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Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Innovative Therapies for Neurodegenerative Diseases

edited by

Rosa María Giráldez-Pérez

, María Victoria Naval,

Javier Garcia-Pardo

and

Maria João Ramalho

submission deadline 10 May 2026 | 1 articles | Viewed by 2323 | Submission Open

Keywords: nanotechnology-based therapies; cellular and regenerative therapies; stem cell therapy; gene therapy and RNA interference; protein aggregation inhibitors; neuroinflammation modulators; mitochondrial dysfunction-targeted drugs; preclinical and clinical trials

(This special issue belongs to the Section Gene and Cell Therapy)

“The Power of Light” in Biomedical and Pharmaceutics: New Approaches for Photodynamic Purposes

edited by

Lucinda V. Reis

and

Eurico Lima

submission deadline 20 May 2026 | Viewed by 439 | Submission Open

Keywords: light; photosensitizers; photochemistry; photobiology; photodynamic therapy

(This special issue belongs to the Section Molecular and Translational Medicine)

Feature Reviews in Gastrointestinal and Liver Diseases

edited by

Agata Michalak

submission deadline 30 May 2026 | Viewed by 408 | Submission Open

Keywords: gastrointestinal diseases; gut– brain interaction; gut microbiota; inflammatory bowel disease; liver disorders; Crohn’ s disease; cancer; fatty liver disease; malnutrition

(This special issue belongs to the Section Molecular and Translational Medicine)

State-of-the-Art Molecular and Translational Medicine in Poland, 3rd Edition

edited by

Małgorzata Wrzosek

and

Arkadiusz Kocur

submission deadline 31 May 2026 | 7 articles | Viewed by 28512 | Submission Open

Keywords: molecular medicine; molecular mechanisms; disease pathogenesis; genetic variants; gene expression; epigenetics; metabolic disorders; cancer

(This special issue belongs to the Section Molecular and Translational Medicine)

Cell Signaling and Molecular Regulation in Neurodegenerative Disease

edited by Shao-Ming Wang

submission deadline 31 May 2026 | 2 articles | Viewed by 19100 | Submission Open

Keywords: neurological diseases; gene regulation; molecular neurobiology; neurodegenerative disease

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Progress in Neonatal Pulmonary Biology

edited by

Fumihiko Namba

submission deadline 31 May 2026 | 5 articles | Viewed by 18547 | Submission Open

Keywords: neonate; preterm infant; bronchopulmonary dysplasia; animal model; in vivo model; in vitro model; basic research; translational research; respiratory outcome; neurodevelopmental outcome

(This special issue belongs to the Section Molecular and Translational Medicine)

Synaptic Function and Modulation in Health and Disease

edited by Jean-Marie C. Bouteiller

submission deadline 31 May 2026 | 4 articles | Viewed by 17503 | Submission Open

Keywords: synaptic function; synaptic plasticity; neurotransmitter release; receptor dynamics

(This special issue belongs to the Section Molecular and Translational Medicine)

Molecular Research in Obesity, 2nd Edition

edited by Zaida Abad-Jiménez and

Teresa Vezza

submission deadline 31 May 2026 | 3 articles | Viewed by 17431 | Submission Open

Keywords: obesity; genetics; molecular pathways; adipose tissue; metabolism; leukocytes; prevention; new targets for treatment; translational studies

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Advanced Cancer Diagnosis and Treatment: Third Edition

edited by

Takaaki Hirotsu

and Hideshi Ishii

submission deadline 31 May 2026 | 5 articles | Viewed by 16351 | Submission Open

Keywords: cancer biology; epigenetics; early detection; diagnosis; biodiagnosis; novel therapeutics; new paradigms

(This special issue belongs to the Section Cancer Biology and Oncology)

Organoid, Organ-on-Chip and Advanced 2D/3D Models for Human Tissue Engineering Applications

edited by

Ahmad Salti

submission deadline 31 May 2026 | 7 articles | Viewed by 15115 | Submission Open

Keywords: organoid; organ-on-chip; 2D/3D model; tissue engineering; induced pluripotent stem cells; in vitro model

(This special issue belongs to the Section Biomedical Engineering and Materials)

