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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Interaction Between Systemic Diseases and Oral Diseases: 2nd Edition
edited by
submission deadline 25 Jul 2026 | 1 articles | Viewed by 474 | Submission Open
Keywords: medical dental interaction; saliva; xerostomia; diagnostics; inflammatory bowel disease; cancer survivors; dental erosion; Sjö gren’ s disease; liver transplantation
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Cardiac Electrophysiology: New Insights and Future Directions: 2nd Edition
edited by
submission deadline 25 Jul 2026 | Viewed by 289 | Submission Open
Keywords: catheter ablation; pulsed-field ablation; conduction-system pacing; arrhythmias; implantable cardiac devices; leadless pacing; mapping technologies; digital health; artificial intelligence; sudden cardiac death
(This special issue belongs to the Section Cardiology)
Diagnosis and Treatment of Pleura and Lung: Clinical Advances in Intensive Care
edited by Alen Protić and
submission deadline 25 Jul 2026 | Viewed by 259 | Submission Open
Keywords: thoracic drainage; lung recruitment; lung ultrasound; pleural effusion; pneumothrax; B-line; lung atelectasis
(This special issue belongs to the Section Intensive Care)
Complications Related to Coronary Artery Disease and Secondary Prevention Strategies
edited by Nazanin Rajai
submission deadline 25 Jul 2026 | Viewed by 240 | Submission Open
Keywords: coronary artery disease; complications; secondary prevention; myocardial infarction; cardiovascular risk; heart failure; arrhythmias; imaging; biomarkers; cardiovascular pharmacotherapy
(This special issue belongs to the Section Cardiovascular Medicine)
Recent Advances in Bariatric Surgery submission deadline 25 Jul 2026 | Viewed by 221 | Submission Open
Keywords: bariatric surgery; metabolic surgery; minimally invasive surgery; robotic surgery; endoscopic bariatric procedures; obesity management; type 2 diabetes remission; perioperative care; long-term outcomes; enhanced recovery
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Updates on Transcatheter Structural Heart Disease Interventions
edited by Nazan Puluca and Hendrik Ruge
submission deadline 25 Jul 2026 | Viewed by 205 | Submission Open
Keywords: interventional valve therapy; TAVR; TEER; TMVR; mitral valve; tricuspid valve; coronary access
(This special issue belongs to the Section Cardiology)
Clinical Application of Endoscopic Submucosal Dissection in Malignant Gastrointestinal Tumors and Precursors—2nd Edition submission deadline 25 Jul 2026 | Viewed by 198 | Submission Open
Keywords: endoscopy; endoscopic submucosal dissection; endoscopic surgery; laparoscopic surgery; minimally invasive surgery
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Current Advances and Future Perspectives in Cardiac Arrest and Cardiogenic Shock
edited by Giulia Maj
submission deadline 25 Jul 2026 | Viewed by 185 | Submission Open
Keywords: cardiogenic shock; left ventricular unloading; biomarkers; recovery; cardiac arrest
(This special issue belongs to the Section Emergency Medicine)
Updates in the Diagnosis, Imaging, and Treatment of Retinal and Macular Diseases
edited by
submission deadline 26 Jul 2026 | 3 articles | Viewed by 2257 | Submission Open
Keywords: retinal diseases; macular degeneration; diagnostic imaging; OCT/OCTA; artificial intelligence; deep learning; clinical ophthalmology; gene therapy; treatment innovations
(This special issue belongs to the Section Ophthalmology)
Challenges in Diagnosis and Treatment of Infertility—2nd Edition
edited by Konstantinos A. Zikopoulos
submission deadline 27 Jul 2026 | 4 articles | Viewed by 14953 | Submission Open
Keywords: fertility; regeneration; age-related infertility; preimplantation diagnosis; precision assessment; individualized fertility needs; clinical diagnosis; in vitro fertilization
(This special issue belongs to the Section Reproductive Medicine & Andrology)
Heart Valve Surgery: Recent Trends and Future Perspective
edited by Per Nils J.F. Wierup, Johan Sjögren and Nina Hakacova
submission deadline 27 Jul 2026 | 1 articles | Viewed by 773 | Submission Open
Keywords: heart valve; diagnostics; surgery; echocardiography; computer simulation; prediction models
(This special issue belongs to the Section Cardiology)
