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Ensuring a sustainable source of nutritious food is critical for long-duration space missions. Thai landrace rice 466HM exhibits high nutritional value and stress resilience, making it a promising candidate for space cultivation, yet its response to...

Background: Type 2 diabetes mellitus (T2DM) is associated with increased vulnerability to depression and other affective disturbances, potentially mediated by neurobiological alterations in the serotonergic brainstem raphe nuclei. This study examined...

Sex differences in gut microbiota may affect health and aging, but evidence in elderly populations is limited and inconsistent. This study examined sex-specific similarities and differences in gut microbiota diversity and composition among apparently...

Developmental and epileptic encephalopathies (DEEs) represent the most severe group of epilepsies, characterized by drug-resistant seizures, frequent occurrence of epileptiform activity, developmental delay or cognitive impairment. Recent insights ha...

Idiopathic pulmonary fibrosis represents a chronic, progressive, lethal lung disease of various etiologies exerting a dramatic impact on patients’ survival and quality of life. Its increasing prevalence and high mortality rates indicate the imp...

The oral cavity contains a complex and dynamic microbial ecosystem that plays a central role in maintaining both local and systemic homeostasis. Emerging evidence indicates that disturbances in oral microbial communities-including genetic and functio...

Neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), and stroke, are among the most devastating neurological disorders worldwide. Glioblastoma (GBM) is a rapidly growing cancer that originates in astro...

Background: Inadvertent arterial cannulation during central venous catheter placement is a recognized complication with potentially serious consequences, particularly when involving large-caliber catheters. While management strategies have evolved fr...

Kidney disease is a growing global public health challenge that accounts for substantial morbidity, premature mortality, and rising healthcare costs. Although diabetes mellitus and hypertension remain the principal clinical risk factors for renal inj...

Background: The traditional A1-centric paradigm for trigger finger (TF) management does not fully capture heterogeneous pathology spanning isolated pulley stenosis, tendon degeneration, and impaired tendon–sheath gliding. Methods: A comprehensi...

Dercum’s disease (DD) is a rare condition characterized by intense, asymmetrical, chronic burning pain localized in adipose tissue, often accompanied by subcutaneous fat nodules, leading to a significant reduction in quality of life. It typical...

Osteosarcoma is the most common primary malignant bone tumor, predominantly affecting adolescents and young adults. Survival outcomes vary widely, and previous studies have suggested differences in patient characteristics and disease patterns across...

Floccularia luteovirens is a rare and edible fungus endemic to the Qinghai–Tibet Plateau. Traditional viewpoints have inferred it to be a mycorrhizal fungus based on its spatial association with Kobresia, yet direct morphological evidence (e.g....

Plant defensin-like proteins, as the core effector molecules of innate immunity, play an important role in resistance against fungi and bacteria. However, their function in plant antiviral resistance remains unclear. Here, NbDLP, a defensin-like prot...

Identifying structurally similar ligand-binding sites in unrelated proteins can facilitate drug repurposing, reveal off-target effects, and deepen our understanding of protein function. A number of tools were developed for structural screening, but m...

Background/Objectives: Pancreatic cancer is one of the most lethal malignancies, with poor survival and few established modifiable risk factors. While Helicobacter pylori (H. pylori) infection is a known cause of gastric cancer, its role in pancreati...

Background: Local specific biomarkers for MASLD risk stratification are urgently needed in Argentina. Aim: The aim of the study was to characterize the interaction of gut microbiome signatures and genetic and clinical risk factors for MASLD in patien...

Objective: We aimed to characterize the somatic mutational landscape of oropharyngeal squamous cell carcinoma (OPSCC) and identify potential genomic drivers of tumor progression and therapeutic resistance using the AACR GENIE database. Study Design:...

Endothelial integrity is essential for cardiovascular health, and circulating endothelial progenitor cells, particularly endothelial colony-forming cells (ECFCs), are key contributors to vascular repair and maintenance. Long non-coding RNAs (lncRNAs)...

As human space exploration advances towards establishing sustainable Martian habitats, achieving autonomous food production is a critical requirement. The potato (Solanum tuberosum L.), with its notable environmental resilience and nutritional effici...

Background: Postoperative bladder drainage is commonly required following major pelvic or abdominal surgery. Existing evidence indicates substantial variation in urinary tract infection (UTI) risk across different catheterization methods. However, th...

Cardiac arrhythmias are prevalent complications in pregnancy, yet their precise association with acute maternal cardiovascular morbidity and mortality remains unclear due to heterogeneous evidence. This systematic review and meta-analysis evaluated t...

Acute kidney injury (AKI) is a systemic syndrome capable of inducing remote organ dysfunction. Kidney–lung crosstalk is a form of interorgan communication in acute nephrology, with the heart acting as a pivotal intermediary. Emerging evidence s...

Greenhouse gases emitted by humans have exacerbated global climate change. Forests can effectively sequester atmospheric carbon dioxide through photosynthesis, and afforestation has been widely adopted worldwide to mitigate climate change. Cunningham...

