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Peripheral Nerves: Imaging, Electrophysiology and Surgical Techniques
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Peripheral Nerves: Imaging, Electrophysiology and Surgical Techniques

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Neurology".

Deadline for manuscript submissions: 15 July 2025 | Viewed by 1697

Special Issue Editors

Dr. Raffaele Natella

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Guest Editor
Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy
Interests: MRI; MSK Imaging; bone tumors; soft tiffue tumors; DTI; radiomics; cardiac CT; cardiac MRI; prostate MRI; MSK ultrasound
Special Issues, Collections and Topics in MDPI journals
Dr. Aniello Iovino

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Guest Editor
Department of Medicine and Surgery, Neurology Unit, University Hospital “San Giovanni di Dio e Ruggi d’Aragona”, University of Salerno, Salerno, Italy
Interests: neuropathies; inflammatory neuropathies; nerve entrapment; motor-neuron disease; neurophysiology
Dr. Vito Stifano

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Guest Editor
Department of Neurosurgery, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy
Interests: peripheral nerve tumor; nerve entrapment; nerve reconstruction; brain tumor; pituitary; cerebrovascular disease; spine disorders

Special Issue Information

Dear Colleagues,

According to the World Health Organisation, 22% of primary care patients worldwide suffer from such intense pain that it impairs their capacity to carry out regular activities. Experiencing long-lasting pain can have harmful consequences for both physical and emotional health. Collaborative efforts involving musculoskeletal radiologists, neurologists, neurosurgeons, orthopedists, and physiatrists are crucial for accurately diagnosing and treating neurological pain resulting from nerve compression, trauma, and tumors. Peripheral nerve entrapments in the limbs can occur due to multiple factors and manifest at different levels of severity. Peripheral nerve injuries originating from accidents can lead to substantial impairment and greatly affect individuals’ lives. Early evaluation, precise and immediate intervention, and attentive oversight are all critical. Peripheral nerve tumors, which are primarily benign, are uncommon in adults without pre-existing health issues. Neurofibromas and schwannomas are separate types of tumors that can occur alone or together with neurofibromatosis (NF).

Dr. Raffaele Natella
Dr. Aniello Iovino
Dr. Vito Stifano
Guest Editors

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • MRI
  • MSK imaging
  • soft-tissue tumors
  • DTI
  • neuropathies
  • inflammatory neuropathies
  • nerve entrapment
  • motor neuron disease
  • neurophysiology
  • MSK ultrasound
  • peripheral nerve tumor
  • nerve entrapment
  • nerve reconstruction

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Published Papers (2 papers)

