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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Latest Advances in Lower Urinary Tract Symptoms and Pelvic Floor Dysfunction Diseases

edited by Marianne Koch, Rufus Cartwright and Kim W.M. Van Delft

submission deadline 6 May 2025 | 5 articles | Viewed by 4327

Keywords: pelvic organ prolapse; urinary incontinence; overactive bladder syndrome; stress urinary incontinence; postpartum pelvic floor dysfunction; bladder dysfunction; obstetric anal sphincter injury; lower urinary tract dysfunction

(This special issue belongs to the Section Nephrology & Urology)

Urologic Surgery: From Bench to Bedside

edited by

Riccardo Lombardo

submission deadline 6 May 2025 | 2 articles | Viewed by 3118

Keywords: minimally invasive; robotics; partial nephrectomy; radical prostatectomy; focal therapy; benign prostatic hyperplasia; iTind; Urolift; Rezum; aquablation; enucleation

(This special issue belongs to the Section Nephrology & Urology)

Innovations in Breast Cancer Surgery: Advancing Treatment Paradigms

edited by

Kefah Mokbel

submission deadline 6 May 2025 | 1 articles | Viewed by 2447

Keywords: breast cancer; reconstructive surgery; robotic nipple sparring mastectomy ; minimally invasive surgery; oncoplastic breast surgery; wire-free breast localisation; de-escalation of breast cancer surgery

(This special issue belongs to the Section Oncology)

New Insights into Exercise Intervention for Aging and Geriatric Diseases: 2nd Edition

edited by

Hyuntae Park

submission deadline 10 May 2025 | 4 articles | Viewed by 4463 | Submission Open

Keywords: exercise intervention; exercise adherence and feasibility; digital exercise therapy; digital therapeutics; mild cognitive impairment; osteoporosis; dementia; sarcopenia; frailty; depression; sleep disorder; obesity; geriatric disease

(This special issue belongs to the Section Sports Medicine)

Nuclear Medicine Procedures in Oncology: New Prospects

edited by

Susanna M. Nuvoli

submission deadline 10 May 2025 | 2 articles | Viewed by 3768 | Submission Open

Keywords: nuclear medicine procedures; oncology; PET/CT; radiotracer in oncology; lung cancer; thyroid cancer; prostate cancer; head and neck cancer; artificial intelligence

(This special issue belongs to the Section Nuclear Medicine & Radiology)

New Trends in Endodontics

edited by Michael Solomonov and

Moshe Davidovitch

submission deadline 10 May 2025 | 1 articles | Viewed by 3689 | Submission Open

Keywords: orthodontics; endodontics; resorptions; pulpal reactions; timing; ECR; OIIRR; algorithm; TAB

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

New Challenges in Urolithiasis

edited by Alessandro Calarco and

Giuseppe Celentano

submission deadline 10 May 2025 | 2 articles | Viewed by 2617 | Submission Open

Keywords: urolithiasis; PCNL; RIRS; urology; ureteroscopy; kidney stones

(This special issue belongs to the Section Nephrology & Urology)

State of the Art in Pediatric Neurosurgery

edited by

Petra Klinge

and Konstantina Svokos

submission deadline 10 May 2025 | 2 articles | Viewed by 1820 | Submission Open

Keywords: pediatric neurosurgery; neuroimaging; minimally invasive; neuroendoscopy; functional neurosurgery; neuro-oncology; neurocritical care; multidisciplinary care; congenital disease

(This special issue belongs to the Section Clinical Neurology)

Extracorporeal Membrane Oxygenation (ECMO): Clinical Challenges and Opportunities

edited by

Yutaka Fujii

submission deadline 15 May 2025 | 8 articles | Viewed by 15830 | Submission Open

Keywords: extracorporeal membrane oxygenation (ECMO); clinical emergencies; intensive care; respiratory failure; COVID-19; cardiovascular– pulmonary disease; organ support; challenges; strategies; complications; acute respiratory distress syndrome (ARDS); cardiopulmonary bypass; cardiac function; basic research

(This special issue belongs to the Section Respiratory Medicine)

Recent Advances in Therapy of Trauma and Surgical Critical Care

edited by Rita Galeiras

submission deadline 15 May 2025 | 4 articles | Viewed by 7149 | Submission Open

Keywords: trauma management; trauma care; burn; critical care; damage control surgery; traumatic spinal cord injury

(This special issue belongs to the Section Emergency Medicine)

