Announcements

2 July 2025
Biomedicines | Hot Papers in the “Immunology and Immunotherapy” Section

The “Immunology and Immunotherapy” Section publishes reviews and original peer-reviewed papers of a high scientific level covering all aspects of immunology and oncoimmunology. Papers aim to uncover modulations in the immune system, active and passive immunotherapies, diagnostic tests based on specific markers, and new technologies to identify novel predictive factors to respond to immunotherapy. Topics include but are not limited to in vivo/in vitro immune response research; targeted therapies (including antibody research and vaccine research); virotherapy and oncolytic vaccines; use of nanoparticles and microvesicles for developing immunotherapeutics; etc.

1. “Urokinase-Type Plasminogen Activator Receptor (uPAR) in Inflammation and Disease: A Unique Inflammatory Pathway Activator”
by Mostafa Hamada, Kyle Steven Varkoly, Omer Riyadh, Roxana Beladi, Ganesh Munuswamy-Ramanujam, Alan Rawls, Jeanne Wilson-Rawls, Hao Chen, Grant McFadden and Alexandra R. Lucas
Biomedicines 2024, 12(6), 1167; https://doi.org/10.3390/biomedicines12061167
Available online: https://www.mdpi.com/2227-9059/12/6/1167

2. “Pathogenesis, Prophylaxis, and Treatment of Candida auris
by Madalina Preda, Razvan Daniel Chivu, Lia Mara Ditu, Oana Popescu and Loredana Sabina Cornelia Manolescu
Biomedicines 2024, 12(3), 561; https://doi.org/10.3390/biomedicines12030561
Available online: https://www.mdpi.com/2227-9059/12/3/561

3. “Anti-Inflammatory Therapeutic Mechanisms of Isothiocyanates: Insights from Sulforaphane”
by Solomon Habtemariam
Biomedicines 2024, 12(6), 1169; https://doi.org/10.3390/biomedicines12061169
Available online: https://www.mdpi.com/2227-9059/12/6/1169

4. “Intestinal Dysbiosis: Microbial Imbalance Impacts on Colorectal Cancer Initiation, Progression and Disease Mitigation”
by Mary Garvey
Biomedicines 2024, 12(4), 740; https://doi.org/10.3390/biomedicines12040740
Available online: https://www.mdpi.com/2227-9059/12/4/740

5. “The Potential Role of Butyrate in the Pathogenesis and Treatment of Autoimmune Rheumatic Diseases”
by Carmela Coccia, Francesco Bonomi, Anna Lo Cricchio, Edda Russo, Silvia Peretti, Giulia Bandini, Gemma Lepri, Francesca Bartoli, Alberto Moggi-Pignone, Serena Guiducci et al.
Biomedicines 2024, 12(8), 1760; https://doi.org/10.3390/biomedicines12081760
Available online: https://www.mdpi.com/2227-9059/12/8/1760

6. “The Role of Biomarkers in Diagnosis of Sepsis and Acute Kidney Injury”
by Gillene Santos Ferreira, Melissa Lopes Frota, Maria José Dias Gonzaga, Maria de Fátima Fernandes Vattimo and Camila Lima
Biomedicines 2024, 12(5), 931; https://doi.org/10.3390/biomedicines12050931
Available online: https://www.mdpi.com/2227-9059/12/5/931

7. “Advanced Glycation End-Products Acting as Immunomodulators for Chronic Inflammation, Inflammaging and Carcinogenesis in Patients with Diabetes and Immune-Related Diseases”
by Chieh-Yu Shen, Cheng-Hsun Lu, Chiao-Feng Cheng, Ko-Jen Li, Yu-Min Kuo, Cheng-Han Wu, Chin-Hsiu Liu, Song-Chou Hsieh, Chang-Youh Tsai and Chia-Li Yu
Biomedicines 2024, 12(8), 1699; https://doi.org/10.3390/biomedicines12081699
Available online: https://www.mdpi.com/2227-9059/12/8/1699

8. “Dupilumab Efficacy on Asthma Functional, Inflammatory, and Patient-Reported Outcomes across Different Disease Phenotypes and Severity: A Real-Life Perspective”
by Marco Caminati, Matteo Maule, Roberto Benoni, Diego Bagnasco, Bianca Beghè, Fulvio Braido, Luisa Brussino, Paolo Cameli, Maria Giulia Candeliere, Giovanna Elisiana Carpagnano et al.
Biomedicines 2024, 12(2), 390; https://doi.org/10.3390/biomedicines12020390
Available online: https://www.mdpi.com/2227-9059/12/2/390

9. “Unraveling the Link between Insulin Resistance and Bronchial Asthma”
by Konstantinos Bartziokas, Andriana I. Papaioannou, Fotios Drakopanagiotakis, Evanthia Gouveri, Nikolaos Papanas and Paschalis Steiropoulos
Biomedicines 2024, 12(2), 437; https://doi.org/10.3390/biomedicines12020437
Available online: https://www.mdpi.com/2227-9059/12/2/437

10. “Insight into IL-5 as a Potential Target for the Treatment of Allergic Diseases”
by Katarzyna Antosz, Joanna Batko, Marta Błażejewska, Antoni Gawor, Jakub Sleziak and Krzysztof Gomułka
Biomedicines 2024, 12(7), 1531; https://doi.org/10.3390/biomedicines12071531
Available online: https://www.mdpi.com/2227-9059/12/7/1531

To acknowledge the above authors’ excellent contributions, we are happy to provide a full waiver to each team of the above publications. We also would like to take this opportunity to thank all the research groups that have submitted to Biomedicines (ISSN: 2227-9059). We would appreciate it if you would circulate this document among your colleagues and network. Furthermore, the following opportunities for collaboration may be of interest to you:

Submitting a manuscript:
This Section is currently open for submissions. Papers may be submitted via the following link:
https://www.mdpi.com/user/manuscripts/upload/?journal=biomedicines.

Joining the Volunteer Reviewer Board:
If you are an active researcher in the field of biomedicinal research and are interested in joining the Volunteer Reviewer Board of Biomedicines, please do not hesitate to submit your application via the following link: https://susy.mdpi.com/volunteer/profile/edit.

Biomedicines Editorial Office

2 July 2025
Biomedicines | Hot Papers in the “Molecular and Translational Medicine” Section

The “Molecular and Translational Medicine” Section publishes reviews and original peer-reviewed papers which aim to cover studies concerning disease pathogenesis at the molecular or physiological level, as well as basic preclinical, clinical, and translational aspects. We encourage scientists to submit their results that have the potential for application in human disease, as well as research obtained from clinical trials or animal models of human diseases that has the potential to shed light on the underlying causes of various human diseases and cancer, allowing for the development of future human medicines, medical devices, and diagnostics. In this context, we are pleased to feature some recently published papers on molecular and translational medicine in Biomedicines (ISSN: 2227-9059), which will provide valuable insights into this exciting field.

