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Multiple Myeloma: Therapeutic and Management Strategies

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Hematology".

Deadline for manuscript submissions: 20 January 2026 | Viewed by 563

Special Issue Editor


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Guest Editor
Section of Hematology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510, USA
Interests: hematology; multiple myeloma; AL amyloidosis; monoclonal gammopathy of undetermined significance (MGUS); plasma cell leukemia

Special Issue Information

Dear Colleagues,

The treatment landscape of multiple myeloma has changed over the past several years with the development and approval of several new therapies. Therapies including CD38 monoclonal antibodies and immunotherapy in the form of both CAR T and bispecific T cell engagers have changed the management of relapsed and refractory multiple myeloma.  Despite these new therapies, multiple myeloma is still considered to be an incurable hematologic malignancy. Recent and ongoing clinical trials have evaluated these therapies in earlier lines and looked to define the optimal sequencing of treatments.

For example, CD38 antibodies have been used in combinations in both transplant eligible and ineligible patients in the frontline setting resulting in improved efficacy. This shift in management, in turn, has altered second-line treatment and beyond. As more patients are treated with immunotherapies earlier in their disease course, the management and prevention of complications related to treatment needs to be considered in the overall management of multiple myeloma.

This Special Issue will address the most recent and relevant scientific findings regarding frontline treatment, treatment of relapsed refractory multiple myeloma, and optimal sequencing of therapies. In addition, the Special Issue will also address the management of toxicities specific to these emerging treatments.

Dr. Terri Parker
Guest Editor

Manuscript Submission Information

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Keywords

  • multiple myeloma
  • frontline treatment
  • monoclonal antibodies
  • sequencing of treatment
  • immunotherapy
  • CAR T
  • Bi-specific T cell engagers
  • toxicity management

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Published Papers (1 paper)

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Research

12 pages, 696 KB  
Article
The Impact of Endothelial Cell Values in Bone Marrow on the Survival of Patients with Multiple Myeloma—A Single-Center Observational Study
by Krzysztof Gawroński, Nadia Hussein, Elżbieta Rutkowska, Iwona Kwiecień, Agata Raniszewska, Katarzyna Gawrońska and Piotr Rzepecki
J. Clin. Med. 2025, 14(19), 6710; https://doi.org/10.3390/jcm14196710 - 23 Sep 2025
Viewed by 289
Abstract
Background: This study aimed to analyze the survival of patients with multiple myeloma in relation to the value of endothelial cells involved in the process of tumor neoangiogenesis. Methods: In this non-randomized observational study, we prospectively evaluated a cohort of 74 adult patients [...] Read more.
Background: This study aimed to analyze the survival of patients with multiple myeloma in relation to the value of endothelial cells involved in the process of tumor neoangiogenesis. Methods: In this non-randomized observational study, we prospectively evaluated a cohort of 74 adult patients with multiple myeloma who underwent a baseline assessment of the endothelial cell count in their bone marrow and received VCD or VTD anti-myeloma therapy followed by autoPBSCT. They were then evaluated for survival via long-term follow-up. Results: The survival of myeloma patients undergoing these therapies was analyzed, and we found that patients with higher endothelial cell counts had higher mortality rates during long-term follow-up. In the group of patients who died, the endothelial cell count was significantly higher (p = 0.024). We also observed that patients who initially had >2 osteolytic lesions had higher endothelial cell counts (p = 0.021). However, our analysis of endothelial cell count in relation to patient survival using antiangiogenic drugs showed that, in this group, the endothelial cell count was significantly higher in patients who died (p = 0.048). Conclusions: We found that patients with higher endothelial cell counts and those who did not receive antiangiogenic drugs from the start of therapy had higher mortality rates during long-term follow-up. Full article
(This article belongs to the Special Issue Multiple Myeloma: Therapeutic and Management Strategies)
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