Background: Due to the congested competition calendar and the high physical demands of elite basketball, the selection of effective recovery strategies is essential to optimize performance and reduce exercise-induced fatigue and muscle damage. This p...

Background: The implantable miniature telescope is used to provide functional vision for patients with advanced AMD. However, despite the considerable cost of the device, there are strict criteria to be met for this procedure, since the patients requ...

Background/Objectives: Exercise-induced fatigue is a fundamental component of running performance and training, yet it is also implicated in altered movement mechanics and increased injury risk. While numerous studies have examined fatigue-related bi...

Ocimum (basil) is a globally significant medicinal and culinary herb. While its bioactive secondary metabolites are well-studied, the medicinal potential of its abundant primary metabolites (amino acids, vitamins, carbohydrates, steroids) remains lar...

Environmental exposures are increasingly recognized as important drivers of ocular surface inflammation, yet their combined contribution to the onset, exacerbation, and clinical burden of allergic conjunctivitis (AC) has not been comprehensively synt...

Objective: To synthesize current evidence on the relationships between adolescent idiopathic scoliosis (AIS), stress-related mechanisms, neuroanatomical asymmetry, and mental disorders, and to propose an integrative conceptual framework describing th...

Polyhydroxyalkanoates (PHAs) are microbial polyesters that belong to a group of bioplastics with the potential to replace petroleum-derived plastics. Their main drawback is the high production cost, which puts them at a disadvantage compared to conve...

Myocardial and vascular injury secondary to SARS-CoV-2 infection and vaccination has emerged as a clinically relevant phenomenon, with distinct but overlapping mechanisms. Myocardial injury in COVID-19 results from a complex interplay between direct...

In the original publication [...]

Neurodegenerative diseases, such as Parkinson’s and Alzheimer’s, are becoming an increasingly serious challenge for modern medicine because of the significant increase in incidence and the narrow range of effective therapeutic strategies....

This case report presents a three-month follow-up of a patient who self-administered Melanotan II injections over a period of 64 days with the goal of achieving a deeper tanning effect. Melanotan II is an unlicensed synthetic peptide analog belonging...

Water is essential for human life, and access to clean water is considered a basic human right by the United Nations. Around the world, a high proportion of the population still does not have access to safe fresh water, with high impact on health. Th...

Background/Objectives: Precise staging and tumor delineation are essential for optimizing treatment and enhancing outcomes of radiotherapy (RT). While computed tomography (CT)-based RT remains standard, fluorine-18-fluorodeoxyglucose positron emissio...

Osteoporosis develops silently and is strongly influenced by both genetic and environmental factors. This study investigated whether three well-established osteoporosis-related polymorphisms—SOST rs1513670, LRP5 rs3736228, and ESR1 rs6929137&md...

Lower-extremity peripherally inserted central catheters (PICCs) are used in critically ill adults when upper-extremity access is limited, yet real-world data on indications, dwell time, and device-related outcomes remain scarce. We retrospectively re...

Understanding interactions among sympatric mesocarnivore populations is essential for making sound management decisions. The golden jackal has rapidly expanded in Europe, raising questions about its potential intraguild effects. Using long-term hunti...

In the published article [...]

As humanity continues to strive for extraplanetary exploration, which is quickly gaining marked governmental and industrial support and recognition, there are still substantial detriments to astronaut health during long-duration spaceflight (i.e., mu...

Background: Motor as well as attentional skills are deficient in children with attention deficit hyperactivity disorder (ADHD). The aim of the present study was to explore whether a short immersive rehabilitation therapy could improve motor and visuo...

Background: Comparative real-world data on the pharmacokinetics of once-daily tacrolimus formulations in de novo kidney transplantation remain limited. We compared tacrolimus exposure and dosing requirements with Envarsus and Advagraf during the earl...

Transcription factors (TFs) are ubiquitously distributed in plants and play pivotal roles in regulating plant growth and development. The present study aims to elucidate the function of transcription factors (TFs) in highland barley’s response...

Metabolic dysfunction-associated steatotic liver disease (MASLD) is defined by hepatic steatosis in individuals with at least one cardiometabolic risk factor, most commonly type 2 diabetes mellitus (T2DM). People with non-alcoholic fatty liver diseas...

Background: Total sleep deprivation (TSD) negatively affects athletic performance by impairing mood, anaerobic performance, and decision-making in martial arts athletes. This study examined whether a 45 min nap can alleviate deficits in mood, anaerob...

In recent decades, the rate of kidney transplantation has risen significantly, leading to better outcomes in terms of cardiovascular and overall mortality for patients with kidney failure. Although kidney transplantation represents the most effective...

Petroleum contamination poses a serious threat to human health and ecosystems worldwide, and microbially driven natural attenuation is an effective approach for accelerating hydrocarbon removal. Species of the genus Rhodococcus are recognized for the...

Rapid detection of β-lactamase activity is becoming increasingly important as β-lactam resistance spreads at an alarming rate and conventional diagnostics often require several hours to deliver actionable results. Over the past decade, meth...