1. “Navigating Challenges and Opportunities in Multi-Omics Integration for Personalized Healthcare”
by Alex E. Mohr, Carmen P. Ortega-Santos, Corrie M. Whisner, Judith Klein-Seetharaman and Paniz Jasbi
Biomedicines 2024, 12(7), 1496; https://doi.org/10.3390/biomedicines12071496
Available online: https://www.mdpi.com/2227-9059/12/7/1496

2. “Transient Left Ventricular Dysfunction from Cardiomyopathies to Myocardial Viability: When and Why Cardiac Function Recovers”
by Giancarlo Trimarchi, Lucio Teresi, Roberto Licordari, Alessandro Pingitore, Fausto Pizzino, Patrizia Grimaldi, Danila Calabrò, Paolo Liotta, Antonio Micari, Cesare de Gregorio et al
Biomedicine. 2024, 12(5), 1051; https://doi.org/10.3390/biomedicines12051051
Available online: https://www.mdpi.com/2227-9059/12/5/1051

3. “Fibromyalgia: A Review of the Pathophysiological Mechanisms and Multidisciplinary Treatment Strategies”
by Lina Noelia Jurado-Priego, Cristina Cueto-Ureña, María Jesús Ramírez-Expósito and José Manuel Martínez-Martos
Biomedicines 2024, 12(7), 1543; https://doi.org/10.3390/biomedicines12071543
Available online: https://www.mdpi.com/2227-9059/12/7/1543

4. “Diabetes and Renal Complications: An Overview on Pathophysiology, Biomarkers and Therapeutic Interventions”
by Rajesh Jha, Sara Lopez-Trevino, Haritha R. Kankanamalage and Jay C. Jha
Biomedicines 2024, 12(5), 1098. https://doi.org/10.3390/biomedicines12051098
Available online: https://www.mdpi.com/2227-9059/12/5/1098

5. “Immunosuppression in Sepsis: Biomarkers and Specialized Pro-Resolving Mediators”
by Cristina M. Padovani and Kingsley Yin
Biomedicines 2024, 12(1), 175. https://doi.org/10.3390/biomedicines12010175
Available online: https://www.mdpi.com/2227-9059/12/1/175

6. “Osteoporosis, Osteoarthritis, and Subchondral Insufficiency Fracture: Recent Insights”
by Shunichi Yokota, Hotaka Ishizu, Takuji Miyazaki, Daisuke Takahashi, Norimasa Iwasaki and Tomohiro Shimizu
Biomedicines 2024, 12(4), 843; https://doi.org/10.3390/biomedicines12040843
Available online: https://www.mdpi.com/2227-9059/12/4/843

7. “Impact of Sodium Glucose Cotransporter 2 Inhibitors (SGLT2i) Therapy on Dementia and Cognitive Decline”
by Antonio Lardaro, Ludovica Quarta, Stefania Pagnotta, Giorgio Sodero, Sandro Mariani, Maria Del Ben, Giovambattista Desideri, Evaristo Ettorre and Francesco Baratta
Biomedicines 2024, 12(8),1750; https://doi.org/10.3390/biomedicines12081750
Available online: https://www.mdpi.com/2227-9059/12/8/1750

8. “Current Knowledge on the Use of Neuromonitoring in Thyroid Surgery”
by Beata Wojtczak, Karolina Sutkowska-Stępień, Mateusz Głód, Krzysztof Kaliszewski, Krzysztof Sutkowski and Marcin Barczyński
Biomedicines 2024, 12(3), 675; https://doi.org/10.3390/biomedicines12030675
Available online: https://www.mdpi.com/2227-9059/12/3/675

9. “Carriers of Heterozygous Loss-of-Function ACE Mutations Are at Risk for Alzheimer’s Disease”
by Sergei M. Danilov, Ivan A. Adzhubei, Alexander J. Kozuch, Pavel A. Petukhov, Isolda A. Popova, Ananyo Choudhury, Dhriti Sengupta and Steven M. Dudek
Biomedicines 2024, 12(1), 162; https://doi.org/10.3390/biomedicines12010162
Available online: https://www.mdpi.com/2227-9059/12/1/162

10. “Revisiting Treatment of Metastatic Urothelial Cancer: Where Do Cisplatin and Platinum Ineligibility Criteria Stand?”
by Mohammad Jad Moussa, Matthew T. Campbell and Omar Alhalabi
Biomedicines 2024, 12(3), 519; https://doi.org/10.3390/biomedicines12030519
Available online: https://www.mdpi.com/2227-9059/12/3/519

To acknowledge the above authors’ excellent contributions, we are happy to provide a full waiver to each team of the above publications. We also would like to take this opportunity to thank all the research groups that have submitted to Biomedicines. We would appreciate it if you would circulate this document among your colleagues and network. Furthermore, the following opportunities for collaboration may be of interest to you:

Submitting a manuscript:
This Section is currently open for submissions. Papers may be submitted via the following link: https://www.mdpi.com/user/manuscripts/upload/?journal=biomedicines

Joining the Volunteer Reviewer Board:
If you are an active researcher in the field of biomedicinal research and are interested in joining the Volunteer Reviewer Board of Biomedicines, please do not hesitate to submit your application via the following link: https://susy.mdpi.com/volunteer/profile/edit

Biomedicines Editorial Office

2 July 2025
Biomedicines | Hot Papers in the “Gene and Cell Therapy” Section

The “Gene and Cell Therapy” Section publishes reviews and original peer-reviewed papers. This section of Biomedicines aims to rapidly publish contributions on all aspects of the latest research results concerning gene and cell therapy. We encourage submissions of manuscripts that provide novel and mechanistic insights, including but not limited to gene transfer; vector development and design; autologous and allogeneic cell therapies (hematopoietic and mesenchymal stem cell therapies); the development of genes, peptides, proteins, oligonucleotides, and cell therapies to correct genetic and acquired diseases; vaccine development; preclinical target validation; and other research aspects. In this context, we are pleased to feature some recently published papers from the “Gene and Cell Therapy” Section in Biomedicines (ISSN: 2227-9059), which will provide valuable insights into this exciting field.

1. “Protective Effects of High-Density Lipoprotein on Cancer Risk: Focus on Multiple Myeloma”
by Alessandro Allegra, Giuseppe Murdaca, Giuseppe Mirabile and Sebastiano Gangemi
Biomedicines 2024, 12(3), 514; https://doi.org/10.3390/biomedicines12030514
Available online: https://www.mdpi.com/2227-9059/12/3/514

2. “MicroRNA Monitoring in Human Alveolar Macrophages from Patients with Smoking-Related Lung Diseases: A Preliminary Study”
by Davida Mirra, Renata Esposito, Giuseppe Spaziano, Liberata Sportiello, Francesca Panico, Antonio Squillante, Maddalena Falciani, Ida Cerqua , Luca Gallelli, Erika Cione and Bruno D’Agostino
Biomedicines 2024, 12(5), 1050; https://doi.org/10.3390/biomedicines12051050
Available online: https://www.mdpi.com/2227-9059/12/5/1050

3. “Biomarkers and Signaling Pathways Implicated in the Pathogenesis of Idiopathic Multicentric Castleman Disease/Thrombocytopenia, Anasarca, Fever, Reticulin Fibrosis, Renal Insufficiency, and Organomegaly (TAFRO) Syndrome”
by Remi Sumiyoshi, Tomohiro Koga and Atsushi Kawakami
Biomedicines 2024, 12(6), 1141; https://doi.org/10.3390/biomedicines12061141
Available online: https://www.mdpi.com/2227-9059/12/6/1141

4. “Structural Changes Likely Cause Chemical Differences between Empty and Full AAV Capsids”
by Caryn L. Heldt, Molly A. Skinner and Ganesh S. Anand
Biomedicines 2024, 12(9), 2128; https://doi.org/10.3390/biomedicines12092128
Available online: https://www.mdpi.com/2227-9059/12/9/2128

