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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Point of Care Sonography, an Essential Tool for Anesthesiology and Acute Care

edited by

Stefan U. Weber

and Se-Chan Kim

submission deadline 1 Oct 2025 | Viewed by 369 | Submission Open

Keywords: ultrasound; anesthesia; acute care; critical care; regional anesthesia; vascular access; lung ultrasound; echocardiography; gastric ultrasound; point of care

(This special issue belongs to the Section Anesthesiology)

Mitral Valve Surgery: Current Status and Future Challenges

edited by Antonio Lio and Marco Russo

submission deadline 5 Oct 2025 | 9 articles | Viewed by 8328 | Submission Open

Keywords: mitral valve; mitral valve repair; mitral valve replacement; minimally invasive surgery; robotic surgery

(This special issue belongs to the Section Cardiology)

Endovascular Surgery: State of the Art and Clinical Perspectives

edited by

Andrea Xodo

and Francesco Squizzato

submission deadline 9 Oct 2025 | 2 articles | Viewed by 1103 | Submission Open

Keywords: complex aortic endovascular repair; aortic arch endovascular surgery; endoleaks; PMEG; spinal cord ischemia; endograft-related adverse events

(This special issue belongs to the Section Vascular Medicine)

Current Measures for Diagnosis, Monitoring, and Outcome Assessment in Orthopedics, Traumatology, and Hand Surgery

edited by

Paweł Reichert

and

Piotr Morasiewicz

submission deadline 10 Oct 2025 | 8 articles | Viewed by 14693 | Submission Open

Keywords: clinical evaluation; hand surgery; orthopaedics; performance-based measures; physical examination; reliability; traumatology

(This special issue belongs to the Section Orthopedics)

Prevention and Sports Rehabilitation

edited by Sergio Hernandez-Sanchez and

Juan Cortell-Tormo

submission deadline 10 Oct 2025 | 3 articles | Viewed by 10892 | Submission Open

Keywords: musculoskeletal pain; sport injury; therapeutic exercise; physiotherapy; load management; psychosocial; quality of life; prevention

(This special issue belongs to the Section Sports Medicine)

Breast Cancer: Clinical Diagnosis and Personalized Therapy

edited by

Edy Ippolito

submission deadline 10 Oct 2025 | 6 articles | Viewed by 8183 | Submission Open

Keywords: breast cancer; imaging biomarkers; molecular biomarkers; precision medicine; loco-regional treatment; breast surgery; breast radiotherapy

(This special issue belongs to the Section Oncology)

Neurosurgery and Spine Surgery: From Up-to-Date Practitioners, 2nd Edition

edited by

Massimiliano Visocchi

submission deadline 10 Oct 2025 | 5 articles | Viewed by 5035 | Submission Open

Keywords: neurosurgery; spine surgery; surgical techniques; research; advances; patient outcomes; interdisciplinary collaboration; healthcare; medical innovation; clinical practices

(This special issue belongs to the Section Clinical Neurology)

Pediatric Obesity: Causes, Prevention and Treatment

edited by

Julie St-Pierre

submission deadline 10 Oct 2025 | 2 articles | Viewed by 3500 | Submission Open

Keywords: 1000 first days of life; childhood obesity; lipids; healthy lifestyle; fetal programming

(This special issue belongs to the Section Endocrinology & Metabolism)

New Insights into Physical Therapy

edited by

Patsaki Irini

and

George A. Koumantakis

submission deadline 10 Oct 2025 | 2 articles | Viewed by 3481 | Submission Open

Keywords: physical rehabilitation; new technologies; virtual reality; augmented reality; telerehabilitation; clinical pilates; blood flow restriction; manual therapy; motor imagery; electrophysical modalities; therapeutic exercises; neurology; musculoskeletal; geriatric; respiratory; acute illness; cardiovascular

(This special issue belongs to the Section Sports Medicine)

Clinical Practice Guidelines for the Treatment and Management of Peripartum Depression, 2nd Edition

edited by

Silvia Cimino

submission deadline 10 Oct 2025 | 1 articles | Viewed by 3449 | Submission Open

Keywords: peripartum depression; early detection; clinical health psychology; psychotherapy interventions; parental– infant well-being

(This special issue belongs to the Section Mental Health)

