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Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cellular and Molecular Mechanisms in Gastrointestinal Tract Disease: 2nd Edition

edited by Felipe Leite De Oliveira

submission deadline 29 Apr 2026 | 3 articles | Viewed by 2376 | Submission Open

Keywords: cellular mechanisms; molecular mechanisms; diagnosis; treatment; experimental models; signaling pathways; comorbidities

(This special issue belongs to the Section Cell Biology and Pathology)

Women’s Special Issue Series: Biomedicines (2nd Edition)

edited by

Letizia Polito

Federica Falà

and

Riuko Ohashi

submission deadline 30 Apr 2026 | 8 articles | Viewed by 31047 | Submission Open

Keywords: antibody; biomedicines; biopharmaceutical products; cancer therapy; drug delivery; immunoconjugates; immunotoxins; immunotherapy; immunotargeting; nanodelivery; toxins

(This special issue belongs to the Section Molecular and Translational Medicine)

Advances in Fetal Medicine and Neonatology

edited by

Robert Brawura-Biskupski-Samaha

submission deadline 30 Apr 2026 | 10 articles | Viewed by 24997 | Submission Open

Keywords: fetal medicine; neonatology; research innovations; perinatal care; clinical practices

(This special issue belongs to the Section Molecular and Translational Medicine)

Head and Neck Tumors, 4th Edition

edited by

Silvia Di Agostino

and

Jan B. Vermorken

submission deadline 30 Apr 2026 | 7 articles | Viewed by 20253 | Submission Open

Keywords: head and neck tumors; predictive markers; liquid biopsy; therapy; precision medicine; biomaterials

(This special issue belongs to the Section Cancer Biology and Oncology)

Neurodevelopmental Disorders: From Pathophysiology to Novel Therapeutic Approaches—2nd Edition

edited by Nader Perroud and Markus Mathaus Kosel

submission deadline 30 Apr 2026 | 5 articles | Viewed by 16605 | Submission Open

Keywords: intellectual disability; autism spectrum disorder; attention-deficit/hyperactivity disorder; drug treatment; neuroimaging

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Thyroid Disorders: Current Status and Future Prospects

edited by Anna Małgorzata Kucharska

submission deadline 30 Apr 2026 | 3 articles | Viewed by 11513 | Submission Open

Keywords: thyroid diseases; autoimmune thyroid diseases; hypothyroidism; hyperthyroidism; treatment; children; adults

(This special issue belongs to the Section Molecular and Translational Medicine)

Biomedicine in Dental and Oral Rehabilitation

edited by

Sanda Mihaela Popescu

and

Mihaela Ionescu

submission deadline 30 Apr 2026 | 6 articles | Viewed by 8792 | Submission Open

Keywords: diagnosis; treatment; oral rehabilitation; dental and oral disease; biomedicine; biomaterial; regeneration; functional; esthetics

(This special issue belongs to the Section Biomedical Engineering and Materials)

Gastrointestinal Diseases: From Pathophysiology to Innovative Therapeutic Approaches

edited by

Francisco Tustumi

submission deadline 30 Apr 2026 | 7 articles | Viewed by 6838 | Submission Open

Keywords: gastrointestinal diseases; pathophysiology; microbiome; inflammation; gastrointestinal cancer; translational medicine; therapeutic innovation; personalized treatment

(This special issue belongs to the Section Molecular and Translational Medicine)

Role of Endothelial Cells in Cardiovascular Disease—2nd Edition

edited by

Lorenzo Falsetti

and

Vincenzo Zaccone

submission deadline 30 Apr 2026 | 2 articles | Viewed by 5908 | Submission Open

Keywords: endothelial cells; endothelial dysfunction; cardiovascular disease; endothelial progenitor cells; atherosclerosis; thrombosis; vessel inflammation; regenerative medicine

(This special issue belongs to the Section Cell Biology and Pathology)

Advanced Research in Metabolic Syndrome (2nd Edition)

edited by

Balazs Varga

submission deadline 30 Apr 2026 | 3 articles | Viewed by 5273 | Submission Open

Keywords: obesity; diabetes; dyslipidemia; hypertension; microcirculatory damage; ischemia– reperfusion; necro-apopto-autophagy; laboratory animals; bioactive agents

