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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Clinical Management and Radiological Assessment in Traumatic Brain Injury

edited by Daniel Pinggera

submission deadline 20 Oct 2025 | 2 articles | Viewed by 2970 | Submission Open

Keywords: traumatic brain injury; MRI; MR spectroscopy; neuroimaging; biomarker; neurocritical care; decompressive craniectomy; neuromonitoring; surgery; metabolomics; biomarker; rehabilitation

(This special issue belongs to the Section Clinical Neurology)

Transcatheter Aortic Valve Implantation: Recent Advances and Future Directions

edited by

Alon Shechter

and Pablo Codner

submission deadline 20 Oct 2025 | 4 articles | Viewed by 2768 | Submission Open

Keywords: transcatheter aortic valve implantation; transcatheter aortic valve replacement; aortic valve stenosis; aortic valve regurgitation; aoric valve disease; cardiac imaging; artifical intelligence; machine learning

(This special issue belongs to the Section Cardiovascular Medicine)

Current State of the Art in Breast Reconstruction

edited by Ara A. Salibian and David Daar

submission deadline 20 Oct 2025 | 3 articles | Viewed by 2417 | Submission Open

Keywords: breast reconstruction; microsurgery; breast cancer; breast implant; DIEP Flap

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Cardiovascular Risks in Autoimmune and Inflammatory Diseases

edited by

Elena Rezus

and

Ciprian Rezus

submission deadline 20 Oct 2025 | 3 articles | Viewed by 2275 | Submission Open

Keywords: autoimmune diseases; inflammation; cardiovascular risk; atherosclerosis; biological therapy; immunomodulatory therapy; lipid metabolism; cardiovascular risk factors; thrombosis; endothelial dysfunction

(This special issue belongs to the Section Immunology)

Craniofacial Surgery: State of the Art and the Perspectives

edited by Fabio Roccia and Federica Sobrero

submission deadline 20 Oct 2025 | 2 articles | Viewed by 2028 | Submission Open

Keywords: craniofacial deformities; osteotomy; plate osteosynthesis; piezosurgery; microsurgery; navigation; virtual surgical planning; 3D printing

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Clinical Advances in Diabetes, Obesity, and Hypertension

edited by

Piotr Matłosz

and

Justyna Wyszyńska

submission deadline 20 Oct 2025 | 2 articles | Viewed by 1955 | Submission Open

Keywords: obesity; hypertension; diabetes; lifestyle; physical activity; risk factors

(This special issue belongs to the Section Endocrinology & Metabolism)

Patient-Oriented Treatments for Heart Failure

edited by Elisa Fabbri

submission deadline 20 Oct 2025 | 3 articles | Viewed by 1759 | Submission Open

Keywords: heart failure; personalized care; patient-centered treatment; aging; comorbidity; multimorbidity; frailty

(This special issue belongs to the Section Cardiology)

Advances in the Management of Oral Lichen Planus: A Comprehensive Clinical Perspective

edited by Zuzanna Ślebioda and

Elzbieta Paszynska

submission deadline 20 Oct 2025 | 2 articles | Viewed by 980 | Submission Open

Keywords: oral lichen planus; treatment; topical treatment; systemic treatment; oral mucosa; oral pathology; immunosuppressive therapy

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Current Clinical Treatments and Challenges for Heart Failure and Cardiogenic Shock

edited by

Andrea Montisci

and

Federico Pappalardo

submission deadline 20 Oct 2025 | Viewed by 338 | Submission Open

Keywords: cardiogenic shock; heart failure; mechanical circulatory support; Impella; veno-arterial ECMO; unloading; heart failure; heart transplant; artificial heart; left ventricular assist devices

(This special issue belongs to the Section Cardiology)

Current Status of Endovascular Therapy for Acute Ischemic Stroke—2nd Edition

edited by

Iris Quasar Grunwald

submission deadline 20 Oct 2025 | Viewed by 336 | Submission Open

Keywords: endovascular therapy (EVT); cerebrovascular disease; thrombectomy; thrombolysis; ischemic stroke; interventional stroke therapy

(This special issue belongs to the Section Clinical Neurology)