Skin Disease and Inflammation: Current Treatment and Future Options

edited by

Annunziata Dattola

submission deadline 10 Oct 2025 | 1 articles | Viewed by 2273 | Submission Open

Keywords: eczema; psoriasis; hidradenitis suppurativa; alopecia areata; acne; atopic dermatitis; urticaria; prurigo nodularis; lichen

(This special issue belongs to the Section Dermatology)

Oral and Maxillofacial Surgery: Recent Clinical Advances and Future Directions

edited by Funda Göker,

Gianluca M. Tartaglia

and

Massimo Del Fabbro

submission deadline 10 Oct 2025 | 2 articles | Viewed by 1774 | Submission Open

Keywords: oral and maxillofacial reconstructive surgery; MRONJ management; temporomandibular joint disorders; sental implants; zygomatic implants; guided surgery; alveolar bone regeneration; maxillofacial deformities; bone regeneration; head and neck cancer

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

New Insights into Diabetes and Cardiovascular Diseases

edited by

Simona Giubilato

submission deadline 10 Oct 2025 | 2 articles | Viewed by 1347 | Submission Open

Keywords: diabetes; cardiovascular diseases; heart failure; pharmacological approaches; SGLT2 inhibitors; GLP-1 receptor agonists

(This special issue belongs to the Section Cardiology)

Clinical Outcomes Improvement and Perioperative Management of Surgical Patients: 2nd Edition

edited by

Dimitrios E. Magouliotis

and

Dimitris Zacharoulis

submission deadline 12 Oct 2025 | 7 articles | Viewed by 11649 | Submission Open

Keywords: clinical outcomes; surgery; quality; quality of life; quality improvement; postoperative; morbidity; postoperative care

(This special issue belongs to the Section General Surgery)

Interventional Ultrasound Associated with Rehabilitation in the Treatment of Muscolo-Skeletal Disease

edited by Stefano Galletti and

Danilo Donati

submission deadline 12 Oct 2025 | Viewed by 97 | Submission Open

Keywords: ultrasound; infiltrative treatment; musculoskeletal imaging; rehabilitation; orthopedic; rheumatology; interventional ultrasound

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Clinical Management of Skin Cancer: From Pathology Advances to Techniques Applications

edited by Guy Orchard

submission deadline 15 Oct 2025 | 6 articles | Viewed by 12150 | Submission Open

Keywords: skin cancer; surgery; chemotherapy; radiotherapy; photothermal therapy; combination therapy; molecular target strategies

(This special issue belongs to the Section Dermatology)

Diabetic Foot Complications: Current Challenges and Future Prospects—3rd Edition

edited by

Luigi Uccioli

and

José Luis Lázaro-Martínez

submission deadline 15 Oct 2025 | 10 articles | Viewed by 11594 | Submission Open

Keywords: diabetic foot ulcers; diabetic foot infections; charcot foot; peripheral vascular disease; prevention diabetic foot; lower limb amputation; diabetic foot mortality; biomechanics of diabetic foot

(This special issue belongs to the Section Endocrinology & Metabolism)

New Concepts in the Diagnosis and Treatment of Orthopedic Diseases in Children

edited by

Sergio De Salvatore

and

Laura Ruzzini

submission deadline 15 Oct 2025 | 8 articles | Viewed by 11466 | Submission Open

Keywords: pediatric orthopedics; flatfoot; genu valgum; genu varum; hip dysplasia; clubfoot; early-onset scoliosis; Scheuermann disease; perthes; epiphysiolysis; scoliosis; pediatric trauma

(This special issue belongs to the Section Clinical Pediatrics)

Gallbladder, Bile Duct and Pancreas Disorders: Current Challenges, New Perspectives and Innovative Techniques

edited by

Daniel Paramythiotis

Robert Grützmann

, Vasileios Papaziogas, Dimitrios Raptis and

Eleni Karlafti

submission deadline 15 Oct 2025 | 4 articles | Viewed by 7806 | Submission Open

Keywords: pancreas; biliary tract; pancreatobiliary diseases; pancreas neoplasm; tumor; ERCP; EUS; management; therapy; technique; surgery

(This special issue belongs to the Section General Surgery)

Musculoskeletal Diagnosis and Treatment: Connecting Gaps to Enhance Patient Care

edited by

Gali Dar

submission deadline 15 Oct 2025 | 3 articles | Viewed by 6818 | Submission Open

Keywords: musculoskeletal; back pain; neck pain; knee; shoulder; diagnosis; physiotherapy