5. “Long-Term Follow-Up of Phase I Trial of Oncolytic Adenovirus-Mediated Cytotoxic and Interleukin-12 Gene Therapy for Treatment of Metastatic Pancreatic Cancer”
by Aseem Rai Bhatnagar, Farzan Siddiqui, Gazala Khan, Robert Pompa, David Kwon and Shyam Nyati
Biomedicines 2024, 12(5), 1065; https://doi.org/10.3390/biomedicines12051065
Available online: https://www.mdpi.com/2227-9059/12/5/1065

6. “Potential Causal Association between C-Reactive Protein Levels in Age-Related Macular Degeneration: A Two-Sample Mendelian Randomization Study”
by Byung Woo Yoon, Young Lee and Je Hyun Seo
Biomedicines 2024, 12(4), 807; https://doi.org/10.3390/biomedicines12040807
Available online: https://www.mdpi.com/2227-9059/12/4/807

7. “A Comprehensive Exploration of Therapeutic Strategies in Inflammatory Bowel Diseases: Insights from Human and Animal Studies”
by Inês Esteves Dias, Isabel Ribeiro Dias, Teresa Franchi-Mendes, Carlos Antunes Viegas and Pedro Pires Carvalho
Biomedicines 2024, 12(4), 735; https://doi.org/10.3390/biomedicines12040735
Available online: https://www.mdpi.com/2227-9059/12/4/735

8. “Regenerative Therapy for Corneal Scarring Disorders”
by Christine Chandran, Mithun Santra, Elizabeth Rubin, Moira L. Geary and Gary Hin-Fai Yam
Biomedicines 2024, 12(3), 649; https://doi.org/10.3390/biomedicines12030649
Available online: https://www.mdpi.com/2227-9059/12/3/649

9. “Application of SWATH Mass Spectrometry and Machine Learning in the Diagnosis of Inflammatory Bowel Disease Based on the Stool Proteome”
by Elmira Shajari, David Gagné, Mandy Malick, Patricia Roy, Jean-François Noël, Hugo Gagnon, Marie A. Brunet, Maxime Delisle, François-Michel Boisvert and Jean-François Beaulieu
Biomedicines 2024, 12(2), 333; https://doi.org/10.3390/biomedicines12020333
Available online: https://www.mdpi.com/2227-9059/12/2/333

10. “CAR NK92 Cells Targeting BCMA Can Effectively Kill Multiple Myeloma Cells Both In Vitro and In Vivo”
by Eunhee Park, Hui-jin Mun, Eunju Seo, Seojin Hwang, Jae Hee Lee, Sukgil Song, Hyeran Sung, Hoi-Yul Kim and Mi-Jin Kwon
Biomedicines 2024, 12(1), 248; https://doi.org/10.3390/biomedicines12010248
Available online: https://www.mdpi.com/2227-9059/12/1/248

To acknowledge the above authors’ excellent contributions, we are happy to provide a full waiver to each team of the above publications. We also would like to take this opportunity to thank all the research groups that have submitted to Biomedicines. We would appreciate it if you would circulate this document among your colleagues and network. Furthermore, the following opportunities for collaboration may be of interest to you:

Submitting a manuscript:

This Section is currently open for submissions. Papers may be submitted via the following link:

https://www.mdpi.com/user/manuscripts/upload/?journal=biomedicines.

Joining the Volunteer Reviewer Board:

If you are an active researcher in the field of biomedicinal research and are interested in joining the Volunteer Reviewer Board of Biomedicines, please do not hesitate to submit your application via the following link: https://susy.mdpi.com/volunteer/profile/edit.

Biomedicines Editorial Office

2 July 2025
Biomedicines | Hot Papers in the “Molecular Genetics and Genetic Diseases” Section

The Section “Molecular Genetics and Genetic Diseases” covers the basic and translational aspects of human genetic diseases and genomics research, from fundamental molecular investigation to preclinical animal models. In particular, this Section aims to facilitate the rapid publication of innovative research encompassing the genetic basis of human health and disease, as well as the treatment of genetic disorders and heritable or acquired cancers. We welcome submissions that apply new and emerging technologies in the fields of genomics, transcriptomics and bioinformatic tools to advance knowledge in human genetic diseases.

1. “Role of Genetics in Diagnosis and Management of Hypertrophic Cardiomyopathy: A Glimpse into the Future”
by Mohammed Tiseer Abbas, Nima Baba Ali, Juan M. Farina, Ahmed K. Mahmoud, Milagros Pereyra, Isabel G. Scalia, Moaz A. Kamel, Timothy Barry, Steven J. Lester, Charles R. Cannan et al.
Biomedicines 2024, 12(3), 682; https://doi.org/10.3390/biomedicines12030682
Available online: https://www.mdpi.com/2227-9059/12/3/682#

2. “Lipid Toxicity in the Cardiovascular-Kidney-Metabolic Syndrome (CKMS)
by John A. D’Elia and Larry A. Weinrauch
Biomedicines 2024, 12(5), 978; https://doi.org/10.3390/biomedicines12050978
Available online: https://www.mdpi.com/2227-9059/12/5/978

3. “Predictors of Successful Testicular Sperm Extraction: A New Era for Men with Non-Obstructive Azoospermia”
by Aris Kaltsas, Sofoklis Stavros, Zisis Kratiras, Athanasios Zikopoulos, Nikolaos Machairiotis, Anastasios Potiris, Fotios Dimitriadis, Nikolaos Sofikitis, Michael Chrisofos and Athanasios Zachariou
Biomedicines 2024, 12(12), 2679; https://doi.org/10.3390/biomedicines12122679
Available online: https://www.mdpi.com/2227-9059/12/12/2679

4. “Burning Mouth Syndrome Treated with Low-Level Laser and Clonazepam: A Randomized, Single-Blind Clinical Trial”
by Ana Garcia Martinez, Pia Lopez-Jornet, Luis Pardo Marin, Eduardo Pons-Fuster and Asta Tvarijonaviciute
Biomedicines 2024, 12(5), 1048; https://doi.org/10.3390/biomedicines12051048
Available online: https://www.mdpi.com/2227-9059/12/5/1048

5. “Physiological Consequences of Nonsense-Mediated Decay and Its Role in Adaptive Responses”
by Zhengxin Ma, Ratna Sharma and Aric N. Rogers
Biomedicines 2024, 12(5), 1110; https://doi.org/10.3390/biomedicines12051110
Available online: https://www.mdpi.com/2227-9059/12/5/1110

6. “Sarcoidosis Associated Pulmonary Hypertension”
by Alexander Liu, Laura C. Price, Rakesh Sharma, Athol U. Wells and Vasileios Kouranos
Biomedicines 2024, 12(1), 177; https://doi.org/10.3390/biomedicines12010177
Available online: https://www.mdpi.com/2227-9059/12/1/177

7. “Overexpression of SMYD3 Promotes Autosomal Dominant Polycystic Kidney Disease by Mediating Cell Proliferation and Genome Instability”
by Ewud Agborbesong, Julie Xia Zhou, Hongbing Zhang, Linda Xiaoyan Li, Peter C. Harris, James P. Calvet and Xiaogang Li
Biomedicines 2024, 12(3), 603; https://doi.org/10.3390/biomedicines12030603
Available online: https://www.mdpi.com/2227-9059/12/3/603

8. “Epigenetic Regulation of DNA Methylation and RNA Interference in Gastric Cancer: A 2024 Update”
by Iulia Lupan, Vasile Bintintan, Diana Deleanu and Gabriel Samasca
Biomedicines 2024, 12(9), 2001; https://doi.org/10.3390/biomedicines12092001
Available online: https://www.mdpi.com/2227-9059/12/9/2001

