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Recent Clinical Research on Nonalcoholic Fatty Liver Disease: 2nd Edition
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Recent Clinical Research on Nonalcoholic Fatty Liver Disease: 2nd Edition

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 896

Special Issue Editor

Dr. Gerond V. Lake-Bakaar

E-Mail Website
Guest Editor
Transplant Center, Presbyterian Saint Luke's Medical Center, Denver, CO 80218, USA
Interests: hepatitis; liver cirrhosis; alcoholic liver disease; liver failure; nonalcoholic steatohepatitis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is my pleasure to invite you to contribute to the Special Issue entitled “Recent Clinical Research on Nonalcoholic Fatty Liver Disease: 2nd Edition”. We published seven papers in the first volume and this is a new volume of this Special Issue. For more details, please visit: https://www.mdpi.com/journal/jcm/special_issues/39EPKBNY7D.

The last decade saw enormous progress in our ability to treat and control chronic hepatitis C virus liver disease. In more recent years, nonalcoholic fatty liver disease (NAFLD) has emerged as a significant cause of liver disease, affecting millions worldwide. This chronic condition is characterized by the build-up of fat in the liver, which can lead to inflammation, fibrosis, and even cirrhosis. While the traditional risk factors for liver disease, such as hepatitis C, have declined due to effective treatment and prevention measures, NAFLD has become more prevalent due to changes in lifestyle and diet.

In this Special Issue, we welcome authors to submit papers on the global changes in disease prevalence. Clinical advances in the diagnoses; factors associated with disease progression; and the results of ongoing trials and advances in disease treatment are encouraged.

Dr. Gerond V. Lake-Bakaar
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • NAFLD
  • NASH
  • cirrhosis
  • hepatocellular carcinoma
  • hepatitis

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Published Papers (1 paper)

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Research

12 pages, 2705 KiB  
Article
Persistently Active Helicobacter pylori Infection Is Associated with the Development of Metabolic Dysfunction-Associated Steatotic Liver Disease
by Jun Young Kim, Byung Soo Kwan, Jung Hwan Cho, Hye In Kim, Nak Gyeong Ko, Mihyeon Jin and Ok Jae Lee
J. Clin. Med. 2025, 14(4), 1073; https://doi.org/10.3390/jcm14041073 - 7 Feb 2025
Viewed by 702
Abstract
Background/Objectives: Previous studies suggested a link between Helicobacter pylori (H. pylori) infection and steatotic liver disease, now termed metabolic dysfunction-associated steatotic liver disease (MASLD). This study aimed to identify the association of active H. pylori infection and the new concept of MASLD [...] Read more.
Background/Objectives: Previous studies suggested a link between Helicobacter pylori (H. pylori) infection and steatotic liver disease, now termed metabolic dysfunction-associated steatotic liver disease (MASLD). This study aimed to identify the association of active H. pylori infection and the new concept of MASLD in a longitudinal cohort. Methods: We reviewed 1497 health examinees who had two endoscopic biopsies for H. pylori activity without hepatic steatosis at the baseline abdominal ultrasonography. Subjects were classified into four groups based on H. pylori activity. Multivariable Cox models assessed the link between active H. pylori infection status and incident MASLD. Results: Over a median follow-up of 31.1 months, 247 subjects (16.5%) developed MASLD. The groups were: H. pylori naïve (n = 57, 15.6%), de novo (n = 31, 15.3%), eradicated (n = 32, 16.1%), and persistent (n = 127, 17.4%). The H. pylori persistent group had a higher risk of MASLD compared to naïve group (hazard ratio: 1.41; 95% confidence interval: 1.01–1.96; p-value = 0.045). The association between H. pylori infection and incident MASLD was significant only with ongoing infection. Conclusions: Persistent H. pylori infection increases the risk of MASLD, indicating that active infection may contribute to MASLD development. Eradicating active H. pylori infection might help lower the incidence of MASLD. Full article
(This article belongs to the Special Issue Recent Clinical Research on Nonalcoholic Fatty Liver Disease: 2nd Edition)
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