Allergen-Specific Immunotherapy (AIT) for Allergic Diseases of the Respiratory Tract and Food Allergies

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Immunology".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 555

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Guest Editor
Institute of Medical Statistics and Computational Biology (IMSB), Faculty of Medicine, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany
Interests: allergic disease; infectious diseases; upper respiratory tract
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Special Issue Information

Dear Colleagues,

Allergen-specific immunotherapy (AIT) is the only disease-modifying treatment for respiratory allergies such as allergic rhinoconjunctivitis and allergic asthma. In view of the still increasing prevalence of these diseases in many regions of the world, it is therefore of fundamental health and economic importance.

Over the last decade, clinical research in the field of allergen-specific immunotherapy has focused on intensive research efforts to create evidence for sublingual tablets and liquids that contain high-dose native allergens for allergic rhinoconjunctivitis but also, for the first time, for allergic asthma, which no longer represents a contraindication for AIT. At the same time, however, there is no end to the number of studies that could examine new therapeutic approaches for clinical implementation. Suitable topics of interest for this Special Issue include, but are not limited to, the following: recombinant allergens, peptides targeting B or T cells, as well as novel adjuvants coupled with chemically modified allergens, so-called allergoids. Numerous clinical trials are nearing completion or have already been analyzed and could be presented here. This Special Issue also aims to shed light on the use of innovative diagnostic methods in AIT phase two and three trials. Food allergy is now also a target of AIT and should be highlighted as well.

Prof. Dr. Ralph Mösges
Guest Editor

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Keywords

  • allergy
  • allergic rhinitis
  • allergic conjunctivitis
  • allergic asthma
  • food allergy
  • peptide immunotherapy
  • allergoids
  • SLIT
  • SCIT
  • OIT

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Published Papers (1 paper)

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Research

16 pages, 1691 KiB  
Article
TAPAS—A Prospective, Multicentre, Long-Term Cohort Study in Children, Adolescents and Adults with Seasonal Allergic Rhinitis—Design and Early Results
by Michael Gerstlauer, Julia Hiller, Jennifer Raab, Katrin Birkholz, Martin Tapparo, Christian Neuhof, Laura Day, Anna Rybachuk, Cengizhan Acikel, Hacer Sahin, Kim Hebbeler, Sven Becker, Christian Vogelberg, Silke Allekotte, Matthias F. Kramer and the TAPAS Study Group
J. Clin. Med. 2025, 14(8), 2609; https://doi.org/10.3390/jcm14082609 - 10 Apr 2025
Viewed by 363
Abstract
Background/Objectives: The guideline on allergen-specific immunotherapy of the European Academy of Allergy and Clinical Immunology recommends subcutaneous allergen-specific immunotherapy for the treatment of allergic rhinitis in children and adults with moderate to severe symptoms. The five years cohort study described below was [...] Read more.
Background/Objectives: The guideline on allergen-specific immunotherapy of the European Academy of Allergy and Clinical Immunology recommends subcutaneous allergen-specific immunotherapy for the treatment of allergic rhinitis in children and adults with moderate to severe symptoms. The five years cohort study described below was designed in 2020 to demonstrate non-inferiority in terms of safety, tolerability and efficacy in a paediatric population compared with adult patients treated with microcrystalline tyrosine-adsorbed allergoids for their tree and grass pollen allergy in a perennial setting. Here, we present the preliminary findings from the first year. Methods: The Combined Symptom and Medication Score was chosen as the primary endpoint of this therapy. Secondary endpoints include the Rhinoconjunctivitis Quality of Life Questionnaire, the retrospective Rhinoconjunctivitis score, the Asthma Control Test and the Rhinitis Control Test, as well as an analysis of adverse drug reactions. Results: A total number of 320 patients were enrolled into this study, with 129 of these patients in the age group between 5 and 17 years and 191 patients in the adult age group. Mean Combined Symptom and Medication Score values did not differ significantly between minors and adults in the first pollen season after treatment induction. The retrospective score showed a strong and significant reduction in rhinoconjunctivitis and asthma symptoms. Treatment was well tolerated, with more than 80% of patients reporting no adverse drug reactions. Conclusions: The validity of this study approach of a cohort study has been confirmed by this first interim analysis for the initial course of therapy in the first year. Full article
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