Inflammatory Bowel Disease: Pathogenesis and Management Strategies
edited by
submission deadline 28 Jul 2026 | 3 articles | Viewed by 3995 | Submission Open
Keywords: inflammatory bowel diseases; ulcerative colitis; Crohn’ s disease; biomarkers; risk factors; pharmacology; advanced therapy; endoscopic evaluation and procedures; extraintestinal manifestations; IBD-associated neoplasm
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Diagnosis and Treatment Strategies in Sjogren's Disease (SjD)
edited by , and Nancy McNamara
submission deadline 29 Jul 2026 | Viewed by 309 | Submission Open
Keywords: Sjogren; Sjogren’ s disease; lymphocytic tissue infiltration; interdisciplinary care; pathogenesis; caries; corneal erosions; autoimmunity; lymphoproliferative (or lymphoma)
(This special issue belongs to the Section Immunology & Rheumatology)
Mind–Body Connection: The Impact of Mental Health on Physical Well-Being
edited by
submission deadline 30 Jul 2026 | 4 articles | Viewed by 7724 | Submission Open
Keywords: mind– body connection; mental health; well-being; metabolic balance; immune system; chronic medical conditions; body perception; self-image; eating disorders; psychosomatic disorders; psychosomatic medicine; innovative thera-peutic approaches; mindfulness; mind-wandering; integrated healthcare
(This special issue belongs to the Section Mental Health)
Current Advances in General and Regional Anesthesia
edited by Eleni Laou, Eleana Garini and
submission deadline 30 Jul 2026 | 2 articles | Viewed by 5261 | Submission Open
Keywords: anesthesiology; general anesthesia; regional anesthesia; pediatric anesthesia; perioperative medicine; surgery; postoperative outcome; monitoring; analgesia; safety
(This special issue belongs to the Section Anesthesiology)
Improving Outcomes in Systemic Lupus Erythematosus: Latest Advances and Prospects in Relation to Comorbidity, Damage, and Quality of Life
edited by and Shaye Kivity
submission deadline 30 Jul 2026 | 2 articles | Viewed by 1106 | Submission Open
Keywords: systemic lupus erythematosus; comorbidities; outcome measures; damage accrual; quality of life; cognitive im-pairment; infections and vaccination; treat-to-target; digital biomarkers
(This special issue belongs to the Section Immunology & Rheumatology)
Endoscopic Management of Pancreaticobiliary Diseases
edited by
submission deadline 30 Jul 2026 | 1 articles | Viewed by 987 | Submission Open
Keywords: pancreaticobiliary endoscopy; endoscopic ultrasound (EUS); endoscopic retrograde cholangiopancreatography (ERCP); biliary drainage; gallbladder drainage; lumen-opposing metal stents; cholangioscopy; pancreatoscopy; confocal laser endomicroscopy; pancreatic cysts; molecular diagnostics; lithotripsy (electrohydraulic and laser); radiofrequency ablation (RFA); photodynamic therapy (PDT); pancreatic and biliary tumors; interventional endoscopy; altered anatomy access; diagnostic and therapeutic endoscopy
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Effects of Exercise Training on Physiological and Functional Outcomes in Age and Frailty submission deadline 30 Jul 2026 | 1 articles | Viewed by 811 | Submission Open
Keywords: exercise training  ; older adults  ; frailty  ; cardiovascular system  ; autonomic system  ; quality of life  ; healthy aging  ; functional capacity
(This special issue belongs to the Section Geriatric Medicine)
Clinical Insights in Preventive Cardiology
edited by and
submission deadline 30 Jul 2026 | 1 articles | Viewed by 710 | Submission Open
Keywords: preventive cardiology; cardiovascular prevention; cardiovascular risk assessment; risk stratification; primary prevention; secondary prevention; exposome; environmental determinants of health; lifestyle modification; digital health; wearable technologies
(This special issue belongs to the Section Cardiology)
Clinical and Laboratory Applications of Artificial Intelligence in Haematology
edited by and Bingwen Eugene Fan
submission deadline 30 Jul 2026 | Viewed by 342 | Submission Open
Keywords: hematology; artificial intelligence/AI; machine learning/ML; innovation; hemostasis; thrombosis; diagnostics; prog-nosis; laboratory automation; clinical decision support; precision medicine; big data; digital pathology
(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Clinical Medicine)