(This special issue belongs to the Section Orthopedics)

Clinical Research in Radiation Oncology: Current Status and Future Directions

edited by Paolo Borghetti

submission deadline 15 Oct 2025 | 2 articles | Viewed by 2517 | Submission Open

Keywords: radiation oncology; radiobiology; stereotactic body radiotherapy; multidisciplinary team; integrated treatment; predictive and prognostic biomarkers; cancer treatment

(This special issue belongs to the Section Oncology)

Chronic Kidney Disease Management: Integrating Pharmacotherapy, Biomarkers, and Lifestyle Interventions for Improved Outcomes

edited by

Ioannis Bellos

submission deadline 15 Oct 2025 | 2 articles | Viewed by 1104 | Submission Open

Keywords: nephrology; chronic kidney disease; cardiovascular risk; risk stratification; biomarkers; evidence-based treatment

(This special issue belongs to the Section Nephrology & Urology)

New Approaches in Bariatric Surgery

edited by

Marius Nedelcu

submission deadline 15 Oct 2025 | 1 articles | Viewed by 587 | Submission Open

Keywords: bariatric surgery; metabolic surgery; endoscopic sleeve gastroplasty; PROM in bariatric surgery; BariClip

(This special issue belongs to the Section General Surgery)

Diagnosis and Treatment of Sjogren’s Syndrome: 2nd Edition

edited by

Yoshiro Horai

submission deadline 15 Oct 2025 | 1 articles | Viewed by 552 | Submission Open

Keywords: biological agents; JAK inhibitors; magnetic resonance imaging; noncoding RNA; Sjö gren's syndrome; ultrasound

(This special issue belongs to the Section Immunology)

Retinal Dystrophies—Structure and Function Relationship

edited by

Katarzyna Nowomiejska

submission deadline 15 Oct 2025 | 1 articles | Viewed by 356 | Submission Open

Keywords: retinal dystrophies; structural changes; functional impairment; in retinal degenerative diseases; retinitis pigmentosa

(This special issue belongs to the Section Ophthalmology)

Clinical Diagnostics and Therapeutic Advances in Pregnancy Complications

edited by

Theresa Reischer

and

Gülen Yerlikaya-Schatten

submission deadline 15 Oct 2025 | Viewed by 180 | Submission Open

Keywords: prenatal diagnosis; pre-eclampsia; gestational diabetes; pregnancy complications; preterm labor; congenital mal-formations; prenatal genetic testing

(This special issue belongs to the Section Obstetrics & Gynecology)

Recent Advancements in Periodontal and Peri-Implant Disease Management

edited by

João Martins de Mello-Neto

and Leticia Helena Theodoro

submission deadline 15 Oct 2025 | Viewed by 127 | Submission Open

Keywords: periodontal disease; peri-implantitis; periodontal medicine; complications and management

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Psychogerontology: Psychological Insights into Aging

edited by Sónia Martins and

Sara Lima

submission deadline 17 Oct 2025 | Viewed by 229 | Submission Open

Keywords: psychogerontology; aging process; adjustment; mental health; psychopatology; personality; emotions; well-being; spir-ituality; quality of life; caregiving; psychogerontology assessment and interventions

(This special issue belongs to the Section Mental Health)

New Advances in the Diagnosis and Treatment of Breast Cancer

edited by Massimo Ferrucci, Giacomo Montagna,

Gianluca Franceschini

and Alberto Marchet

submission deadline 17 Oct 2025 | Viewed by 189 | Submission Open

Keywords: breast cancer; innovative imaging technologies; personalized treatment approaches; surgical de-escalation; onco-plastic and reconstructive surgery; targeted therapies; immunotherapy; artificial intelligence; radiotherapy ad-vancements; lifestyle factors

(This special issue belongs to the Section Oncology)

Structural Heart Diseases: Current Challenges and Opportunities

edited by Anton Camaj

submission deadline 19 Oct 2025 | Viewed by 107 | Submission Open

Keywords: structural heart disease; transcatheter; electrosurgery; valvular heart disease; radiation safety; hypertrophic obstructive cardiomyopathy; adult congenital cardiac disease

(This special issue belongs to the Section Cardiology)

Mood Disorders: Diagnosis, Management and Future Opportunities

edited by

Natalia Lagunas

submission deadline 20 Oct 2025 | 13 articles | Viewed by 26131 | Submission Open