(This special issue belongs to the Section Cell Biology and Pathology)

Advances in Stroke Neuroprotection and Repair

edited by

Konstantinos Tsamakis

submission deadline 30 Apr 2026 | 3 articles | Viewed by 4610 | Submission Open

Keywords: stroke; cerebral infarction; neuronal damage; neural regeneration; neuroprotection

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Unraveling New Horizon in Vascular Diseases: From Pathophysiology to Novel Therapeutic

edited by Miguel A. Ortega and

Raul Diaz-Pedrero

submission deadline 30 Apr 2026 | 2 articles | Viewed by 3939 | Submission Open

Keywords: vascular diseases; artery; venous disease; venous hypertension; heart; lymph; diabetes; surgery; immune system; translational medicine

(This special issue belongs to the Section Molecular and Translational Medicine)

Biomaterials for Bone Regeneration: 2nd Edition

edited by

Kyeong-Hyeon Park

submission deadline 30 Apr 2026 | 3 articles | Viewed by 3789 | Submission Open

Keywords: bone regeneration; bone defect; induced membrane technique; bone transport; biomaterials

(This special issue belongs to the Section Biomedical Engineering and Materials)

Advances in Periodontal Disease and Systemic Disease

edited by

Hye-Sun Shin

submission deadline 30 Apr 2026 | 3 articles | Viewed by 3120 | Submission Open

Keywords: periodontal disease; systemic health; inflammation; oral microbiome; cardiovascular disease; diabetes; cancer; oral– gut– brain axis; precision medicine; biomarkers

(This special issue belongs to the Section Molecular and Translational Medicine)

New Perspectives in the Treatment of Head and Neck Vascular Malformations

edited by Paolo Gennaro

submission deadline 30 Apr 2026 | 1 articles | Viewed by 2891 | Submission Open

Keywords: vascular anomalies; vascular malformations; AVMs; venous malformations; electrosclerotherapy

(This special issue belongs to the Section Molecular and Translational Medicine)

Integrative Roles of Natural Products in Cancer Treatment and Chronic Inflammatory Disease

edited by

Seungho Baek

submission deadline 30 Apr 2026 | 4 articles | Viewed by 2819 | Submission Open

Keywords: natural products; cancer; chronic inflammatory diseases; therapy; oxidative stress

(This special issue belongs to the Section Molecular and Translational Medicine)

Mechanisms and Novel Therapeutic Approaches for Gliomas: 2nd Edition

edited by Maria V. Chatziathanasiadou

submission deadline 30 Apr 2026 | 2 articles | Viewed by 2625 | Submission Open

Keywords: glioma; molecular mechanisms; tumour immunity; tumour metabolism; tumour microenvironment; metabolic therapies; immunotherapies; combination treatment

(This special issue belongs to the Section Cancer Biology and Oncology)

Mechanobiology and Extracellular Vesicle-Based Strategies for Osteochondral Regeneration

edited by Zhen Yang

submission deadline 30 Apr 2026 | 2 articles | Viewed by 2625 | Submission Open

Keywords: biomechanics; stem cells; osteoarthritis; tissue engineering; extracellular vesicles

(This special issue belongs to the Section Biomedical Engineering and Materials)

Modern Applications of Advanced Imaging to Neurological Disease

edited by Manisha Koneru and

Hamza Adel Salim

submission deadline 30 Apr 2026 | 3 articles | Viewed by 2622 | Submission Open

Keywords: neuroimaging; cerebrovascular disease; neuro-oncology; compted tomography; magnetic resonance imaging; patient outcomes; neurosciences; neuroradiology

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Epigenetic Regulation of Kidney Development

edited by Hongbing Liu

submission deadline 30 Apr 2026 | 1 articles | Viewed by 2474 | Submission Open

Keywords: epigenetic regulation; kidney development; gene expression patterns; targeted therapeutic strategies; epigenetic regulation of kidney development

