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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Robot-Assisted Surgery: Current Trends and Future Directions

edited by

Michele Di Dio

, Claudio Bisegna and Michele Morelli

submission deadline 25 Oct 2025 | Viewed by 319 | Submission Open

Keywords: robotic surgery; minimally invasive surgery; urology; artificial intelligence; augmented reality; public health; innovation; laparoscopic surgery; surgical platforms; surgical outcomes

(This special issue belongs to the Section General Surgery)

Testicular Cancer: Clinical Advances in Diagnosis and Treatment

edited by

Markus Lerchbaumer

, Andreas Maxeiner and

Thomas Fischer

submission deadline 25 Oct 2025 | Viewed by 203 | Submission Open

Keywords: testicular cancer; ultrasound imaging; computed tomography; new imaging modalities; personalized medicine; oncology; surgical treatment

(This special issue belongs to the Section Oncology)

New Clinical Insights into Cardiac Pacing and Cardiac Resynchronization Therapy

edited by Massimo Zecchin

submission deadline 25 Oct 2025 | Viewed by 157 | Submission Open

Keywords: cardiac pacing; cardiac resynchronization therapy (CRT); cardiac conduction system pacing; left bundle branch area pacing; leadless pacing; short- and long-term outcomes; implantation technique

(This special issue belongs to the Section Cardiology)

Advances in Primary Sclerosing Cholangitis: Pathogenesis, Diagnosis and Emerging Therapies

edited by Konstantinos H. Katsanos and Fotios S. Fousekis

submission deadline 25 Oct 2025 | Viewed by 153 | Submission Open

Keywords: cholangiocarcinoma; primary sclerosing cholangitis; cholestatic; inflammatory bowel disease; liver

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

New Advances and Clinical Outcomes of Endocrinology

edited by Stefana Catalina Bilha and

Cristina Preda

submission deadline 25 Oct 2025 | Viewed by 151 | Submission Open

Keywords: endocrinology; obesity; metabolic and bone disease; chronic conditions

(This special issue belongs to the Section Endocrinology & Metabolism)

Respiratory Medicine in the Oldest-Old

edited by

Takae Ebihara

submission deadline 25 Oct 2025 | Viewed by 147 | Submission Open

Keywords: oldest-old; respiratory system with aging; pneumonia; epidemiology; COPD; interstitial lung disease; bronchial asthma; lung cancer; mycobacterial or fungal infections; peri-/post-operative status; respiratory frailty; social problems and end of life

(This special issue belongs to the Section Respiratory Medicine)

Management and Prognosis of Spinal Surgery

edited by Francesco Costa

submission deadline 25 Oct 2025 | Viewed by 142 | Submission Open

Keywords: spine; spinal surgery; spinal biomechanics; microneurosurgery; vertebral oncology

(This special issue belongs to the Section Clinical Neurology)

Novel Insights into Colorectal Surgery

edited by

Valentin Calu

submission deadline 25 Oct 2025 | Viewed by 130 | Submission Open

Keywords: colorectal surgery; robotic surgery; neoadjuvant treatment; minimally invasive techniques; enhanced recovery

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Global Expert Views on Aortic Valve Repair and Replacement: 2nd Edition

edited by

Jose Alberto De Agustín

submission deadline 25 Oct 2025 | Viewed by 129 | Submission Open

Keywords: aortic valve pathologies; minimally invasive approach; aortic valve repair; aortic valve replacement; imaging techniques

(This special issue belongs to the Section Cardiovascular Medicine)

New Concepts in Minimally Invasive Spine Surgery

edited by

Yi Lu

and Michael Y. Wang

submission deadline 25 Oct 2025 | Viewed by 119 | Submission Open

Keywords: minimally invasive spine surgery; image navigation; tubular retractor; endoscopic spine surgery; virtual and aug-mented reality; lateral spine surgery

(This special issue belongs to the Section Clinical Neurology)

Recent Advances in the Diagnosis and Treatment of Gastrointestinal Diseases

edited by

Ahamed Khalyfa

submission deadline 27 Oct 2025 | 3 articles | Viewed by 2866 | Submission Open

Keywords: advanced endoscopy; innovation in GI; pathophysiology of GI disorders; artificial intelligence in GI; gastrointestinal diseases

