Next Article in Journal
Genomes and Genome Projects of Protozoan Parasites
Previous Article in Journal
Genomes and Evolution
Current Issues in Molecular Biology is published by MDPI from Volume 43 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on as a courtesy and upon agreement with Caister Press.

Detection of Single Nucleotide Polymorphisms

Cardiovascular Research Institute, University of California, 505 Parnassus Avenue, Long 1332A, Box 0130, San Francisco, CA 94143-0130, USA
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, 800 E. Leigh Street, Suite 1-101, Richmond, VA 23298-0424, USA
Author to whom correspondence should be addressed.
Curr. Issues Mol. Biol. 2003, 5(2), 43-60;
Received: 14 December 2002 / Revised: 14 February 2003 / Accepted: 13 March 2003 / Published: 1 April 2003
Single nucleotide polymorphism (SNP) detection technologies are used to scan for new polymorphisms and to determine the allele(s) of a known polymorphism in target sequences. SNP detection technologies have evolved from labor intensive, time consuming, and expensive processes to some of the most highly automated, efficient, and relatively inexpensive methods. Driven by the Human Genome Project, these technologies are now maturing and robust strategies are found in both SNP discovery and genotyping areas. The nearly completed human genome sequence provides the reference against which all other sequencing data can be compared. Global SNP discovery is therefore only limited by the amount of funding available for the activity. Local, target, SNP discovery relies mostly on direct DNA sequencing or on denaturing high performance liquid chromatography (dHPLC). The number of SNP genotyping methods has exploded in recent years and many robust methods are currently available. The demand for SNP genotyping is great, however, and no one method is able to meet the needs of all studies using SNPs. Despite the considerable gains over the last decade, new approaches must be developed to lower the cost and increase the speed of SNP detection.
MDPI and ACS Style

Kwok, P.-Y.; Chen, X. Detection of Single Nucleotide Polymorphisms. Curr. Issues Mol. Biol. 2003, 5, 43-60.

AMA Style

Kwok P-Y, Chen X. Detection of Single Nucleotide Polymorphisms. Current Issues in Molecular Biology. 2003; 5(2):43-60.

Chicago/Turabian Style

Kwok, Pui-Yan, and Xiangning Chen. 2003. "Detection of Single Nucleotide Polymorphisms" Current Issues in Molecular Biology 5, no. 2: 43-60.

Find Other Styles

Article Access Map by Country/Region

Only visits after 24 November 2015 are recorded.
Back to TopTop