Clinical Management of Patients with Multiple Sclerosis (MS)

edited by Maddalena Sparaco

submission deadline 15 May 2025 | 6 articles | Viewed by 4798 | Submission Open

Keywords: multiple sclerosis; clinical management; patient reported outcomes; patient-reported outcome measures; biomarkers; therapeutic approaches; monitoring strategies

(This special issue belongs to the Section Clinical Neurology)

Hypertension in Adults: Current Updates on Diagnosis, Treatment and Management

edited by Emelina Stambolliu and Antonios A. Argyris

submission deadline 15 May 2025 | 3 articles | Viewed by 3695 | Submission Open

Keywords: essential hypertension; nighttime blood pressure; blood pressure measurement; blood pressure management; blood pressure medical treatment; hypertension thresholds

(This special issue belongs to the Section Vascular Medicine)

New Insights into Diagnostic and Interventional Radiology

edited by

Domenico Laganà

and

Roberto Minici

submission deadline 15 May 2025 | 2 articles | Viewed by 3506 | Submission Open

Keywords: radiomics; interventional radiology; endovascular interventions; interventional oncology; ablation therapy; locore-gional treatments; artificial intelligence; peripheral arterial disease (PAD); aortic disease; vascular access

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Joint Arthroplasties: From Surgery to Recovery

edited by Paolo Schiavi and Guido Grappiolo

submission deadline 15 May 2025 | 2 articles | Viewed by 2943 | Submission Open

Keywords: total joint arthroplasty; hip; knee; ankle; shoulder; elbow; rehabilitation

(This special issue belongs to the Section Orthopedics)

Clinical Applications of Artificial Intelligence (AI) in Surgery: Future Trends and Challenges

edited by

Michał H. Strzelecki

and

Rafał Obuchowicz

submission deadline 15 May 2025 | 1 articles | Viewed by 741 | Submission Open

Keywords: artificial intelligence; surgical planning; surgical medical robots; machine learning in surgery; AI-supported post-operative care

(This special issue belongs to the Section General Surgery)

Pediatric Palliative Care and Surgery

edited by Danielle B. Cameron and Amy Porter

submission deadline 15 May 2025 | Viewed by 252 | Submission Open

Keywords: palliative care; pediatric surgery; pediatric surgical oncology; pediatric palliative care; palliative medicine

(This special issue belongs to the Section Clinical Pediatrics)

Biomarkers and Diagnostics in Respiratory Diseases: 2nd Edition

edited by

Silvano Dragonieri

and

Andras Bikov

submission deadline 15 May 2025 | Viewed by 166 | Submission Open

Keywords: respiratory diseases; biomarkers; non-invasive approaches; novel diagnostic tests

(This special issue belongs to the Section Respiratory Medicine)

Technological Advancements and Clinical Innovations in Diagnostic and Interventional Radiology

edited by

Massimo Venturini

and

Federico Fontana

submission deadline 20 May 2025 | 17 articles | Viewed by 34308 | Submission Open

Keywords: artificial intelligence; radiomics; image fusion; spectral computed tomography; functional magnetic resonance imaging; CO2 angiography; balloon-occluded transcatheter arterial chemoembolization

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Refractive Surgery—Where Are We Now?

edited by

Anna Maria Roszkowska

Domenico Schiano-Lomoriello

and

Davide Borroni

submission deadline 20 May 2025 | 15 articles | Viewed by 34275 | Submission Open

Keywords: refractive surgery; laser refractive surgery; intra-ocular lens for refractive surgery; PRK; LASEK; transPRK; LASIK; FemtoLASIK; SMILE; Phakic IOLs; presbyopia treatments; monovision

(This special issue belongs to the Section Ophthalmology)

What We See through Cardiac Imaging

edited by

Valeria Pergola

and Martina Perazzolo Marra

submission deadline 20 May 2025 | 9 articles | Viewed by 23552 | Submission Open

Keywords: cardiomyopathies; multimodality imaging; echocardiography; cardiac-computed tomography; cardiac magnetic resonance; prognosis; arrhythmias; heart failure

(This special issue belongs to the Section Cardiology)

Clinical Advances in Critical Care Medicine

edited by Pietro Caironi

submission deadline 20 May 2025 | 7 articles | Viewed by 21813 | Submission Open

Keywords: critical care; artificial intelligence; extra-corporeal life support; mechanical ventilation; sepsis; infection; airway management; acute kidney injury; biomarkers; trauma

