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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Recent Advances in Pulmonary Embolism and Thrombosis

edited by

Andrea Boccatonda

and Mauro Silingardi

submission deadline 30 Jun 2025 | 10 articles | Viewed by 43592 | Submission Open

Keywords: pulmonary embolism; embolism and thrombosis; thrombus aspiration for pulmonary embolism; deep vein throm-bosis; venous thromboembolism

(This special issue belongs to the Section Respiratory Medicine)

Current and Future Trends in Otorhinolaryngology–Head and Neck Surgery

edited by

Konstantinos Chaidas

submission deadline 30 Jun 2025 | 15 articles | Viewed by 24246 | Submission Open

Keywords: otorhinolaryngology; head and neck; innovation; diagnosis; treatment; surgery

(This special issue belongs to the Section Otolaryngology)

New Advances in Optic Nerve Diseases

edited by

Livio Vitiello

submission deadline 30 Jun 2025 | 9 articles | Viewed by 20322 | Submission Open

Keywords: optic nerve; optic nerve diseases; optic neuritis; glaucoma; optic neuropathies; optical coherence tomography; OCT; ocular ultrasonography

(This special issue belongs to the Section Ophthalmology)

An Update on Retinal Diseases: From Diagnosis to Treatment

edited by

Shigeru Honda

, Masahiko Sugimoto and Kenji Yamashiro

submission deadline 30 Jun 2025 | 12 articles | Viewed by 15443 | Submission Open

Keywords: retinal diseases; diagnosis; treatment; etiology; original article; review paper

(This special issue belongs to the Section Ophthalmology)

Updates on Neurostimulation: From Mechanistic Principles to Clinical Applications

edited by

Jose Gomez Tames

and

Mariano Fernández-Corazza

submission deadline 30 Jun 2025 | 6 articles | Viewed by 15126 | Submission Open

Keywords: brain stimulation; non-invasive brain stimulation; deep brain stimulation; neuroimaging; computational modelling; therapy

(This special issue belongs to the Section Clinical Neurology)

Diagnosis, Treatment and Prognosis of Coronary Heart Disease

edited by

Simona Giubilato

submission deadline 30 Jun 2025 | 9 articles | Viewed by 14959 | Submission Open

Keywords: coronary heart disease; acute coronary syndrome; chronic coronary syndrome; ischemia with no obstructive coronary arteries (INOCA); guideline-directed optimal medical therapy; precision medicine; artificial intelligence; interventional cardiology; percutaneous coronary intervention (PCI)

(This special issue belongs to the Section Cardiology)

Chronicity, Multimorbidity, and Medication Appropriateness

edited by

Ignatios Ioakeim-Skoufa

Mercedes Aza-Pascual-Salcedo

and Helena Coelho

submission deadline 30 Jun 2025 | 9 articles | Viewed by 14396 | Submission Open

Keywords: multimorbidity; chronic diseases; drug utilization; polypharmacy; medication appropriateness; medication adherence; drug interactions; care models; chronic inflammation; interventions

(This special issue belongs to the Section Pharmacology)

Current Trends and Innovations in Coronary Artery Disease and Myocardial Ischemia

edited by

Edoardo Conte

submission deadline 30 Jun 2025 | 6 articles | Viewed by 13174 | Submission Open

Keywords: coronary artery disease; fractional flow reserve; invasive coronary angiography; cardiac CT; cardiac MRI

(This special issue belongs to the Section Cardiovascular Medicine)

Early Clinical Diagnosis of and Intervention in Pediatric Cerebral Palsy

edited by

Ann Kristin G. Elvrum

and

Ann-Christin Eliasson

submission deadline 30 Jun 2025 | 8 articles | Viewed by 12337 | Submission Open

Keywords: cerebral palsy; early diagnosis; family factors; associated impairments; outcome measures; intervention; mental health

(This special issue belongs to the Section Clinical Pediatrics)

Vitreoretinal Disease: Clinical Insights and Treatment Strategies

edited by

Makoto Inoue

submission deadline 30 Jun 2025 | 8 articles | Viewed by 11247 | Submission Open

Keywords: vitreoretinal disease; age-related macular degeneration; diabetic retinopathy; retinal detachments; retinitis pig-mentosa; flashes and floaters; macular holes

(This special issue belongs to the Section Ophthalmology)

