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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cardiac Imaging Techniques in Heart Failure Care
edited by David Snipelisky
submission deadline 25 Jun 2025 | Viewed by 148 | Submission Open
Keywords: heart failure; advanced imaging; cardiac imaging; echocardiography; cardiomyopathies
(This special issue belongs to the Section Cardiology)
Hematologic Malignancies: Treatment Strategies and Future Challenges
edited by Masaaki Noguchi
submission deadline 26 Jun 2025 | 6 articles | Viewed by 7180 | Submission Open
Keywords: hematologic malignancies; relapse; refractory; drug resistance; therapeutic strategies; new target; biomarkers; new insights
(This special issue belongs to the Section Hematology)
Clinical Advances in Hepatobiliary Surgery: Diagnosis, Prognosis, Management & Surgery for Colorectal Liver Metastases
edited by Alexandros Giakoustidis, Vasileios N. Papadopoulos, , and
submission deadline 26 Jun 2025 | 4 articles | Viewed by 6961 | Submission Open
Keywords: liver metastases; colorectal cancer; liver surgery; laparoscopic surgery; robotic surgery; pancreas
(This special issue belongs to the Section General Surgery)
Cardiac Rehabilitation: Clinical Challenges and New Insights
edited by Melissa Tracy
submission deadline 26 Jun 2025 | 1 articles | Viewed by 311 | Submission Open
Keywords: cardiovascular disease; cardiac rehabilitation; atrial fibrillation
(This special issue belongs to the Section Cardiology)
Pediatric Surgery—Current Hurdles and Future Perspectives
edited by
submission deadline 27 Jun 2025 | 6 articles | Viewed by 4819 | Submission Open
Keywords: congenital anomalies; esophageal atresia; anorectoal malformations; pediatric trauma; necrotizing enterocoloitis; pediatric oncology; Biliary atresia
(This special issue belongs to the Section Clinical Pediatrics)
Clinical Challenges of Pelvic Floor Disorders Management
edited by
submission deadline 27 Jun 2025 | 3 articles | Viewed by 2477 | Submission Open
Keywords: pelvic floor disorders; pelvic organ prolapse; urinary incontinence; surgery; diagnostics; pelvic pain; vulvodynia; urinary tract symptoms; mesh-related complications
(This special issue belongs to the Section Obstetrics & Gynecology)
Thyroid Disease: Updates from Diagnosis to Treatment
edited by and Petra Petranović Ovčariček
submission deadline 28 Jun 2025 | 8 articles | Viewed by 8518 | Submission Open
Keywords: autoimmune thyroid diseases; thyroiditis; thyroid cancers; PET/CT; hyperthyroidism
(This special issue belongs to the Section Endocrinology & Metabolism)
Atrial Fibrillation Rhythm Management: Outcomes, Innovations, and Future Directions
edited by Roberto Scacciavillani and Gemma Pelargonio
submission deadline 28 Jun 2025 | Viewed by 192 | Submission Open
Keywords: atrial fibrillation; catheter ablation; radiofrequency; cryoablation; pulsed field ablation; cardioneuroablation; left bundle branch area pacing
(This special issue belongs to the Section Cardiology)
Lung Transplantation: Current Strategies and Future Directions
edited by Omer Senbaklavaci and György Lang
submission deadline 28 Jun 2025 | Viewed by 177 | Submission Open
Keywords: lung transplantation; graft optimization; immunosuppression; artificial lung; xenotransplantation; end-stage lung disease; donor lung preservation; chronic lung allograft dysfunction
(This special issue belongs to the Section Respiratory Medicine)
Pediatric Neurosurgery: Clinical Advances in Diagnostics and Perioperative Management
edited by Kara Leigh Krajewski and Ulrich-Wilhelm Thomale
submission deadline 29 Jun 2025 | Viewed by 227 | Submission Open
Keywords: rapid sequence MRI; intraoperative MRI; perioperative management; neurocritical care; patient selection; M&M conferences; surgical team; rehabilitation
(This special issue belongs to the Section Clinical Pediatrics)