9. “The Influence of Tacrolimus Exposure and Metabolism on the Outcomes of Kidney Transplants”
by Rima Maslauskiene, Ruta Vaiciuniene, Aurelija Radzeviciene, Peteris Tretjakovs, Gita Gersone, Edgaras Stankevicius and Inga Arune Bumblyte
Biomedicines 2024, 12(5), 1125; https://doi.org/10.3390/biomedicines12051125
Available online: https://www.mdpi.com/2227-9059/12/5/1125

10. “Current Immunotherapy Treatments of Primary Breast Cancer Subtypes”
by Savannah R. Brown and Emilie E. Vomhof-DeKrey
Biomedicines 2024, 12(4), 895; https://doi.org/10.3390/biomedicines12040895
Available online: https://www.mdpi.com/2227-9059/12/4/895

To acknowledge the above authors’ excellent contributions, we are happy to provide a full waiver to each team of the above publications. We also would like to take this opportunity to thank all the research groups that have submitted to Biomedicines (ISSN: 2227-9059). We would appreciate it if you would circulate this document among your colleagues and network. Furthermore, the following opportunities for collaboration may be of interest to you:

Submitting a manuscript:
This Section is currently open for submissions. Papers may be submitted via the following link:
https://www.mdpi.com/user/manuscripts/upload/?journal=biomedicines.

Joining the Volunteer Reviewer Board:
If you are an active researcher in the field of biomedicinal research and are interested in joining the Volunteer Reviewer Board of Biomedicines, please do not hesitate to submit your application via the following link: https://susy.mdpi.com/volunteer/profile/edit.

Biomedicines Editorial Office

2 July 2025
Biomedicines | Hot Papers in the “Nanomedicine and Nanobiology” Section

The “Nanomedicine and Nanobiology” Section publishes reviews and original peer-reviewed papers of a high scientific level covering all aspects of nanomedicine. Papers aim to uncover the synthesis, bioavailability, and biodistribution of nanomedicines; the delivery, pharmacodynamics, and pharmacokinetics of nanomedicines; imaging; diagnostics; improved therapeutics; innovative biomaterials; and interactions of nanomaterials with cells, tissues, and living organisms. In this context, we are pleased to feature some recently published papers from the “Nanomedicine and Nanobiology” Section in Biomedicines (ISSN: 2227-9059), which provide valuable insights into this exciting field.

1. “An In Vitro Model to Assess Early Immune Markers Following Co-Exposure of Epithelial Cells to Carbon Black (Nano)Particles in the Presence of S. aureus: A Role for Stressed Cells in Toxicological Testing”
by Scott Brown, Stephen J. Evans, Michael J. Burgum, Kirsty Meldrum, Jack Herridge, Blessing Akinbola, Llinos G. Harris, Rowena Jenkins, Shareen H. Doak, Martin J. D. Clift et al.
Biomedicines 2024, 12(1), 128; https://doi.org/10.3390/biomedicines12010128
Available online: https://www.mdpi.com/2227-9059/12/1/128

2. “Innovative Biomedical and Technological Strategies for the Control of Bacterial Growth and Infections”
by Lídia Leonize Rodrigues Matias, Karla Suzanne Florentino da Silva Chaves Damasceno, Annemberg Salvino Pereira, Thaís Souza Passos and Ana Heloneida de Araujo Morais
Biomedicines 2024, 12(1), 176; https://doi.org/10.3390/biomedicines12010176
Available online: https://www.mdpi.com/2227-9059/12/1/176

3. “Nanotechnology Innovations in Pediatric Cardiology and Cardiovascular Medicine: A Comprehensive Review”
by Stefana Maria Moisa, Alexandru Burlacu, Lacramioara Ionela Butnariu, Corina Maria Vasile, Crischentian Brinza, Elena Lia Spoiala, Alexandra Maștaleru, Maria Magdalena Leon, Solange Tamara Rosu, Radu Vatasescu et al.
Biomedicines 2024, 12(1), 185; https://doi.org/10.3390/biomedicines12010185
Available online: https://www.mdpi.com/2227-9059/12/1/185

4. “Biological Effects of Small Sized Graphene Oxide Nanosheets on Human Leukocytes”
by Michele Aventaggiato, Federica Valentini, Daniela Caissutti, Michela Relucenti, Marco Tafani, Roberta Misasi, Alessandra Zicari, Sara Di Martino, Sara Virtuoso, Anna Neri et al.
Biomedicines 2024, 12(2), 256; https://doi.org/10.3390/biomedicines12020256
Available online: https://www.mdpi.com/2227-9059/12/2/256

5. “Advancing Cancer Treatment: Enhanced Combination Therapy through Functionalized Porous Nanoparticles”
by Kibeom Kim and Myoung-Hwan Park
Biomedicines 2024, 12(2), 326; https://doi.org/10.3390/biomedicines12020326
Available online: https://www.mdpi.com/2227-9059/12/2/326

6. “Nanomaterials Based on 2,7,12,17-Tetra-tert-butyl-5,10,15,20-tetraaza-21H,23H-porphine Exhibiting Bifunctional Sensitivity for Monitoring Chloramphenicol and Co2+
by Ionela Fringu, Diana Anghel, Ion Fratilescu, Camelia Epuran, Mihaela Birdeanu and Eugenia Fagadar-Cosma
Biomedicines 2024, 12(4), 770; https://doi.org/10.3390/biomedicines12040770
Available online: https://www.mdpi.com/2227-9059/12/4/770

7. “Sinus Floor Augmentation with Synthetic Hydroxyapatite (NanoBone®) in Combination with Platelet-Rich Fibrin: A Case Series”
by Luís Francisco, Manuel Francisco, Rosana Costa, Miguel Nunes Vasques, Marta Relvas, António Rajão, Luís Monteiro, Paulo Rompante, Fernando Guerra and Marco Infante da Câmara
Biomedicines 2024, 12(8), 1661; https://doi.org/10.3390/biomedicines12081661
Available online: https://www.mdpi.com/2227-9059/12/8/1661

8. “Toxicological Assessment of Biodegradable Poli-ε-Caprolactone Polymer Composite Materials Containing Hydroxyapatite, Bioglass, and Chitosan as Potential Biomaterials for Bone Regeneration Scaffolds”
by Aleksandra Skubis-Sikora, Andrzej Hudecki, Bartosz Sikora, Patrycja Wieczorek, Mateusz Hermyt, Marek Hreczka, Wirginia Likus, Jarosław Markowski, Krzysztof Siemianowicz, Aleksandra Kolano-Burian et al.
Biomedicines 2024, 12(9), 1949; https://doi.org/10.3390/biomedicines12091949
Available online: https://www.mdpi.com/2227-9059/12/9/1949

9. “A General Method to Screen Nanobodies for Cytochrome P450 Enzymes from a Yeast Surface Display Library”
by Yudong Sun, Cristian Martinez-Ramos, Eugene Chen, Yoichi Osawa and Haoming Zhang
Biomedicines 2024, 12(8), 1863; https://doi.org/10.3390/biomedicines12081863
Available online: https://www.mdpi.com/2227-9059/12/8/1863

10. “Multifractal Analysis and Experimental Evaluation of MCM-48 Mesoporous Silica as a Drug Delivery System for Metformin Hydrochloride”
by Mousa Sha’at, Maria Ignat, Liviu Sacarescu, Adrian Florin Spac, Alexandra Barsan (Bujor), Vlad Ghizdovat, Emanuel Nazaretian, Catalin Dumitras, Maricel Agop, Cristina Marcela Rusu et al.
Biomedicines 2024, 12(12), 2838; https://doi.org/10.3390/biomedicines12122838
Available online: https://www.mdpi.com/2227-9059/12/12/2838

To acknowledge the above authors’ excellent contributions, we are happy to provide a full waiver to each team of the above publications. We also would like to take this opportunity to thank all the research groups that have submitted to Biomedicines. We would appreciate it if you would circulate this document among your colleagues and network. Furthermore, the following opportunities for collaboration may be of interest to you:

Submitting a manuscript:

This Section is currently open for submissions. Papers may be submitted via the following link:

https://www.mdpi.com/user/manuscripts/upload/?journal=biomedicines.

