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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Ovarian Cancer: Clinical Updates and Advances
edited by
submission deadline 25 Sep 2025 | Viewed by 358 | Submission Open
Keywords: ovarian cancer; prehabilitation; ultrasound; radiologic staging; cytoreductive surgery; targeted treatment; prevention; screening
(This special issue belongs to the Section Obstetrics & Gynecology)
Current Advances in Interventional Oncology
edited by
submission deadline 25 Sep 2025 | Viewed by 314 | Submission Open
Keywords: interventional oncology/radiology; vascular locoregional therapies; thermal ablation; treatment options; imaging-guided biopsies
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Clinical Perspectives in Cardiac Imaging: How to See the Unseen
edited by and Wanda Acampa
submission deadline 25 Sep 2025 | Viewed by 276 | Submission Open
Keywords: cardiac imaging; MPI; PET; SPECT; CCTA; MR; CAD; heart failure; cardiac sarcoidosis; cardiac amyloidosis; valvular disease; artificial intelligence
(This special issue belongs to the Section Cardiology)
Recent Advances in Prenatal Diagnosis and Maternal Fetal Medicine submission deadline 25 Sep 2025 | Viewed by 264 | Submission Open
Keywords: prenatal; obstetrics; fetal abnormalities; intrauterine treatments; genetic disorders; pregnancy
(This special issue belongs to the Section Obstetrics & Gynecology)
Recent Advances in Cognitive Rehabilitation
edited by Yuko Koshimori
submission deadline 25 Sep 2025 | Viewed by 238 | Submission Open
Keywords: cognitive training; cognitive rehabilitation; cognitive stimulation; cognitive dysfunction; dementia; cognition; cognitive ability; cognitive development
(This special issue belongs to the Section Clinical Rehabilitation)
Clinical Therapy in Dementia and Related Diseases
edited by
submission deadline 25 Sep 2025 | Viewed by 207 | Submission Open
Keywords: dementia; aging society; disease-modifying therapies (DMT); early diagnosis; lifestyle interventions; multimorbidity management; non-pharmacological treatments; personalized medicine; quality of life (QOL); digital health technologies
(This special issue belongs to the Section Mental Health)
Recent Advances in Head and Neck Surgery
edited by Lisa Catarzi, and
submission deadline 25 Sep 2025 | Viewed by 189 | Submission Open
Keywords: head and neck surgery; reconstructive surgery; microsurgical reconstruction; new technologies; computer-assisted surgery; surgical innovation; post-operative care
(This special issue belongs to the Section Otolaryngology)
Management of Intra-Abdominal Infections: Current Challenges and Perspectives submission deadline 25 Sep 2025 | Viewed by 188 | Submission Open
Keywords: intra-abdominal infection; anastomotic dehiscence; acute cholecystitis; acute appendicitis; acute diverticulitis; infected pancreatic necrosis; secondary peritonitis; tertiary peritonitis; intra-abdominal abscess; peptic ulcer perforation; minimally invasive surgery; surgical endoscopy; antimicrobic stewardship; antibiotic therapy; artificial intelligence
(This special issue belongs to the Section General Surgery)
Attention-Deficit–Hyperactivity Disorder (ADHD): Bridging Theory and Clinical Application
edited by Rafał R. Jaeschke
submission deadline 25 Sep 2025 | Viewed by 183 | Submission Open
Keywords: ADHD; emotional dysregulation; diagnosis and assessment; pharmacological and non-pharmacological treatments; neurobiology; comorbidities
(This special issue belongs to the Section Mental Health)
New Advances in Age-Related Macular Degeneration
edited by Omer Trivizki
submission deadline 25 Sep 2025 | Viewed by 172 | Submission Open
Keywords: wet age-related macular degeneration; dry age-related macular degeneration; retinal imaging; drusen; intravitreal injections; ocular angiogenesis; visual rehabilitation
(This special issue belongs to the Section Ophthalmology)
