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  • Review
  • Open Access

Epilepsy affects approximately 50 million people worldwide, with nearly one-third of patients experiencing inadequate seizure control with conventional anti-epileptic drugs. The GABAergic system, responsible for inhibitory neurotransmission in the ce...

  • Article
  • Open Access

Evaluation of the Role of AID-Induced Mutagenesis in Resistance to B-Cell Receptor Pathway Inhibitors in Chronic Lymphocytic Leukemia

  • Chiara Pighi,
  • Alessandro Gasparetto,
  • Elisa Genuardi,
  • Jianli Tao,
  • Qi Wang,
  • Candida Vitale,
  • Valentina Griggio,
  • Rocco Piazza,
  • Sabino Ciavarella and
  • Marta Coscia
  • + 4 authors

Chronic lymphocytic leukemia (CLL) is the most common leukemia in Western countries, and B-cell receptor (BCR) pathway inhibitors such as idelalisib and ibrutinib are currently established therapies for CLL. Although effective, these drugs frequently...

  • Review
  • Open Access

Microbial Biofertilizers for Salinity Stress Mitigation in Hydroponic Systems

  • Prabhaharan Renganathan,
  • Lira A. Gaysina and
  • Edgar Omar Rueda-Puente

Salinity accumulation is a critical abiotic constraint in hydroponic agriculture, particularly in recirculating systems, where limited leaching and nutrient cycling intensify ionic accumulation and increase the conductivity of nutrient solutions. Hyd...

  • Article
  • Open Access

Summer savory (Satureja hortensis L.) is an annual herbaceous plant belonging to the Lamiaceae family and widely used as a culinary spice. The present research aimed to investigate the physicochemical characteristics, phenolic profile, antioxidant po...

  • Article
  • Open Access

Dexmedetomidine is a commonly used sedative because it has minimal adverse effects on respiratory function. Nevertheless, its cardiovascular safety profile, particularly bradycardia risk and drug–drug interactions (DDIs), remains incompletely u...

  • Article
  • Open Access

NUMB in Endometrial Pathology: From Adenomyosis Expression Patterns to Endometrial Cancer Survival Implications

  • Walid Shaalan,
  • Nourhan Hassan,
  • Mohamed Gamal Ibrahim,
  • Benedikt Schäfgen,
  • Kathrin Haßdenteufel,
  • Julia Gallwas,
  • Ludwig Kiesel,
  • Andreas N. Schüring and
  • Martin Götte

Adenomyosis, a prevalent gynecologic condition involving invasion of endometrial tissue into the myometrium, remains poorly understood in terms of its molecular pathogenesis. Numb, an important regulator of cellular destiny and stem cell maintenance,...

  • Review
  • Open Access
24 Views
17 Pages

In recent years, the relationship between the gut microbiota and gastrointestinal tumors has become a growing focus in tumor biology research. Ferroptosis, an iron-dependent form of programmed cell death, serves as a crucial link mediating the intera...

  • Article
  • Open Access
48 Views
16 Pages

Colorectal cancer (CRC) is a prevalent and lethal malignancy worldwide. Despite extensive research, core genes for diagnosis and prognosis in CRC remain to be fully elucidated. This study aims to identify novel gene biomarkers for CRC diagnosis and p...

  • Review
  • Open Access
78 Views
26 Pages

Effects of Nanomaterials on Crops

  • Xiaofang Yang,
  • Huilian Xu,
  • Wenrui Li,
  • Xianchao Chang,
  • Xiaohan Jiang,
  • Xiaoyong Liu and
  • Mengmeng Kong

It is essential to review the outcome of nanomaterials on crop growth and development, as well as their underlying applications and risks in agriculture. The agricultural department need to seek a more efficient and sustainable production approach wi...

  • Article
  • Open Access
54 Views
22 Pages

C2H2-type zinc-finger transcription factors (ZFPs) play essential roles in plant stress signaling and development; however, their putative functions in safflower have not been systematically characterized. Leveraging the reference genome of the saffl...

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Curr. Issues Mol. Biol. - ISSN 1467-3045