(This special issue belongs to the Section Intensive Care)

Head and Neck Surgery: Clinical Updates on Diagnosis, Management and Prognosis

edited by Gabriele Molteni and

Albino Eccher

submission deadline 20 May 2025 | 9 articles | Viewed by 14719 | Submission Open

Keywords: head and neck surgery; laryngeal cancer; immunotherapy; AI; head and neck radiology

(This special issue belongs to the Section General Surgery)

Subarachnoid Hemorrhage: Clinical Advances and Challenges

edited by

Tihamér Molnár

and

Péter Csécsei

submission deadline 20 May 2025 | 6 articles | Viewed by 10986 | Submission Open

Keywords: subarachnoid hemorrhage; epidural and subdural hematomas; intracerebral and intraventricular hemorrhage; hemorrhagic stroke; cerebral infarction; hypertension; early brain damage; delayed cerebral vasospasm; neurobehavioral aspects; ruptured intracranial aneurysm; neuroinflammation; epidemiological studies; neuroimaging; clinical guidelines; neurocritical care management; surgery; new drug therapies; diagnosis; treatment; management; risk factors; prognosis; clinical outcome

(This special issue belongs to the Section Clinical Neurology)

Advances in Trauma and Orthopedic Surgery: 2nd Edition

edited by

Christian von Rüden

submission deadline 20 May 2025 | 8 articles | Viewed by 8265 | Submission Open

Keywords: trauma; fracture; fracture fixation; osteosynthesis; biomechanics; bone; approach; nonunion; joint replacement; outcome

(This special issue belongs to the Section Orthopedics)

Association Between Sleep Disorders and Diabetes

edited by

Patrizio Tatti

and Desiderio Passàli

submission deadline 20 May 2025 | 1 articles | Viewed by 7231 | Submission Open

Keywords: diabetes; OSAS; complications; insulin; resistance

(This special issue belongs to the Section Endocrinology & Metabolism)

Further Advances in Electrocardiography, Cardiac Arrhythmias, and Arrhythmogenic Disorders

edited by

Paweł T. Matusik

submission deadline 20 May 2025 | 5 articles | Viewed by 6731 | Submission Open

Keywords: electrocardiography; cardiac arrhythmias; genetics; cardiac pacing; implantable cardioverter-defibrillators; cardiac resynchronization therapy; magnetic resonance imaging; catheter ablation; arrhythmogenic disorders; channelopathy; cardiomyopathy

(This special issue belongs to the Section Cardiology)

Thromboembolic Disease and Antithrombotic Therapy

edited by Prahlad Ho

submission deadline 20 May 2025 | 5 articles | Viewed by 6688 | Submission Open

Keywords: thrombosis; pulmonary embolism; manticoagulation; DOAC (direct oral anticoagulants); DVT (deep vein thrombosis); novel anticoagulants (factor XIa inhibitors); thrombin; fibrin generation; risk stratification; biomarkers; Virchow’ s triad; post thrombotic syndrome

(This special issue belongs to the Section Hematology)

Challenges in Liver and Nephrology Diseases in Pediatrics

edited by

Anna Di Sessa

submission deadline 20 May 2025 | 2 articles | Viewed by 3769 | Submission Open

Keywords: pediatric; liver disease; nephrology disease; renal and urinary tract diseases; nonalcoholic fatty liver disease (NAFLD); metabolic syndrome; liver transplantation; diagnosis; treatment; challenges; metabolic (dysfunction) associated fatty liver disease (MAFLD); omics; biomarkers; early diagnosis

(This special issue belongs to the Section Clinical Pediatrics)

Updates on Renal Transplantation and Its Complications

edited by Nada Kanaan and Arnaud Devresse

submission deadline 20 May 2025 | 3 articles | Viewed by 3482 | Submission Open

Keywords: cardiovascular complications; infections; CMV; EBV; viral hepatitis; mineral bone disease; cancer; rejection; post-transplant diabetes; immunosuppression

(This special issue belongs to the Section Nephrology & Urology)

Applications of Artificial Intelligence and Digital Therapeutics in Clinical Medicine

edited by

Carlos Escobar

submission deadline 20 May 2025 | 6 articles | Viewed by 3180 | Submission Open

Keywords: artificial intelligence; biometric sensors; deep learning; digital therapies; Internet of Things; machine learning; virtual reality; augmented reality