Recent Advances in Pulmonary Embolism and Thrombosis
edited by and Mauro Silingardi
submission deadline 30 Jun 2025 | 8 articles | Viewed by 37641 | Submission Open
Keywords: pulmonary embolism; embolism and thrombosis; thrombus aspiration for pulmonary embolism; deep vein throm-bosis; venous thromboembolism
(This special issue belongs to the Section Respiratory Medicine)
Current and Future Trends in Otorhinolaryngology–Head and Neck Surgery submission deadline 30 Jun 2025 | 14 articles | Viewed by 20778 | Submission Open
Keywords: otorhinolaryngology; head and neck; innovation; diagnosis; treatment; surgery
(This special issue belongs to the Section Otolaryngology)
New Advances in Optic Nerve Diseases
edited by
submission deadline 30 Jun 2025 | 9 articles | Viewed by 18396 | Submission Open
Keywords: optic nerve; optic nerve diseases; optic neuritis; glaucoma; optic neuropathies; optical coherence tomography; OCT; ocular ultrasonography
(This special issue belongs to the Section Ophthalmology)
An Update on Retinal Diseases: From Diagnosis to Treatment
edited by , Masahiko Sugimoto and Kenji Yamashiro
submission deadline 30 Jun 2025 | 12 articles | Viewed by 13595 | Submission Open
Keywords: retinal diseases; diagnosis; treatment; etiology; original article; review paper
(This special issue belongs to the Section Ophthalmology)
Diagnosis, Treatment and Prognosis of Coronary Heart Disease
edited by
submission deadline 30 Jun 2025 | 9 articles | Viewed by 13102 | Submission Open
Keywords: coronary heart disease; acute coronary syndrome; chronic coronary syndrome; ischemia with no obstructive coronary arteries (INOCA); guideline-directed optimal medical therapy; precision medicine; artificial intelligence; interventional cardiology; percutaneous coronary intervention (PCI)
(This special issue belongs to the Section Cardiology)
Chronicity, Multimorbidity, and Medication Appropriateness submission deadline 30 Jun 2025 | 8 articles | Viewed by 12152 | Submission Open
Keywords: multimorbidity; chronic diseases; drug utilization; polypharmacy; medication appropriateness; medication adherence; drug interactions; care models; chronic inflammation; interventions
(This special issue belongs to the Section Pharmacology)
Updates on Neurostimulation: From Mechanistic Principles to Clinical Applications submission deadline 30 Jun 2025 | 5 articles | Viewed by 11712 | Submission Open
Keywords: brain stimulation; non-invasive brain stimulation; deep brain stimulation; neuroimaging; computational modelling; therapy
(This special issue belongs to the Section Clinical Neurology)
Current Trends and Innovations in Coronary Artery Disease and Myocardial Ischemia
edited by
submission deadline 30 Jun 2025 | 5 articles | Viewed by 11233 | Submission Open
Keywords: coronary artery disease; fractional flow reserve; invasive coronary angiography; cardiac CT; cardiac MRI
(This special issue belongs to the Section Cardiovascular Medicine)
Early Clinical Diagnosis of and Intervention in Pediatric Cerebral Palsy submission deadline 30 Jun 2025 | 8 articles | Viewed by 10250 | Submission Open
Keywords: cerebral palsy; early diagnosis; family factors; associated impairments; outcome measures; intervention; mental health
(This special issue belongs to the Section Clinical Pediatrics)
Vitreoretinal Disease: Clinical Insights and Treatment Strategies
edited by
submission deadline 30 Jun 2025 | 8 articles | Viewed by 10107 | Submission Open
Keywords: vitreoretinal disease; age-related macular degeneration; diabetic retinopathy; retinal detachments; retinitis pig-mentosa; flashes and floaters; macular holes
(This special issue belongs to the Section Ophthalmology)
Clinical Advances in Vascular and Endovascular Surgery
edited by Toshifumi Kudo
submission deadline 30 Jun 2025 | 9 articles | Viewed by 9392 | Submission Open