Vitamin D: Latest Scientific Discoveries in Health and Disease

edited by

Mohamed Abouzid

submission deadline 31 May 2026 | 5 articles | Viewed by 14471 | Submission Open

Keywords: vitamin D; vitamin D metabolites; metabolic pathways; vitamin D receptor; polymorphisms; pathogenesis; vitamin D deficiency

(This special issue belongs to the Section Endocrinology and Metabolism Research)

The Role of NK Cells in Cancer Immunotherapy: Mechanisms, Evasion Strategies, and Therapeutic Advances

edited by Maria Eugenia Garcia Rubino

submission deadline 31 May 2026 | 1 articles | Viewed by 13790 | Submission Open

Keywords: NK cells; cancer immunotherapy; tumor evasion; cytotoxicity; CAR-NK; cytokines; IL-2; immunotherapy; tumor microenvironment

(This special issue belongs to the Section Cancer Biology and Oncology)

Skin Diseases: From Molecular Mechanisms to Novel Therapeutic Approaches

edited by

Guangtong Deng

submission deadline 31 May 2026 | 6 articles | Viewed by 13205 | Submission Open

Keywords: skin diseases; cell death; ferroptosis; cuproptosis; melanoma; cancer immunotherapy; psoriasis

(This special issue belongs to the Section Molecular and Translational Medicine)

Advances in Pathogenesis and Therapeutics of Gastrointestinal Diseases

edited by

Jinghua Wang

submission deadline 31 May 2026 | 9 articles | Viewed by 12920 | Submission Open

Keywords: gastrointestinal diseases; IBD; IBS; GERD; functional dyspepsia; gut microbiome

(This special issue belongs to the Section Molecular and Translational Medicine)

Advanced Research on Nanomedicine

edited by

Rongcheng Han

submission deadline 31 May 2026 | 3 articles | Viewed by 12531 | Submission Open

Keywords: multifunctional nanomaterials; nanomedicine; tumor; theranostics; artificial intelligence (AI); immunotherapy

(This special issue belongs to the Section Biomedical Engineering and Materials)

Animal Models for Neurological Disease Research

edited by

Sreeja Sarasamma

submission deadline 31 May 2026 | 6 articles | Viewed by 12450 | Submission Open

Keywords: animal models; neurological diseases; genetic models; CRISPR/Cas9; transgenic organisms; behavioral analysis; neurodegeneration; single-cell approaches; zebrafish; lamprey; biocomputational approaches; gene therapy; pharmacological interventions; translational neurobiology; disease pathways

(This special issue belongs to the Section Molecular and Translational Medicine)

Non-Invasive Brain Stimulation Techniques and Their Application in the Study of Cognitive Function Physiology and Neuro-Psychiatric Rehabilitation

edited by

Mattia Ferro

Jacopo Lamanna

and Andrea Stefano Moro

submission deadline 31 May 2026 | 8 articles | Viewed by 11443 | Submission Open

Keywords: non-invasive brain stimulation; neurophysiology; cognitive function; depression; schizophrenia

(This special issue belongs to the Section Molecular and Translational Medicine)

Mechanisms and Therapeutic Strategies of Brain and Spinal Cord Injury

edited by

Hatice Kumru

and Xabier Urra

submission deadline 31 May 2026 | 7 articles | Viewed by 11143 | Submission Open

Keywords: brain injury; spinal cord injury; stem cells; gene therapy; neuromodulation techniques

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Advances in Liver Oncology: Molecular Mechanisms and Therapeutic Innovations

edited by

Rui Caetano Oliveira

, Rui Miguel Martins and

José Guilherme Tralhão

submission deadline 31 May 2026 | 3 articles | Viewed by 9996 | Submission Open

Keywords: liver cancer; hepatocellular carcinoma; cholangiocarcinoma; liver metastases; tumor microenvironment; targeted therapy; immunotherapy; biomarkers; drug resistance

(This special issue belongs to the Section Cancer Biology and Oncology)

Molecular Regulation of Spermatozoa—Second Edition

edited by

Atefeh Najafi

submission deadline 31 May 2026 | 3 articles | Viewed by 8909 | Submission Open

Keywords: spermatogenesis; spermiogenesis; sperm; capacitation; acrosome reaction; hyperactivation; fertilization; male infertility; antioxidants; redox regulation

(This special issue belongs to the Section Cell Biology and Pathology)