Innovative Approaches to the Epidemiology, Diagnosis, and Treatment of Systemic Sclerosis: Bridging Gaps in Early Detection and Personalized Therapy

edited by

Antonio-Javier Chamorro

submission deadline 20 Oct 2025 | Viewed by 271 | Submission Open

Keywords: systemic sclerosis; scleroderma; epidemiology; biomarkers; personalized therapy; therapeutic strategies

(This special issue belongs to the Section Clinical Neurology)

Clinical Updates on Cardiac Electrophysiology

edited by Roberto Rordorf

submission deadline 20 Oct 2025 | Viewed by 209 | Submission Open

Keywords: percutaneous cardiac ablation; surgical cardiac ablation; atrial fibrillation; ventricula tachycardia; non invasive radiotherapy of cardiac arrhythmias; neuromodulation of cardiac arrhythmias

(This special issue belongs to the Section Cardiology)

Minimally Invasive Heart Surgery: 2nd Edition

edited by

Manuel Wilbring

submission deadline 20 Oct 2025 | Viewed by 158 | Submission Open

Keywords: minimally invasive; aortic valve; mitral valve; hybrid approaches; techniques; strategies

(This special issue belongs to the Section Cardiology)

Implant Dentistry: New Challenges and Complication Management

edited by Jordi Gargallo

submission deadline 20 Oct 2025 | Viewed by 126 | Submission Open

Keywords: navigation surgery; accuracy; computer-aided surgery; computer-assisted; three-dimensional imaging; fixed implant prostheses; zirconia; CAD/CAM; patient satisfaction; peri-implantitis; quality of life; retreatment; tooth loss; connective tissue; keratinized tissue; soft tissue management; bone regeneration; bone grafting; immediate implant placement; immediate implant loading

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Clinical Prevention and Treatment of Graft-Versus-Host Disease (GVHD)

edited by

Roberto Crocchiolo

submission deadline 20 Oct 2025 | Viewed by 122 | Submission Open

Keywords: graft-versus-host disease (GVHD); hematopoietic stem cell transplantation; immunosuppressive therapy; JAK inhibitors; GVHD biomarkers; transplantation complications

(This special issue belongs to the Section Hematology)

Clinical Updates and Perspectives on Corneal Surgery

edited by Nicola Cardascia, Maria Gabriella la Tegola,

Francesco D'Oria

, Giovanni Alessio and Giacomo Boscia

submission deadline 23 Oct 2025 | Viewed by 144 | Submission Open

Keywords: cornea; corneal surgey; keratoplasty; amniotic membrane; rejection; failure

(This special issue belongs to the Section Ophthalmology)

Clinical Updates and Perspectives on Transcranial Magnetic Stimulation (TMS)—2nd Edition

edited by

Mariagiovanna Cantone

submission deadline 23 Oct 2025 | Viewed by 107 | Submission Open

Keywords: non-invasive brain stimulation; transcranial magnetic stimulation; motor cortex; neuroplasticity; motor learning; dementia; stroke; movement disorders; depression; spinal cord; neuropsychiatric disorders

(This special issue belongs to the Section Clinical Neurology)

News in the Pathogenesis, Diagnosis and Treatment of Systemic Sclerosis

edited by Mayka Freire and Bernardo Sopeña

submission deadline 24 Oct 2025 | 2 articles | Viewed by 2171 | Submission Open

Keywords: systemic sclerosis; scleroderma; capillaroscopy; autoantibodies; pathogenesis

(This special issue belongs to the Section Immunology)

Challenges and Advances in Geriatrics and Gerontology

edited by Elisa Fabbri

submission deadline 24 Oct 2025 | 1 articles | Viewed by 695 | Submission Open

Keywords: aging; geriatric medicine; frailty; multimorbidity; sarcopenia; cognition; personalized-care; healthy longevity; decision making-management; prevention; artificial intelligence

(This special issue belongs to the Section Geriatric Medicine)

Clinical Advances in Skin Cancer: A Closer Look at Non-Melanoma Types

edited by Andrea Paradisi

submission deadline 24 Oct 2025 | Viewed by 149 | Submission Open

Keywords: basal cell carcinoma; squamous cell carcinoma; actinic keratosis; diagnosis; treatment; non-melanoma skin cancer (NMSC)

(This special issue belongs to the Section Dermatology)