Joining the Volunteer Reviewer Board:

If you are an active researcher in the field of biomedicinal research and are interested in joining the Volunteer Reviewer Board of Biomedicines, please do not hesitate to submit your application via the following link: https://susy.mdpi.com/volunteer/profile/edit.

Biomedicines Editorial Office

2 July 2025
Biomedicines | Hot Papers in the “Drug Discovery, Development and Delivery” Section

The “Drug Discovery, Development and Delivery” Section publishes original and innovative scientific papers, as well as comprehensive review papers. In this context, we are pleased to feature some recently published papers in Biomedicines (ISSN: 2227-9059) on drug discovery, drug design, basic and clinical pharmacology, formulation and delivery, and toxicology, which will provide valuable insights into this exciting field.

1. “Aptamer-Based Smart Targeting and Spatial Trigger–Response Drug-Delivery Systems for Anticancer Therapy”
by Dongsik Park, Su Jin Lee and Jee-Woong Park
Biomedicines 2024, 12(1), 187; https://doi.org/10.3390/biomedicines12010187
Available online: https://www.mdpi.com/2227-9059/12/1/187

2. “The Use of Nigella sativa in Cardiometabolic Diseases”
by Giuseppe Derosa, Angela D’Angelo, Pamela Maffioli, Laura Cucinella and Rossella Elena Nappi
Biomedicines 2024, 12(2), 405; https://doi.org/10.3390/biomedicines12020405
Available online: https://www.mdpi.com/2227-9059/12/2/405

3. “Safety Profile of the Trastuzumab-Based ADCs: Analysis of Real-World Data Registered in EudraVigilance”
by Claudiu Morgovan, Carmen Maximiliana Dobrea, Anca Butuca, Anca Maria Arseniu, Adina Frum, Luca Liviu Rus, Adriana Aurelia Chis, Anca Maria Juncan, Felicia Gabriela Gligor, Cecilia Georgescu et al.
Biomedicines 2024, 12(5), 953; https://doi.org/10.3390/biomedicines12050953
Available online: https://www.mdpi.com/2227-9059/12/5/953

4. “Use of Oleuropein and Hydroxytyrosol for Cancer Prevention and Treatment: Considerations about How Bioavailability and Metabolism Impact Their Adoption in Clinical Routine”
by Francesco Gervasi and Fanny Pojero
Biomedicines 2024, 12(3), 502; https://doi.org/10.3390/biomedicines12030502
Available online: https://www.mdpi.com/2227-9059/12/3/502

5. “Vitamin D and Cardiovascular Diseases: From Physiology to Pathophysiology and Outcomes”
by Matteo Nardin, Monica Verdoia, Simone Nardin, Davide Cao, Mauro Chiarito, Elvin Kedhi, Gennaro Galasso, Gianluigi Condorelli and Giuseppe De Luca
Biomedicines 2024, 12(4), 768; https://doi.org/10.3390/biomedicines12040768
Available online: https://www.mdpi.com/2227-9059/12/4/768

6. “Recombinant Adeno-Associated Virus Vectors for Gene Therapy of the Central Nervous System: Delivery Routes and Clinical Aspects”
by Żaneta Słyk, Natalia Stachowiak and Maciej Małecki
Biomedicines 2024, 12(7), 1523; https://doi.org/10.3390/biomedicines12071523
Available online: https://www.mdpi.com/2227-9059/12/7/1523

7. “Repurposing of the Cardiovascular Drug Statin for the Treatment of Cancers: Efficacy of Statin–Dipyridamole Combination Treatment in Melanoma Cell Lines”
by Nanami Irie, Kana Mizoguchi, Tomoko Warita, Mirai Nakano, Kasuga Sasaki, Jiro Tashiro, Tomohiro Osaki, Takuro Ishikawa, Zoltán N. Oltvai and Katsuhiko Warita
Biomedicines 2024, 12(3), 698; https://doi.org/10.3390/biomedicines12030698
Available online: https://www.mdpi.com/2227-9059/12/3/698

8. “Role of Functionalized Peptides in Nanomedicine for Effective Cancer Therapy”
by Kibeom Kim and Myoung-Hwan Park
Biomedicines 2024, 12(1), 202; https://doi.org/10.3390/biomedicines12010202
Available online: https://www.mdpi.com/2227-9059/12/1/202

9. “Conjecturing about Small-Molecule Agonists and Antagonists of α4β1 Integrin: From Mechanistic Insight to Potential Therapeutic Applications”
by Tingting He, Daria Giacomini, Alessandra Tolomelli, Monica Baiula and Luca Gentilucci
Biomedicines 2024, 12(2), 316; https://doi.org/10.3390/biomedicines12020316
Available online: https://www.mdpi.com/2227-9059/12/2/316

10. “Fluocinolone Acetonide Implant for Uveitis: Dissecting Responder and Non-Responder Outcomes at a Tertiary Center”
by Jasmin Abu Arif, Vitus André Knecht, Anne Rübsam, Vanessa Lussac, Zohreh Jami, Dominika Pohlmann, Bert Müller and Uwe Pleyer
Biomedicines 2024, 12(5), 1106; https://doi.org/10.3390/biomedicines12051106
Available online: https://www.mdpi.com/2227-9059/12/5/1106

To acknowledge the above authors’ excellent contributions, we are happy to provide a full waiver to each team of the above publications. We also would like to take this opportunity to thank all the research groups that have submitted to Biomedicines. We would appreciate it if you would circulate this document among your colleagues and network. Furthermore, the following opportunities for collaboration may be of interest to you:

Submitting a manuscript:
This Section is currently open for submissions. Papers may be submitted via the following link: https://www.mdpi.com/user/manuscripts/upload/?journal=biomedicines.

Joining the Volunteer Reviewer Board:
If you are an active researcher in the field of biomedicinal research and are interested in joining the Volunteer Reviewer Board of Biomedicines, please do not hesitate to submit your application via the following link: https://susy.mdpi.com/volunteer/profile/edit.

Biomedicines Editorial Office

2 July 2025
Biomedicines | Hot Papers in the “Cancer Biology and Oncology” Section

The “Cancer Biology and Oncology” Section publishes reviews and original peer-reviewed papers of a high scientific standard, covering all aspects of innovative cancer therapies. Papers aim to uncover novel therapeutic approaches toward overcoming conventional anticancer drug resistance and a better understanding of the interrelations between cancer and metabolism in addition to a better understanding of the tumor and its microenvironment, along with the discovery of novel diagnostic and prognostic makers. Topics include but are not limited to in vitro and in vivo cancer therapeutic responses, targeted therapies (including metabolism and immunotherapy, such as those involving CAR-T cells), identification of novel therapeutic targets, and evaluation of novel diagnosis and prognosis markers and the assessment of their impact on morphological, phenotypical, and molecular classifications.

