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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Artificial Intelligence and Eye Disease submission deadline 30 Sep 2025 | 4 articles | Viewed by 4362 | Submission Open
Keywords: Artificial Intelligence; machine learning; deep learning; ophthalmology; eye disease; eye disorder
(This special issue belongs to the Section Ophthalmology)
Renal Cell Carcinoma: From Diagnostic to Therapy
edited by Ithaar H. Derweesh and Zachary A. Hamilton
submission deadline 30 Sep 2025 | 3 articles | Viewed by 3880 | Submission Open
Keywords: biomarkers; clinical practice patterns; diagnosis; kidney cancer; metastasis; renal cell carcinoma; renal mass; staging; systemic therapy; surveillance
(This special issue belongs to the Section Nephrology & Urology)
Improving Diagnosis and Treatment of Vestibular Disorder: Latest Advances and Challenges
edited by , and Athanasia Korda
submission deadline 30 Sep 2025 | 2 articles | Viewed by 3469 | Submission Open
Keywords: vestibular system; balance disorders; dizziness; vertigo; vestibular testing; videonystagmography; video head impulse test; vestibular evoked myogenic potentials; vestibular rehabilitation therapy
(This special issue belongs to the Section Otolaryngology)
Innovations in Head and Neck Surgery
edited by and Giovanni Badiali
submission deadline 30 Sep 2025 | 1 articles | Viewed by 3179 | Submission Open
Keywords: reconstructive surgery; head and neck surgery; 3D printing; new technologies; virtual surgical planning; computer-assisted surgery; personalized reconstructive surgery; patient-specific implants; augmented reality; artificial intelligence; robotic surgery; surgical navigation
(This special issue belongs to the Section Otolaryngology)
Periodontal and Other Associated Oral Diseases: Diagnosis and Management in the Context of Systemic Pathology, 2nd Edition submission deadline 30 Sep 2025 | 4 articles | Viewed by 3152 | Submission Open
Keywords: periodontitis; oral diseases; periimplantitis; biomarkers; cytokines; oxidative stress markers; PCR test; point-of-care test; CBCT; periodontal treatment; immunomodulatory therapy; local drug delivery
(This special issue belongs to the Section Otolaryngology)
Mitral and Tricuspid Valve Disease and Imaging Techniques—2nd Edition
edited by and Annalisa Pasquini
submission deadline 30 Sep 2025 | 5 articles | Viewed by 3012 | Submission Open
Keywords: imaging in valvular heart disease; mitral valve disease; tricuspid valve disease; computed tomography; echocardiography; transesophageal echocardiography; cardiac magnetic resonance imaging; cardiac surgery; structural interventional cardiology; multi-modality imaging
(This special issue belongs to the Section Cardiovascular Medicine)
Clinical and Surgical Updates on Bariatric Surgery submission deadline 30 Sep 2025 | 2 articles | Viewed by 2867 | Submission Open
Keywords: bariatric surgery; morbid obesity; sleeve gastrectomy; gastric bypass; surgical complications; diabetes remission; hypertension remission; hypercholesterolemia remission; GERD; de novo GERD
(This special issue belongs to the Section General Surgery)
Advanced Strategy for Diagnosis and Treatment of Obstructive Sleep Apnea Syndrome (OSAS)
edited by
submission deadline 30 Sep 2025 | 2 articles | Viewed by 2855 | Submission Open
Keywords: obstructive sleep apnea syndrome; diagnosis; obesity; treatment; CPAP; comorbidities; cardiovascular risk
(This special issue belongs to the Section Respiratory Medicine)
Innovative Approaches to Upper Limb Rehabilitation in Orthopaedics: Advances in Functional Recovery and Pain Management
edited by and Danilo Donati
submission deadline 30 Sep 2025 | 1 articles | Viewed by 2642 | Submission Open
Keywords: upper limb rehabilitation; orthopaedics; musculoskeletal disorders; functional recovery; pain management
(This special issue belongs to the Section Orthopedics)
Multiple Sclerosis and Demyelinating Diseases: Diagnosis, Treatment and Prognosis