Treatment of Atopic Dermatitis

edited by

Francisco José Navarro-Triviño

and Ricardo Ruíz-Villaverde

submission deadline 30 Jun 2025 | 5 articles | Viewed by 10529 | Submission Open

Keywords: atopic dermatitis; eczema; topical treatment; systemic treatment; biological therapy; JAK inhibitor; antipruritic treatment

(This special issue belongs to the Section Dermatology)

Advances in Orthopedic Trauma Surgery in Geriatrics

edited by Ulrich Christoph Liener

submission deadline 30 Jun 2025 | 7 articles | Viewed by 10208 | Submission Open

Keywords: geriatric fractures; orthogeriatric care; osteoporosis; frailty; fragillity fractures; multidisciplinary care

(This special issue belongs to the Section Orthopedics)

Oral and Maxillofacial Surgery: Recent Advances and Future Directions

edited by

Tomasz Gredes

and

Ute Ulrike Botzenhart

submission deadline 30 Jun 2025 | 7 articles | Viewed by 9236 | Submission Open

Keywords: orthodontics; dentofacial orthopedics; bone regeneration; oral health; dentistry; digital technologies; virtual care

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Clinical Advances in Traumatic Brain Injury

edited by

Abhijit V. Lele

submission deadline 30 Jun 2025 | 4 articles | Viewed by 7981 | Submission Open

Keywords: traumatic brain injury; guideline/recommendations; concordant care; resource limited clinical setting; multimodal monitoring; neuroprognostication; safe/effective/patient-centered/timely/efficient/equitable care; quality improvement

(This special issue belongs to the Section Clinical Neurology)

Microsurgery: Current and Future Perspectives

edited by

Pier Camillo Parodi

, Michele Riccio, Luca Vaienti,

Francesco De Francesco

and

Nicola Zingaretti

submission deadline 30 Jun 2025 | 5 articles | Viewed by 7824 | Submission Open

Keywords: plastic surgery; reconstructive surgery; microsurgery; free flap; free tissue transfer

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

New Insights into Corneal Regeneration and Transplantation

edited by

Zala Lužnik Marzidovšek

and

Rohan Bir Singh

submission deadline 30 Jun 2025 | 4 articles | Viewed by 6948 | Submission Open

Keywords: cornea; corneal surface disease; corneal transplantation; eye banking; corneal stem cells; corneal immunology

(This special issue belongs to the Section Ophthalmology)

Polycystic Ovary Syndrome (PCOS): State of the Art: 2nd Edition

edited by

Enrico Carmina

submission deadline 30 Jun 2025 | 4 articles | Viewed by 6616 | Submission Open

Keywords: polycystic ovary syndrome; hirsutism; obesity; insulin resistance; amenorrhea; adult acne; female pattern hair loss; polycystic ovaries; anti-Mullerian hormone

(This special issue belongs to the Section Obstetrics & Gynecology)

Clinical Application of Physical Therapy in Neurorehabilitation: 2nd Edition

edited by

‪Sofia Straudi

and

Roberto Cano de la Cuerda

submission deadline 30 Jun 2025 | 3 articles | Viewed by 6362 | Submission Open

Keywords: physical therapy; technology-aided rehabilitation; exercise; neurorehabilitation; neuroplasticity; engagement; self-management

(This special issue belongs to the Section Clinical Rehabilitation)

Clinical Advances in Aortic Disease and Revascularization

edited by Andrej Udelnow

submission deadline 30 Jun 2025 | 6 articles | Viewed by 6332 | Submission Open

Keywords: aortic disease; aortic aneurysm; endovascular aortic repair; atherosclerosis; aortic dissections; overall survival; quality of life; intravascular ultrasound

(This special issue belongs to the Section Vascular Medicine)

New Clinical Advances in Sudden Cardiac Arrest and Ventricular Arrhythmias

edited by

Simone Savastano

submission deadline 30 Jun 2025 | 4 articles | Viewed by 5838 | Submission Open

Keywords: cardiac arrest; defibrillation; ventricular tachycardia; ventricular fibrillation; catheter ablation; non-invasive ablation; neuromodulation; stellate ganglion block

(This special issue belongs to the Section Cardiology)

Cardiac Electrophysiology: New Insights and Future Directions

edited by

Michael Spartalis

submission deadline 30 Jun 2025 | 4 articles | Viewed by 5541 | Submission Open

Keywords: cardiac arrhythmias; atrial fibrillation; ventricular arrhythmias; remote monitoring; implantable cardioverter– defibrillators; cardiac resynchronization therapy; catheter ablation; channelopathies