Keywords: aortic aneurysm; peripheral arterial disease; chronic limb-threatening ischemia; endovascular aneurysm repair; endovascular treatment; non-invasive blood flow measurements; varicose veins; deep venous thrombosis
(This special issue belongs to the Section Vascular Medicine)
Advances in Orthopedic Trauma Surgery in Geriatrics
edited by Ulrich Christoph Liener
submission deadline 30 Jun 2025 | 7 articles | Viewed by 9206 | Submission Open
Keywords: geriatric fractures; orthogeriatric care; osteoporosis; frailty; fragillity fractures; multidisciplinary care
(This special issue belongs to the Section Orthopedics)
Sepsis and Organ Dysfunction: New Insights into Diagnosis and Treatment
edited by
submission deadline 30 Jun 2025 | 7 articles | Viewed by 8546 | Submission Open
Keywords: intensive care; sepsis; septic shock; biomarkers; multiorgan dysfunction syndrome; ex-tracorporeal methods; mortality
(This special issue belongs to the Section Intensive Care)
Treatment of Atopic Dermatitis
edited by and Ricardo Ruíz-Villaverde
submission deadline 30 Jun 2025 | 4 articles | Viewed by 8388 | Submission Open
Keywords: atopic dermatitis; eczema; topical treatment; systemic treatment; biological therapy; JAK inhibitor; antipruritic treatment
(This special issue belongs to the Section Dermatology)
Clinical Advances in Traumatic Brain Injury
edited by
submission deadline 30 Jun 2025 | 4 articles | Viewed by 7251 | Submission Open
Keywords: traumatic brain injury; guideline/recommendations; concordant care; resource limited clinical setting; multimodal monitoring; neuroprognostication; safe/effective/patient-centered/timely/efficient/equitable care; quality improvement
(This special issue belongs to the Section Clinical Neurology)
Microsurgery: Current and Future Perspectives
edited by , Michele Riccio, Luca Vaienti, and
submission deadline 30 Jun 2025 | 5 articles | Viewed by 6853 | Submission Open
Keywords: plastic surgery; reconstructive surgery; microsurgery; free flap; free tissue transfer
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Oral and Maxillofacial Surgery: Recent Advances and Future Directions submission deadline 30 Jun 2025 | 5 articles | Viewed by 6665 | Submission Open
Keywords: orthodontics; dentofacial orthopedics; bone regeneration; oral health; dentistry; digital technologies; virtual care
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
New Insights into Corneal Regeneration and Transplantation submission deadline 30 Jun 2025 | 4 articles | Viewed by 6360 | Submission Open
Keywords: cornea; corneal surface disease; corneal transplantation; eye banking; corneal stem cells; corneal immunology
(This special issue belongs to the Section Ophthalmology)
Clinical Advances in Aortic Disease and Revascularization
edited by Andrej Udelnow
submission deadline 30 Jun 2025 | 6 articles | Viewed by 5578 | Submission Open
Keywords: aortic disease; aortic aneurysm; endovascular aortic repair; atherosclerosis; aortic dissections; overall survival; quality of life; intravascular ultrasound
(This special issue belongs to the Section Vascular Medicine)
Clinical Application of Physical Therapy in Neurorehabilitation: 2nd Edition submission deadline 30 Jun 2025 | 3 articles | Viewed by 5544 | Submission Open
Keywords: physical therapy; technology-aided rehabilitation; exercise; neurorehabilitation; neuroplasticity; engagement; self-management
(This special issue belongs to the Section Clinical Rehabilitation)
Polycystic Ovary Syndrome (PCOS): State of the Art: 2nd Edition
edited by
submission deadline 30 Jun 2025 | 3 articles | Viewed by 5458 | Submission Open
Keywords: polycystic ovary syndrome; hirsutism; obesity; insulin resistance; amenorrhea; adult acne; female pattern hair loss; polycystic ovaries; anti-Mullerian hormone
(This special issue belongs to the Section Obstetrics & Gynecology)
Cardiac Electrophysiology: New Insights and Future Directions
edited by