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Chronic Kidney Disease: Global Dimension and Perspectives

edited by Valentina Câmpean

submission deadline 28 Oct 2025 | 1 articles | Viewed by 1510 | Submission Open

Keywords: histological changes; renal dysfunction; kidney diseases; glomerulonephritis; polycystic kidney disease; kidney failure; kidney cancer; atherosclerosis; heart disease; renal and renovascular hypertension

(This special issue belongs to the Section Nephrology & Urology)

Prostate Surgery: The Latest Advances and Future Trends

edited by Akhil K. Das and

Bruce Gao

submission deadline 28 Oct 2025 | Viewed by 170 | Submission Open

Keywords: benign prostatic hyperplasia (BPH); minimally invasive surgical therapies (MIST); laser enucleation (HoLEP; ThuLEP); Aquablation; Rezum; robotic prostatectomy; anatomic enucleation

(This special issue belongs to the Section Nephrology & Urology)

Symptoms and Treatment of Cardiac Amyloidosis

edited by Syed Bukhari

submission deadline 28 Oct 2025 | Viewed by 168 | Submission Open

Keywords: cardiac amyloidosis; transthyretin amyloidosis; light chain amyloidosis; cardiac magnetic resonance; echocardiography; nuclear scintigraphy; endomyocardial biopsy; gene silencers; transthyretin stabilizers; immunotherapy

(This special issue belongs to the Section Cardiology)

Recent Advances and Clinical Outcomes of Hip and Knee Arthroplasty

edited by

Andrea Volpin

submission deadline 28 Oct 2025 | Viewed by 130 | Submission Open

Keywords: hip arthroplasty; knee arthroplasty; joint replacement; clinical outcomes; surgical innovation; patient recovery; prosthetics; perioperative care

(This special issue belongs to the Section Orthopedics)

Diagnosis, Treatment, and Management of Gastrointestinal Oncology

edited by Toufic A. Kachaamy and Madappa N. Kundranda

submission deadline 30 Oct 2025 | 3 articles | Viewed by 9959 | Submission Open

Keywords: gastrointestinal oncology; endoscopic oncology; biliary tract cancer; colorectal cancer; esophageal cancer; stomach cancer

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Biomarkers and Lung Cancer: Clinical Application

edited by

Roberto Gasparri

submission deadline 30 Oct 2025 | 5 articles | Viewed by 6482 | Submission Open

Keywords: lung cancer; early diagnosis; prognosis; biomarkers; body fluids; liquid biopsy

(This special issue belongs to the Section Respiratory Medicine)

New Update on Personalized Treatment of Autism Spectrum Disorder and Related Disorders

edited by

Francesca Cucinotta

, Rosamaria Siracusano and Erica Pironti

submission deadline 30 Oct 2025 | 3 articles | Viewed by 6277 | Submission Open

Keywords: autism spectrum disorder; autism related disorders; children and adolescents; intervention strategies; therapeutic advance; new technologies; evidence-based practices

(This special issue belongs to the Section Mental Health)

Clinical Highlights in Chronic Obstructive Pulmonary Disease (COPD)

edited by

Richard Zuwallack

and Dimosthenis Lykouras

submission deadline 30 Oct 2025 | 4 articles | Viewed by 5642 | Submission Open

Keywords: COPD treatment; inhalers; patient-reported outcomes; COPD rehabilitation; cardiovascular risk

(This special issue belongs to the Section Respiratory Medicine)

Clinical Challenges in High-Risk Pregnancy and Delivery

edited by

Salvatore Andrea Mastrolia

submission deadline 30 Oct 2025 | 2 articles | Viewed by 5503 | Submission Open

Keywords: high-risk pregnancy; preeclampsia; cesarean section; maternal– fetal medicine; ultrasound; fetal monitoring; complications; delivery; placental abruption; great obstetrical syndromes

(This special issue belongs to the Section Obstetrics & Gynecology)

Advances in Anesthesia for Cardiac Surgery

edited by Christopher M. Munch and

Pietro Giorgio Malvindi

submission deadline 30 Oct 2025 | 5 articles | Viewed by 5486 | Submission Open

Keywords: enhanced recovery after cardiac surgery (ERACS); minimally invasive cardiac surgery (MICS); ultra-fast-track an-esthesia; chest wall blocks in cardiac anesthesia; opioid-free anesthesia in cardiac surgery; neurologic dysfunction and cardiac surgery; pre- and posthabilitation in cardiac surgery

(This special issue belongs to the Section Anesthesiology)