(This special issue belongs to the Section Clinical Guidelines)

Early-Stage and Operable Non-Small Cell Lung Cancer Treatment: Current Practice and Future Perspectives

edited by

Francisco Aécio Almeida

and Debora S. Bruno

submission deadline 20 May 2025 | 2 articles | Viewed by 3158 | Submission Open

Keywords: non-small cell lung cancer; biomarker testing; checkpoint inhibitors; perioperative therapy; targeted therapy; next-generation sequencing; radiation therapy; pulmonary rehabilitation in NSCLC

(This special issue belongs to the Section Oncology)

Advances in Pediatric Anesthesiology

edited by

Keira Mason

submission deadline 20 May 2025 | 2 articles | Viewed by 3003 | Submission Open

Keywords: pediatric anesthesiology; anesthesia; pediatric deep sedation; perioperative anesthesia; general anesthesia

(This special issue belongs to the Section Clinical Pediatrics)

New Clinical Advances in Macular Degeneration

edited by

Alaa Din Abdin

and

Berthold Seitz

submission deadline 20 May 2025 | 2 articles | Viewed by 2916 | Submission Open

Keywords: age-related macular degeneration; anti-vascular endothelial growth factor; complement factor; geographic atrophy; macular neovascularization; OCT and OCT angiography; biomarkers

(This special issue belongs to the Section Ophthalmology)

Clinical Research of Novel Therapeutic Approaches in Dentistry (2nd Edition)

edited by

Jacek Matys

Kinga Grzech-Lesniak

and

Tomasz Gedrange

submission deadline 20 May 2025 | 2 articles | Viewed by 2353 | Submission Open

Keywords: oral medicine; tissue regeneration; lasers; photobiomodulation; periodontology; dentistry; biological safety

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Psoriatic Arthritis—New Insights, Challenges, Unmet Needs and Controversies

edited by

Daniela Opris-Belinski

submission deadline 20 May 2025 | 2 articles | Viewed by 2255 | Submission Open

Keywords: psoriatic arthritis; psoriasis; enthesitis; dactylitis; spondyloarthritis; radiological progression; biologics; JAK-inhibitors; immune-mediated inflammatory diseases; comorbidities

(This special issue belongs to the Section Immunology)

Clinical Advances in Orthopedic Infections

edited by

Hyonmin Choe

submission deadline 20 May 2025 | 2 articles | Viewed by 1913 | Submission Open

Keywords: orthopedic surgery; orthopedic infections; periprosthetic joint infection; surgical site infection; infection management

(This special issue belongs to the Section Orthopedics)

Clinical Advances in Therapy of Trauma and Surgical Critical Care

edited by Rabail Chaudhry, George W. Williams and Tanya Anand

submission deadline 20 May 2025 | 1 articles | Viewed by 1196 | Submission Open

Keywords: regional anesthesia; critical care; trauma resuscitation; transfusion strategies; thermal injury; obstetric critical care; epitheliopathy; metabolomics; ICU pain management; trauma care subpopulations

(This special issue belongs to the Section Intensive Care)

PET Imaging in Bone and Non-Bone Diseases

edited by

Tanuj Puri

and

Glen Blake

submission deadline 20 May 2025 | 2 articles | Viewed by 1139 | Submission Open

Keywords: PET; bone metabolism; bone diseases; metabolic bone diseases; image analysis; radiomics; artificial intelligence

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Enteric Nervous System: Neuropathic Gastrointestinal Motility—2nd Edition

edited by

Carolina Pellegrini

and

Vanessa D’Antongiovanni

submission deadline 20 May 2025 | 1 articles | Viewed by 1018 | Submission Open

Keywords: gastrointestinal dysmotility; intestinal inflammation; enteric bacteria– neuro– immune network; brain– gut axis; metabolic disorders; neurological disorders; enteric neuroplasticity

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Cardiovascular Disease in the Elderly: Prevention and Diagnosis

edited by Ioana Dana Alexa, Gabriel Ioan Prada and

Ciprian Rezus

submission deadline 20 May 2025 | 2 articles | Viewed by 920 | Submission Open

Keywords: cardiovascular risk factors; elderly patients; frailty; sarcopenia; heart rate variability; insulin resistance; physical resilience; intrinsic capacity; diastolic dysfunction

(This special issue belongs to the Section Cardiovascular Medicine)