Clinical Management of Complications Following Kidney Transplant Surgery
edited by Ryoichi Imamura
submission deadline 25 Sep 2025 | Viewed by 155 | Submission Open
Keywords: kidney transplantation; complication; rejection; infectious disease; de novo cancer; cardiovascular disease; biomarkers
(This special issue belongs to the Section Nephrology & Urology)
Treatment Strategies for Prostate Cancer: An Update submission deadline 25 Sep 2025 | Viewed by 136 | Submission Open
Keywords: prostate cancer; robotic surgery; uro-oncology; focal therapy; single-port; radiotherapy
(This special issue belongs to the Section Nephrology & Urology)
Clinical Application of Artificial Intelligence in Vascular Surgery
edited by
submission deadline 25 Sep 2025 | Viewed by 121 | Submission Open
Keywords: artificial intelligence; machine learning; vision; vascular imaging; natural language processing; innovation; vascular surgery; vascular diseases; endovascular; aortic disease; carotid disease; peripheral artery disease; venous disease
(This special issue belongs to the Section Vascular Medicine)
Clinical Advances and Challenges in Laparoscopic Surgery
edited by Leonid Barkhatov
submission deadline 25 Sep 2025 | Viewed by 119 | Submission Open
Keywords: laparoscopic surgery; minimally invasive surgery; surgical outcomes; oncologic surgery; general surgery; learning curve
(This special issue belongs to the Section General Surgery)
State of the Art in Clinical Management of Sedation and Anesthesia Challenges
edited by Basavana Goudra
submission deadline 25 Sep 2025 | Viewed by 93 | Submission Open
Keywords: anesthesia; oxygenation; sedative agents; ventilation; airway management
(This special issue belongs to the Section Anesthesiology)
Vascular and Endovascular Surgery: Current Progress and Future Challenges
edited by Michael Keese and Martin Sigl
submission deadline 28 Sep 2025 | 5 articles | Viewed by 5527 | Submission Open
Keywords: vascular; endovascular; surgery; therapy; aneurysm; vascular; PAD; venous; interdisciplinary
(This special issue belongs to the Section Vascular Medicine)
New Perspectives in Liver Transplantation and Biliary Complications
edited by and Francesco Frongillo
submission deadline 28 Sep 2025 | 3 articles | Viewed by 3631 | Submission Open
Keywords: liver transplant; cholangiopathy; ischemia/reperfusion injury; machine perfusion; extended-criteria donors
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Echocardiographic Imaging in Transcatheter Structural Intervention: Current Practices and Future Directions
edited by and Fausto Pizzino
submission deadline 28 Sep 2025 | 2 articles | Viewed by 3505 | Submission Open
Keywords: echocardiographic imaging; transcatheter intervention; aortic stenosis; mitral regurgitation; tricuspid regurgitation; left atrial appendage closure; patent foramen ovale closure; atrial septal defect repair
(This special issue belongs to the Section Cardiology)
Clinical Management and Treatment of Orthopedic Oncology: 2nd Edition
edited by and Danielle Elizabeth Greig
submission deadline 28 Sep 2025 | 3 articles | Viewed by 2063 | Submission Open
Keywords: bone metastasis; primary bone tumors; soft tissue sarcoma; limb salvage; multimodal treatment strategies
(This special issue belongs to the Section Orthopedics)
High-Flow Nasal Cannula (HFNC) and Noninvasive Ventilation: What Is New in Acute, Chronic and Rehabilitation Settings? submission deadline 28 Sep 2025 | 1 articles | Viewed by 2036 | Submission Open
Keywords: NIV; HFNC; noninvasive ventilation; acute respiratory insufficiency; chronic respiratory insufficiency
(This special issue belongs to the Section Respiratory Medicine)
Current Progress in the Treatment of Cornea and Ocular Surface Diseases
edited by Marco Messina and
submission deadline 28 Sep 2025 | 2 articles | Viewed by 1732 | Submission Open