Clinical New Insights into Management of Scoliosis

edited by Piotr Janusz and Marcin Tyrakowski

submission deadline 30 Oct 2025 | 4 articles | Viewed by 5143 | Submission Open

Keywords: scoliosis; idiopathic scoliosis; congenital scoliosis; neuromuscular scoliosis; degenerative scoliosis; kyphosis; spine deformation; scoliosis etiology; surgical treatment; non-surgical treatment

(This special issue belongs to the Section Orthopedics)

Facial Plastic and Cosmetic Medicine

edited by

Neelam Vashi

submission deadline 30 Oct 2025 | 3 articles | Viewed by 4238 | Submission Open

Keywords: cosmetics; aesthetics; plastic surgery; skin rejuvenation; beauty; procedures

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

New Advances in Minimally Invasive Surgery for Gynecologic Cancer

edited by

Rafał Watrowski

and

Valerio Gallotta

submission deadline 30 Oct 2025 | 1 articles | Viewed by 2978 | Submission Open

Keywords: minimally invasive surgery; gynecologic surgery; gynecologic oncology; surgical techniques; patient safety; personalized medicine

(This special issue belongs to the Section Obstetrics & Gynecology)

Advances in Anesthesia and Intensive Care During Perioperative Period

edited by

Philipp Simon

submission deadline 30 Oct 2025 | 3 articles | Viewed by 2198 | Submission Open

Keywords: general anesthesia; intensive care medicine; post intensive care syndrome; perioperative management; fast track; pain management; complications; postoperative outcome; digitalization; big data; AI; closed-loop systems; machine learning; clinical decision support; telemedicine

(This special issue belongs to the Section Intensive Care)

Spine Surgery: Current Practice and Future Directions

edited by Claudio Bernucci and Francesco Costa

submission deadline 30 Oct 2025 | 1 articles | Viewed by 2067 | Submission Open

Keywords: degenerative; spinal trauma; spine tumors; neurosurgery; spine surgery; spinal deformity; scoliosis; robotics surgery; spinal cord injury; clinical practices; regenerative therapies

(This special issue belongs to the Section Clinical Neurology)

Innovations in Perioperative Anesthesia and Intensive Care

edited by

Ivan Gornik

and Ileana Lulic

submission deadline 30 Oct 2025 | 2 articles | Viewed by 1764 | Submission Open

Keywords: perioperative anesthesia; intensive care; artificial intelligence in anesthesia; precision medicine in perioperative care; hemodynamic monitoring; multimodal analgesia; opioid-free anesthesia; ventilation strategies in ICU and surgery; neuromonitoring and sedation; perioperative resuscitation and ECMO

(This special issue belongs to the Section Intensive Care)

Artificial Intelligence and Deep Learning in Medical Imaging

edited by Eros Montin and Giuseppe Carluccio

submission deadline 30 Oct 2025 | 2 articles | Viewed by 1459 | Submission Open

Keywords: magnetic resonance imaging; radiomics; artificial intelligence (AI); deep learning; clinical and translational medicine; MRI safety; radiogenomics; multiomics

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Advancements and Challenges in Reconstructive Urology and Urethral Surgery

edited by

Francesco Chierigo

submission deadline 30 Oct 2025 | 2 articles | Viewed by 1440 | Submission Open

Keywords: reconstructive urology; urethral surgery; urethroplasty; minimally invasive surgery; robotic-assisted surgery; urinary tract reconstruction; surgical innovation; patient-reported outcomes

(This special issue belongs to the Section Nephrology & Urology)

Advances in Gastroenterological Surgery

edited by Alan Biloslavo and Antonio La Greca

submission deadline 30 Oct 2025 | 2 articles | Viewed by 1061 | Submission Open

Keywords: mini-invasive surgery; technology; artificial intelligence; negative pressure; indocyanine green; ultrasound; GE surgery; emergency surgery; precision surgery

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Advances in Ocular Surface Research: Exploring Antimicrobial Resistance and Emerging Therapeutics

edited by

Francesco D'Oria

, Giovanni Alessio and Maria Gabriella la Tegola

submission deadline 30 Oct 2025 | 1 articles | Viewed by 1017 | Submission Open

Keywords: ocular surface microbiome; antimicrobial resistance; ocular infections and therapeutics; novel diagnostics in ophthalmology; biofilms and pathogen evolution; infection control and public health

(This special issue belongs to the Section Ophthalmology)