Keywords: mood disorders; depression; anxiety; stress; trauma; suicide; mental health diagnosis and treatment

(This special issue belongs to the Section Mental Health)

Inflammatory Bowel Disease: Clinical Advances and Therapeutic Prospects

edited by

Antonio M. Caballero-Mateos

submission deadline 20 Oct 2025 | 8 articles | Viewed by 17222 | Submission Open

Keywords: inflammatory bowel disease; Crohn's disease; ulcerative colitis; risk factors; therapeutic strategies

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Treatment Personalization in Clinical Psychology and Psychotherapy

edited by

Dariusz Krok

submission deadline 20 Oct 2025 | 10 articles | Viewed by 16696 | Submission Open

Keywords: treatment personalization; clinical psychology; psychotherapy; personalized treatment; psychosomatic interventions; coping and personalization

(This special issue belongs to the Section Mental Health)

Applications of Artificial Intelligence and Digital Therapeutics in Clinical Medicine

edited by

Carlos Escobar

submission deadline 20 Oct 2025 | 10 articles | Viewed by 11328 | Submission Open

Keywords: artificial intelligence; biometric sensors; deep learning; digital therapies; Internet of Things; machine learning; virtual reality; augmented reality

(This special issue belongs to the Section Clinical Guidelines)

Metabolic Syndrome and Its Burden on Global Health

edited by Umberto Goglia, Luca Monge,

Elena Succurro

Livia Pisciotta

and

Salvatore De Rosa

submission deadline 20 Oct 2025 | 8 articles | Viewed by 11151 | Submission Open

Keywords: insulin resistance; chronic low-grade inflammation; gut microbiota; energy balance; obesity; hyperlipidemia; metabolic dysfunction-associated steatotic liver (MASLD); type 2 diabetes mellitus; heart failure; diabetic cardiomyopathy; cardio-nephro-metabolic syndrome; metabolic syndrome sex differences; metabolic syndrome and health inequity; metabolic syndrome health-economic burden

(This special issue belongs to the Section Endocrinology & Metabolism)

Novelties in the Treatment of Glomerulonephritis

edited by

Francesco Locatelli

submission deadline 20 Oct 2025 | 5 articles | Viewed by 9552 | Submission Open

Keywords: glomerulonephritis; primary and secondary; IGA nephritis; membranous nephropathy; minimal change nephropathy; glomerulosclerosis; C3 glomerulonephritis; vasculitis systemic steroids; budesonide; alkilants; cyclosporine; complement; rituximab; SGLT2; sparsentan

(This special issue belongs to the Section Nephrology & Urology)

Advances in Allergic Diseases and Asthma: Clinical Insights and Emerging Therapies

edited by

Zenon Brzoza

submission deadline 20 Oct 2025 | 5 articles | Viewed by 9426 | Submission Open

Keywords: allergic diseases; asthma management; airway obstruction; allergy diagnosis; angioedema; urticaria

(This special issue belongs to the Section Immunology)

Clinical Application of Endoscopic Submucosal Dissection in Malignant Gastrointestinal Tumors and Precursors

edited by

Rainer Schöfl

and

Reinhold Függer

submission deadline 20 Oct 2025 | 5 articles | Viewed by 8255 | Submission Open

Keywords: endoscopy; endoscopic submucosal dissection; endoscopic surgery; laparoscopic surgery; minimally invasive surgery

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

General Anesthesia: Recent Developments and Emerging Trends

edited by Basavana Goudra

submission deadline 20 Oct 2025 | 3 articles | Viewed by 7397 | Submission Open

Keywords: general anesthesia; recent advances; drug development; memory and awareness; brain monitoring; sugammadex; tegileridine

(This special issue belongs to the Section Anesthesiology)

Clinical Updates on Shoulder Arthroplasty

edited by Pietro Gregori,

Edoardo Franceschetti

Rocco Papalia

and

Umile Giuseppe Longo

submission deadline 20 Oct 2025 | 6 articles | Viewed by 7334 | Submission Open

Keywords: reverse shoulder arthroplasty (RSA); rotator cuff arthropathy; revisions; hemiarthroplasty; proximal humeral fractures; osteoarthritis; 3D planning; complications; total shoulder arthroplasty (TSA)

(This special issue belongs to the Section Orthopedics)