Keywords: dry eye disease; meibomian gland dysfunction; microbial keratitis; auto-immune keratitis; peripheral ulcerative keratitis; neurotrophic keratopathy; corneal dystrophies; corneal degenerations; mucous membrane pemphigoid; ocular cicatricial disease; Stevens– Johnson syndrome; pterygium; ocular graft-versus-host disease; limbal stem cell deficiency; keratoplasty; amniotic membrane transplantation; keratoconus; corneal collagen cross-linking; antimicrobial therapy; corneal neurotization; vernal keratoconjunctivitis; atopic keratoconjunctivitis
(This special issue belongs to the Section Ophthalmology)
Advances in the Diagnosis, Treatment of Intestinal Cancer: 2nd Edition
edited by and
submission deadline 28 Sep 2025 | Viewed by 145 | Submission Open
Keywords: colorectal cancer; early detection; treatment; immune therapy; radiation therapy; chemotherapy; risk factors; improved prognosis
(This special issue belongs to the Section Oncology)
Orthodontics: Current Advances and Future Options submission deadline 30 Sep 2025 | 17 articles | Viewed by 21975 | Submission Open
Keywords: digital orthodontics; functional devices; cranial growth; orthodontic therapy; customized devices
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
New Advances in COVID-19 and Pregnancy
edited by
submission deadline 30 Sep 2025 | 13 articles | Viewed by 20620 | Submission Open
Keywords: COVID-19 and pregnancy; SARS-CoV-2 infection; maternal mortality and morbidity; pregnancy complication; management protocol; maternal comorbidities; severe disease; prevention; diagnosis; treatment; management
(This special issue belongs to the Section Obstetrics & Gynecology)
Atrial Fibrillation and Its Complications: Preventive Strategies and Relative Evidence
edited by Roberto Galea
submission deadline 30 Sep 2025 | 9 articles | Viewed by 18278 | Submission Open
Keywords: atrial fibrillation; catheter ablation; oral anticoagulation; left atrial appendage closure; stroke prevention
(This special issue belongs to the Section Cardiology)
New Insights into Pancreatic Surgery
edited by Mario Serradilla-Martín and José Manuel Ramia
submission deadline 30 Sep 2025 | 5 articles | Viewed by 10975 | Submission Open
Keywords: pancreas; pancreatectomy; surgery; outcomes; cancer; fistula; minimally invasive surgery; IPMT
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Musculoskeletal Disorders: Clinical Diagnosis, Treatment and Rehabilitation submission deadline 30 Sep 2025 | 4 articles | Viewed by 10766 | Submission Open
Keywords: musculoskeletal disorders; therapeutic exercise; functional evaluation; rehabilitation protocols; musculoskeletal ultrasound; biomechanical aná lisis; quality of life; functional assessment of the musculoskeletal system; strength training; physical therapy; morphofunctional assessment; conservative treatments; range of motion evaluation; randomized controlled trials
(This special issue belongs to the Section Clinical Rehabilitation)
Clinical Advances in Malaria
edited by Marc Thellier
submission deadline 30 Sep 2025 | 2 articles | Viewed by 10674 | Submission Open
Keywords: malaria; diagnosis; treatment; vaccination; resistance; epidemiology; public health
(This special issue belongs to the Section Infectious Diseases)
Diagnosis, Treatment, and Prevention of Glaucoma: Second Edition submission deadline 30 Sep 2025 | 7 articles | Viewed by 9584 | Submission Open
Keywords: glaucoma; OCT; visual field; blindness; glaucoma surgery; intraocular pressure; glaucoma prevention; glaucoma treatment
(This special issue belongs to the Section Ophthalmology)
Recent Advances in Facial Palsy Management
edited by
submission deadline 30 Sep 2025 | 3 articles | Viewed by 9539 | Submission Open
Keywords: facial palsy; transplantation; facial cybernetics; facial therapy; nerve supermicrosurgery
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Geriatric Diseases: Management and Epidemiology
edited by
submission deadline 30 Sep 2025 | 6 articles | Viewed by 8109 | Submission Open
