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Current Issues in Molecular Biology publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Latest Review Papers in Molecular Biology 2025

edited by

Madhav Bhatia

submission deadline 31 Dec 2025 | 26 articles | Viewed by 81153 | Submission Open

Keywords: molecular biology; molecular plant sciences; molecular cell biology; molecular medicine; molecular pathology

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Technological Advances Around Next-Generation Sequencing Application

edited by

Gaurav Tripathi

submission deadline 31 Dec 2025 | 9 articles | Viewed by 32893 | Submission Open

Keywords: next-generation sequencing; single-cell sequencing; long-read sequencing; metagenomics; epigenomics; cancer genomics; clinical applications; liquid biopsy; CRISPR-Cas9; precision medicine; personalized healthcare

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Natural Compounds: An Adjuvant Strategy in Cancer Management

edited by Monia Cecati and

Arianna Vignini

submission deadline 31 Dec 2025 | 9 articles | Viewed by 31377 | Submission Open

Keywords: cancer; phytochemicals; bioactive compounds; anti-tumor; cancer treatment

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Effects of Environmental Factors on Cardiovascular Disease: From Molecular Effects to Possible Future Clinic Application

edited by

Angelika Edyta Charkiewicz

submission deadline 31 Dec 2025 | 6 articles | Viewed by 26967 | Submission Open

Keywords: environmental factors; cardiovascular diseases; disease and chronic risk; health status; healthy eating; healthy lifestyle; physical activity; alcohol consumption reduction; tobacco cessation; public health; population health; psychosocial factors; dietary recommendations; nutrient intake; health outcomes

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Targeting Tumor Microenvironment for Cancer Therapy, 3rd Edition

edited by

Ming-Wei Lin

and

Cheng-Che Lee

submission deadline 31 Dec 2025 | 11 articles | Viewed by 26667 | Submission Open

Keywords: chemotherapy; cancer; tumor; tumor microenvironment; cancer stem cells; cancer therapy; cancer stemness; chemoresistance

(This special issue belongs to the Section Molecular Medicine)

The Contribution and Application of Molecular Biology in the Applied Biosciences—Focusing on Medicine, Biomaterials and Tissue Engineering Fields, 2nd Edition

edited by

Ioannis Tsamesidis

and

Evangelia Stalika

submission deadline 31 Dec 2025 | 8 articles | Viewed by 17929 | Submission Open

Keywords: medicine; biomaterials; tissue engineering; molecular biology; patients’ reported outcomes; personalized medicine

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Advances in Pharmacotherapeutic Strategies to Prevent Tumor Development, Progression and Treatment Resistance, 2nd Edition

edited by

Peter C. Hart

submission deadline 31 Dec 2025 | 9 articles | Viewed by 17524 | Submission Open

Keywords: cancer; therapeutic resistance; drug tolerance; mechanisms of tumor development; mechanisms of tumor progression

(This special issue belongs to the Section Molecular Pharmacology)

Recombinant Proteins for Molecular Biology Research: Technologies and Applications

edited by

Tsutomu Arakawa

and

Yasunari Matsuzaka

submission deadline 31 Dec 2025 | 8 articles | Viewed by 16417 | Submission Open

Keywords: recombinant proteins; vaccine; intra-cellular signaling factors; membrane proteins; drug targets

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Mechanism of HPV’s Involvement in Cancers

edited by Xuesong Wen

submission deadline 31 Dec 2025 | 5 articles | Viewed by 12857 | Submission Open

Keywords: HPV; HPV carcinogenesis; viral interaction; HPV genotyping; head and neck cancer; immune balance; cervical cancer

(This special issue belongs to the Section Molecular Medicine)

Functional Genomics and Comparative Genomics Analysis in Plants, 3rd Edition

edited by

Quan Zou

, Ran Su and Qiangguo Jin

submission deadline 31 Dec 2025 | 10 articles | Viewed by 10381 | Submission Open

Keywords: de novo genome sequencing; pan-genomic analyses; genome re-sequencing; GWAS analyses; RNA-seq; metabolomics; gene family analyses; plant evolutionary analyses; bioinformatics; database

(This special issue belongs to the Section Molecular Plant Sciences)