Clinical Insights and Applications in Cardiac Electrophysiology
edited by and Fabrizio Guarracini
submission deadline 30 Jul 2026 | Viewed by 337 | Submission Open
Keywords: atrial fibrillation; catheter ablation; transvenous lead extraction; left atrial appendage occlusion; heart failure; subcutaneous ICD; extravascular ICD; conduction system pacing; cardiac electrophysiology; cardiac rhythm disorders; arrhythmia mapping; supraventricular arrhythmias; ventricular arrhythmias; cardiomyopathies; implantable cardiac devices; minimally invasive devices; left atrial appendage closure; personalized arrhythmia care; clinical management; innovative electrophysiological techniques
(This special issue belongs to the Section Cardiology)
Innovations in Elbow and Shoulder Surgery: Techniques, Outcomes, and Rehabilitation
edited by Andrea Celli
submission deadline 30 Jul 2026 | Viewed by 270 | Submission Open
Keywords: orthopedic; elbow surgery; shoulder surgery; infection; nonunion; malunion; ligaments injuries; tendon injuries; el-bow and shoulder replacement; arthroscopy
(This special issue belongs to the Section Orthopedics)
Integrated Assessment and Management of Heart Failure Syndromes
edited by Damiano Magrì and Emiliano Fiori
submission deadline 30 Jul 2026 | Viewed by 216 | Submission Open
Keywords: heart failure; functional capacity; multimodality assessment; advanced imaging; coronary and structural interventions; device therapies
(This special issue belongs to the Section Cardiology)
Molecular Injection Therapy in Orthopedic and Musculoskeletal Disorders: Conservative Approaches and Innovative Treatments
edited by , Paolo Domenico Parchi and Andrea del Chiaro
submission deadline 31 Jul 2026 | 5 articles | Viewed by 5908 | Submission Open
Keywords: injection therapy; conservative approaches; medical devices; collagen; polyribonucleotide; plasma-rich platelets; hyaluronic acids; anti-inflammatory therapy; tendinitis; osteoarthritis; musculoskeletal disorder; pain reduction; regenerative medicine; new clinical approaches; physiotherapy; comparative studies: surgery vs. conservative approaches
(This special issue belongs to the Section Orthopedics)
Catheter Ablation of Atrial Fibrillation: Current Progress and New Challenges
edited by Sorin Stefan Popescu, Roland Richard Tilz and Karl-Heinz Kuck
submission deadline 31 Jul 2026 | 3 articles | Viewed by 5719 | Submission Open
Keywords: atrial fibrillation; novel technologies; pulmonary vein isolation; same-day discharge; pulsed field ablation; cryo-ablation; radiofrequency; safety; efficacy; sustainability
(This special issue belongs to the Section Cardiology)
Clinical Application of Physical Therapy in Neurorehabilitation: 3rd Edition submission deadline 31 Jul 2026 | 2 articles | Viewed by 3302 | Submission Open
Keywords: physical therapy; technology-aided rehabilitation; exercise; neurorehabilitation; neuroplasticity; engagement; self-management
(This special issue belongs to the Section Clinical Rehabilitation)
The Future Direction of Medical Imaging in Hepato-Bilio-Pancreatic Oncology: Challenges and Opportunities
edited by
submission deadline 31 Jul 2026 | 1 articles | Viewed by 1469 | Submission Open
Keywords: MRI; CT; molecular imaging; radiomics; imaging; radiogenomics; precision medicine; outcome prediction; cholangiocarcinoma; pancreatic cancer; imaging biomarkers; treatment response
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Neuro-Psychiatric Disorders: Updates on Diagnosis and Treatment—2nd Edition
edited by
submission deadline 31 Jul 2026 | 1 articles | Viewed by 711 | Submission Open
Keywords: neuropsychiatric disorder; diagnosis; treatment; neurobiology; organic psychiatry
(This special issue belongs to the Section Mental Health)
Pulmonary Hypertension: From Pathophysiology to Clinical Management
edited by and
submission deadline 31 Jul 2026 | 1 articles | Viewed by 670 | Submission Open
Keywords: pulmonary hypertension; pulmonary arterial hypertension; chronic thromboembolic pulmonary hypertension; pulmonary endarterectomy; balloon pulmonary angioplasty; pharmacological treatment; pathophysiology
(This special issue belongs to the Section Respiratory Medicine)
Interventional Cardiology: Evolving Evidence and Emerging Horizons
edited by