Prostatectomy: Clinical Updates and Perspectives

edited by Antonio Nacchia

submission deadline 30 Oct 2025 | 1 articles | Viewed by 1008 | Submission Open

Keywords: single port; prostatectomy; robotics; RARP; prostate cancer

(This special issue belongs to the Section Nephrology & Urology)

Catheter Ablation of Atrial Fibrillation: Current Progress and New Challenges

edited by Sorin Stefan Popescu, Roland Richard Tilz and Karl-Heinz Kuck

submission deadline 30 Oct 2025 | 1 articles | Viewed by 850 | Submission Open

Keywords: atrial fibrillation; novel technologies; pulmonary vein isolation; same-day discharge; pulsed field ablation; cryo-ablation; radiofrequency; safety; efficacy; sustainability

(This special issue belongs to the Section Cardiology)

Prosthetic Joint Infections: Contemporary Insights into Their Management and Prevention

edited by

Sebastian Scheidt

and Uwe Maus

submission deadline 30 Oct 2025 | 1 articles | Viewed by 819 | Submission Open

Keywords: arthroplasty; infection; replacement; antibiotics; management; hip; knee; shoulder; periprosthetic; prevention; implant retention; procedure; implant retention; debridement; cellular infection; infection markers

(This special issue belongs to the Section Orthopedics)

Novel Insights into Clinical Diagnosis and Management of Degenerative Cervical Myelopathy

edited by

Carlo Brembilla

, Francesco Costa and Filippo Maria Polli

submission deadline 30 Oct 2025 | 1 articles | Viewed by 697 | Submission Open

Keywords: degenerative cervical myelopathy (DCM); cervical spondylotic myelopathy (CSM); cervical spinal stenosis; cervical cord compression; MRI of the cervical spine; cervical spine surgery; physical therapy; rehabilitation; ossification of the posterior longitudinal ligament (OPLL); cervical deformity (e.g.; kyphosis and lordosis); patient-reported out-comes; surgical outcome prediction

(This special issue belongs to the Section Clinical Neurology)

Advances in Atrial Fibrillation Treatment

edited by Iwona Woźniak-Skowerska

submission deadline 30 Oct 2025 | 1 articles | Viewed by 609 | Submission Open

Keywords: pulmonary vein ablation; atrial fibrillation; heart failure; arrhythmia; personalized medicine

(This special issue belongs to the Section Cardiovascular Medicine)

Advancements in Venous Thrombosis Management: From Prevention to Long-Term Care

edited by

Luca Costanzo

submission deadline 30 Oct 2025 | Viewed by 409 | Submission Open

Keywords: venous thromboembolism; post-thrombotic syndrome; direct oral anticoagulant; pulmonary embolism; thrombosis; factor xia inhibitors; thrombolysis; cancer; antiphospholipid syndrome; catheter-directed thrombolysis; inferior vena cava filters

(This special issue belongs to the Section Vascular Medicine)

Drug Therapy and Prognosis in Patients with Heart Failure

edited by

Manuel Méndez-Bailón

submission deadline 30 Oct 2025 | Viewed by 198 | Submission Open

Keywords: heart failure; drug therapy; prognosis; pharmacological innovations; cardiovascular outcomes; personalized medicine; heart failure management

(This special issue belongs to the Section Cardiology)

Clinical Update on Thoracic Trauma

edited by

Duilio Divisi

submission deadline 30 Oct 2025 | Viewed by 170 | Submission Open

Keywords: flail chest; isolated sternal fractures; manubrio-sternal dislocation; pneumothorax; hemothorax; thoracic aortic injury; heart and pulmonary vessels lesion; intercostal artery injury; diaphragm rupture; thoracoabdominal hernia; chylothorax; esophageal perforation

(This special issue belongs to the Section Respiratory Medicine)

Myeloproliferative Neoplasms (MPN): Recent Advances, Current Practices and Future Perspectives

edited by Arumugam Manoharan

submission deadline 31 Oct 2025 | 8 articles | Viewed by 15815 | Submission Open

Keywords: diagnosis; pathogenesis; prognosis; thromboprophylaxis; treatment

(This special issue belongs to the Section Hematology)

Progress in Patient Safety and Quality in Maternal–Fetal Medicine

edited by Samuel T. Bauer

submission deadline 31 Oct 2025 | 8 articles | Viewed by 12672 | Submission Open

Keywords: maternal– fetal medicine; pregnancy; postpartum; medical error; maternity; fetus

(This special issue belongs to the Section Obstetrics & Gynecology)