Phytochemicals in Cancer Chemoprevention and Treatment: 2nd Edition

edited by

Wojciech Trybus

Ewa Trybus

and

Aneta Wȩgierek-Ciuk

submission deadline 31 Dec 2025 | 3 articles | Viewed by 9895 | Submission Open

Keywords: phytochemicals; chemoprevention; cancer therapy; oxidative stress; apoptosis; autophagy; mitotic catastrophe; cell cycle; cytotoxicity; DNA damage; molecular pathways

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Innovations in Marine Biotechnology and Molecular Biology

edited by Huarong Guo

submission deadline 31 Dec 2025 | 6 articles | Viewed by 9631 | Submission Open

Keywords: marine animal; marine algae; marine microorganism; marine biotechnology; molecular biology

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Applications of Natural and Pseudo-Natural Products in Drug Discovery and Development 2025

edited by

Hidayat Hussain

submission deadline 31 Dec 2025 | 7 articles | Viewed by 8802 | Submission Open

Keywords: natural products; pseudo-natural products; drug discovery; molecular level; in vitro studies; in vivo studies; computational methods; mode of action; computational methods

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Feature Papers in Molecular Medicine 2025

edited by

Ru Chih C. Huang

and

Kotohiko Kimura

submission deadline 31 Dec 2025 | 8 articles | Viewed by 8321 | Submission Open

Keywords: pathogenesis; angiogenesis; autoimmune diseases; inflammatory; cancer; cardiovascular diseases; development and differentiation; endocrinology; genetics; epigenetics; hematology; hypoxia research; immunology; infectious diseases; metabolic disorders; neuroscience of diseases; regenerative medicine; prevention; therapeutics; stem cell research

(This special issue belongs to the Section Molecular Medicine)

Oral Cancer: Prophylaxis, Etiopathogenesis and Treatment, 2nd Edition

edited by

Violeta Popovici

and

Emma Adriana Ozon

submission deadline 31 Dec 2025 | 4 articles | Viewed by 8190 | Submission Open

Keywords: oral carcinogenesis; biomarkers; cell signaling; natural products; phytochemicals; medicinal plants; essential oils; antimicrobial activity; cytotoxicity; phytotherapy; drug discovery; drug delivery; pharmaceutical formulation

(This special issue belongs to the Section Molecular Medicine)

New Immunological Therapeutic Strategies in Kidney Disease

edited by

Yasunari Matsuzaka

submission deadline 31 Dec 2025 | 2 articles | Viewed by 7520 | Submission Open

Keywords: IgA nephritis; IL-23/IL-17 pathway; CAR T-cell therapy; mesenchymal stem cells; innate lymphoid cells

(This special issue belongs to the Section Molecular Medicine)

Multiple Myeloma: From Molecular Mechanism to Diagnosis and Therapy

edited by

Jari Intra

submission deadline 31 Dec 2025 | 4 articles | Viewed by 7144 | Submission Open

Keywords: multiple myeloma; blood cancer; immunopathogenesis; biomarker; immunoglobulin

(This special issue belongs to the Section Molecular Medicine)

Advances in Bioinformatics and Molecular Research on Alzheimer’s Disease

edited by Aristidis G. Vrahatis

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1769 | Submission Open

Keywords: Alzheimer’ s disease; single-cell sequencing; molecular biomarkers; single-cell RNA-seq; single-cell ATAC-seq; spatial transcriptomics

(This special issue belongs to the Section Molecular Medicine)

New Advances in Plant Responses to Environmental Stresses

edited by

Fuyuan Zhu

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1263 | Submission Open

Keywords: abiotic stress; functional proteomics; stress response; salt stress; heavy metal stress

(This special issue belongs to the Section Molecular Plant Sciences)

Innovative Strategies in Overcoming Antimicrobial Resistance: From Phage Therapy to Combination

edited by Rajnikant Sharma

submission deadline 31 Dec 2025 | Viewed by 130 | Submission Open

Keywords: bacteriophages; phage therapy; antimicrobial resistance; phage engineering; phage-antibiotic combination; phage pharmacokinetics

(This special issue belongs to the Section Molecular Microbiology)