Convergence of Allergology and Immunology: Unveiling Mechanistic Insights

edited by

Kinga Lis

submission deadline 31 May 2026 | 3 articles | Viewed by 8747 | Submission Open

Keywords: allergy; hypersensitivity; allergens; immunological mechanisms; immunological diagnostics; immunotherapy

(This special issue belongs to the Section Immunology and Immunotherapy)

State-of-the-Art Endocrine Cancer Biology and Oncology

edited by

Piotr Glinicki

submission deadline 31 May 2026 | 7 articles | Viewed by 8252 | Submission Open

Keywords: thyroid and parathyroid tumors; adrenal tumors (hormonally active and inactive; ACC); neuroendocrine tumors (NEN); pituitary neuroendocrine tumors (PiNETs)

(This special issue belongs to the Section Cancer Biology and Oncology)

The Human Proteinomics in Disease, Diagnostics and Translation into Precision Medicine: Current Status and Future Prospects—2nd Edition

edited by

M. Walid Qoronfleh

submission deadline 31 May 2026 | 4 articles | Viewed by 6703 | Submission Open

Keywords: proteomics; human proteome; systems biology; precision medicine; biomarker(s); disease pathogenesis; diagnostics; mass spectrometry; tandem mass spectrometry; LC-MS/MS; peptides and proteins; multiplex protein analysis; protein network; protein– protein interaction; splice variants; post-translational modifications; omics analysis; data integration; bioinformatics; artificial intelligence; deep learning

(This special issue belongs to the Section Molecular and Translational Medicine)

Advanced Research in Anticancer Inhibitors and Targeted Therapy

edited by

Changmin Peng

and

Hassan Ebrahim

submission deadline 31 May 2026 | 5 articles | Viewed by 6213 | Submission Open

Keywords: histone deacetylases (HDACs); YAP signaling; targeted therapy; oncogenic signaling; biomarker discovery; small-molecule inhibitors; cancer drug resistance; epigenetic therapy

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Biomedical Devices—Applications for Disease Treatment and Tissue Regeneration

edited by Eleni Papachristou

submission deadline 31 May 2026 | 2 articles | Viewed by 6155 | Submission Open

Keywords: biomedical devices; mesenchymal stem cell; biomedical applications; Tissue engineering

(This special issue belongs to the Section Biomedical Engineering and Materials)

Advances in the Pathogenesis and Treatment of Heart Failure and Cardiomyopathy

edited by

Andrey Jorge Serra

, Ednei Luiz Antonio, Gianna Móes de Albuquerque-Pontes and Luis Felipe Neves dos Santos

submission deadline 31 May 2026 | 4 articles | Viewed by 5802 | Submission Open

Keywords: cardiomyopathy; cardiac remodeling; heart disease; heart failure; mechanisms; new therapies; targeted therapies

(This special issue belongs to the Section Molecular and Translational Medicine)

Spinal Muscular Atrophy: Pathogenesis, Diagnosis, Therapeutics and Future Directions

edited by

Dinko Vitezić

Andrej Belančić

and Valentino Rački

submission deadline 31 May 2026 | 1 articles | Viewed by 5459 | Submission Open

Keywords: genetic diseases; neuromuscular disorders; rare diseases; spinal muscular atrophy; survival motor neuron protein

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

New Molecular Insights into the Pathogenesis and Drug Development of Neurodegenerative Diseases: 2nd Edition

edited by Aifang Cheng, Beika Zhu and Fulin Ma

submission deadline 31 May 2026 | 2 articles | Viewed by 5129 | Submission Open

Keywords: neurodegenerative diseases; pathogenesis; molecular mechanisms; high-throughput drug screening; drug repurposing; cellular and animal models; brain organoids; mode of action; pharmacological evaluations; preclinical study

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Osteoarthritis: Molecular Pathways and Novel Therapeutic Strategies—2nd Edition

edited by

Antonia Patruno

Teresa Paolucci

Mirko Pesce

and Andrea Pantalone

submission deadline 31 May 2026 | 2 articles | Viewed by 4530 | Submission Open

Keywords: osteoarthritis; cartilage; pain; orthopedics; rehabilitation

(This special issue belongs to the Section Molecular and Translational Medicine)