(This special issue belongs to the Section Cardiology)

Advances in Cardiac Resynchronization Treatment

edited by

George Leventopoulos

, Konstantinos A. Gatzoulis and

Nikolaos K. Fragakis

submission deadline 30 Jun 2025 | 4 articles | Viewed by 5458 | Submission Open

Keywords: conduction system; risk stratification; resynchronization; cardiac pacing; sudden cardiac death

(This special issue belongs to the Section Cardiology)

Inflammatory Bowel Diseases in 2024 and Beyond: From Diagnosis to Treatment

edited by

Amalia Di Petrillo

and Sara Onali

submission deadline 30 Jun 2025 | 4 articles | Viewed by 4937 | Submission Open

Keywords: inflammatory bowel disease; Crohn’ s disease; ulcerative colitis; target therapy; nutrition; early diagnosis; inflammatory biomarkers

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Thoracic Surgery: Current Challenges and Future Perspectives

edited by

Jon Zabaleta

and José Luis Campo-Cañaveral de la Cruz

submission deadline 30 Jun 2025 | 5 articles | Viewed by 4848 | Submission Open

Keywords: minimally invasive surgery; robotic-assisted thoracic surgery; lung cancer management; esophageal surgery; pleural diseases and interventions; thoracic trauma surgery; tracheal and bronchial surgery; thoracic endoscopy; lung transplantation; lung segmentectomy; 3D printing; pneumothorax; surgical planification; education; simulation; artificial intelligence

(This special issue belongs to the Section Respiratory Medicine)

Targeted Treatment of Kidney Stones

edited by Carmen Gonzalez-Enguita and

Alberto Budía-Alba

submission deadline 30 Jun 2025 | 2 articles | Viewed by 4568 | Submission Open

Keywords: shockwave lithotripsy; ureteroscopy; percutaneous nephrolithotomy; laser lithotripsy; minimally invasive techniques; stone recurrence prevention

(This special issue belongs to the Section Nephrology & Urology)

Clinical Perspectives for Headache and Neuropathic Pain

edited by Soo-Jin Cho

submission deadline 30 Jun 2025 | 5 articles | Viewed by 4159 | Submission Open

Keywords: headache; migraine; reversible vasoconstrictino syndrome; calcitonine-gene-related peptide; neuropathic pain; chemothera-py-induced peripheral neuropathy; central sensitization

(This special issue belongs to the Section Clinical Neurology)

Clinical Advances in Cardiac Anesthesia and Critical Care

edited by

Marc Licker

and Tiziano Cassina

submission deadline 30 Jun 2025 | 3 articles | Viewed by 4140 | Submission Open

Keywords: cardiac anesthesia; critical care; perioperative organ protection; multimodal analgesia; regional anesthesia; spinal analgesia; perioperative imaging; 3D transesophageal echocardiography

(This special issue belongs to the Section Anesthesiology)

The Influence of Laparoscopic and Robotic Surgery on Abdominal Diseases and Current Clinical Treatments

edited by

Gianluca Costa

, Maurizio De Maria and Niccolò Petrucciani

submission deadline 30 Jun 2025 | 1 articles | Viewed by 4125 | Submission Open

Keywords: laparoscopic surgery; robotic surgery; minimally invasive surgery; upper GI surgery; colorectal surgery; HBP surgery; transplantation; urology; obstetrics and gynecology

(This special issue belongs to the Section General Surgery)

Male Infertility Update: Current Knowledge on Etiology, Comorbidities, Diagnosis and Treatment: Clinical Topics

edited by

Francesco Lotti

and

Mario Maggi

submission deadline 30 Jun 2025 | 1 articles | Viewed by 3917 | Submission Open

Keywords: male infertility; diagnosis; treatment; etiology; pre-testicular/testicular/post-testicular causes; genetic causes; seminal parameters; hormonal parameters; ultrasound; general health; azoospermia

(This special issue belongs to the Section Reproductive Medicine & Andrology)

Targeted Diagnosis and Treatment of Dementia: Current Concepts and New Horizons

edited by Eli Wertman

submission deadline 30 Jun 2025 | 3 articles | Viewed by 3778 | Submission Open

Keywords: dementia; pre-dementia; diagnosis; targeted therapies; cognitive assessment; behavioral syndromes neuroimaging; multimorbidity; pharmacological interventions; non-pharmacological approaches; case management; supportive care; remediability