Ischemic and Hemorrhagic Complications of Uncommon Cerebrovascular Diseases: Cutting-Edge Clinical Research, Reviews, and Expert Opinions

edited by Mariel G. Kozberg and Alexis T. Roy

submission deadline 24 Oct 2025 | Viewed by 137 | Submission Open

Keywords: cerebrovascular disease; ischemic stroke; hemorrhagic stroke; genetics; vasculopathy; headache; superficial siderosis; vascular malformations

(This special issue belongs to the Section Clinical Neurology)

Hypertension and Cardiovascular Disease: Clinical Updates and Perspectives

edited by

Valeria Visco

Michele Ciccarelli

and

Costantino Mancusi

submission deadline 25 Oct 2025 | 10 articles | Viewed by 13359 | Submission Open

Keywords: hypertension management; cardiovascular risk assessment; novel antihypertensive therapies; hypertension in pregnancy; hypertensive emergencies; cardiovascular disease prevention; pharmacological interventions for cardiovascular disease

(This special issue belongs to the Section Cardiovascular Medicine)

Hereditary Hemorrhagic Telangiectasia: Recent Advances and Future Challenges—2nd Edition

edited by

Carmelo Bernabeu

Marco Post

and

Hans-Jurgen Mager

submission deadline 25 Oct 2025 | 8 articles | Viewed by 9040 | Submission Open

Keywords: hereditary hemorrhagic telangiectasia (HHT); ALK1; ACVRL1; endoglin (ENG); arteriovenous malformations; embolization; VEGF

(This special issue belongs to the Section Vascular Medicine)

Colon and Rectal Surgery: Current Clinical Practice and Future Trends

edited by Konstantinos Romanidis

submission deadline 25 Oct 2025 | 6 articles | Viewed by 8627 | Submission Open

Keywords: colorectal surgery; colorectal cancer; complications; metastasis; artificial intelligence; cancer metabolism

(This special issue belongs to the Section General Surgery)

Digital Health Technologies in Parkinson’s Disease and Related Disorders

edited by Ruth B. Schneider and Christine Doss Esper

submission deadline 25 Oct 2025 | 8 articles | Viewed by 7677 | Submission Open

Keywords: digital health technologies; telehealth; wearables; smartphones; Parkinson’ s disease; atypical parkinsonism

(This special issue belongs to the Section Clinical Neurology)

Clinical Perspectives on Surgical Management of Knee Injuries

edited by Min Jung

submission deadline 25 Oct 2025 | 4 articles | Viewed by 5896 | Submission Open

Keywords: osteoarthritis; meniscal repair; ligament reconstruction; cartilage restoration; knee surgery

(This special issue belongs to the Section Orthopedics)

Current Status, Challenges and Future Directions in Aortic Valve Replacement

edited by Guglielmo Saitto and Giovanni Alfonso Chiariello

submission deadline 25 Oct 2025 | 5 articles | Viewed by 5439 | Submission Open

Keywords: aortic valve; aortic valve replacement; minimally invasive surgery; robotic surgery; TAVI; ross operation; root enlargement techniques; heart team; lifetime management

(This special issue belongs to the Section Cardiology)

Migraine Headache: Symptoms, Diagnosis, and Current Treatment

edited by Ināra Logina

submission deadline 25 Oct 2025 | 3 articles | Viewed by 4428 | Submission Open

Keywords: migraine; headache disorders; burden of headache disorders; acute and preventive treatment of migraine; neuropathic pain

(This special issue belongs to the Section Clinical Neurology)

Management in Autism Spectrum Disorder: From Biomarkers to Precision Medicine

edited by

Michele Roccella

and

Alessandra Carta

submission deadline 25 Oct 2025 | 2 articles | Viewed by 3811 | Submission Open

Keywords: autism; autism spectrum disorder; neurodevelopmental disorders; epigenetics of autism; genetic inheritance; immunogenetics

(This special issue belongs to the Section Mental Health)

Paediatric Anaesthesia: Clinical Updates and Perspectives

edited by Peter Marhofer, Philipp Opfermann and Markus Zadrazil

submission deadline 25 Oct 2025 | 4 articles | Viewed by 3555 | Submission Open

Keywords: pediatric anesthesia; anesthesia; conduction; ultrasonography; conscious sedation; deep sedation; drug-related side effects and adverse reactions; neurotoxicity syndromes

(This special issue belongs to the Section Anesthesiology)