Updates on Tissue Repair and Regeneration Pathways

edited by

Cornel Baltă

and

Oana-Maria Boldura

submission deadline 31 May 2026 | 4 articles | Viewed by 4419 | Submission Open

Keywords: tissue repair; tissue regeneration; molecular pathways involved in repair and regeneration; extracellular matrix; drug delivery systems

(This special issue belongs to the Section Biomedical Engineering and Materials)

Pathogenesis and Targeted Therapy of Autoimmune Diseases

edited by

Marcella Prete

submission deadline 31 May 2026 | 1 articles | Viewed by 4278 | Submission Open

Keywords: autoimmune diseases; pathogenesis; targeted therapy

(This special issue belongs to the Section Molecular and Translational Medicine)

Unveiling the Genetic Architecture of Complex and Common Diseases

edited by

Mahmut Cerkez Ergoren

submission deadline 31 May 2026 | 3 articles | Viewed by 4258 | Submission Open

Keywords: polygenetic score; cardiovascular disorders; metabolic disorders; neurodegenerative disorders

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

Advanced Research into Adipose‐Derived Stem Cells

edited by

Anna Barbara Di Stefano

and Mara Franza

submission deadline 31 May 2026 | 2 articles | Viewed by 4001 | Submission Open

Keywords: adipose stem cells; regenerative medicine; stemness; differentiative potential; pre-clinical and clinical applications

(This special issue belongs to the Section Molecular and Translational Medicine)

Biological Role of Oxidative Stress in Inflammatory Processes

edited by

Magdalena Paulina Kasprzak

submission deadline 31 May 2026 | 1 articles | Viewed by 3565 | Submission Open

Keywords: oxidative stress; redox balance; antioxidants; NRF2; microbiota; bilirubin; Tlr4; inflammation

(This special issue belongs to the Section Cell Biology and Pathology)

Allergic Rhinitis: From Pathology to Novel Therapeutic Approaches

edited by

Shaoqing Yu

submission deadline 31 May 2026 | 3 articles | Viewed by 3531 | Submission Open

Keywords: allergic rhinitis; immunotherapy; immune mechanisms in allergy; rhinitis biomarkers

(This special issue belongs to the Section Immunology and Immunotherapy)

Gut–Brain Axis and Diabetes

edited by Nikolett Bódi

submission deadline 31 May 2026 | 1 articles | Viewed by 3504 | Submission Open

Keywords: diabetes; gut– brain axis; enteric nervous system; central nervous system; microbiota; enteroendocrine cells; inflammation; immune responses

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Prostate Cancer Pathology: Recent Advances and Future Perspectives

edited by

Kostis Gyftopoulos

submission deadline 31 May 2026 | 2 articles | Viewed by 3452 | Submission Open

Keywords: prostate cancer; pathology; digital pathology; Gleason grading; molecular biomarkers; precision medicine; molecular pathology; molecular profiling; therapy resistance

(This special issue belongs to the Section Cancer Biology and Oncology)

Immunotherapy and Targeted Treatment in Solid Tumors: Biomarkers and Novel Therapeutic Strategies

edited by

Dana Lucia Stănculeanu

and

Adelina Silvana Gheorghe

submission deadline 31 May 2026 | 3 articles | Viewed by 3360 | Submission Open

Keywords: immunotherapy; targeted therapy; biomarkers; tumor microenvironment; molecular profiling; precision oncology; treatment resistance; solid tumors; translational oncology

(This special issue belongs to the Section Cancer Biology and Oncology)

Rheumatology Diseases: Advances in the Understanding of Pathogenesis, Biomarker Research and Treatment Target

edited by Russka Shumnalieva

submission deadline 31 May 2026 | 2 articles | Viewed by 3207 | Submission Open

Keywords: pathogenesis of rheumatic diseases; epigenetic modifications; biomarkers; new imaging modalities; therapeutic strategies; new treatment targets

(This special issue belongs to the Section Molecular and Translational Medicine)

Advances in Drug Discovery and Development: From Rational Design to Experimental Validation

edited by

Vikas Kumar

submission deadline 31 May 2026 | 2 articles | Viewed by 3177 | Submission Open

Keywords: drug discovery; drug development; rational drug design; molecular docking; virtual screening; pharmacophore modeling; molecular dynamics simulations; machine learning in drug discovery; deep learning in drug discovery; experimental validation; structure– activity relationship; bioactive compounds