1. “Dysbiosis Signature of Fecal Microbiota in Patients with Pancreatic Adenocarcinoma and Pancreatic Intraductal Papillary Mucinous Neoplasms”
by Theodoros Sidiropoulos, Nikolas Dovrolis, Hector Katifelis, Nikolaos V. Michalopoulos, Panagiotis Kokoropoulos, Nikolaos Arkadopoulos and Maria Gazouli
Biomedicines 2024, 12(5), 1040; https://doi.org/10.3390/biomedicines12051040
Available online: https://www.mdpi.com/2227-9059/12/5/1040

2. “IKZF1 Alterations and Therapeutic Targeting in B-Cell Acute Lymphoblastic Leukemia”
by Jonathan Paolino, Harrison K. Tsai, Marian H. Harris and Yana Pikman
Biomedicines 2024, 12(1), 89; https://doi.org/10.3390/biomedicines12010089
Available online: https://www.mdpi.com/2227-9059/12/1/89

3. “miR-331-5p Affects Motility of Thyroid Cancer Cell Lines and Regulates BID Expression”
by Francesca Maria Orlandella, Esther Imperlini, Katia Pane, Neila Luciano, Mariantonia Braile, Anna Elisa De Stefano, Paola Lucia Chiara Iervolino, Alessandro Ruocco, Stefania Orrù, Monica Franzese et al.
Biomedicines 2024, 12(3), 658. https://doi.org/10.3390/biomedicines12030658
Available online: https://www.mdpi.com/2227-9059/12/3/658

4. “Current and Emerging Diagnostic, Prognostic, and Predictive Biomarkers in Head and Neck Cancer”
by Hänel W. Eberly, Bao Y. Sciscent, F. Jeffrey Lorenz, Eleni M. Rettig and Neerav Goyal
Biomedicines 2024, 12(2), 415; https://doi.org/10.3390/biomedicines12020415
Available online: https://www.mdpi.com/2227-9059/12/2/415

5. “Tumor-Infiltrating Lymphocytes (TILs) in Breast Cancer: Prognostic and Predictive Significance across Molecular Subtypes”
by Aleksandra Ciarka, Michał Piątek, Rafał Pęksa, Michał Kunc and Elżbieta Senkus
Biomedicines 2024, 12(4), 763; https://doi.org/10.3390/biomedicines12040763
Available online: https://www.mdpi.com/2227-9059/12/4/763

6. “Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma or a Metaphor for Heterogeneity: From Single-Cell Analysis to Whole-Body Imaging”
by Rita Saúde-Conde, Ayça Arçay Öztürk, Kosta Stosic, Oier Azurmendi Senar, Julie Navez, Christelle Bouchart, Tatjana Arsenijevic, Patrick Flamen and Jean-Luc Van Laethem
Biomedicines 2024, 12(3), 591; https://doi.org/10.3390/biomedicines12030591
Available online: https://www.mdpi.com/2227-9059/12/3/591

7. “Molecular Pathology of Thyroid Tumors: Essential Points to Comprehend Regarding the Latest WHO Classification”
by Tomohiro Chiba
Biomedicines 2024, 12(4), 712; https://doi.org/10.3390/biomedicines12040712
Available online: https://www.mdpi.com/2227-9059/12/4/712

8. “Charting the Course in Sequencing Antibody-Drug Conjugates in Breast Cancer”
by Giuseppe Saltalamacchia, Rosalba Torrisi, Rita De Sanctis, Giovanna Masci, Chiara Miggiano, Mariangela Gaudio, Chiara Benvenuti, Flavia Jacobs, Riccardo Gerosa, Armando Santoro et al.
Biomedicines 2024, 12(3), 500; https://doi.org/10.3390/biomedicines12030500
Available online: https://www.mdpi.com/2227-9059/12/3/500

9. “Clinical Developments and Challenges in Treating FGFR2-Driven Gastric Cancer”
by David K. Lau, Jack P. Collin and John M. Mariadason
Biomedicines 2024, 12(5), 1117; https://doi.org/10.3390/biomedicines12051117
Available online: https://www.mdpi.com/2227-9059/12/5/1117

10. “Current Non-Metal Nanoparticle-Based Therapeutic Approaches for Glioblastoma Treatment”
by Agata M.Gawel, Anna Betkowska, Ewa Gajda, Marlena Godlewska and Damian Gawel
Biomedicines 2024, 12(8), 1822; https://doi.org/10.3390/biomedicines12081822
Available online: https://www.mdpi.com/2227-9059/12/8/1822

To acknowledge the above authors’ excellent contributions, we are happy to provide a full waiver to each team of the above publications. We also would like to take this opportunity to thank all the research groups that have submitted to Biomedicines (ISSN: 2227-9059). We would appreciate it if you would circulate this document among your colleagues and network. Furthermore, the following opportunities for collaboration may be of interest to you:

Submitting a manuscript:

This Section is currently open for submissions. Papers may be submitted via the following link:

https://www.mdpi.com/user/manuscripts/upload/?journal=biomedicines.

Joining the Volunteer Reviewer Board:

If you are an active researcher in the field of biomedicinal research and are interested in joining the Volunteer Reviewer Board of Biomedicines, please do not hesitate to submit your application via the following link: https://susy.mdpi.com/volunteer/profile/edit.

Biomedicines Editorial Office

2 July 2025
Biomedicines | Hot Papers in the “Endocrinology and Metabolism Research” Section

The “Endocrinology and Metabolism Research” Section publishes original and innovative scientific papers, as well as comprehensive review papers. In this context, we are pleased to feature some recently published papers in Biomedicines (ISSN: 2227-9059) on gene regulation, cell biology, signaling, mutations, growth factors, cytokines, hormone receptors, hormone action and regulation, developmental endocrinology, genetic endocrinology, endocrine diseases (diabetes, obesity, osteoporosis, hyperthyroidism, etc.), and metabolic diseases, which will provide valuable insights into this exciting field.

1. “Exploring the Multifaceted Landscape of MASLD: A Comprehensive Synthesis of Recent Studies, from Pathophysiology to Organoids and Beyond”
by Allison Soto, Colby Spongberg, Alessandro Martinino and Francesco Giovinazzo
Biomedicines 2024, 12(2), 397; https://doi.org/10.3390/biomedicines12020397
Available online: https://www.mdpi.com/2227-9059/12/2/397

2. “The Triglyceride/HDL Ratio as a Surrogate Biomarker for Insulin Resistance”
by Petru Baneu, Cristina Văcărescu, Simona-Ruxanda Drăgan, Liviu Cirin, Alexandra-Iulia Lazăr-Höcher, Andreea Cozgarea, Adelina-Andreea Faur-Grigori, Simina Crișan, Dan Gaiță, Constantin-Tudor Luca et al.
Biomedicines 2024, 12(7), 1493; https://doi.org/10.3390/biomedicines12071493
Available online: https://www.mdpi.com/2227-9059/12/7/1493

3. “Novel Factors Regulating Proliferation, Migration, and Differentiation of Fibroblasts, Keratinocytes, and Vascular Smooth Muscle Cells during Wound Healing”
by Jacob Smith and Vikrant Rai
Biomedicines 2024, 12(9), 1939; https://doi.org/10.3390/biomedicines12091939
Available online: https://www.mdpi.com/2227-9059/12/9/1939

4. “The Emerging Role of Glucagon-like Peptide-1 Receptor Agonists in the Management of Obesity-Related Heart Failure with Preserved Ejection Fraction: Benefits beyond What Scales Can Measure?”
by Paschalis Karakasis, Nikolaos Fragakis, Dimitrios Patoulias, Panagiotis Theofilis, Marios Sagris, Theocharis Koufakis, Panayotis K. Vlachakis, Imran Rashid Rangraze, Mohamed El Tanani, Konstantinos Tsioufis et al. 
Biomedicines 2024, 12(9), 2112; https://doi.org/10.3390/biomedicines12092112
Available online: https://www.mdpi.com/2227-9059/12/9/2112