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

Molecular and Cellular Mechanisms of Cardiovascular Diseases: 2nd Edition

edited by

Antonella Galeone

submission deadline 30 Apr 2026 | 3 articles | Viewed by 2437 | Submission Open

Keywords: hypertension; diabetes; coronary heart disease; valvular heart disease; infective endocarditis; aortic dissection; aortic aneurysm; heart failure; cardiomyopathy

(This special issue belongs to the Section Molecular and Translational Medicine)

Pathogenesis, Diagnosis and Treatment of Melanoma

edited by Vijayasteltar B. Liju

submission deadline 30 Apr 2026 | 2 articles | Viewed by 2129 | Submission Open

Keywords: melanoma; metastasis; targeted therapies; immunotherapy; tumor microenvironment; combination therapies; molecular pathways

(This special issue belongs to the Section Molecular and Translational Medicine)

Heart Failure: New Diagnostic and Therapeutic Approaches, 2nd Edition

edited by

Anand Prakash Singh

submission deadline 30 Apr 2026 | 2 articles | Viewed by 2051 | Submission Open

Keywords: heart failure; clinical treatment; basic cardiac research; future perspective; heart failure therapy; cardiotoxicity

(This special issue belongs to the Section Molecular and Translational Medicine)

Emerging Trends in Kidney Disease (2nd Edition)

edited by Andrea Angioi

submission deadline 30 Apr 2026 | 2 articles | Viewed by 1813 | Submission Open

Keywords: kidney disease; glomerular diseases; vasculitis; dialysis; hypertension; pediatric nephrology; transplantation; precision medicine; therapeutic advancements

(This special issue belongs to the Section Molecular and Translational Medicine)

Decoding Colorectal Cancer: Innovations in Biomarkers, Microbiota, and Therapeutic Resistance

edited by

Yinghao Cao

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1797 | Submission Open

Keywords: colorectal cancer; tumor biomarkers; nanomaterials; drug delivery; microbiome– tumor interaction; therapeutic resistance; exosomes; tumor microenvironment; prognostic model; neoadjuvant therapy; conversion therapy

(This special issue belongs to the Section Cancer Biology and Oncology)

Selected Papers from the Tanawwo Workshop on Clinical Research in Precision Medicine, Rare Diseases, and Pharmacogenomics (Doha, Qatar, 2025)

edited by

Felipe Fregni

and Radja Messai Badji

submission deadline 30 Apr 2026 | 2 articles | Viewed by 1716 | Submission Open

Keywords: precision medicine; rare diseases; pharmacogenomics; adaptive and platform trials; multi-omics integration; artificial intelligence in clinical research; big data and digital health; translational medicine

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Advances in Skin Tumors: From Pathogenesis to Treatment Strategies

edited by Zhongxin Yu and Sepideh Nikki Asadbeigi

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1710 | Submission Open

Keywords: melanoma skin; tumor epigenetic alterations; genetic mutations; tumor microenvironment immunotherapy; targeted therapy; nanomedicine

(This special issue belongs to the Section Cancer Biology and Oncology)

Recent Advances in Hypertension, Hypercholesterolemia and Type 2 Diabetes—2nd Edition

edited by

Tomislav Bulum

submission deadline 30 Apr 2026 | 3 articles | Viewed by 1640 | Submission Open

Keywords: type 2 diabetes; hypertension; LDL-cholesterol; serum lipids; metabolic syndrome; cardiovascular disease; chronic complications; nephropathy

(This special issue belongs to the Section Endocrinology and Metabolism Research)

New Advances in Neuropharmacology

edited by

Yu-Cheng Ho

and

Ming Tatt Lee

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1593 | Submission Open

Keywords: behavioral neuropharmacology; molecular neuropharmacology; neuropharmacology; neurological disorders; neurodegenerative diseases

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

The Brain–Body Interplay in Pain, Anesthesia, and Oncology

edited by

Hui Xu

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1588 | Submission Open

Keywords: brain– body axis; neuroimmune communication; microbiome– gut– brain axis; nociception; anesthetic outcomes; cancer biology

(This special issue belongs to the Section Molecular and Translational Medicine)