edited by Alberto Gajofatto
submission deadline 30 Sep 2025 | 1 articles | Viewed by 2624 | Submission Open
Keywords: multiple sclerosis; neuromyelitis optica; MOG-antibody disease; diagnosis; prognosis; treatment
(This special issue belongs to the Section Clinical Neurology)
Clinical Management of Movement Disorders (Second Edition)
edited by
submission deadline 30 Sep 2025 | 2 articles | Viewed by 2558 | Submission Open
Keywords: Parkinson’ s disease; parkinsonism; tremor; tic; dystonia; chorea; athetosis; ballism; myoclonus; ataxia; diagnosis; symptom monitoring; treatments
(This special issue belongs to the Section Clinical Neurology)
Innovations in the Treatment for Depression and Anxiety
edited by Lucie Bartova
submission deadline 30 Sep 2025 | 1 articles | Viewed by 2415 | Submission Open
Keywords: depression; anxiety; antidepressant; anxiolytic; psychopharmacotherapy; psychotherapy; brain stimulation; treatment; response; resistance
(This special issue belongs to the Section Mental Health)
Advances in Structural Heart Diseases
edited by , and Erwan Donal
submission deadline 30 Sep 2025 | 2 articles | Viewed by 2403 | Submission Open
Keywords: valvular heart diseases; transcatheter interventions; TEER; LAA closure; ASD closure; interventional echocardiography; multimodality cardiac imaging; three-dimensional echocardiography
(This special issue belongs to the Section Cardiovascular Medicine)
Experience and New Application in Otolaryngology and Maxillofacial Surgery
edited by Riccardo Nocini
submission deadline 30 Sep 2025 | 1 articles | Viewed by 2062 | Submission Open
Keywords: new surgical techniques; robotics; endoscopy; revascularized free flaps; innovation; 3D surgical planning.
(This special issue belongs to the Section Otolaryngology)
New Advances in Musculoskeletal Physiotherapy: Exercise, Manual Therapy and Invasive Physiotherapy
edited by and Ignacio Cancela-Cilleruelo
submission deadline 30 Sep 2025 | 2 articles | Viewed by 1885 | Submission Open
Keywords: musculoskeletal disorders; exercise therapy; manual therapy; invasive physical therapy; rehabilitation
(This special issue belongs to the Section Orthopedics)
Hemodialysis: Clinical Updates and Advances
edited by
submission deadline 30 Sep 2025 | 3 articles | Viewed by 1861 | Submission Open
Keywords: hemodiafiltration; medium cut-off membranes; expanded hemodialysis; vascular calcifications; renal anemia; vas-cular access; arterio-venous fistula; anticoagulation; outcomes
(This special issue belongs to the Section Nephrology & Urology)
Targeted Diagnosis and Treatment of Coronary Artery Disease: 2nd Edition
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1861 | Submission Open
Keywords: coronary artery disease; myocardial revascularization; percutaneous coronary intervention; cardiac surgery; coronary artery bypass graft; intravascular ultrasound; fractional flow reserve; instantaneous wave-free ratio; angiogenesis
(This special issue belongs to the Section Cardiology)
New Clinical Advances in Minimally Invasive Cardiac Surgery submission deadline 30 Sep 2025 | 2 articles | Viewed by 1793 | Submission Open
Keywords: minimally invasive cardiac surgery; valve surgery; coronary artery bypass grafting; heart failure management; surgical techniques
(This special issue belongs to the Section Cardiology)
Artificial Intelligence, Computer Modeling and Technology: Clinical Changing Practice in Reconstructive Surgery submission deadline 30 Sep 2025 | 1 articles | Viewed by 1676 | Submission Open
Keywords: reconstructive surgery; plastic surgery; breast surgery; breast reconstruction; oncologic surgery
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Clinical Medicine and Surgery in the Digital Age: Advances in Virtual, Augmented, Mixed, and Extended Reality
edited by Mohsen Annabestani and
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1627 | Submission Open