Innovations and Challenges in Clinical Toxicology and Therapeutic Drug Monitoring

edited by Zhicheng Jin

submission deadline 31 Oct 2025 | 1 articles | Viewed by 9171 | Submission Open

Keywords: toxicology screen; therapeutic drug monitoring; mass spectrometry; immunoassays; pain management; opioids

(This special issue belongs to the Section Pharmacology)

Current Advances in Endodontics and Dental Traumatology

edited by Karin Christine Huth

submission deadline 31 Oct 2025 | 8 articles | Viewed by 7468 | Submission Open

Keywords: endodontology; traumatology; regeneration; biocompatibility; dental materials; antimicrobial; dynamic and static navigation in endodontics; under- and postgraduate education in endodontology and traumatology; artificial intelligence; autotransplantation

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Chronic Renal Disease: Diagnosis, Treatment, and Management

edited by

Anna Clementi

submission deadline 31 Oct 2025 | 3 articles | Viewed by 5123 | Submission Open

Keywords: acute kidney injury; chronic kidney disease; cardio– renal syndromes; clinical nephrology; diagnosis and management

(This special issue belongs to the Section Nephrology & Urology)

Clinical Management of Oral Healthcare in Diverse Patient Populations: Second Edition

edited by

Antonella Polimeni

and

Iole Vozza

submission deadline 31 Oct 2025 | 5 articles | Viewed by 4763 | Submission Open

Keywords: special needs patients; oral healthcare; pediatric dentistry; dental hygiene; oral pathology; orthodontics; periodontics

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Youth Sports Injuries: From Prevalence to Prevention

edited by Swarup Mukherjee and

Gregory C. Bogdanis

submission deadline 31 Oct 2025 | 4 articles | Viewed by 3652 | Submission Open

Keywords: youth sports injuries; musculoskeletal injuries; injury prevention; sport safety; youth athletes

(This special issue belongs to the Section Sports Medicine)

Clinical Advances in Abdominal Surgery

edited by

Juan José Segura-Sampedro

and César P. Ramírez-Plaza

submission deadline 31 Oct 2025 | 5 articles | Viewed by 3031 | Submission Open

Keywords: abdominal surgery; oncologic surgery; minimal invasive techniques; HIPEC; PIPAC; peritoneal carcinomatosis; liver metastasis

(This special issue belongs to the Section General Surgery)

Grand Challenges in the Diagnosis and Management of Cardiovascular and Cerebrovascular Diseases

edited by

Sonu M. M. Bhaskar

submission deadline 31 Oct 2025 | 2 articles | Viewed by 2900 | Submission Open

Keywords: cardiovascular diseases; cerebrovascular diseases; diagnosis; management; imaging; biomarkers; artificial intelligence; therapeutic strategies; pharmacology; surgery; rehabilitation; multidisciplinary care

(This special issue belongs to the Section Cardiovascular Medicine)

Advancing Minimally Invasive Spine Surgery: A Special Edition on Endoscopic Spine Surgery

edited by

Adham M. Khalafallah

and Gregory W. Basil

submission deadline 31 Oct 2025 | 2 articles | Viewed by 2565 | Submission Open

Keywords: minimally invasive spine surgery (MIS); endoscopic spine surgery (ESS); spine surgery; percutaneous spine surgery; full-endoscopic spine surgery; biportal endoscopic spine surgery (BESS); unilateral biportal endoscopy (UBE); percutaneous endoscopic lumbar discectomy (PELD); endoscopic decompression; transforaminal endoscopic lumbar discectomy (TELD); interlaminar endoscopic lumbar discectomy (IELD); endoscopic lumbar fusion; endoscopic transforaminal lumbar interbody fusion (Endo-TLIF)

(This special issue belongs to the Section Clinical Neurology)

New Perspective of Oral and Maxillo-Facial Surgery

edited by

Valentino Vellone

Umberto Committeri

and Alessandra Lucchese

submission deadline 31 Oct 2025 | 5 articles | Viewed by 2434 | Submission Open

Keywords: maxillofacial surgery; esthetic surgery; orthognatic surgery; TMJ disorders; TMJ surgery; dental implant surgery; 3D imaging; printing applications; tissue engineering; personalized treatment planning; artificial intelligence; squamous cell carcinoma; skin tumors; plastic and reconstructive surgery; head and neck surgery; ENT surgery

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Displaying special issue 451-500 on page 10 of 30.

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