Management of Postoperative Care in Neurosurgery

edited by

Slavica Kvolik

submission deadline 20 May 2025 | 1 articles | Viewed by 839 | Submission Open

Keywords: postoperative care; neurosurgery; neurotrauma; enhanced recovery after surgery (ERAS); postoperative pain; postoperative treatment

(This special issue belongs to the Section Intensive Care)

Challenges and Opportunities in Geriatric Nephrology and Urology

edited by Giulio Romano

submission deadline 20 May 2025 | Viewed by 323 | Submission Open

Keywords: kidney disease; elderly patient; epidemiology; pharmacological therapy; lifestyle diet

(This special issue belongs to the Section Nephrology & Urology)

Cardiovascular Issues in Critical Care

edited by

Epaminondas G. Zakynthinos

and

Vasiliki Tsolaki

submission deadline 20 May 2025 | 1 articles | Viewed by 307 | Submission Open

Keywords: circulatory failure; hemodynamic monitoring; heart– lung interactions; shock; ultrasonography; cardiomyopathy; septic shock; cardiogenic shock; tachyarrhythmias; atrial fibrillation; right ventricular function; left ventricular function; fluid responsiveness

(This special issue belongs to the Section Cardiovascular Medicine)

Prostate Cancer: Diagnosis, Clinical Management and Prognosis

edited by Giovanni Muto

submission deadline 20 May 2025 | Viewed by 255 | Submission Open

Keywords: prostate cancer; diagnosis; clinical management; prognosis; treatments

(This special issue belongs to the Section Nephrology & Urology)

Kidney Health Under Microscope

edited by

Magdi Yaqoob

submission deadline 20 May 2025 | Viewed by 182 | Submission Open

Keywords: complications; IgA nephropathy; glomerulonephritis; atypical haemolytic uraemic syndrome; systemic vasculitis; lupus nephritis; mineral bone disease; anaemia; xenotransplantation; nephrolithiasis

(This special issue belongs to the Section Nephrology & Urology)

State of the Art in Pediatric Surgery

edited by Vincenzo Bagnara and

Carmelo Romeo

submission deadline 20 May 2025 | Viewed by 174 | Submission Open

Keywords: pediatric surgery; abdominal diseases; pediatric urology; laparoscopy; minimally invasive surgery

(This special issue belongs to the Section Clinical Pediatrics)

Robotic Technology Applied to Kidney Transplantation

edited by Pierpaolo Di Cocco and Ivo G. Tzvetanov

submission deadline 20 May 2025 | Viewed by 149 | Submission Open

Keywords: end-stage renal disease; robotic-assisted kidney transplant; kidney transplantation; transplantation surgery; robotic and minimally invasive surgery; solid organ transplantation

(This special issue belongs to the Section Nephrology & Urology)

Clinical Features and Management of Psychosis

edited by

Maria Margariti

, George Konstantakopoulos and Michael Hadjulis

submission deadline 23 May 2025 | Viewed by 322 | Submission Open

Keywords: psychosis; clinical features of psychosis; diagnosis of psychosis; schizophrenia; psychotic depression; affective disorder with psychotic features; psychosis in substance use disorders; psychosis in neurological disorders; psychosis in medical conditions; management of psychosis; treatment of psychosis

(This special issue belongs to the Section Mental Health)

Patent Foramen Ovale 2023: More Lights than Shadows

edited by

Eustaquio Maria Onorato

and Christian Pristipino

submission deadline 25 May 2025 | 2 articles | Viewed by 4990 | Submission Open

Keywords: patent foramen ovale; patent foramen ovale closure; paradoxical embolism; right-to-left shunt; stroke; cryptogenic stroke; decompression illness; migraine aura; platypnea– orthodeoxia syndrome; posterior fossa neurosurgery; major orthopaedic surgery and paradoxical fat embolism

(This special issue belongs to the Section Cardiology)

Cardiothoracic Surgery and Enhanced Recovery: Recent Advances and Perspectives

edited by Edris A.F. Mahtab

submission deadline 25 May 2025 | 3 articles | Viewed by 3725 | Submission Open

Keywords: coronary artery bypass surgery; valve repair/replacement; minimally invasive cardiac procedures; aortic dissection repair; thoracic aortic aneurysm surgery; lung transplantation; ventricular assist devices; esophagectomy; lung surgery; heart transplantation; use of XR and AI in Enhanced recovery

(This special issue belongs to the Section General Surgery)

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