submission deadline 31 Jul 2026 | Viewed by 249 | Submission Open
Keywords: coronary artery disease; percutaneous coronary intervention; drug-coated balloon; intravascular imaging; fractional flow reserve; transcatheter aortic valve implantation; transcatheter mitral valve repair; clinical outcomes
(This special issue belongs to the Section Cardiology)
Advances in Artificial Intelligence Applications for Invasive and Non-Invasive Cardiovascular Procedures
edited by and Rahul Chaudhary
submission deadline 31 Jul 2026 | Viewed by 216 | Submission Open
Keywords: artificial intelligence and machine learning; interventional cardiology; electrophysiology; cardiovascular imaging; remote patient monitoring; digital biomarkers; clinical decision support
(This special issue belongs to the Section Cardiovascular Medicine)
Breakthroughs in the Treatment of Colorectal Cancer
edited by Laura Fortuna and
submission deadline 31 Jul 2026 | Viewed by 169 | Submission Open
Keywords: colorectal cancer; targeted therapy; minimally invasive surgery; immune– oncology integration; enhanced recovery protocols; multidisciplinary care
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Game-Changing Advances in Minimally Invasive Spine Surgery
edited by Rouzbeh Motiei-Langroudi
submission deadline 31 Jul 2026 | Viewed by 160 | Submission Open
Keywords: minimally invasive spine surgery (MISS); technological innovation; navigation systems/robotic-assisted; endoscopic techniques; artificial intelligence/machine learning
(This special issue belongs to the Section Clinical Neurology)
Exercise, Injury and Rehabilitation: Integrated Perspectives in Sports Medicine submission deadline 3 Aug 2026 | 3 articles | Viewed by 12428 | Submission Open
Keywords: sports medicine; biomechanics; injury prevention; exercise physiology; sports performance; load management; exercise prescription; return to play; recovery
(This special issue belongs to the Section Sports Medicine)
Blood Pressure Disorders: Risk Assessment, Surveillance and Clinical Interventions
edited by
submission deadline 7 Aug 2026 | Viewed by 169 | Submission Open
Keywords: hypertension; secondary hypertension; hypotension; target organ damage; hypertension phenotypes; hypertension emergency; hypertension urgency; microangiopathy; macroangiopathy; endothelial dysfunction; hypovolaemia; cardiogenic shock; dysautonomia
(This special issue belongs to the Section Cardiovascular Medicine)
Sepsis: Current Updates and Perspectives submission deadline 10 Aug 2026 | 11 articles | Viewed by 35110 | Submission Open
Keywords: sepsis biomarkers; diagnostic tools; cytokines; inflammation; infection; antibiotherapy; blood purification; novel therapies
(This special issue belongs to the Section Intensive Care)
The Journey of Hearing and Hearing-Related Disorders over Time—2nd Edition submission deadline 10 Aug 2026 | 5 articles | Viewed by 11804 | Submission Open
Keywords: hearing; hearing journey; hearing-related disorders; tinnitus; hyperacusis; digital phenotyping; big data
(This special issue belongs to the Section Otolaryngology)
Clinical Advances in Pediatric Critical Care Medicine
edited by
submission deadline 10 Aug 2026 | 5 articles | Viewed by 3859 | Submission Open
Keywords: acute renal failure; acute respiratory failure; pediatric oncology; pediatric ICU; pediatric critical care medicine; multi-organ dysfunction
(This special issue belongs to the Section Clinical Pediatrics)
Advancements and Future Directions in Clinical Psychosis submission deadline 10 Aug 2026 | 3 articles | Viewed by 3704 | Submission Open
Keywords: clinical psychosis; schizophrenia spectrum disorders; early detection of psychosis; treatment-resistant psychosis; long-term outcomes; personalized psychiatry; digital mental health; AI in psychiatry; neurocognitive interventions; psychosocial therapies; translational psychiatry; interdisciplinary mental health; psychosis clinical trials; innova-tive diagnostic tools
(This special issue belongs to the Section Mental Health)
Sports Cardiology: Current Clinical Status and Outlook into the Future
edited by Aakash Bavishi and Matthew W Martinez
submission deadline 10 Aug 2026 | 1 articles | Viewed by 1013 | Submission Open
Keywords: sports cardiology; athletes; cardiac imaging; hypertrophic cardiomyopathy; screening; electrocardiogram; electrophysiology; echocardiography; sudden cardiac death