Assessment and Treatment of Trauma Patients

edited by

Arne Driessen

submission deadline 25 Oct 2025 | 2 articles | Viewed by 3545 | Submission Open

Keywords: trauma surgery; prehospital detection of trauma; assessment of trauma; trauma scale; trauma evaluation; trauma surgery

(This special issue belongs to the Section Emergency Medicine)

Current Treatment and Future Options of Ischemic Stroke

edited by Raluca Elena Sandu and Carmen Valeria Albu

submission deadline 25 Oct 2025 | 1 articles | Viewed by 3317 | Submission Open

Keywords: ischemic stroke; stroke; neuroinflammation; cerebral ischemia; thrombolysis; neuroprotection; rehabilitation strate-gies; stroke biomarkers; extracellular vesicles; stem cell therapy; post-stroke recovery; cerebral ischemia; advanced imaging in stroke; personalized stroke treatment

(This special issue belongs to the Section Clinical Neurology)

Clinical Management of Temporomandibular Joint Diseases

edited by

Nansi López-Valverde

and

Bruno Macedo Sousa

submission deadline 25 Oct 2025 | 3 articles | Viewed by 2766 | Submission Open

Keywords: temporomandibular joint disorders; dental occlusion; chronic pain; occlusal splints; risk factors

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Optimizing Outcomes in Scoliosis and Complex Spinal Surgery

edited by Francis C. Lovecchio

submission deadline 25 Oct 2025 | 4 articles | Viewed by 2721 | Submission Open

Keywords: outcomes; complications; scoliosis; adult spinal deformity; proximal junctional kyphosis; complex spine; pseudarthrosis

(This special issue belongs to the Section Orthopedics)

Autoimmune Skin Diseases: Innovations, Challenges, and Opportunities

edited by Shany Sherman

submission deadline 25 Oct 2025 | 3 articles | Viewed by 2162 | Submission Open

Keywords: healthcare utilization; inflammatory skin diseases; photodermatoses; collagen vascular disease; immunobullous disorders; graft-versus-host disease

(This special issue belongs to the Section Dermatology)

Advances in Clinical Anesthesia and Analgesia: Novel Approaches for Optimal Patient Safety and Comfort

edited by Cesare Gregoretti and Giuliano Lo Bianco

submission deadline 25 Oct 2025 | 3 articles | Viewed by 1891 | Submission Open

Keywords: pain management; pain medicine; anesthesia; analgesia; anesthesiology

(This special issue belongs to the Section Anesthesiology)

Targeted Medicine in Postoperative Pain Management

edited by

Martina Rekatsina

and Eleni Moka

submission deadline 25 Oct 2025 | 2 articles | Viewed by 1880 | Submission Open

Keywords: precision medicine; postoperative analgesia; pain control; drug delivery systems; surgical pain management; personalized interventions

(This special issue belongs to the Section Anesthesiology)

Advancements in Diagnostic Innovations in Sports Cardiology

edited by Giuseppe Di Gioia, Maria Rosaria Squeo and

Stefano Palermi

submission deadline 25 Oct 2025 | 1 articles | Viewed by 1686 | Submission Open

Keywords: athletes; cardiovascular prevention; risk factors; sport cardiology; sudden cardiac death

(This special issue belongs to the Section Cardiology)

Clinical Trends and Prospects in Laboratory Hematology

edited by

Olga Ciepiela

submission deadline 25 Oct 2025 | 2 articles | Viewed by 1309 | Submission Open

Keywords: laboratory hematology; hemostasis; flow cytometry; molecular diagnostics; blood cells; complete blood count

(This special issue belongs to the Section Clinical Laboratory Medicine)

Application of Echocardiography in the Diagnosis and Management of Cardiac Diseases

edited by

Calin Pop

and

Antoniu Petris

submission deadline 25 Oct 2025 | 1 articles | Viewed by 929 | Submission Open

Keywords: echocardiography; cardiac diseases; 3D echo; stress; myocardial strain; intracardiac; subclinical cardiac disease

(This special issue belongs to the Section Cardiology)

Cardiac Magnetic Resonance Imaging: Current Techniques and Future Directions

edited by Ioannis Botis and

Theodoros D. Karamitsos

submission deadline 25 Oct 2025 | 1 articles | Viewed by 903 | Submission Open

Keywords: cardiac magnetic resonance imaging; cardiovascular magnetic resonance; cardiac imaging; multimodality imaging; parametric mapping; late gadolinium enhancement; myocardial perfusion; myocardial viability; cardiomyopathies; heart failure