(This special issue belongs to the Section Mental Health)

New Insights in the Endovascular Treatment of Aortic Type A Dissection

edited by

Markus Kofler

submission deadline 30 Jun 2025 | 2 articles | Viewed by 3333 | Submission Open

Keywords: aortic dissection; endovascular treatment; type A dissection; thoracic aorta; stent graft; minimally invasive surgery; hybrid procedures; complications; long-term outcomes; patient selection

(This special issue belongs to the Section Cardiology)

Clinical Trends and Prospects in Urology Surgery

edited by

Lazaros Tzelves

Bhaskar K. Somani

and Patrick Juliebø-Jones

submission deadline 30 Jun 2025 | 3 articles | Viewed by 3064 | Submission Open

Keywords: robotic surgery; laparoscopic surgery; endourology; minimally invasive surgery; artificial intelligence

(This special issue belongs to the Section Nephrology & Urology)

Clinical Advances in Urinary Surgery

edited by Nir Kleinmann and

Asaf Shvero

submission deadline 30 Jun 2025 | 2 articles | Viewed by 2833 | Submission Open

Keywords: endourology; laparoscopic urology; urologic oncology; urolithiasis; robot-assisted surgery; endoscopic surgery

(This special issue belongs to the Section Nephrology & Urology)

Emerging Therapies for Multiple Myeloma

edited by Brea C. Lipe

submission deadline 30 Jun 2025 | 2 articles | Viewed by 2802 | Submission Open

Keywords: multiple myeloma; immunotherapy; targeted therapy; CAR-T cell therapy; new drugs; transplant

(This special issue belongs to the Section Hematology)

Current Practice and Future Perspectives of Neurological Conditions Caused by Neurodegeneration, 2nd Edition

edited by

Lilla Bonanno

submission deadline 30 Jun 2025 | 2 articles | Viewed by 2797 | Submission Open

Keywords: neurodegenerative diseases; amyotrophic lateral sclerosis; multiple sclerosis; Parkinson's disease; Alzheimer's disease; Huntington's disease; multiple-system atrophy; prion diseases; stroke

(This special issue belongs to the Section Clinical Neurology)

New Insights into Orthopedic Trauma Surgery—Pelvic and Acetabular Fracture Management

edited by Vera Jaecker and

Sven Märdian

submission deadline 30 Jun 2025 | 2 articles | Viewed by 2643 | Submission Open

Keywords: acetabular fractures; pelvic fractures; trauma surgery; intrapelvic approaches; fragility fractures of the pelvis; minimally invasive approaches; new implants; innovations

(This special issue belongs to the Section Orthopedics)

Pelvic Organ Prolapse: Current Challenges and Future Perspectives

edited by Marco Soligo

submission deadline 30 Jun 2025 | 2 articles | Viewed by 2596 | Submission Open

Keywords: pelvic organ prolapse; urinary incontinence; lower urinary disorders; quality of life; patient-reported outcomes

(This special issue belongs to the Section Obstetrics & Gynecology)

Gastroesophageal Cancer: Outcomes and Therapeutic Management

edited by Michael K. Gibson

submission deadline 30 Jun 2025 | 3 articles | Viewed by 2539 | Submission Open

Keywords: gastroesophageal cancer; targeted therapy; circulating tumor DNA; precision medicine; immune checkpoint inhibitors; esophageal cancer; gastric cancer; biomarkers; molecular characterization

(This special issue belongs to the Section Oncology)

Targeted Diagnosis and Advances in the Clinical Application of Infectious Diseases

edited by

José Antonio Mirón-Canelo

submission deadline 30 Jun 2025 | 2 articles | Viewed by 2499 | Submission Open

Keywords: care-associated infections; emerging infections; prevention and control measures and guidelines; prevention and control training

(This special issue belongs to the Section Infectious Diseases)

Current Challenges in the Management of Vitreoretinal Conditions: 2nd Edition

edited by

Georgios Panos

submission deadline 30 Jun 2025 | 1 articles | Viewed by 2451 | Submission Open

Keywords: retina; anti-VEGF; implants; macular degeneration; diabetic retinopathy; vein occlusions; retinal detachments; vit-reoretinal surgery; COVID-19 impact