submission deadline 30 Jun 2025 | 4 articles | Viewed by 5075 | Submission Open
Keywords: cardiac arrhythmias; atrial fibrillation; ventricular arrhythmias; remote monitoring; implantable cardioverter– defibrillators; cardiac resynchronization therapy; catheter ablation; channelopathies
(This special issue belongs to the Section Cardiology)
New Clinical Advances in Sudden Cardiac Arrest and Ventricular Arrhythmias
edited by
submission deadline 30 Jun 2025 | 3 articles | Viewed by 4950 | Submission Open
Keywords: cardiac arrest; defibrillation; ventricular tachycardia; ventricular fibrillation; catheter ablation; non-invasive ablation; neuromodulation; stellate ganglion block
(This special issue belongs to the Section Cardiology)
Clinical Epidemiology in Chronic Kidney Disease
edited by and Claudia Torino
submission deadline 30 Jun 2025 | 5 articles | Viewed by 4794 | Submission Open
Keywords: chronic kidney disease; end-stage kidney disease; dialysis; hypertension; renal disease; clinical nephrology; chronic renal failure
(This special issue belongs to the Section Nephrology & Urology)
State-of-the-Art Innovations in Oral and Maxillofacial Surgery
edited by Marcin Kozakiewicz and Katarzyna Bogusiak
submission deadline 30 Jun 2025 | 6 articles | Viewed by 4317 | Submission Open
Keywords: oral surgery; maxillofacial surgery; traumatology; orthognatic surgery; infections; oncology; diagnostics; treatment; implantology; augmentation; imaging; computer-assisted techniques
(This special issue belongs to the Section Otolaryngology)
Trauma and Acute Care Surgery Research: Innovations, Challenges, and Future Directions
edited by Frederick Rogers
submission deadline 30 Jun 2025 | 3 articles | Viewed by 4207 | Submission Open
Keywords: trauma care; best practices; clinical care; trauma system development; optimal trauma care
(This special issue belongs to the Section Intensive Care)
Bruxism and Temporomandibular Disorders: Current Advances and Future Challenges submission deadline 30 Jun 2025 | 4 articles | Viewed by 4109 | Submission Open
Keywords: TMDs; TMJ; rehabilitation; physiotherapy; craniofacial disorder; oral health; biomechanics; masticatory muscles; electromyography; parafunction; nocturnal bruxism; tooth contact habit
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Advances in Cardiac Resynchronization Treatment
edited by , Konstantinos A. Gatzoulis and
submission deadline 30 Jun 2025 | 4 articles | Viewed by 3896 | Submission Open
Keywords: conduction system; risk stratification; resynchronization; cardiac pacing; sudden cardiac death
(This special issue belongs to the Section Cardiology)
Targeted Treatment of Kidney Stones
edited by Carmen Gonzalez-Enguita and
submission deadline 30 Jun 2025 | 2 articles | Viewed by 3807 | Submission Open
Keywords: shockwave lithotripsy; ureteroscopy; percutaneous nephrolithotomy; laser lithotripsy; minimally invasive techniques; stone recurrence prevention
(This special issue belongs to the Section Nephrology & Urology)
Inflammatory Bowel Diseases in 2024 and Beyond: From Diagnosis to Treatment
edited by and Sara Onali
submission deadline 30 Jun 2025 | 3 articles | Viewed by 3662 | Submission Open
Keywords: inflammatory bowel disease; Crohn’ s disease; ulcerative colitis; target therapy; nutrition; early diagnosis; inflammatory biomarkers
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
The Influence of Laparoscopic and Robotic Surgery on Abdominal Diseases and Current Clinical Treatments
edited by , Maurizio De Maria and Niccolò Petrucciani
submission deadline 30 Jun 2025 | 1 articles | Viewed by 3642 | Submission Open
Keywords: laparoscopic surgery; robotic surgery; minimally invasive surgery; upper GI surgery; colorectal surgery; HBP surgery; transplantation; urology; obstetrics and gynecology
(This special issue belongs to the Section General Surgery)
Thoracic Surgery: Current Challenges and Future Perspectives