New Advances in Oral Pathology and Medicine

edited by

Christian Bacci

submission deadline 30 Apr 2026 | 2 articles | Viewed by 1581 | Submission Open

Keywords: molecular diagnostics; imaging technologies; artificial intelligence; targeted therapies; regenerative medicine

(This special issue belongs to the Section Molecular and Translational Medicine)

From Pathogenesis to Therapies: Innovations in Kidney Disease

edited by

Tao Qiu

Jiefu Zhu

and Chenglin Wu

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1438 | Submission Open

Keywords: renal ischemia-reperfusion injury; acute kidney injury; renal fibrosis; chronic kidney disease; ureteral obstructive nephropathy; kidney transplantation; macrophage-myofibroblast transition; inflammation; fibroblast activation; chronic allograft rejection; potential therapy

(This special issue belongs to the Section Molecular and Translational Medicine)

Digestive Disorders: Translation and Bridging the Gap Between Research, Diagnosis, and Treatment (2nd Edition)

edited by Goran Poropat and Goran Hauser

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1410 | Submission Open

Keywords: acute pancreatitis; clinical nutrition; metabolic disorders; NAFLD; obesity; DGBA; gut microbiota

(This special issue belongs to the Section Molecular and Translational Medicine)

Gynecological Cancers: Progress and Challenges

edited by

Yi-Fen Chiang

submission deadline 30 Apr 2026 | 2 articles | Viewed by 1364 | Submission Open

Keywords: gynecological cancer; therapeutic targets; precision medicine; immunotherapy; drug resistance; biomarkers; molecular mechanisms; natural compound; translational research; adjuvant therapy

(This special issue belongs to the Section Cancer Biology and Oncology)

Isoflavones as Therapeutic Leads: From Natural Sources to Mechanisms and Translational

edited by

Bruno Kaufmann Robbs

and

Lucas Silva Abreu

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1151 | Submission Open

Keywords: isoflavones; phytoestrogens; natural bioactive compounds; mechanisms of action; translational medicine; therapeutic development; drug discovery

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Innovative Approaches in Drug Discovery

edited by Jitendra Gour

submission deadline 30 Apr 2026 | Viewed by 954 | Submission Open

Keywords: PROTACs; molecular glue; personalized medicine; high-throughput screening (HTS); targeted therapy; drug repurposing; safety profiles

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Advances in Chronic Obstructive Pulmonary Disease (COPD)

edited by Fabio Manzo and

Pasquale Ambrosino

submission deadline 30 Apr 2026 | 1 articles | Viewed by 939 | Submission Open

Keywords: chronic obstructive pulmonary disease; COPD; emphysema; chronic bronchitis; chronic disease; disability; rehabilitation

(This special issue belongs to the Section Cell Biology and Pathology)

Oxidative Stress, Inflammation and Endothelial Dysfunction in COVID-19 Era and Long COVID-19 Complications

edited by

Ekaterina Georgieva

submission deadline 30 Apr 2026 | 1 articles | Viewed by 934 | Submission Open

Keywords: oxidative stress; redox-disbalance; COVID-19; post-COVID-19; cytokines; mitochondrial dysfunction; endothelial damages; ROS and RNS; thrombosis; antioxidant therapy; oxidative shock

(This special issue belongs to the Section Molecular and Translational Medicine)

Innovative Therapeutic Strategies and Molecular Mechanisms in Breast Cancer

edited by

Oana Gabriela Trifanescu

and

Laurentia Nicoleta Gales

submission deadline 30 Apr 2026 | 1 articles | Viewed by 913 | Submission Open

Keywords: breast cancer; immunotherapy; medical imaging; biomarkers; translational research

(This special issue belongs to the Section Cancer Biology and Oncology)

Targeted Biologic Therapies for Allergic Conditions: From Bench to Bedside

edited by

Antonio Francesco Maria Giuliano

and Maria Teresa Ventura

submission deadline 30 Apr 2026 | 1 articles | Viewed by 843 | Submission Open

Keywords: biologics; allergic disease; atopic dermatitis; allergic rhinitis; asthma; precision medicine; biomarkers; immunotherapy

(This special issue belongs to the Section Immunology and Immunotherapy)