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Research

10 pages, 244 KiB  
Article
Validation of the Romanian Version of the 6-Item Carpal Tunnel Syndrome Symptoms Scale and Palmar Pain Scale Questionnaire
by Daniel-Corneliu Leucuța, Nicu Catalin Draghici, Maria Geanina Balea, Roxana Toader, Hanna Maria Dragos, Livia Livinț Popa and Dafin Fior Mureșanu
J. Clin. Med. 2025, 14(9), 3059; https://doi.org/10.3390/jcm14093059 - 29 Apr 2025
Viewed by 54
Abstract
Background/Objectives: Carpal tunnel syndrome (CTS) is a common neuropathy that significantly impacts patients’ quality of life and incurs substantial healthcare costs. The 6-item Carpal Tunnel Syndrome Symptom Scale and the Palmar Pain Scale (PPS) are concise, reliable tools widely used to assess CTS [...] Read more.
Background/Objectives: Carpal tunnel syndrome (CTS) is a common neuropathy that significantly impacts patients’ quality of life and incurs substantial healthcare costs. The 6-item Carpal Tunnel Syndrome Symptom Scale and the Palmar Pain Scale (PPS) are concise, reliable tools widely used to assess CTS symptom severity. Our study aimed to translate, culturally adapt, and validate the Romanian version of the 6-item CTS Symptoms Scale in a sample of Romanian-speaking patients. Methods: This cross-sectional study involved 118 wrists from 59 Romanian-speaking patients. Each participant completed the CTS-6 scale and nerve conduction studies were carried out on their wrists. The CTS-6 scale was translated into Romanian using a forward–backward translation process. The psychometric properties of the Romanian CTS-6 were assessed, including internal consistency and construct validity (criterion validity, convergent, and divergent validity). Results: The Romanian CTS-6 and PPS demonstrated high internal consistency (Cronbach’s alpha = 0.93, respectively, 0.92, and strong item-total correlations). Factor analysis confirmed their unidimensional structure, with factor loadings ranging from 0.80 to 0.90. The CTS-6 scores showed moderate correlations with electrophysiological parameters, supporting criterion validity. Divergent validity was shown too. Conclusions: The Romanian version of the 6-item CTS Symptoms Scale and PPS is a valid tool for assessing CTS symptom severity in Romanian-speaking populations. Full article
(This article belongs to the Special Issue Peripheral Nerves: Imaging, Electrophysiology and Surgical Techniques)
10 pages, 448 KiB  
Article
Phrenic Nerve Sonography Alterations in Patients with ALS: Insight with Clinical and Neurophysiological Findings
by Ovidijus Laucius, Justinas Drūteika, Renata Balnytė, Jolita Palačionytė, Miglė Ališauskienė, Kęstutis Petrikonis and Antanas Vaitkus
J. Clin. Med. 2024, 13(21), 6302; https://doi.org/10.3390/jcm13216302 - 22 Oct 2024
Viewed by 1063
Abstract
Background: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder, and although the diagnosis is primarily based on clinical criteria, ENMG, as the “gold standard”, does not always show detectable changes. Therefore, our study suggests that alterations in echogenicity and heterogeneity of the [...] Read more.
Background: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder, and although the diagnosis is primarily based on clinical criteria, ENMG, as the “gold standard”, does not always show detectable changes. Therefore, our study suggests that alterations in echogenicity and heterogeneity of the phrenic nerve (PN) may serve as potential additional diagnostic tools for ALS. Methods: Our study included 32 patients in the ALS group and 64 individuals in the control group. Each participant underwent an interview and completed questionnaires to collect clinical and demographic data, including age, gender, height, body mass index (BMI), hip and waist circumference, duration of illness, ALS-FRS-R score, comorbidities, and medication use. Ultrasound examinations of the PN were performed by two authors using a high-resolution “Philips EPIQ 7” ultrasound machine equipped with a linear 4–18 MHz transducer. The ALS group participants underwent PN sonography and conduction examinations, arterial blood gas (ABG) analysis, respiratory function tests (RFT), and electroneuromyography (ENMG). Results: The study demonstrated that the phrenic nerve is significantly smaller on both sides in patients with ALS compared to the control group (p < 0.01). Changes in the homogeneity and echogenicity of the PN were also observed on both sides. On the right side, 43.8% of the nerves showed heterogeneity, 40.6% were isoechoic, and 21.9% were hyperechoic. On the left side, 59.4% of the nerves exhibited heterogeneity, 34.4% were isoechoic, and 28.1% were hyperechoic. Moreover, sonography on both sides showed significant correlation with ALS-FRS-R, COMPASS-31, and ENMG results. Conclusions: Our study highlights the importance of phrenic nerve ultrasound as a promising supplementary diagnostic tool for ALS. The significant differences in phrenic nerve size, echogenicity, and homogeneity between patients with ALS and the control group demonstrate that ultrasound imaging can detect morphological changes in the phrenic nerve. Incorporating phrenic nerve ultrasound into routine diagnostic protocols could improve early detection, enhance disease monitoring, and offer a more comprehensive understanding of the neurodegenerative processes in ALS. Full article
(This article belongs to the Special Issue Peripheral Nerves: Imaging, Electrophysiology and Surgical Techniques)
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