jcm-logo

Journal Browser

Journal Browser

Cardiac Arrest Research: Neuroprognostication and Improving Outcomes

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiovascular Medicine".

Deadline for manuscript submissions: 20 January 2026 | Viewed by 774

Special Issue Editors


E-Mail
Guest Editor
Department of Emergency Medicine, Dong-A University College of Medicine, Busan 49201, Republic of Korea
Interests: post-cardiac arrest care; emergency imaging; frontal EEG; echocardiography; volume responsiveness

E-Mail
Guest Editor
Department of Emergency Medicine, College of Medicine, Chungnam National University, 266, Munhwa-ro, Jung-gu, Daejeon, Republic of Korea
Interests: cardiac arrest; post-cardiac arrest care; emergency imaging; frontal EEG; echocardiography; volume responsiveness

Special Issue Information

Dear Colleagues,

Many efforts have been made to improve the survival rates of cardiac arrest patients. Despite ongoing debates, there remains a pressing need for better treatment methods and guidelines. Prognostic tools to identify groups at risk of moderate to severe anoxic ischemia and management strategies to improve their outcomes are critical topics of our time. While concerns about early prognostication persist, it is essential to use modalities such as brain MRI, EEG, and others for early prognosis prediction and to consider therapeutic interventions for eligible patients. Rapid CPR, early defibrillation, cause-specific treatments for cardiac arrest, and various supportive care options can enhance the neurological outcomes of these patients. In this Special Issue, we invite authors to submit papers on novel approaches and improved therapeutic options based on prognosis in cardiac arrest patients.

Dr. Jae Hoon Lee
Dr. Jin-hong Min
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiac arrest
  • prognosis
  • hypothermia, induced
  • resuscitation
  • magnetic resonance imaging
  • electroencephalography
  • blood pressure
  • hypoxia-ischemia, brain
  • extracorporeal membrane oxygenation

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

13 pages, 1824 KB  
Article
The Prediction of Early Neurological Outcomes in Out-of-Hospital Cardiac Arrest Patients: A Multicenter Prospective Cohort Study by the KORHN Registry
by Wook Jin Choi and Jae Hoon Lee
J. Clin. Med. 2025, 14(18), 6466; https://doi.org/10.3390/jcm14186466 - 13 Sep 2025
Viewed by 527
Abstract
Background/Objectives: Early neuroprognostication after cardiac arrest is essential for guiding treatment strategies and providing accurate prognostic information to families. While several early risk scores have been proposed, few have incorporated a wide range of variables in large cohorts. This study aimed to [...] Read more.
Background/Objectives: Early neuroprognostication after cardiac arrest is essential for guiding treatment strategies and providing accurate prognostic information to families. While several early risk scores have been proposed, few have incorporated a wide range of variables in large cohorts. This study aimed to develop and validate a novel prognostic model, the KORHN risk score, and to compare its performance with established tools including MIRACLE, TTM, CAHP, C-GRApH, and OHCA scores; Methods: We conducted a prospective multicenter observational study using data from the KORean Hypothermia Network registry. Risk variables identified in previous studies, along with extensive data from 1371 patients in the KORHN registry, were analyzed. The primary endpoint was poor neurological outcome at 6 months; Results: Key predictors included low-flow time, diastolic shock index, cardiac etiology, bilateral absence of pupil reflex, shockable initial rhythm, Glasgow Coma Scale motor response, epinephrine use, and age. Compared with established risk scores, the KORHN score demonstrated superior performance (AUC 0.925 vs. 0.827–0.902 with all variables, and AUC 0.914 vs. 0.85–0.903 with the top five variables with identical cut-off). External validation in a non-KORHN cohort (AUC 0.890) confirmed its robustness; Conclusions: The KORHN score provides a simple, accurate tool for early neuroprognostication, supporting clinical decision-making and family communication. Full article
(This article belongs to the Special Issue Cardiac Arrest Research: Neuroprognostication and Improving Outcomes)
Show Figures

Figure 1

Back to TopTop