5. “Pharmacological Approaches Using Diabetic Drugs Repurposed for Alzheimer’s Disease”
by Muna A. Adem, Boris Decourt and Marwan N. Sabbagh
Biomedicines 2024, 12(1), 99; https://doi.org/10.3390/biomedicines12010099
Available online: https://www.mdpi.com/2227-9059/12/1/99

6. “NAFLD in the 21st Century: Current Knowledge Regarding Its Pathogenesis, Diagnosis and Therapeutics”
by Dimitris Kounatidis, Natalia G. Vallianou, Eleni Geladari, Maria Paraskevi Panoilia, Anna Daskou, Theodora Stratigou, Irene Karampela, Dimitrios Tsilingiris and Maria Dalamaga
Biomedicines 2024, 12(4), 826; https://doi.org/10.3390/biomedicines12040826
Available online: https://www.mdpi.com/2227-9059/12/4/826

7. “Hypoglycemia Unawareness—A Review on Pathophysiology and Clinical Implications”
by Laura Hölzen, Bernd Schultes, Bernd Schultes and Svenja Meyhöfer
Biomedicines 2024, 12(2), 391; https://doi.org/10.3390/biomedicines12020391
Available online: https://www.mdpi.com/2227-9059/12/2/391

8. “Methylglyoxal and Advanced Glycation End Products (AGEs): Targets for the Prevention and Treatment of Diabetes-Associated Bladder Dysfunction?”
by Akila Lara Oliveira, Mariana Gonçalves de Oliveira, Fabíola Zakia Mónica and Edson Antunes
Biomedicines 2024, 12(5), 939; https://doi.org/10.3390/biomedicines12050939
Available online: https://www.mdpi.com/2227-9059/12/5/939

9. “The Role of Fecal Microbiota Transplantation (FMT) in the Management of Metabolic Diseases in Humans: A Narrative Review”
by Eva Zikou, Chrysi Koliaki and Konstantinos Makrilakis
Biomedicines 2024, 12(8), 1871; https://doi.org/10.3390/biomedicines12081871
Available online: https://www.mdpi.com/2227-9059/12/8/1871

10. “Incretin Hormone Secretion in Women with Polycystic Ovary Syndrome: Roles of Obesity, Insulin Sensitivity and Treatment with Metformin and GLP-1s”
by Andrea Etrusco, Mislav Mikuš, Antonio D’Amato, Fabio Barra, Petar Planinić, Trpimir Goluža, Giovanni Buzzaccarini, Jelena Marušić, Mara Tešanović and Antonio Simone Laganà
Biomedicines 2024, 12(3), 653; https://doi.org/10.3390/biomedicines12030653
Available online: https://www.mdpi.com/2227-9059/12/3/653

To acknowledge the above authors’ excellent contributions, we are happy to provide a full waiver to each team of the above publications. We also would like to take this opportunity to thank all the research groups that have submitted to Biomedicines. We would appreciate it if you would circulate this document among your colleagues and network. Furthermore, the following opportunities for collaboration may be of interest to you:

Submitting a manuscript:
This Section is currently open for submissions. Papers may be submitted via the following link:
https://www.mdpi.com/user/manuscripts/upload/?journal=biomedicines.

Joining the Volunteer Reviewer Board:
If you are an active researcher in the field of biomedicinal research and are interested in joining the Volunteer Reviewer Board of Biomedicines, please do not hesitate to submit your application via the following link: https://susy.mdpi.com/volunteer/profile/edit.

Biomedicines Editorial Office

2 July 2025
Biomedicines | Hot Papers in the “Biomedical Engineering and Materials” Section

The “Biomedical Engineering and Materials” Section publishes reviews and original peer-reviewed papers which aim to cover studies of the preparation, performance, and evaluation of biomaterials; the chemical, physical, toxicological, and mechanical behavior of materials in physiological environments; and the response of blood and tissues to biomaterials. It also covers biomedical engineering approaches as solutions to clinical practice. In this context, we are pleased to feature some recently published papers on biomedical engineering and materials in Biomedicines (ISSN: 2227-9059), which will provide valuable insights into this exciting field.

1. “Artificial Intelligence in Pediatric Emergency Medicine: Applications, Challenges, and Future Perspectives”
by Lorenzo Di Sarno, Anya Caroselli, Giovanna Tonin, Benedetta Graglia, Valeria Pansini, Francesco Andrea Causio, Antonio Gatto and Antonio Chiaretti
Biomedicines 2024, 12(6), 1220; https://doi.org/10.3390/biomedicines12061220
Available online: https://www.mdpi.com/2227-9059/12/6/1220

2. “Machine Learning and Texture Analysis of [18F]FDG PET/CT Images for the Prediction of Distant Metastases in Non-Small-Cell Lung Cancer Patients”
by Armin Hakkak Moghadam Torbati, Sara Pellegrino, Rosa Fonti, Rocco Morra, Sabino De Placido and Silvana Del Vecchio
Biomedicines 2024, 12(3), 472; https://doi.org/10.3390/biomedicines12030472
Available online: https://www.mdpi.com/2227-9059/12/3/472

3. “Design of Alginate/Gelatin Hydrogels for Biomedical Applications: Fine-Tuning Osteogenesis in Dental Pulp Stem Cells While Preserving Other Cell Behaviors”
by Zied Ferjaoui, Roberto López-Muñoz, Soheil Akbari, Fatiha Chandad, Diego Mantovani, Mahmoud Rouabhia and Roberto D. Fanganiello
Biomedicines 2024, 12(7), 1510; https://doi.org/10.3390/biomedicines12071510
Available online: https://www.mdpi.com/2227-9059/12/7/1510

4. “Improving Surgical Scene Semantic Segmentation through a Deep Learning Architecture with Attention to Class Imbalance”
by Claudio Urrea, Yainet Garcia-Garcia and John Kern
Biomedicines 2024, 12(6), 1309; https://doi.org/10.3390/biomedicines12061309
Available online: https://www.mdpi.com/2227-9059/12/6/1309

5. “A Combined Computational and Experimental Analysis of PLA and PCL Hybrid Nanocomposites 3D Printed Scaffolds for Bone Regeneration”
by Spyros V. Kallivokas, Lykourgos C. Kontaxis, Spyridon Psarras, Maria Roumpi, Ourania Ntousi, Ioannis Kakkos, Despina Deligianni, George K. Matsopoulos, Dimitrios I. Fotiadis and Vassilis Kostopoulos
Biomedicines 2024, 12(2), 261; https://doi.org/10.3390/biomedicines12020261
Available online: https://www.mdpi.com/2227-9059/12/2/261

6. “A Comprehensive Review of Muscle–Tendon Junction: Structure, Function, Injury and Repair”
by Siqi Tong, Yuzhi Sun, Baian Kuang, Mingyue Wang, Zhixuan Chen, Wei Zhang and Jialin Chen
Biomedicines 2024, 12(2), 423; https://doi.org/10.3390/biomedicines12020423
Available online: https://www.mdpi.com/2227-9059/12/2/423