Keywords: ageing and health; older care; chronic diseases; preventive health strategies; multidisciplinary approaches; health inequalities; innovation in care; global ageing challenges; epidemiology of ageing; quality of life in older adults
(This special issue belongs to the Section Geriatric Medicine)
Dental Implantology: Clinical Updates and Perspectives
edited by
submission deadline 30 Sep 2025 | 6 articles | Viewed by 7536 | Submission Open
Keywords: dental implantology; reconstructive surgery; biomaterials; tissue engineering; regenerative medicine; digital dentistry; perimplantitis; peri-implant soft tissues
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Chronic Kidney Disease: Clinical Challenges and Management submission deadline 30 Sep 2025 | 5 articles | Viewed by 7243 | Submission Open
Keywords: chronic kidney disease; clinical trial; end-stage renal disease; kidney dysfunction; management; challenge
(This special issue belongs to the Section Nephrology & Urology)
Clinical Diagnosis of Lung Cancer
edited by Andrea Bille and
submission deadline 30 Sep 2025 | 5 articles | Viewed by 7203 | Submission Open
Keywords: biomarkers; bronchoscopy; diagnosis; imaging; liquid biopsy; lung cancer; mediastinoscopy; minimally invasive surgery; pathology; screening; staging
(This special issue belongs to the Section Respiratory Medicine)
Advancements in Venous Disease Management: From Conservative to Interventional Treatments
edited by and Chiara Lomazzi
submission deadline 30 Sep 2025 | 2 articles | Viewed by 5875 | Submission Open
Keywords: chronic venous disease; varicose veins; venoactive drugs; saphenous vein; venous stent; iliac vein; compression therapy; venous insufficiency
(This special issue belongs to the Section Vascular Medicine)
Innovation in Hand Surgery
edited by Rocco De Vitis and Marco Passiatore
submission deadline 30 Sep 2025 | 6 articles | Viewed by 5759 | Submission Open
Keywords: hand surgery; hand reconstruction; hand deformities; reconstructive surgery; peripheral nerve surgery; hand tumors; thumb arthritis; wrist arthritis; arthroscopy; prosthesis
(This special issue belongs to the Section Orthopedics)
Current Advances in Aortic Valve Stenosis
edited by
submission deadline 30 Sep 2025 | 4 articles | Viewed by 5288 | Submission Open
Keywords: valvular heart diseases; aortic stenosis; prevention; diagnosis; management
(This special issue belongs to the Section Cardiology)
Clinical Management for Metabolic Syndrome and Obesity
edited by and Antonio De Arriba-Muñoz
submission deadline 30 Sep 2025 | 4 articles | Viewed by 5157 | Submission Open
Keywords: obesity; metabolic syndrome; estatosis hepatic; diabetes mellitus; children; GLP-1
(This special issue belongs to the Section Endocrinology & Metabolism)
Gastrointestinal Endoscopy: Clinical Advances in Diagnosis and Treatment, 2nd Edition
edited by Joao Santos-Antunes and
submission deadline 30 Sep 2025 | 2 articles | Viewed by 4935 | Submission Open
Keywords: diagnostic endoscopy; therapeutic endoscopy; gastrointestinal neoplasia; endoscopic mucosal resection; endoscopic submucosal dissection; early cancer; subepithelial lesions
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Toward Improved Evaluation, Treatment, and Management of Movement Disorders and Cognitive Impairments in People with Cerebral Palsy
edited by Elegast Monbaliu and
submission deadline 30 Sep 2025 | 5 articles | Viewed by 4659 | Submission Open
Keywords: cerebral palsy; movement disorders; cognition; technology; artificial intelligence; wearables; neuroimaging; telehealth
(This special issue belongs to the Section Clinical Neurology)
Clinical Advances in Ischemic Heart Disease
edited by Stefano Schena and
submission deadline 30 Sep 2025 | 2 articles | Viewed by 4533 | Submission Open
