edited by Nikolina Basic-Jukic
submission deadline 31 Aug 2025 | 11 articles | Viewed by 18760 | Submission Open
Keywords: kidney failure; renal dysfunction; hyponatremia; peritoneal dialysis; hemodialysis; renal transplantation; immunoadsorption; plasma exchange
(This special issue belongs to the Section Nephrology & Urology)
Acute Ischemic Stroke: Current Status and Future Challenges
edited by
submission deadline 31 Aug 2025 | 11 articles | Viewed by 18016 | Submission Open
Keywords: acute ischemic stroke; atrial fibrillation; endovascular thrombectomy; intravenous thrombolysis; direct oral anticoagulants
(This special issue belongs to the Section Clinical Neurology)
Clinical Management of Pregnancy-Related Complications: 2nd Edition
edited by , Stephanos Zervoudis and
submission deadline 31 Aug 2025 | 4 articles | Viewed by 14221 | Submission Open
Keywords: diabetes; hypertension; post-partum hemorrhage; preterm labor; infection; cancer
(This special issue belongs to the Section Obstetrics & Gynecology)
Cardiometabolic Disease and Atherosclerosis: Epidemiology, Prevention, Diagnosis, and Clinical Treatment
edited by and Konstantinos Mourouzis
submission deadline 31 Aug 2025 | 7 articles | Viewed by 9741 | Submission Open
Keywords: atherosclerosis; obesity; cardiometabolic disease; prevention; diabetes mellitus; endothelium; arteriosclerosis; coronary artery disease
(This special issue belongs to the Section Cardiology)
Advances in Child Neurology submission deadline 31 Aug 2025 | 5 articles | Viewed by 8782 | Submission Open
Keywords: pediatric neurological disorders; pediatric sleep disorders; pediatric epilepsy; autoimmune encephalitis; pediatric acute-onset neuropsychiatric syndrome (PANS); pediatric headaches; RASopathies; neurogenetic disorders; developmental coordination disorder (DCD); pedaitric neurological rehabilitation; AI application for diagnosis and therapeutic management of pediatric neurological diseases
(This special issue belongs to the Section Clinical Pediatrics)
New Challenges and Perspectives in Polycystic Ovary Syndrome
edited by
submission deadline 31 Aug 2025 | 3 articles | Viewed by 7862 | Submission Open
Keywords: polycystic ovary syndrome; evolutionary origins; developmental origins; pathogenesis; pathophysiology; microbiome; pregnancy complications; lifestyle
(This special issue belongs to the Section Obstetrics & Gynecology)
Chronic Obstructive Pulmonary Disease (COPD): Treatment and Management
edited by and Alfredo Chetta
submission deadline 31 Aug 2025 | 6 articles | Viewed by 7697 | Submission Open
Keywords: COPD; treatable traits; precision medicine; COPD comorbidities; COPD mortality
(This special issue belongs to the Section Respiratory Medicine)
New Diagnostic and Therapeutic Trends in Sepsis and Septic Shock submission deadline 31 Aug 2025 | 3 articles | Viewed by 7684 | Submission Open
Keywords: sepsis; septic shock; diagnostics; therapeutics; biomarkers; critical care
(This special issue belongs to the Section Hematology)
Cerebrovascular Disease: Symptoms, Diagnosis and Current Treatment
edited by Alba Scerrati and Giorgio Mantovani
submission deadline 31 Aug 2025 | 5 articles | Viewed by 6909 | Submission Open
Keywords: ischemic stroke; cerebral aneurysms; cerebral vascular malformation; cerebral venous disease; cerebral venous thrombosis
(This special issue belongs to the Section Clinical Neurology)
Blood Disorders: Diagnosis, Management, and Future Opportunities submission deadline 31 Aug 2025 | 3 articles | Viewed by 6616 | Submission Open
Keywords: blood disorders; biomarkers; personalized medicine; diagnosis; NGS; metabolomics; digital droplet PCR (ddPCR)
(This special issue belongs to the Section Hematology)
Pediatric Critical Care: Clinical Recognition, Management, and Outcomes
edited by Janet Hume
submission deadline 31 Aug 2025 | 5 articles | Viewed by 6227 | Submission Open
Keywords: pediatric critical care medicine; sepsis; pediatric acute respiratory distress syndrome; mechanical ventilation; renal replacement therapy; chronic critical illness; post-intensive care syndrome
(This special issue belongs to the Section Clinical Pediatrics)
The Future of Inflammatory Biomarkers: Challenges and Clinical Integration submission deadline 31 Aug 2025 | 3 articles | Viewed by 4612 | Submission Open