Keywords: virtual reality (VR); augmented reality (AR); mixed reality (MR); extended reality (XR); clinical medicine; surgery; diagnostic accuracy; surgical outcome; patient care; medical training
(This special issue belongs to the Section General Surgery)
Chronic Kidney Disease: Clinical Updates and Perspectives, Opportunities and Challenges, 2nd Edition
edited by Botond Csiky
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1621 | Submission Open
Keywords: chronic kidney disease progression; cardiovascular risk factors; diabetes mellitus; obesity; kidney transplantation; survival; pathophysiology of CKD; hemodialysis; peritoneal dialysis; metabolic and mineral bone disease
(This special issue belongs to the Section Nephrology & Urology)
Clinical Perspectives on Physical Activity and Health Across the Lifespan
edited by , and Rocío Izquierdo-Gómez
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1581 | Submission Open
Keywords: physical activity; sedentary behavior; health promotion; childhood obesity; well-being; fitness
(This special issue belongs to the Section Clinical Pediatrics)
Advancements in Otitis Media Diagnosis and Management
edited by Sharon Ovnat Tamir and Tal Marom
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1287 | Submission Open
Keywords: otitis media; mastoidectomy for cholesteatoma; vaccines; diagnosis; AI; mastoiditis; artificial intelligence; hearing loss
(This special issue belongs to the Section Otolaryngology)
New Progress in Pediatric Orthopedics and Pediatric Spine Surgery
edited by
submission deadline 30 Sep 2025 | 2 articles | Viewed by 1205 | Submission Open
Keywords: pediatric spine; scoliosis; clubfoot; flatfoot; developmental dysplasia of the hip; rare diseases
(This special issue belongs to the Section Clinical Pediatrics)
Imaging and Surgery in Endometriosis—Recent Advances submission deadline 30 Sep 2025 | 1 articles | Viewed by 1168 | Submission Open
Keywords: robotic-assisted surgery; MR imaging; radiomics; transvaginal ultrasound; deep endometriosis; ovarian endometriosis; fluorescence-guided surgery; artificial intelligence; adhesions in endometriosis; infertility; classification systems
(This special issue belongs to the Section Obstetrics & Gynecology)
Sequelae of COVID-19: Clinical to Prognostic Follow-Up submission deadline 30 Sep 2025 | 1 articles | Viewed by 1111 | Submission Open
Keywords: COVID-19; post-COVID-19 syndromes; sequelae of COVID-19; pathophysiological pathways; multiorgan sequelae; long-term management of post-COVID-19 syndromes; quality of life; long-term prognosis of COVID-19
(This special issue belongs to the Section Vascular Medicine)
Pediatric Sleep-Disordered Breathing
edited by Audrey Yoon
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1105 | Submission Open
Keywords: pediatric sleep-disordered breathing; growth modification; pediatric obstructive sleep apnea; interdisciplinary management; craniofacial development; obstructive sleep disorders; cognitive behavioral sleep medicine; pediatric dental sleep medicine; pediatric sleep surgery
(This special issue belongs to the Section Clinical Pediatrics)
General Orthopedic Surgery: Trends and Prospects
edited by John T. Riehl
submission deadline 30 Sep 2025 | 2 articles | Viewed by 1104 | Submission Open
Keywords: general orthopedic surgery; orthopedic trauma; hand; tumor; foot and ankle; spine; sports medicine; arthroplasty
(This special issue belongs to the Section Orthopedics)
Multiple Sclerosis: Advances in Therapeutic Approaches
edited by Renata Balnytė
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1083 | Submission Open
Keywords: multiple sclerosis; disease modifying treatment; immunomodulating teratment; new therapeutic approaches; neuroinflammation; neurodegeneration
(This special issue belongs to the Section Clinical Neurology)
Modern Approaches to the Management of Orthopedic Injuries
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 980 | Submission Open