(This special issue belongs to the Section Cardiology)

Hand Surgery: Latest Advances and Prospects

edited by

Camillo Fulchignoni

and Lorenzo Rocchi

submission deadline 25 Oct 2025 | 2 articles | Viewed by 898 | Submission Open

Keywords: hand surgery; musculoskeletal and nerve disorders; innovative surgical procedures; minimally invasive techniques; rehabilitation strategies; robotic surgery

(This special issue belongs to the Section Orthopedics)

Oral Cancer: Clinical Updates and Perspectives

edited by

Jutta Ries

Mayte Buchbender

and

Ulrike Simone Speth

submission deadline 25 Oct 2025 | 1 articles | Viewed by 861 | Submission Open

Keywords: oral cancer; oral surgery; dental implant; tooth extraction; oral health; early detection; biomarkers; targeted therapy; immunotherapy

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Oral and Maxillofacial Surgery: Current Advances and Future Directions

edited by Niedzielska Iwona

submission deadline 25 Oct 2025 | 1 articles | Viewed by 817 | Submission Open

Keywords: oral and maxillofacial surgery; reconstructive surgery; periodontitis; dental implants; maxillofacial deformities

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Clinical Management of Frailty

edited by

Alejandro Alvarez-Bustos

, Walter Sepulveda-Loyola and

Isabel Rodríguez-Sánchez

submission deadline 25 Oct 2025 | 1 articles | Viewed by 685 | Submission Open

Keywords: frailty; comprehensive geriatric assessment; assessment; monitoring; functional decline; physical performance; ex-ercise interventions; nutritional strategies; interventions; adverse outcomes

(This special issue belongs to the Section Geriatric Medicine)

Endoscopic Diagnosis and Treatments of Gastrointestinal Diseases

edited by Madalina Ilie and Mihai Ciocîrlan

submission deadline 25 Oct 2025 | 1 articles | Viewed by 677 | Submission Open

Keywords: esogastric lesions; pancreatic diseases; colorectal lesions; hepatobiliary diseases; optical endoscopy; endoscopic ultrasound; upper and lower endoscopy; endoscopic retrograde cholangiopancreatography

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Interventional Cardiology: Recent Advances and Future Perspectives

edited by Cristina Aurigemma and Luigi Cappannoli

submission deadline 25 Oct 2025 | 1 articles | Viewed by 608 | Submission Open

Keywords: interventional cardiology; percutaneous coronary intervention (PCI); transcatheter aortic valve implantation (TAVI); structural heart disease; coronary artery disease; imaging and artificial intelligence; antithrombotic therapy; future technologies in cardiology; personalized cardiovascular care; minimally invasive interventions

(This special issue belongs to the Section Cardiology)

Recent Advances in Imaging and Interventional Techniques for Renal and Adrenal Diseases

edited by Francesco Ziglioli and Umberto Vittorio Maestroni

submission deadline 25 Oct 2025 | 1 articles | Viewed by 575 | Submission Open

Keywords: renal cancer; adrenal mass; robotic surgery; minimally invasive techniques; radiomics; tailored treatment

(This special issue belongs to the Section Nephrology & Urology)

Pathophysiology of Hypertension and Related Diseases: 2nd Edition

edited by

Tomislav Bulum

and

Ingrid Prkačin

submission deadline 25 Oct 2025 | 1 articles | Viewed by 437 | Submission Open

Keywords: arterial hypertension; resistant hypertension; secondary hypertension; prevention and screening of hypertension; hypertensive crisis; treatment of hypertension; obstructive sleep apnea syndrome; pathophysiology of hypertension; hypertension and the environment; (pre)hypertension and genetics

(This special issue belongs to the Section Vascular Medicine)

Clinical Advances in Gastrointestinal Endoscopy

edited by

Ivan Žaja

and Željko Puljiz

submission deadline 25 Oct 2025 | 1 articles | Viewed by 433 | Submission Open

Keywords: endoscopy; polyps; EMR; ESD; POEM; balloon dilatation; coagulation; imaging; AI imaging

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Displaying special issue 401-450 on page 9 of 30.

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