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New Perspectives in Chronic Kidney Disease, Transplantation and Immune System

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Nephrology & Urology".

Deadline for manuscript submissions: 25 July 2025 | Viewed by 401

Special Issue Editors


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Guest Editor
Department of Biological Chemistry, School of Medicine, Aristotle University of Thessaloniki, 45636 Thessaloniki, Greece
Interests: kidney transplantation; immunochemistry; transplantation
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Guest Editor
Director of Thrombosis and Hemostasis and Co-Head Hematology, MEDISYN SA, 6002 Lucerne, Switzerland
Interests: platelet disorders; diagnosis and treatment of bleeding disorders and thrombophilia; hemostasis; endothelial cells and complement in stem cell transplantation

Special Issue Information

Dear Colleagues,

The Special Issue, entitled "New Perspectives in Chronic Kidney Disease, Transplantation and Immune System", focuses on the relationship between chronic kidney disease, transplantation and the immune system, and the clinical implications of this relationship. It is important to advance research in this area in order to achieve the early diagnosis of kidney disease with an immunological etiology, as well as understand the effects of chronic kidney disease on immune function and its alteration after transplantation.

The application of novel methods to understand the disease and evaluate data for diagnostic purposes will ultimately lead to the validation of a therapeutic approach for these conditions.

In addition, the clinical implications of complement and haemostasis in renal disease and transplantation have been considered, as these are biological systems that are sequentially activated under the influence of endogenous or exogenous triggers and act as a defence system against damaging actions or stimuli. The study of these interactive pathways is crucial in the context of renal disease and/or injury. By obtaining a deeper understanding of the common mechanisms involved, this Special Issue may contribute to knowledge regarding the pathophysiology of kidney disease and transplantation and the development of effective treatments.

Dr. Maria Daoudaki
Prof. Dr. Dimitrios A. Tsakiris
Guest Editors

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Keywords

  • kidney transplantation
  • HLA
  • matching at the epitope level
  • DSAs
  • complement
  • kidney disease epigenetics
  • diabetic nephropathy
  • hemostasis
  • graft rejection
  • B and T cell immunophenotyping
  • end stage renal disease

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Published Papers (1 paper)

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Research

15 pages, 814 KiB  
Article
Can Double-Negative B Cells and Marginal Zone B Cells Have a Potential Impact on the Outcome of Kidney Transplantation?
by Ariadni Fouza, Asimina Fylaktou, Maria Daoudaki, Persefoni Talimtzi, Anneta Tagkouta, Lampros Vagiotas, Georgios Katsanos, Georgios Tsoulfas and Nikolaos Antoniadis
J. Clin. Med. 2025, 14(10), 3312; https://doi.org/10.3390/jcm14103312 - 9 May 2025
Viewed by 218
Abstract
Objectives/Background: B lymphocytes are involved in both graft function and rejection. The role of double-negative (DN) and marginal zone B (MZB) lymphocytes in transplantation remains unclear. This study aims to investigate their role one year after transplant. Methods: The frequency and absolute numbers [...] Read more.
Objectives/Background: B lymphocytes are involved in both graft function and rejection. The role of double-negative (DN) and marginal zone B (MZB) lymphocytes in transplantation remains unclear. This study aims to investigate their role one year after transplant. Methods: The frequency and absolute numbers of DN and MZB cells were determined by flow cytometry before transplantation and at 3, 6 and 12 months after transplant. They were correlated with graft function and rejection. Results: Both the frequency and absolute number of MZB and DN cells increased 12 months after transplantation. Variations were observed in the populations studied at different time points. The observed decrease in the frequency of MZB lymphocytes in kidney recipients with rejection at 12 months, the end of follow-up, was associated with rejection episodes. On ROC curve analysis, a cut-off value of <20.6% could be a predictor of rejection risk in the first 12 months after transplantation (sensitivity 72.7%, specificity 69.6%). No relationship was found between the frequencies and absolute numbers of cell populations and graft function at any time point. Conclusions: The kinetics of B cells (DN and MZB) were determined over the course of 12 months after kidney transplantation. The frequency of MZ B cells was associated with rejection episodes. Full article
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