Keywords: orthopedic trauma; surgical integration; trauma management; modern approaches; rehabilitation advances
(This special issue belongs to the Section Orthopedics)
Management of Inflammatory Bowel Disease: A Multidisciplinary Perspective submission deadline 30 Sep 2025 | 1 articles | Viewed by 892 | Submission Open
Keywords: inflammatory bowel disease management; Crohn's disease; ulcerative colitis; patient-centered care; multidisciplinary management; personalized treatment
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Systemic Autoimmune Disorder with Pulmonary Involvement: Novel Insights from Underlying Mechanisms of Drug Development and Intervention
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 845 | Submission Open
Keywords: rheumatic diseases; pulmonary involvement; connective tissue disorders; systemic autoimmune disorders (SARDs); diagnosis; innovative treatments
(This special issue belongs to the Section Respiratory Medicine)
Psoriasis in Focus: Current Research, Treatments, and Future Directions
edited by and Josep Riera-Monroig
submission deadline 30 Sep 2025 | 1 articles | Viewed by 845 | Submission Open
Keywords: psoriasis; biologic therapies; immunopathogenesis; precision medicine; comorbidities in psoriasis; psoriatic arthritis; phototherapy; topical treatments; systemic therapies
(This special issue belongs to the Section Dermatology)
Hepatobiliary and Pancreatic (HPB) Surgery: Current Status and Future Perspectives
edited by Andrea Benedetti Cacciaguerra and Paolo Vincenzi
submission deadline 30 Sep 2025 | 1 articles | Viewed by 720 | Submission Open
Keywords: hepatobiliary and pancreatic surgery; laparoscopic surgery; robot-assisted surgery; artificial intelligence; augmented reality; indocyanine green; liver tumors; pancreatic tumors
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Emerging Trends in Cervical Spine Surgery
edited by Daniel Hafez, Rory Murphy and Jacob Greenberg
submission deadline 30 Sep 2025 | 1 articles | Viewed by 684 | Submission Open
Keywords: cervical disk arthroplasty; laminoplasty; hybrid fusion; endoscopic cervical foraminotomy; endoscopic cervical laminectomy; cervical myelopathy; MIS cervical spine fusion; robotic/navigated cervical surgery
(This special issue belongs to the Section Orthopedics)
Advances in Treatment and Prognosis for Acute Type A and Type B Aortic Dissections
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 627 | Submission Open
Keywords: acute aortic dissection; stent graft; false lumen expansion; thoracic endovascular aortic repair; initial surgery for Type A acute aortic dissection; frozen elephant trunk
(This special issue belongs to the Section Cardiovascular Medicine)
New Advances in Retinal Diseases
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 603 | Submission Open
Keywords: retinal diseases; advanced imaging; biomarkers; diabetic retinopathy; macular degeneration; artificial intelligence; clinical outcomes
(This special issue belongs to the Section Ophthalmology)
Ventricular Tachycardia: Diagnosis, Treatment and Management
edited by Antonio Dello Russo and
submission deadline 30 Sep 2025 | Viewed by 405 | Submission Open
Keywords: ventricular tachycardia; cardiomyopathy; electroanatomical mapping; intracardiac echocardiography (ICE); radiofrequency ablation; pulsed field ablation; catheter ablation
(This special issue belongs to the Section Cardiology)
Clinical Diagnosis and Therapeutic Approaches for Acute and Chronic Coronary Syndromes
edited by Rocco Antonio Montone
submission deadline 30 Sep 2025 | 1 articles | Viewed by 375 | Submission Open
Keywords: coronary artery disease; clinical diagnosis; therapeutic approaches; atherosclerosis; risk factors; percutaneous cor-onary intervention; acute coronary syndrome; MINOCA; INOCA
(This special issue belongs to the Section Cardiology)
Advances in Sarcopenia Research: Clinical Approaches to Muscle Health and Aging