Cancer Immunology: Molecular Tools, New Therapeutic Targets, Challenges, and Opportunities

edited by Pablo C. Ortiz-Lazareno

submission deadline 15 Jan 2026 | 1 articles | Viewed by 1438 | Submission Open

Keywords: cancer immunology; immune response; immune evasion; immune checkpoints; immune response

(This special issue belongs to the Section Molecular Medicine)

Innovative Therapeutics and Biomarkers in Hepatocellular Carcinoma Research

edited by

Alok Raghav

submission deadline 20 Jan 2026 | 3 articles | Viewed by 5321 | Submission Open

Keywords: hepatocellular carcinoma; biomarkers; therapeutics; imaging; artificial intelligence; diagnostics

(This special issue belongs to the Section Molecular Medicine)

Molecular Approaches in Early Detection and Targeted Therapies for Pancreatic Cancer

edited by

Hassan Mubarak Ishqi

submission deadline 25 Jan 2026 | Viewed by 136 | Submission Open

Keywords: pancreatic cancer; early detection; molecular biomarkers; targeted therapy; genomics; tumor microenvironment; precision medicine; transcriptomics; proteomics; cancer diagnostics

(This special issue belongs to the Section Molecular Medicine)

Radiation-Induced Cellular and Molecular Responses

edited by

Carlo Aprile

submission deadline 31 Jan 2026 | 3 articles | Viewed by 13659 | Submission Open

Keywords: radiation; radiobiology; space radiobiology; heavy ions carcinogenesis; LinearNonTreshold; radionuclide therapy; alpha emitters; beta emitters; radiobiology

(This special issue belongs to the Section Molecular Medicine)

Molecular Mechanisms in Plant Stress Tolerance

edited by

Sajid Ali

submission deadline 31 Jan 2026 | 10 articles | Viewed by 12776 | Submission Open

Keywords: plant stress tolerance; molecular mechanisms; stress-responsive gene; signal transduction pathways; epigenetic modifications; phytohormones (ethylene; ABA; SA; JA); reactive oxygen species (ROS); plant– microbe interactions; microbial plant bio-stimulants; omics approaches (genomics; transcriptomics; proteomics; and metabolomics)

(This special issue belongs to the Section Molecular Plant Sciences)

Advanced Molecular Research on Hypertensive Disorders of Pregnancy (HDPs)

edited by

Melissa Wilson

submission deadline 31 Jan 2026 | 8 articles | Viewed by 12541 | Submission Open

Keywords: DNA; RNA; protein; microbiome; hypertensive disorders of pregnancy; preeclampsia; epidemiology; meta-analysis

(This special issue belongs to the Section Molecular Medicine)

Molecular Mechanisms Underlying Fatty Liver Disease: From Pathogenesis to Treatment, 2nd Edition

edited by Haibo Dong and

Wei Guo

submission deadline 31 Jan 2026 | 6 articles | Viewed by 11317 | Submission Open

Keywords: non-alcoholic fatty liver disease (NAFLD); alcohol-associated liver disease (ALD); lipotoxicity; bile acid metabolism; novel biomarker identification; organelle dysfunction and communication; inflammation and oxidative stress; cell signaling and cell death pathways; lipid metabolism and dysregulation; epigenetic modifications (DNA/RNA/non-coding RNA); therapeutic targets and interventions

(This special issue belongs to the Section Molecular Medicine)

Tumor Microenvironment: Crosstalk Between Epigenetics, Metabolism and Immunity

edited by

Liang Chen

submission deadline 31 Jan 2026 | 4 articles | Viewed by 7581 | Submission Open

Keywords: tumor microenvironment; epigenetic modifications; metabolic reprogramming; immune escape; tumor metastasis; therapeutic resistance

(This special issue belongs to the Section Molecular Medicine)

Exploring Molecular Pathways in Skin Health and Diseases

edited by

Sullim Lee

submission deadline 31 Jan 2026 | 2 articles | Viewed by 6129 | Submission Open

Keywords: skin health; skin aging; skin disease; molecular pathways; oxidative stress; immune response; inflammatory skin diseases