Keywords: inflammatory marker; inflammation; biomarker; cancers; rheumatoid arthritis; inflammatory bowel disease; respiratory diseases
(This special issue belongs to the Section Immunology)
Advances in the Prevention, Management, and Rehabilitation of Sports Injuries
edited by
submission deadline 31 Aug 2025 | 2 articles | Viewed by 4011 | Submission Open
Keywords: prevention; rehabilitation; physical therapy; clinical anatomy; exercise; ultrasonography; foot and ankle; tendon; musculoskeletal; female athlete
(This special issue belongs to the Section Sports Medicine)
Clinical Advancements in Kidney Transplantation
edited by Louise Benning
submission deadline 31 Aug 2025 | 4 articles | Viewed by 3501 | Submission Open
Keywords: kidney transplantation; immunosuppression; immune monitoring; biomarkers; rejection; machine perfusion; graft survival
(This special issue belongs to the Section Nephrology & Urology)
Orthodontics: State of the Art and Perspectives submission deadline 31 Aug 2025 | 2 articles | Viewed by 3138 | Submission Open
Keywords: orthodontics; digital orthodontics; intraoral scanners; facial scanners; treatment planning; interdisciplinary treatment; orthodontic implants
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Clinical Advancements in Retinal Diseases submission deadline 31 Aug 2025 | 2 articles | Viewed by 2440 | Submission Open
Keywords: retinal diseases; treatment of retinal diseases; diagnostics of retinal diseases; retinal imaging; retinal surgeries
(This special issue belongs to the Section Ophthalmology)
Updates on Brain Tumors: Diagnosis and Treatment
edited by Jigisha P. Thakkar and
submission deadline 31 Aug 2025 | 1 articles | Viewed by 2079 | Submission Open
Keywords: primary brain tumors; glioblastoma; IDH mutant glioma; meningioma; brain metastases; leptomeningeal disease
(This special issue belongs to the Section Clinical Neurology)
Advances in the Management of Cardiac Amyloidosis and Hypertrophic Cardiomyopathy
edited by Ahmed Abuzaid
submission deadline 31 Aug 2025 | 2 articles | Viewed by 1811 | Submission Open
Keywords: cardiac amyloidosis; hypertrophic cardiomyopathy; left ventricular hypertrophy; non-invasive cardiac imaging; heart failure; clinical manifestations
(This special issue belongs to the Section Cardiology)
Management of Pituitary Tumors: Current and Future Treatment Options—2nd Edition
edited by
submission deadline 31 Aug 2025 | 2 articles | Viewed by 1623 | Submission Open
Keywords: pituitary; cushing syndrome; acromegaly; prolactinoma; non-functioning pituitary adenoma; hypopituitarism; hypophysitis
(This special issue belongs to the Section Endocrinology & Metabolism)
Spinal Rehabilitation for Health and Performance: A Collection of Case Reports and Series
edited by , , Curtis Fedorchuk and
submission deadline 31 Aug 2025 | 1 articles | Viewed by 1451 | Submission Open
Keywords: spinal rehabilitation; cervical; thoracic; lumbar; sacrum; pelvis; radiography; case report; case series; sagittal balance; coronal balance; spinal alignment; spinal posture; spinal deformity; patient-reported outcomes
(This special issue belongs to the Section Clinical Rehabilitation)
Acute Kidney Events in Intensive Care Patients
edited by Kada Klouche
submission deadline 31 Aug 2025 | 2 articles | Viewed by 1383 | Submission Open
Keywords: acute kidney events; ICU; critically ill; RRT; outcome; acute kidney disease; chronic kidney disease; bi-omarkers
(This special issue belongs to the Section Intensive Care)
Current and Emerging Treatment Options in Skull Base Surgery and Neuro-Oncology
edited by Antonio Meola and Leonello Tacconi
submission deadline 31 Aug 2025 | 2 articles | Viewed by 1352 | Submission Open
Keywords: skull base; neuro-oncology; brain tumor; artificial intelligence; radiosurgery; targeted therapy; neuro endoscopy
(This special issue belongs to the Section Clinical Neurology)
Novel Insights into the Prevention and Treatment of Contact Dermatitis
edited by , Christoph Skudlik, Swen Malte John and
submission deadline 31 Aug 2025 | 1 articles | Viewed by 1339 | Submission Open
Keywords: allergic; allergy; contact dermatitis; irritant; occupation; prevention; sensitization; skin; therapy; treatment
(This special issue belongs to the Section Dermatology)
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