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Advancements in the Treatment of Myeloproliferative Neoplasms and Myelodysplastic Syndromes

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Hematology".

Deadline for manuscript submissions: 20 January 2026 | Viewed by 57

Special Issue Editors


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Guest Editor
1. Department of Internal Medicine, General Hospital of Šibenik-Knin County, Šibenik, Croatia
2. Faculty of Medicine, University of Rijeka, Rijeka, Croatia
Interests: hematology; chronic myeloproliferative neoplasms; cardiovascular risk
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Guest Editor
1. Pharmacy Department, General Hospital of Šibenik-Knin County, Šibenik, Croatia
2. Faculty of Medicine, University of Rijeka, Rijeka, Croatia
Interests: clinical trials

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Guest Editor
1. Division of Hematology, University Hospital Rijeka, Rijeka, Croatia
2. Faculty of Medicine, University of Rijeka, Rijeka, Croatia
Interests: hematology; myeloproliferative neoplasms; stem cell transplantation; cellular therapy

Special Issue Information

Dear Colleagues,

This is an invitation to contribute to a new Special Issue of the Journal of Clinical Medicine (JCM) entitled “Advancements in the Treatment of Myeloproliferative Neoplasms and Myelodysplastic Syndromes”. These complex and heterogeneous myeloid neoplasms usually affect the elderly and are characterized by complex pathophysiological processes including the hematopoietic stem cell and bone marrow microenvironment, chronic inflammatory state, various disease-related debilitating symptoms, high cardiovascular risk, and the intrinsic tendency to transform into more aggressive myeloid entities such as secondary myelofibrosis and acute leukemia. In recent years, significant advances in this field have profoundly affected the diagnostic, prognostic, and therapeutic landscapes. Therefore, the aim of this Special Issue is to give JCM readers an update on the pathophysiology, diagnosis, risk stratification, and the contemporary management of these myeloid neoplasms.

Dr. Ivan Krečak
Dr. Marko Skelin
Dr. Zinaida Perić
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • myeloproliferative neoplasms
  • myelodysplastic syndromes
  • treatment
  • risk stratification
  • prognosis

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Published Papers (1 paper)

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Research

15 pages, 534 KiB  
Article
Prognostic Value of Inflammation and Nutrition-Based Scores in Low-Risk Myelodysplastic Syndrome: A Retrospective Cohort Study
by Tuba Ersal, Vildan Özkocaman, Sinem Çubukçu, Tuba Güllü Koca, Fazıl Çağrı Hunutlu, Şeyma Yavuz, Ezel Elgün, Gökhan Ocakoğlu and Fahir Özkalemkaş
J. Clin. Med. 2025, 14(13), 4751; https://doi.org/10.3390/jcm14134751 (registering DOI) - 4 Jul 2025
Abstract
Background/Objectives: The pathogenesis of Myelodysplastic Syndrome (MDS) is diverse; however, increasing evidence suggests that inflammation and oxidative stress play a significant role in the development and progression of the disease. This study aimed to evaluate the prognostic impact of inflammation, nutritional status, and [...] Read more.
Background/Objectives: The pathogenesis of Myelodysplastic Syndrome (MDS) is diverse; however, increasing evidence suggests that inflammation and oxidative stress play a significant role in the development and progression of the disease. This study aimed to evaluate the prognostic impact of inflammation, nutritional status, and oxidative stress at diagnosis in patients with low-risk MDS. Methods: A retrospective analysis was conducted on 175 newly diagnosed low-risk MDS patients. Results: A low Prognostic Nutritional Index (PNI) and a high systemic oxidative stress (SOS) score were independently associated with poorer prognosis (PNI: HR 1.598, 95% CI 1.076–2.372, p = 0.02; SOS: HR 1.003, 95% CI 1.001–1.006, p = 0.002). The optimal PNI cut-off value for predicting mortality was identified as 47.47. Based on this cut-off, 92 patients had a low PNI score, while 83 patients had a high PNI score. The comparison between these groups revealed a statistically significant difference in median overall survival (OS), with 45.5 months for the low-PNI group and 75.1 months for the high-PNI group (p < 0.001). However, PNI was not significantly associated with progression to acute myeloid leukemia (AML) (p = 0.668). In the multivariate OS analysis, several factors were identified as independent predictors of prognosis, including a high Revised International Prognostic Scoring System (R-IPSS) score, low PNI, high SOS score, advanced age, male gender, and transformation to AML. Conclusions: Together, PNI and SOS may serve as simple, accessible tools to improve risk stratification in low-risk MDS patients. Full article
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