7. “In Vivo Osteogenic and Angiogenic Properties of a 3D-Printed Isosorbide-Based Gyroid Scaffold Manufactured via Digital Light Processing”
by Fiona Verisqa, Jeong-Hui Park, Nandin Mandakhbayar, Jae-Ryung Cha, Linh Nguyen, Hae-Won Kim and Jonathan C. Knowles
Biomedicines 2024, 12(3), 609; https://doi.org/10.3390/biomedicines12030609
Available online: https://www.mdpi.com/2227-9059/12/3/609

8. “Proposal and Definition of an Intelligent Clinical Decision Support System Applied to the Prediction of Dyspnea after 12 Months of an Acute Episode of COVID-19”
by Manuel Casal-Guisande, Alberto Comesaña-Campos, Marta Núñez-Fernández, María Torres-Durán and Alberto Fernández-Villar
Biomedicines 2024, 12(4), 854; https://doi.org/10.3390/biomedicines12040854
Available online: https://www.mdpi.com/2227-9059/12/4/854

9. “Mechanical and Material Analysis of 3D-Printed Temporary Materials for Implant Reconstructions—A Pilot Study”
by Adam Nowicki, Karolina Osypko, Adam Kurzawa, Maciej Roszak, Karina Krawiec and Dariusz Pyka
Biomedicines 2024, 12(4), 870; https://doi.org/10.3390/biomedicines12040870
Available online: https://www.mdpi.com/2227-9059/12/4/870

10. “Machine Learning for COVID-19 Determination Using Surface-Enhanced Raman Spectroscopy”
by Tomasz R. Szymborski, Sylwia M. Berus, Ariadna B. Nowicka, Grzegorz Słowiński and Agnieszka Kamińska
Biomedicines 2024, 12(1), 167; https://doi.org/10.3390/biomedicines12010167
Available online: https://www.mdpi.com/2227-9059/12/1/167

To acknowledge the above authors’ excellent contributions, we are happy to provide a full waiver to each team of the above publications. We also would like to take this opportunity to thank all the research groups that have submitted to Biomedicines. We would appreciate it if you would circulate this document among your colleagues and network. Furthermore, the following opportunities for collaboration may be of interest to you:

Submitting a manuscript:
This Section is currently open for submissions. Papers may be submitted via the following link: 
https://www.mdpi.com/user/manuscripts/upload/?journal=biomedicines.

Joining the Volunteer Reviewer Board:
If you are an active researcher in the field of biomedicinal research and are interested in joining the Volunteer Reviewer Board of Biomedicines, please do not hesitate to submit your application via the following link: https://susy.mdpi.com/volunteer/profile/edit.

Biomedicines Editorial Office

2 July 2025
Biomedicines | Hot Papers in the “Neurobiology and Clinical Neuroscience” Section

This Section publishes reviews and original peer-reviewed papers of a high scientific level covering all aspects of the treatment of neurobiology and neurologic diseases. Topics include but are not limited to neurogenesis, neuroplasticity, neuropharmacology and neurotherapeutics, in vitro and in vivo responses to neurological diseases, identification of therapeutic targets, evaluation of diagnostic markers, and assessment of therapies for neurological disorders.

1. “The Orexin/Hypocretin System, the Peptidergic Regulator of Vigilance, Orchestrates Adaptation to Stress”
by Miklós Jászberényi, Balázs Thurzó, Zsolt Bagosi, László Vécsei and Masaru Tanaka
Biomedicines 2024, 12(2), 448; https://doi.org/10.3390/biomedicines12020448
Available online: https://www.mdpi.com/2227-9059/12/2/448

2. “Current and Future Applications of Arterial Spin Labeling MRI in Cerebral Arteriovenous Malformations”
by Matteo De Simone, Marco Maria Fontanella, Anis Choucha, Karl Schaller, Paolo Machi, Giuseppe Lanzino, Philippe Bijlenga, Felix T. Kurz, Karl-Olof Lövblad and Lucio De Maria
Biomedicines 2024, 12(4), 753; https://doi.org/10.3390/biomedicines12040753
Available online: https://www.mdpi.com/2227-9059/12/4/753

3. “Inflammation in the Peripheral Nervous System after Injury”
by Dandan Gu, Yiming Xia, Zihan Ding, Jiaxi Qian, Xi Gu, Huiyuan Bai, Maorong Jiang and Dengbing Yao
Biomedicines 2024, 12(6), 1256; https://doi.org/10.3390/biomedicines12061256
Available online: https://www.mdpi.com/2227-9059/12/6/1256

4. “Molecular Mechanisms of Ischemic Stroke: A Review Integrating Clinical Imaging and Therapeutic Perspectives”
by Sana Rehman, Arsalan Nadeem, Umar Akram, Abeer Sarwar, Ammara Quraishi, Hina Siddiqui, Muhammad Abdullah Javed Malik, Mehreen Nabi, Ihtisham Ul Haq, Andrew Cho et al.
Biomedicines 2024, 12(4), 812; https://doi.org/10.3390/biomedicines12040812
Available online: https://www.mdpi.com/2227-9059/12/4/812

5. “Traumatic Brain Injury and Neuromodulation Techniques in Rehabilitation: A Scoping Review”
by Andrea Calderone, Davide Cardile, Antonio Gangemi, Rosaria De Luca, Angelo Quartarone, Francesco Corallo and Rocco Salvatore Calabrò
Biomedicines 2024, 12(2), 438; https://doi.org/10.3390/biomedicines12020438
Available online: https://www.mdpi.com/2227-9059/12/2/438

6. “Pharmacogenetic Approaches in Personalized Medicine for Postoperative Pain Management”
by Maria Leonor Ferreira do Couto, Sara Fonseca and Daniel Humberto Pozza
Biomedicines 2024, 12(4), 729; https://doi.org/10.3390/biomedicines12040729
Available online: https://www.mdpi.com/2227-9059/12/4/729

7. “Neurotrauma—From Injury to Repair: Clinical Perspectives, Cellular Mechanisms and Promoting Regeneration of the Injured Brain and Spinal Cord”
by Andrew R. Stevens, Antonio Belli and Zubair Ahmed
Biomedicines 2024, 12(3), 643; https://doi.org/10.3390/biomedicines12030643
Available online: https://www.mdpi.com/2227-9059/12/3/643

8. “Role of Microbiota-Derived Hydrogen Sulfide (H2S) in Modulating the Gut–Brain Axis: Implications for Alzheimer’s and Parkinson’s Disease Pathogenesis”
by Constantin Munteanu, Gelu Onose, Mariana Rotariu, Mădălina Poștaru, Marius Turnea and Anca Irina Galaction
Biomedicines 2024, 12(12), 2670; https://doi.org/10.3390/biomedicines12122670
Available online: https://www.mdpi.com/2227-9059/12/12/2670

9. “Diabetic Neuropathic Pain: Directions for Exploring Treatments”
by Yuchen Chen and Xue-Jun Song
Biomedicines 2024, 12(3), 589; https://doi.org/10.3390/biomedicines12030589
Available online: https://www.mdpi.com/2227-9059/12/3/589

10. “Transcutaneous Auricular Vagus Nerve Stimulation to Improve Emotional State”
by Ainara Aranberri Ruiz
Biomedicines 2024, 12(2), 407; https://doi.org/10.3390/biomedicines12020407
Available online: https://www.mdpi.com/2227-9059/12/2/407

To acknowledge the above authors’ excellent contributions, we are happy to provide a full waiver to each team of the above publications. We also would like to take this opportunity to thank all the research groups that have submitted to Biomedicines (ISSN: 2227-9059). We would appreciate it if you would circulate this document among your colleagues and network. Furthermore, the following opportunities for collaboration may be of interest to you:

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