Current and Emerging Therapies for Rheumatoid Arthritis

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Immunology".

Deadline for manuscript submissions: 10 July 2025 | Viewed by 1371

Special Issue Editor


E-Mail Website
Guest Editor
Department of Rheumatology, Sasebo City General Hospital, Sasebo 857-8511, Nagasaki, Japan
Interests: rheumatoid arthritis; Sjögren's syndrome; autoimmune diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The introduction of disease-modifying anti rheumatic drugs (DMARDs) has enabled rheumatologists to rescue patients with rheumatoid arthritis (RA) from joint destruction. Therapy of RA with DMARDs is still evolving, along with clinical applications of molecular targeted therapies: newly introduced biological DMARDs and targeted synthetic DMARDs, i.e., JAK inhibitors. Considering the present situation in the rheumatology department, we planned this Special Issue, titled ‘Current and Emerging Therapies for Rheumatoid Arthritis’, the aim of which is to disseminate up-to-date knowledge on current and emerging therapies for RA worldwide. We welcome authors to submit interesting papers, either original research or review, on the current topics regarding the advances in RA therapy.

Dr. Yoshiro Horai
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • DMARDs (disease-modifying anti-rheumatic drugs)
  • boDMARDs (biological DMARDs)
  • bsDMARDs (biosimilar DMARDs)
  • csDMARDs (conventional synthetic DMARDs)
  • rheumatoid arthritis
  • tsDMARDs (targeted synthetic DMARDs)

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

14 pages, 618 KiB  
Review
A Review of the Impact of Sjögren’s Syndrome and/or the Presence of Anti-Ro/SS-A Antibodies on Therapeutic Strategies for Rheumatoid Arthritis
by Yoshiro Horai, Shota Kurushima, Toshimasa Shimizu, Hideki Nakamura and Atsushi Kawakami
J. Clin. Med. 2025, 14(2), 568; https://doi.org/10.3390/jcm14020568 - 17 Jan 2025
Viewed by 1042
Abstract
Rheumatoid arthritis (RA) is an immune-mediated disease characterized by polyarthritis that affects the small joints of the bilateral upper and lower extremities. RA shares several common clinical symptoms with Sjögren’s syndrome (SS), another rheumatic disease caused by the lymphocytic infiltration of exocrine glands, [...] Read more.
Rheumatoid arthritis (RA) is an immune-mediated disease characterized by polyarthritis that affects the small joints of the bilateral upper and lower extremities. RA shares several common clinical symptoms with Sjögren’s syndrome (SS), another rheumatic disease caused by the lymphocytic infiltration of exocrine glands, with dry eye and dry mouth being the two most common symptoms. Anti-Ro/SS-A antibodies, a diagnostic biomarker of SS, are positive in patients with RA at a certain rate. The coexistence of SS and/or positivity for anti-Ro/SS-A antibodies in patients with RA influences disease activity and the effectiveness of several classes of disease-modifying antirheumatic drugs (DMARDs). Furthermore, RA, SS, and certain DMARDs, including methotrexate, are associated with the onset of lymphoproliferative disorders (LPD). In contrast, several biological DMARDs, such as tocilizumab and rituximab, are plausible options without the risk of LPD relapse. Considering the results of the studies introduced in this article, RA with SS and/or positivity for anti-Ro/SS-A antibodies could be considered a phenotype different from isolated RA from the perspective of refractoriness to DMARD therapy and LPD risk. Hence, rheumatologists should observe caution when choosing DMARDs. Further studies are needed to establish the appropriate treatment for patients with RA, SS, and/or the presence of anti-Ro/SS-A antibodies. Full article
(This article belongs to the Special Issue Current and Emerging Therapies for Rheumatoid Arthritis)
Show Figures

Figure 1

Back to TopTop