Advancements in Understanding and Treating Oral Pathologies: From Dry Mouth to Oral Cancer—2nd Edition

edited by Eleni Georgakopoulou and George Laskaris

submission deadline 30 Apr 2026 | 1 articles | Viewed by 840 | Submission Open

Keywords: oral pathologies; oral diseases; pathogenesis; therapeutic interventions; interdisciplinary nature of oral healthcare; xerostomia; dysgeusia; oral cancer; precancerous lesions; oral inflammatory conditions

(This special issue belongs to the Section Cell Biology and Pathology)

Alzheimer's Disease: Pathogenesis, Diagnostics and Novel Treatment Options

edited by

Rui Zhong

and Ling Li

submission deadline 30 Apr 2026 | 1 articles | Viewed by 837 | Submission Open

Keywords: amyloid and tau pathology; neuroinflammation and oxidative stress; neuromodulation; fluid biomarkers; imaging and other diagnostic approaches; small-molecule therapeutics; novel therapeutics and emerging therapies; disease-modifying therapies; experimental and clinical pharmacology

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

New Advances in Cardiovascular Drugs: In Memory of Professor Akira Endo (2nd Edition)

edited by

Alfredo Caturano

submission deadline 30 Apr 2026 | 1 articles | Viewed by 805 | Submission Open

Keywords: cardiovascular drugs; statins; metformin; SGLT2i; laboratory; drug targets; translational research; targeted therapy

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Expanding Opioid Receptor Pharmacology: From Pain Control to Novel Therapeutic Applications in Neurobiology, Immunology, and Psychiatry

edited by

Luca Gentilucci

submission deadline 30 Apr 2026 | 1 articles | Viewed by 751 | Submission Open

Keywords: opioid; pain; mood; stress; addiction; neuropeptides

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

State-of-the-Art Drug Discovery and Development in Poland (3rd Edition)

edited by

Aleksandra Romaniuk-Drapała

submission deadline 30 Apr 2026 | 1 articles | Viewed by 693 | Submission Open

Keywords: in silico drug target profiling; drug delivery systems; drug– drug interaction; target-based screening; phenotypic screening; pharmaceutical modeling; computational chemistry; targeted therapy; biomarkers; bioimaging

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Selective Glucocorticoid Receptor Agonists and Modulators (SEGRAMs)

edited by

Dimitra Mitsiou

submission deadline 30 Apr 2026 | Viewed by 648 | Submission Open

Keywords: glucocorticoid receptor; glucocorticoids; transactivation; transrepression; selective glucocorticoid receptor agonists; selective glucocorticoid receptor modulators; inflammation; anti-inflammatory action; side effects; therapeutic potential

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Personalized Diagnosis and Therapy in Endocrinology and Gynecology

edited by

Sarah Allegra

submission deadline 30 Apr 2026 | 1 articles | Viewed by 610 | Submission Open

Keywords: personalized medicine; endocrine disorders; gynecological diseases; reproductive endocrinology; pharmacogenomics; hormonal therapy; polycystic ovary syndrome (PCOS); precision medicine; biomarkers; women’ s health

(This special issue belongs to the Section Molecular and Translational Medicine)

Post Tuberculosis Lung Disease from Lung Damage to the Loss of Lung Function

edited by

Oana Cristina Arghir

and Ariadna Petronela Fildan

submission deadline 30 Apr 2026 | Viewed by 507 | Submission Open

Keywords: post-tuberculosis lung disease (PTLD); post-TB conditions; TB sequelae; obstructive post-TB disease; post-TB syndromes

(This special issue belongs to the Section Molecular and Translational Medicine)

Diabetic Nephropathy and Diabetic Atherosclerosis (2nd Edition)

edited by

Satyesh K. Sinha

submission deadline 30 Apr 2026 | 1 articles | Viewed by 497 | Submission Open

Keywords: diabetic nephropathy; diabetic atherosclerosis; diabetes; inflammation; oxidative stress; renal and vascular cell dysfunction; basic science; clinical practice; patient outcomes

(This special issue belongs to the Section Molecular and Translational Medicine)

Bone Diseases: Pathophysiology and Molecular Biology

edited by