(This special issue belongs to the Section Cardiology)
New Insights into Glaucoma: 2nd Edition
edited by and
submission deadline 10 Aug 2026 | 1 articles | Viewed by 1012 | Submission Open
Keywords: glaucoma; intraocular pressure (IOP); risk calculators; glaucoma screening glaucoma surgery; cataract surgery; trabeculectomy; glaucoma drainage devices; minimally invasive glaucoma surgery (MIGS); artificial intelligence (AI)
(This special issue belongs to the Section Ophthalmology)
Current Challenges and Perspectives in Aortic Valve Replacement
edited by , Quentin Fischer and David Del Val
submission deadline 10 Aug 2026 | 1 articles | Viewed by 837 | Submission Open
Keywords: aortic valve replacement; transcatheter aortic valve implantation (TAVI); surgical aortic valve replacement; prosthesis– patient mismatch; structural heart disease; heart team; valve durability; coronary access; valve-in-valve
(This special issue belongs to the Section Cardiovascular Medicine)
Clinical Advances in Cardiothoracic Anesthesiology
edited by
submission deadline 10 Aug 2026 | Viewed by 232 | Submission Open
Keywords: cardiac anesthesiology; thoracic anesthesiology; precision medicine; prevention of organ dysfunction; mechanical circulatory support; minimally invasive surgery
(This special issue belongs to the Section Anesthesiology)
Advances in Musculoskeletal Rehabilitation and Functional Movement
edited by
submission deadline 13 Aug 2026 | 3 articles | Viewed by 2823 | Submission Open
Keywords: corrective exercise; functional training; biomechanics; resistance training; movement impairment; electromyography; muscle activation; musculoskeletal rehabilitation
(This special issue belongs to the Section Clinical Rehabilitation)
Cutaneous Head and Neck Melanoma: Advances in Diagnosis and Management
edited by Shirin Bajaj and Ata Moshiri
submission deadline 13 Aug 2026 | Viewed by 166 | Submission Open
Keywords: head and neck melanoma; lentigo maligna; Mohs micrographic surgery; reflectance confocal microscopy (RCM); line-field OCT (LC-OCT); ex vivo confocal microscopy; margin delineation; facial reconstruction; neoadjuvant immunotherapy; PRAME
(This special issue belongs to the Section Dermatology)
New Insights in Neonatal Intensive Care
edited by , and Martina Ciarcià
submission deadline 14 Aug 2026 | 3 articles | Viewed by 4018 | Submission Open
Keywords: neonatal intensive care; neonatal diseases; critically ill infants; premature infants; neonatal care; intensive care medicine
(This special issue belongs to the Section Clinical Pediatrics)
Infectious Disease Epidemiology: Current Updates and Perspectives submission deadline 15 Aug 2026 | 5 articles | Viewed by 10754 | Submission Open
Keywords: infection prevention and control; infectious diseases epidemiology; public health; novel treatments
(This special issue belongs to the Section Infectious Diseases)
Systemic Lupus Erythematosus: Current Trends and Therapeutic Innovations
edited by Giuseppe Barilaro
submission deadline 15 Aug 2026 | 6 articles | Viewed by 8258 | Submission Open
Keywords: systemic lupus erythematosus; autoantibodies; biomarkers; therapeutic drugs; lupus nephritis; quality of life; new treatment strategies
(This special issue belongs to the Section Immunology & Rheumatology)
New Insight into Pain and Chronic Pain Management
edited by
submission deadline 15 Aug 2026 | 4 articles | Viewed by 7243 | Submission Open
Keywords: chronic pain; pain management; pharmacological treatment; non-pharmacological interventions; neuromodula-tion; multidisciplinary approaches; personalized medicine; quality of life
(This special issue belongs to the Section Clinical Rehabilitation)
Hypertension and Cardiovascular Disease: Clinical Updates and Perspectives: 2nd Edition
edited by and Nicola Virtuoso
submission deadline 15 Aug 2026 | 5 articles | Viewed by 3276 | Submission Open
Keywords: hypertension management; cardiovascular risk assessment; novel antihypertensive therapies; hypertension in pregnancy; hypertensive emergencies; cardiovascular disease prevention; pharmacological interventions for cardiovascular disease
(This special issue belongs to the Section Cardiovascular Medicine)
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