Advances in Thrombosis and Haemostasis

edited by

José A. Páramo

submission deadline 20 Oct 2025 | 3 articles | Viewed by 7006 | Submission Open

Keywords: coagulation; immunothrombosis; inflammation; immune response; venous thrombosis; arterial thrombosis; endothelial dysfunction; neutrophil extracellular traps

(This special issue belongs to the Section Hematology)

Clinical Insights into Pulmonary Hypertension

edited by Simon Schneider

submission deadline 20 Oct 2025 | 5 articles | Viewed by 5959 | Submission Open

Keywords: pulmonary hypertension; pulmonary vascular disease (PVD); pulmonary arterial hypertension (PAH); chronic thromboembolic pulmonary hypertension (CTEPH); interstitial lung disease; chronic obstructive pulmonary disease (COPD); chronic pulmonary fibrosis; emphysema; respiratory disease; physiology; diagnosis; treatment; rehabilitation; altitude research

(This special issue belongs to the Section Respiratory Medicine)

Personalized Therapy and Clinical Outcomes for Congenital Heart Disease

edited by Giancarlo Scognamiglio and Flavia Fusco

submission deadline 20 Oct 2025 | 5 articles | Viewed by 5821 | Submission Open

Keywords: personalized therapy; clinical outcome; heart failure therapy; anti-arrhythmic therapy; sudden death prevention; adult congenital heart failure; prognosis

(This special issue belongs to the Section Cardiology)

Sleep Disorders: Current Research and Future Directions

edited by Martina Vendrame

submission deadline 20 Oct 2025 | 4 articles | Viewed by 4977 | Submission Open

Keywords: obstructive sleep apnea; parasomnia; idiopathic hypersomnia; periodic limb movement disorder; periodic limb move-ment of sleep

(This special issue belongs to the Section Clinical Neurology)

Recent Progress in Multiple Sclerosis and Migraine

edited by

Paolo Immovilli

and Eugenia Rota

submission deadline 20 Oct 2025 | 2 articles | Viewed by 4087 | Submission Open

Keywords: clinical neurology; multiple sclerosis; migraine; brain diseases; epilepsy; emerging diagnostics; MRI

(This special issue belongs to the Section Clinical Neurology)

Recent Clinical Advances in Cardiac Rehabilitation

edited by

Tomasz Rechciński

submission deadline 20 Oct 2025 | 3 articles | Viewed by 4000 | Submission Open

Keywords: cardiac rehabilitation; kinesiotherapy; psychological support; lifestyle modifications; myocardial infarction; heart failure

(This special issue belongs to the Section Cardiology)

Evolution of Breast Reconstruction: Current Techniques, Advances and Future Directions

edited by

Dung Nguyen

and Andrea Moreira

submission deadline 20 Oct 2025 | 3 articles | Viewed by 3798 | Submission Open

Keywords: breast reconstruction; microsurgery; robot-assisted surgery; breast neurotization; lymphatic surgery

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Current Progress in Inflammatory Bowel Disease (IBD)

edited by

Dan Lucian Dumitrascu

and Simona Grad

submission deadline 20 Oct 2025 | 4 articles | Viewed by 3739 | Submission Open

Keywords: assessment and diagnosis of IBD; diet and nutrition in IBD; Microbiota and IBD; RCTs in IBD; new therapies in IBD; meta-analyses and systematic reviews in IBD; psychological impact and quality of life in IBD; imaging techniques in IBD; pathogenesis of IBD (including the impact of disrupted barrier function)

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Advances in Child Neurology

edited by Claire Marie Rangon and

Debopam Samanta

submission deadline 20 Oct 2025 | 3 articles | Viewed by 3331 | Submission Open

Keywords: non-invasive; invasive; neuromodulation; children; neurodevelopmental disorders; autism spectrum disease; refractory epilepsy; vagus nerve stimulation

(This special issue belongs to the Section Clinical Pediatrics)

Burn Wounds Management: Challenges and New Perspectives

edited by Tiberiu Paul Neagu

submission deadline 20 Oct 2025 | 3 articles | Viewed by 3098 | Submission Open

Keywords: burn wound; burn wound healing; eschars and escharotomy; fasciotomy; skin grafting; skin substitutes; skin tissue engineering; hypertrophic or atrophic scar; wound scarring prevention; topical antimicrobial agents; factors influencing burn wound healing; chronic diseases and burn wound healing; rehabilitation in burns

(This special issue belongs to the Section General Surgery)

Displaying special issue 351-400 on page 8 of 30.

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