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Insights: Mechanisms Underlying the Biological Activities of Natural Products—2nd Edition

edited by

Premalatha Balachandran

submission deadline 31 Jan 2026 | 6 articles | Viewed by 5797 | Submission Open

Keywords: natural products; molecular mechanisms; biological activities; pharmacodynamics; drug discovery; therapeutic potential; signaling pathways; target identification; pharmacological properties; bioactive compounds

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Molecular Insights into Food-Derived Natural Products and Their Biological Activities—2nd Edition

edited by

Yanfang Li

submission deadline 31 Jan 2026 | 4 articles | Viewed by 5566 | Submission Open

Keywords: food compounds; natural products; biologically active compounds; oxidative stress; anticancer; functionality of foods

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Insights into Pathogenesis and Targeted Therapy of Gynaecological Cancers

edited by

Stergios Boussios

submission deadline 31 Jan 2026 | 2 articles | Viewed by 3920 | Submission Open

Keywords: ovarian cancers; cervical cancers; endometrial cancers; targeted therapy; molecular markers; immunotherapy

(This special issue belongs to the Section Molecular Medicine)

Autophagy and the Ubiquitin–Proteasome System: Regulators of Protein Homeostasis, Cell Death, and Disease Pathogenesis

edited by

Lei Dong

submission deadline 31 Jan 2026 | 3 articles | Viewed by 3784 | Submission Open

Keywords: autophagy; ubiquitin– proteasome system; protein homeostasis; autophagosome; cell death regulation; cancer; Alzheimer's disease

(This special issue belongs to the Section Molecular Medicine)

Molecular Insights into Phytochemicals: Therapeutic Potential in Metabolic Disorders and Cancer

edited by

Mohamed Addi

submission deadline 31 Jan 2026 | 2 articles | Viewed by 3047 | Submission Open

Keywords: phytochemicals; molecular mechanisms; cancer therapeutics; metabolic disorders; natural compounds; signal transduction; epigenetic regulation; oxidative stress; anti-inflammatory agents; plant-based

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Advances in Phytochemical Research: Molecular Pathways in Health and Disease

edited by

Christiana Charalambous

and

Christiana Neophytou

submission deadline 31 Jan 2026 | 2 articles | Viewed by 2613 | Submission Open

Keywords: phytochemicals; molecular mechanisms; cancer signaling pathways; anti-inflammatory properties; anti-oxidant properties; apoptosis; cardiovascular disorders; metabolic syndromes; chemoprevention

(This special issue belongs to the Section Molecular Medicine)

Molecular and Pharmacological Insights into Bioactive Compounds: Pathways to Therapeutics

edited by

Mosharraf Sarker

and

Talat Nasim

submission deadline 31 Jan 2026 | 2 articles | Viewed by 2448 | Submission Open

Keywords: bioactive compounds; natural products; drug discovery; pharmacology; therapeutic pathways; molecular mechanisms; signal transduction; medicinal chemistry; target identification

(This special issue belongs to the Section Molecular Pharmacology)

Advances in Multi-Omics for Functional Genomics Studies and Molecular Breeding, 2nd Edition

edited by Chen Chen

submission deadline 31 Jan 2026 | 4 articles | Viewed by 2430 | Submission Open

Keywords: sequencing technologies; plant genomics; transcriptomics; proteomics; metabolomics; epigenomics; single-cell sequencing; functional genomics; transformation methods; gene identification

(This special issue belongs to the Section Molecular Plant Sciences)

Plant Hormones, Development, and Stress Tolerance

edited by

Zhaohui Chu

and

Wei Yang

submission deadline 31 Jan 2026 | 2 articles | Viewed by 1412 | Submission Open

Keywords: plant hormones; abiotic stress; auxins; jasmonic acid; signal pathway

(This special issue belongs to the Section Molecular Plant Sciences)

Unraveling the Role of Epigenetics and Molecular Genetics in Disease Progression via the Gut–Brain Axis

edited by Yong-Chan Kim

submission deadline 31 Jan 2026 | 1 articles | Viewed by 546 | Submission Open

Keywords: prion diseases; Parkinson’ s disease; Alzheimer’ s disease; neurodegenerative disease; inflammatory bowel diseases; ulcerative colitis; Crohn’ s disease; brain– gut axis; bioinformatics; polymorphism

