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Aortic Valve Disease: Current Evolution and Future Opportunities

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: 20 January 2026 | Viewed by 462

Special Issue Editor


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Guest Editor
IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy
Interests: aortic valve disease; aortic valve repair; ross procedure; aortic valve replacement; diagnosis of aortic valve disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We invite you to participate in this Special Issue of JCM, titled “Aortic Valve Disease: Current Evolution and Future Opportunities”. As you well know, congenital anomalies of the aortic valve frequently necessitate intervention in childhood. The most common aortic valve pathologies are aortic stenosis and insufficiency, and presentation of aortic valve disease depends on severity and presence of concomitant syndromes and valvular disorders. Treatment options are largely categorized as medical, percutaneous repair or surgical repair, and replacement. This Special Issue will focus on the latest research, treatment strategies, and clinical insights related to aortic valve disorders in children, an area in which you have made significant contributions.

Given your expertise in pediatric cardiology and your extensive work on valvular heart diseases, we believe your perspective would greatly enhance the quality and depth of this Special Issue. We are seeking articles on a range of topics, including, but not limited to, the following:

  • Congenital aortic valve diseases (e.g., bicuspid aortic valve and unicuspid valve);
  • Early diagnosis and imaging techniques;
  • Surgical and interventional approaches (e.g., balloon valvuloplasty and valve repair/replacement);
  • Emerging research and novel therapies for pediatric aortic valve conditions.

We look forward to receiving your submissions to this Special Issue.

Dr. Gianluigi Perri
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • aortic valve disease
  • aortic valve repair
  • Ross procedure
  • aortic valve replacement
  • diagnosis of aortic valve disease

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Published Papers (1 paper)

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Research

12 pages, 1004 KB  
Article
Aortic Stenosis in End-Stage Renal Disease: Incidence, Prevalence, and Mortality in a National Korean Cohort
by Minjeong Kim, Min-Ho Kim, Sang Jun Park and Hyangkyoung Kim
J. Clin. Med. 2025, 14(19), 6921; https://doi.org/10.3390/jcm14196921 - 30 Sep 2025
Viewed by 349
Abstract
Background/Objectives: Aortic stenosis (AS) is an increasingly recognized end-stage renal disease (ESRD) complication. This study aimed to identify AS incidence and prevalence in Korean patients with ESRD, assess the effect of AS on all-cause mortality, and determine associated risk factors unique to [...] Read more.
Background/Objectives: Aortic stenosis (AS) is an increasingly recognized end-stage renal disease (ESRD) complication. This study aimed to identify AS incidence and prevalence in Korean patients with ESRD, assess the effect of AS on all-cause mortality, and determine associated risk factors unique to this population. Methods: This retrospective study used Korean National Health Insurance Service data from 2009 to 2021 and included adult patients with ESRD undergoing maintenance dialysis. AS was identified based on diagnostic codes, and 4:1 propensity score matching was conducted. Temporal trends in AS incidence and prevalence were analyzed in terms of sex and age. Kaplan–Meier survival analysis and Cox proportional hazards models were employed for all-cause mortality assessment. Results: Among 91,466 eligible patients, 708 (0.77%) had AS. AS incidence and prevalence increased from 8.05 to 35.29 and from 8.05 to 77.43 per 10,000, respectively, from 2009 to 2021, and were higher in women than in men. Age-stratified analysis revealed the greatest burden in patients aged ≥80. AS in the matched cohort (n = 2875) was associated with <10-year survival (13% vs. 24%, p < 0.001), with differences evident from age 60 onward. Multivariable analysis revealed AS as an independent mortality predictor (hazard ratio: 1.23, 95% confidence interval: 1.08–1.40, p = 0.002). Older age, atrial fibrillation, stroke, and a higher Charlson Comorbidity Index were significant mortality predictors among patients with AS. Conclusions: AS burden in dialysis-dependent patients with ESRD is markedly increasing, particularly among women and older adults, and is independently associated with elevated mortality. Full article
(This article belongs to the Special Issue Aortic Valve Disease: Current Evolution and Future Opportunities)
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