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Advances in Pain Management: Exploring Molecular Mechanisms and Novel Therapies

edited by

Christopher Robinson

Samuel Ang

and Rodrigo Diez-Tafur

submission deadline 31 May 2026 | 3 articles | Viewed by 3169 | Submission Open

Keywords: chronic pain; neuroinflammation; sensory signaling; epigenetics; neuroimmune interactions; regenerative medicine; stem cells

(This special issue belongs to the Section Molecular and Translational Medicine)

Past, Present and Further Looking for Therapeutic Management of Pancreatic Ductal Adenocarcinoma (2nd Edition)

edited by

Gennaro Nappo

and

Niccola Funel

submission deadline 31 May 2026 | 2 articles | Viewed by 3121 | Submission Open

Keywords: pancreatic cancer; pancreatic ductal adenocarcinoma; treatment pancreatic cancer; chemotherapy pancreatic cancer; radiotherapy pancreatic cancer; pancreatic cancer biology; PDAC preclinical model; biomolecular markers; theragnostic molecules; target therapy

(This special issue belongs to the Section Cancer Biology and Oncology)

Unraveling the Epigenetic Blueprint: Exploring DNA Methylation and Its Integration with Omics in Health and Disease

edited by Priyadarshini Kachroo and Rinku Sharma

submission deadline 31 May 2026 | 2 articles | Viewed by 3023 | Submission Open

Keywords: multiomics; networks; epigenomics; machine learning; causation; early-life exposures; aging; translational therapeutics; metabolomics; epigenomics; exposomics; proteomics; microbiome

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

Dermatology: From Fundamental to Clinical Research

edited by

Piotr K. Krajewski

submission deadline 31 May 2026 | 2 articles | Viewed by 2885 | Submission Open

Keywords: dermatologic agents; skin diseases; translational research; signal transduction; immunity; biomarkers; precision medicine

(This special issue belongs to the Section Molecular and Translational Medicine)

Advances in Drug Discovery and Development Using Mass Spectrometry

edited by Emily G. Werth,

Amirata Saei Dibavar

and Lin-Zhi Chen

submission deadline 31 May 2026 | 1 articles | Viewed by 2736 | Submission Open

Keywords: LC/MS; proteomics; protein therapeutics; PTMs; immunocapture; CQAs

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Poly-Pharmacological Effects and Mechanisms of Phytochemicals

edited by

Jiawen Shou

submission deadline 31 May 2026 | 1 articles | Viewed by 2625 | Submission Open

Keywords: phytochemicals; natural products; poly-pharmacology; novel application; research updates on phytochemicals

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

New Trends in Cancer Immunotherapy

edited by Markella Zannikou

submission deadline 31 May 2026 | 1 articles | Viewed by 2311 | Submission Open

Keywords: tumor microenvironment; cancer vaccines; tumor-infiltrating lymphocytes; combination therapy; BITEs; checkpoint inhibitors; CAR T cell therapy; NK cells; antigen presenting cells; tumor associated antigens

(This special issue belongs to the Section Immunology and Immunotherapy)

Innovations in Kidney Disease: From Pathogenesis to Therapy

edited by

Yupei Li

submission deadline 31 May 2026 | 3 articles | Viewed by 2299 | Submission Open

Keywords: kidney disease pathogenesis; therapeutic innovations; biomarkers; precision medicine

(This special issue belongs to the Section Molecular and Translational Medicine)

Advances in Therapeutic Strategies and Precision Medicine in Solid Tumors and Metastasis—2nd Edition

edited by

Silvia Di Agostino

and

Vittoria Rago

submission deadline 31 May 2026 | 1 articles | Viewed by 2265 | Submission Open

Keywords: kinase inhibitor; immunotherapy; chemotherapy; precision molecular therapy; biomarkers; synthetic lethality; theranostics; drug repurposing; radiomics

(This special issue belongs to the Section Cancer Biology and Oncology)

New Advances in Immunology and Immunotherapy

edited by Narges Baluch

submission deadline 31 May 2026 | 1 articles | Viewed by 2065 | Submission Open

Keywords: immunology; immunotherapy; immune checkpoints; CAR/TCR cell therapy; mRNA vaccines

(This special issue belongs to the Section Immunology and Immunotherapy)

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