(This special issue belongs to the Section Ophthalmology)

Advances in Echocardiography and Its Clinical Applications

edited by

Simona Sperlongano

submission deadline 30 Jun 2025 | 3 articles | Viewed by 2348 | Submission Open

Keywords: Doppler imaging; speckle tracking echocardiography; myocardial work; intracardiac flow dynamics; three-dimensional echocardiography; stress echocardiography; transoesophageal echocardiography; contrast echocardiography; artificial intelligence

(This special issue belongs to the Section Cardiovascular Medicine)

Recent Advances in Glaucoma Management

edited by Bogomil Voykov

submission deadline 30 Jun 2025 | 3 articles | Viewed by 2316 | Submission Open

Keywords: glaucoma; MIGS; microinvasive glaucoma surgery; quality of life; sustained-release drugs; wound healing modula-tion; intraocular pressure; intraocular pressure-lowering medication; microstent-supported bleb surgery; MIBS; neuroprotection

(This special issue belongs to the Section Ophthalmology)

Advances in Rehabilitation Care for Geriatric Diseases

edited by

Justyna Mazurek

submission deadline 30 Jun 2025 | 3 articles | Viewed by 2173 | Submission Open

Keywords: geriatric rehabilitation; holistic physiotherapy; physical activity; health outcomes; elderly people; geriatric care; chronic disease; health promotion

(This special issue belongs to the Section Clinical Rehabilitation)

Differential Effects of Bariatric Surgery (BS) and Endoscopic Bariatric Therapy (EBT) on Long and Short-Term Metabolic Outcomes

edited by Mohamad Mokadem

submission deadline 30 Jun 2025 | 4 articles | Viewed by 1826 | Submission Open

Keywords: obesity; bariatric surgery; endoscopic bariatric therapy; metabolic surgery; weight loss; metabolism; weight management

(This special issue belongs to the Section Endocrinology & Metabolism)

Current Trends and Future Directions in Plastic and Reconstructive Surgery

edited by Emilio Trignano

submission deadline 30 Jun 2025 | 1 articles | Viewed by 1805 | Submission Open

Keywords: plastic and reconstructive surgery; breast reconstruction; liposuction; tarsal tunnel syndrome; vasoconstriction; pneumomediastinum; abdominal wall surgery; vulvectomy

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

New Insights into Diabetic Foot

edited by Prashanth Vas and

Marco Meloni

submission deadline 30 Jun 2025 | 1 articles | Viewed by 1800 | Submission Open

Keywords: diabetic foot syndrome; diabetic foot infection; diabetic foot osteomyelitis; peripheral arterial disease; ischaemic ulcer; diabetic neuropathy

(This special issue belongs to the Section Endocrinology & Metabolism)

Pelvic Organ Prolapse: Clinical Updates and Perspectives

edited by José Antonio García-Mejido

submission deadline 30 Jun 2025 | 1 articles | Viewed by 1412 | Submission Open

Keywords: pelvic floor; ultrasound; pelvic organ prolapse; urogynecology; uterine prolapse; cystocele; rectocele; pelvic organ prolapse quantification system

(This special issue belongs to the Section Obstetrics & Gynecology)

Personalized Diagnosis and Treatment for Intracranial Aneurysm

edited by Nina Zobenica Moore and Mark D. Bain

submission deadline 30 Jun 2025 | 2 articles | Viewed by 1387 | Submission Open

Keywords: cerebral aneurysms; personalized medicine; predictive modeling; simulation imaging; subarachnoid hemorrhage; Intracranial Aneurysm

(This special issue belongs to the Section Clinical Neurology)

Advances in Aortic Surgery

edited by

Antonio Fiore

and Joseph Touma

submission deadline 30 Jun 2025 | 2 articles | Viewed by 1272 | Submission Open

Keywords: aortic surgery; aortic disease; aortic valve surgery; endovascular treatment; aortic imaging techniques; aortic aneurysm; acute aortic syndrome

(This special issue belongs to the Section Vascular Medicine)

Advancements in Spinal Oncology: The Current Landscape

edited by Aladine Elsamadicy and

Daniel M. Sciubba

submission deadline 30 Jun 2025 | 1 articles | Viewed by 1259 | Submission Open

Keywords: spinal oncology; patient outcomes; primary bone tumor; spine metastases; intradural tumors

(This special issue belongs to the Section Clinical Neurology)

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