edited by and Helio José Coelho-Júnior
submission deadline 30 Sep 2025 | Viewed by 278 | Submission Open
Keywords: sarcopenia; functional decline; physical performance; muscle strength; muscle assessment; exercise interventions; nutri-tional strategies; adverse outcomes
(This special issue belongs to the Section Orthopedics)
COVID-19 and Endocrine Complications
edited by
submission deadline 30 Sep 2025 | Viewed by 239 | Submission Open
Keywords: adrenal; ACE2; diabetes; gonads; pituitary; SARS-CoV-2; thyroid
(This special issue belongs to the Section Endocrinology & Metabolism)
Latest Advances in Thoracic Surgery: 2nd Edition
edited by
submission deadline 30 Sep 2025 | Viewed by 235 | Submission Open
Keywords: lung cancer; surgical oncology; robotic surgery; thoracic surgery; lung diseases; minimally invasive surgery
(This special issue belongs to the Section Respiratory Medicine)
Multidisciplinary Approach to the Diagnosis and Treatment of Temporomandibular Disorders: Patient Care Challenges—2nd Edition submission deadline 30 Sep 2025 | Viewed by 229 | Submission Open
Keywords: multidisciplinary approach; mental health; bruxism; masticatory muscles; temporomandibular joint; orofacial pain; temporomandibular disorders
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
State of the Art in Management of Aortic Aneurysm in Vascular Surgery
edited by Rana O. Afifi and Eanas Yassa
submission deadline 30 Sep 2025 | Viewed by 190 | Submission Open
Keywords: aortic dissection; complex aortic surgery; endovascular aortic repair; aortic imaging; aortic aneurysm
(This special issue belongs to the Section Vascular Medicine)
Latest Advances in Ocular Surface Diseases
edited by Barbara Burgos-Blasco
submission deadline 30 Sep 2025 | Viewed by 188 | Submission Open
Keywords: cornea; keratitis; ocular surface disease; dry eye; corneal ulcer; keratoplasty; conjunctival disease
(This special issue belongs to the Section Ophthalmology)
Risk Prediction in Mechanical Circulatory Support (MCS) and Cardiac Transplantation
edited by
submission deadline 30 Sep 2025 | Viewed by 168 | Submission Open
Keywords: advanced heart failure; mechanical circulatory support (MCS); cardiac transplantation; heart transplantation; risk prediction
(This special issue belongs to the Section Cardiology)
Thrombosis and Haemostasis: Clinical Advances
edited by Hui Yin Lim
submission deadline 30 Sep 2025 | Viewed by 165 | Submission Open
Keywords: venous thrombosis; biomarkers; bleeding; direct oral anticoagulants; pulmonary embolism; factor XI inhibitors; factor XII inhibitors; endovascular treatment
(This special issue belongs to the Section Vascular Medicine)
Esophageal and Upper Interventional Endoscopy and Surgery: Latest Advances and Prospects
edited by Giulia Gibiino
submission deadline 30 Sep 2025 | Viewed by 150 | Submission Open
Keywords: gastric preneoplastic and neoplastic lesions; endoscopic submucosal dissection (ESD); endoscopic full-thickness resection (EFTR); subepithelial upper GI lesions; duodenal adenomas; esophageal stenting
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Modern Concepts on Acoustic Neuroma
edited by Alessia Rubini and Davide Soloperto
submission deadline 30 Sep 2025 | Viewed by 148 | Submission Open
Keywords: neurotology; neurosurgery; vestibular schwannoma; acoustic neuroma; middle cranial fossa approach; retrosigmoid approach; translabirynthine approach; gammaknife; wait and scan policy
(This special issue belongs to the Section Otolaryngology)
Breast Cancer: Advances in Clinical and Personalized Practices
edited by Massimo Lodi and Sébastien Molière
submission deadline 30 Sep 2025 | Viewed by 142 | Submission Open
Keywords: breast cancer; radiology; surgical oncology; breast reconstruction; personalized medicine; quality of life; multidisci-plinary approach; new technologies
(This special issue belongs to the Section Oncology)
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