Keywords: multidisciplinary approach; modern imaging; myocardial pre-habilitation; revascularization in severe ischemic cardiomyopathy; guidelines; complex PCI; hybrid treatment; minimally invasive surgery
(This special issue belongs to the Section Cardiology)
The Challenges and Prospects in Cochlear Implantation submission deadline 30 Sep 2025 | 4 articles | Viewed by 4443 | Submission Open
Keywords: cochlear implant; hearing loss; image; modeling; cognition; electrophysiology; AI; big data; interdisciplinary assessment
(This special issue belongs to the Section Otolaryngology)
Clinical Advances in Breast Reconstruction: Treatment and Management
edited by Eric I-Yun Chang
submission deadline 30 Sep 2025 | 4 articles | Viewed by 4415 | Submission Open
Keywords: breast reconstruction; aesthetic breast surgery; robotic surgery; microsurgery; alloplastic breast reconstruction; autologous breast reconstruction
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Causes and Advanced Treatments of Macular Edema submission deadline 30 Sep 2025 | 3 articles | Viewed by 4401 | Submission Open
Keywords: macular edema; laser photocoagulation; subthreshold laser; anti-VEGF; optical coherence tomography; fluorescein angiography; angio-OCT
(This special issue belongs to the Section Ophthalmology)
Artificial Intelligence and Eye Disease submission deadline 30 Sep 2025 | 4 articles | Viewed by 4366 | Submission Open
Keywords: Artificial Intelligence; machine learning; deep learning; ophthalmology; eye disease; eye disorder
(This special issue belongs to the Section Ophthalmology)
Renal Cell Carcinoma: From Diagnostic to Therapy
edited by Ithaar H. Derweesh and Zachary A. Hamilton
submission deadline 30 Sep 2025 | 3 articles | Viewed by 3881 | Submission Open
Keywords: biomarkers; clinical practice patterns; diagnosis; kidney cancer; metastasis; renal cell carcinoma; renal mass; staging; systemic therapy; surveillance
(This special issue belongs to the Section Nephrology & Urology)
Improving Diagnosis and Treatment of Vestibular Disorder: Latest Advances and Challenges
edited by , and Athanasia Korda
submission deadline 30 Sep 2025 | 2 articles | Viewed by 3474 | Submission Open
Keywords: vestibular system; balance disorders; dizziness; vertigo; vestibular testing; videonystagmography; video head impulse test; vestibular evoked myogenic potentials; vestibular rehabilitation therapy
(This special issue belongs to the Section Otolaryngology)
Innovations in Head and Neck Surgery
edited by and Giovanni Badiali
submission deadline 30 Sep 2025 | 1 articles | Viewed by 3179 | Submission Open
Keywords: reconstructive surgery; head and neck surgery; 3D printing; new technologies; virtual surgical planning; computer-assisted surgery; personalized reconstructive surgery; patient-specific implants; augmented reality; artificial intelligence; robotic surgery; surgical navigation
(This special issue belongs to the Section Otolaryngology)
Periodontal and Other Associated Oral Diseases: Diagnosis and Management in the Context of Systemic Pathology, 2nd Edition submission deadline 30 Sep 2025 | 4 articles | Viewed by 3156 | Submission Open
Keywords: periodontitis; oral diseases; periimplantitis; biomarkers; cytokines; oxidative stress markers; PCR test; point-of-care test; CBCT; periodontal treatment; immunomodulatory therapy; local drug delivery
(This special issue belongs to the Section Otolaryngology)
Mitral and Tricuspid Valve Disease and Imaging Techniques—2nd Edition
edited by and Annalisa Pasquini
submission deadline 30 Sep 2025 | 5 articles | Viewed by 3017 | Submission Open
Keywords: imaging in valvular heart disease; mitral valve disease; tricuspid valve disease; computed tomography; echocardiography; transesophageal echocardiography; cardiac magnetic resonance imaging; cardiac surgery; structural interventional cardiology; multi-modality imaging
(This special issue belongs to the Section Cardiovascular Medicine)
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