(This special issue belongs to the Section Molecular Medicine)

Pharmacological Activities and Mechanisms of Action of Natural Products, 2nd Edition

edited by

Shining Loo

Antony Kam

and Lee Simon Ming-Yuen

submission deadline 31 Jan 2026 | 1 articles | Viewed by 392 | Submission Open

Keywords: natural products; pharmacological activity; molecular mechanisms; therapeutic targets; structure– activity relationships; protein– ligand interactions; cell signaling pathways; enzyme inhibition/activation; molecular targets

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Molecular and Real-World Evidence Research of Respiratory Diseases and Infections, 2nd Edition

edited by

Chingyuan Wu

submission deadline 31 Jan 2026 | Viewed by 374 | Submission Open

Keywords: respiratory diseases; pathogenesis; vaccines; therapies; COVID-19

(This special issue belongs to the Section Molecular Medicine)

Cutting-Edge Microscopy and Electron Microscopy Innovations in Molecular Biology Research

edited by

Diana Torge

submission deadline 31 Jan 2026 | Viewed by 315 | Submission Open

Keywords: morphology; microscopy; transmission electron microscopy; molecular biology; medicine; dentistry

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Innovative Approaches in Bone and Cartilage Regeneration: From Stem Cells to Organoids

edited by

Maria Giovanna Rizzo

submission deadline 31 Jan 2026 | 1 articles | Viewed by 208 | Submission Open

Keywords: bone and cartilage biology; physiology; molecular biology; nutraceuticals; regenerative medicine

(This special issue belongs to the Section Molecular Medicine)

Molecular Impacts of DNA Methylation as Epigenetic Drivers of Disease Onset and Progression

edited by Adam G. Marsh

submission deadline 31 Jan 2026 | Viewed by 192 | Submission Open

Keywords: epigenetics; DNA methylation; disease onset; disease progression; molecular mechanisms; molecular biomarkers; gene silencing; gene expression

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Allergic Diseases: Molecular Pathways and Pathogenesis

edited by

Jing Gao

submission deadline 31 Jan 2026 | Viewed by 153 | Submission Open

Keywords: allergic diseases; allergic responses; allergic inflammation; immune response; genetics and susceptibility

(This special issue belongs to the Section Molecular Medicine)

Molecular Dynamics Simulations in Structural Biology: From Proteins to Complex Biomolecular Systems

edited by

Ana E. Ledesma

submission deadline 31 Jan 2026 | Viewed by 120 | Submission Open

Keywords: protein; molecular docking; dynamic simulation; biomolecular systems; molecular interactions; structural modification; enzyme activity; biological function; antioxidant activity; infrared spectroscopy

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Molecular and Cellular Mechanisms of Vascular Function and Dysfunction: Roles of the Endothelium and G-Protein Coupled Receptors

edited by John J. McGuire

submission deadline 31 Jan 2026 | Viewed by 104 | Submission Open

Keywords: endothelium; endothelial cells; vascular smooth muscle; platelets; G-protein coupled receptor; signal transduction; metabolic dysfunction; diabetes; inflammation; angiogenesis

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Mechanisms of Animal Metabolism: Pathophysiological Implications in Tumor Progression

edited by

Cristian Gabriel Torres Mendoza

submission deadline 31 Jan 2026 | Viewed by 88 | Submission Open

Keywords: animal cancer metabolism; animal tumor diseases; Warburg effect; drug-resistance; therapeutic targets

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Mechanisms and Therapeutic Approaches in Fibrosis and Tissue Remodeling

edited by Pulin Che

submission deadline 31 Jan 2026 | Viewed by 59 | Submission Open

Keywords: fibrosis; tissue remodeling; biomarkers; molecular pathways; translational medicine; therapeutic strategies

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Mechanisms and Treatment of Kidney Diseases

edited by Junyi Zhu

submission deadline 10 Feb 2026 | Viewed by 104 | Submission Open

Keywords: nephrotic syndrome; kidney disease; kidney injury

(This special issue belongs to the Section Molecular Medicine)

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