edited by and José Luis Campo-Cañaveral de la Cruz
submission deadline 30 Jun 2025 | 4 articles | Viewed by 3441 | Submission Open
Keywords: minimally invasive surgery; robotic-assisted thoracic surgery; lung cancer management; esophageal surgery; pleural diseases and interventions; thoracic trauma surgery; tracheal and bronchial surgery; thoracic endoscopy; lung transplantation; lung segmentectomy; 3D printing; pneumothorax; surgical planification; education; simulation; artificial intelligence
(This special issue belongs to the Section Respiratory Medicine)
Clinical Advances in Cardiac Anesthesia and Critical Care
edited by and Tiziano Cassina
submission deadline 30 Jun 2025 | 3 articles | Viewed by 3363 | Submission Open
Keywords: cardiac anesthesia; critical care; perioperative organ protection; multimodal analgesia; regional anesthesia; spinal analgesia; perioperative imaging; 3D transesophageal echocardiography
(This special issue belongs to the Section Anesthesiology)
Male Infertility Update: Current Knowledge on Etiology, Comorbidities, Diagnosis and Treatment: Clinical Topics submission deadline 30 Jun 2025 | 1 articles | Viewed by 3256 | Submission Open
Keywords: male infertility; diagnosis; treatment; etiology; pre-testicular/testicular/post-testicular causes; genetic causes; seminal parameters; hormonal parameters; ultrasound; general health; azoospermia
(This special issue belongs to the Section Reproductive Medicine & Andrology)
New Insights in the Endovascular Treatment of Aortic Type A Dissection
edited by
submission deadline 30 Jun 2025 | 2 articles | Viewed by 2915 | Submission Open
Keywords: aortic dissection; endovascular treatment; type A dissection; thoracic aorta; stent graft; minimally invasive surgery; hybrid procedures; complications; long-term outcomes; patient selection
(This special issue belongs to the Section Cardiology)
Innovations in Preeclampsia
edited by Jeffrey M. Denney and
submission deadline 30 Jun 2025 | 2 articles | Viewed by 2902 | Submission Open
Keywords: preeclampsia; pathophysiology; renin; SFlt-1; PlGF; hypertensive disorders of pregnancy; imitators of preeclampsia; vascular reactivity
(This special issue belongs to the Section Obstetrics & Gynecology)
Clinical Perspectives for Headache and Neuropathic Pain
edited by Soo-Jin Cho
submission deadline 30 Jun 2025 | 4 articles | Viewed by 2871 | Submission Open
Keywords: headache; migraine; reversible vasoconstrictino syndrome; calcitonine-gene-related peptide; neuropathic pain; chemothera-py-induced peripheral neuropathy; central sensitization
(This special issue belongs to the Section Clinical Neurology)
Targeted Diagnosis and Treatment of Dementia: Current Concepts and New Horizons
edited by Eli Wertman
submission deadline 30 Jun 2025 | 2 articles | Viewed by 2781 | Submission Open
Keywords: dementia; pre-dementia; diagnosis; targeted therapies; cognitive assessment; behavioral syndromes neuroimaging; multimorbidity; pharmacological interventions; non-pharmacological approaches; case management; supportive care; remediability
(This special issue belongs to the Section Mental Health)
Causes and Advanced Treatments of Macular Edema submission deadline 30 Jun 2025 | 3 articles | Viewed by 2681 | Submission Open
Keywords: macular edema; laser photocoagulation; subthreshold laser; anti-VEGF; optical coherence tomography; fluorescein angiography; angio-OCT
(This special issue belongs to the Section Ophthalmology)
Clinical Trends and Prospects in Urology Surgery
edited by , and Patrick Juliebø-Jones
submission deadline 30 Jun 2025 | 3 articles | Viewed by 2662 | Submission Open
Keywords: robotic surgery; laparoscopic surgery; endourology; minimally invasive surgery; artificial intelligence
(This special issue belongs to the Section Nephrology & Urology)
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