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Journal of Clinical Medicine, Volume 10, Issue 16

2021 August-2 - 311 articles

Cover Story: Myeloid-derived suppressor cells (MDSCs) are immature myeloid precursors which emerged as a potent regulator of the immune system, exerting suppressive properties in diverse disease settings. The contribution of MDSCs in immune regulation during hematologic malignancies and particularly in lymphomas is emerging. The figure depicts the main immune cell subsets and malignant cells that circulate in the blood of lymphoma patients (left side). The MDSC subsets and the respective mechanisms that have been described for MDSC-mediated suppression of antitumor immunity in different types of lymphomas are shown (right side). View this paper
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Articles (311)

  • Article
  • Open Access
10 Citations
5,095 Views
9 Pages

Susceptibility of β-Thalassemia Heterozygotes to COVID-19

  • Sotirios Sotiriou,
  • Athina A. Samara,
  • Dimitra Vamvakopoulou,
  • Konstantinos-Odysseas Vamvakopoulos and ,
  • Andreas Sidiropoulos,
  • Nikolaos Vamvakopoulos,
  • Michel B. Janho,
  • Konstantinos I. Gourgoulianis and
  • Styllianos Boutlas
  • + 4 authors+ 0 author

18 August 2021

Background: β-Thalassemia is the most prevalent single gene blood disorder, while the assessment of its susceptibility to coronavirus disease 2019 (COVID-19) warrants it a pressing biomedical priority. Methods: We studied 255 positive COVID-19 partic...

(This article belongs to the Collection Coronavirus Disease 2019: Clinical Presentation, Pathogenesis and Treatment)
  • Article
  • Open Access
23 Citations
5,277 Views
14 Pages

Effect of Early Peripheral Parenteral Nutrition Support in an Enhanced Recovery Program for Colorectal Cancer Surgery: A Randomized Open Trial

  • Luis Sánchez-Guillén,
  • Leticia Soriano-Irigaray,
  • Francisco López-Rodríguez-Arias,
  • Xavier Barber and ,
  • Ana Murcia,
  • M José Alcaide,
  • Verónica Aranaz-Ostáriz,
  • Álvaro Soler-Silva,
  • Andrés Navarro-Ruiz and
  • Antonio Arroyo
  • + 5 authors+ 0 author

18 August 2021

Background: Peripheral parenteral nutrition allows repletion of acute nutrient deficiencies and could prevent further nutrition deficits before and after colorectal surgery. A randomized open study was performed to evaluate the effect of perioperativ...

(This article belongs to the Special Issue Colorectal Surgery: Latest Advances and Prospects)
  • Article
  • Open Access
5 Citations
3,013 Views
8 Pages

18 August 2021

Purpose: To investigate the factors associated with an increase in the neuroretinal rim (NRR) thickness measured based on Bruch’s membrane opening-minimum rim width (BMO-MRW) after trabeculectomy in patients with primary open-angle glaucoma (POAG). M...

(This article belongs to the Special Issue Intraocular Pressure and Ocular Hypertension)
  • Article
  • Open Access
12 Citations
2,973 Views
9 Pages

Pain as Defining Feature of Health Status and Prominent Therapeutic Target in Patients with Hidradenitis Suppurativa

  • Francesca Sampogna,
  • Irene Campana,
  • Luca Fania,
  • Simona Mastroeni and ,
  • Roberta Fusari,
  • Davide Ciccone,
  • Sabatino Pallotta and
  • Damiano Abeni
  • + 3 authors+ 0 author

18 August 2021

Background. Pain is one of the main aspects of hidradenitis suppurativa that strongly affects the quality of life of patients. We explored the relationship between pain and clinical severity as well as its role in defining the health status in patien...

(This article belongs to the Special Issue Hidradenitis Suppurativa (HS): Research Advances in Pathogenesis, Diagnosis and Treatment)
  • Article
  • Open Access
3 Citations
2,652 Views
9 Pages

Survival of Peritoneal Membrane Function on Biocompatible Dialysis Solutions in a Peritoneal Dialysis Cohort Assessed by a Novel Test

  • Olga Balafa,
  • Anila Duni,
  • Paraskevi Tseke,
  • Karolos Rapsomanikis and ,
  • Paraskevi Pavlakou,
  • Margarita Ikonomou,
  • Vasileios Tatsis and
  • Evangelia Dounousi
  • + 3 authors+ 0 author

18 August 2021

Background: Longitudinal surveillance of peritoneal membrane function is crucial in defining patients with a risk of ultrafiltration failure. Long PD is associated with increased low molecular weight solute transport and decreased ultrafiltration and...

(This article belongs to the Special Issue Optimizing Drug Therapy and Developing Novel Therapeutic Interventions in Nephrology)
  • Article
  • Open Access
16 Citations
9,897 Views
12 Pages

Improved Visibility of Early Gastric Cancer after Successful Helicobacter pylori Eradication with Image-Enhanced Endoscopy: A Multi-Institutional Study Using Video Clips

  • Shinya Matsumura,
  • Osamu Dohi,
  • Nobuhisa Yamada,
  • Akihito Harusato and ,
  • Takeshi Yasuda,
  • Takuma Yoshida,
  • Tsugitaka Ishida,
  • Yuka Azuma,
  • Hiroaki Kitae and
  • Yoshito Itoh
  • + 18 authors+ 13 authors

18 August 2021

The visibility and diagnostic accuracy of early gastric cancer (EGC) after Helicobacter pylori (HP) eradication have been reported to improve using image-enhanced endoscopy (IEE) compared with white light imaging (WLI). The present study clarified th...

(This article belongs to the Special Issue Latest Advances in Endoscopic Imaging and Therapy—Part I)
  • Article
  • Open Access
6 Citations
2,955 Views
10 Pages

Analysis of Factors Associated with the Postoperative Healing of Medication-Related Osteonecrosis of the Jaw in Patients with Osteoporosis

  • Young-Ho Shim,
  • Sang-Hwan Jung,
  • Obida Boboeva,
  • Sung-Tak Lee and ,
  • Jin-Wook Kim,
  • Tae-Geon Kwon and
  • So-Young Choi
  • + 2 authors+ 0 author

18 August 2021

Background: Surgical treatment is considered the best approach by many researchers for medication-related osteonecrosis of the jaws (MRONJ). While postoperative outcomes are mainly favorable, wound healing still fails in some cases. This retrospectiv...

(This article belongs to the Special Issue Bone Regeneration in Dentistry, Oral and Maxillofacial Surgery)
  • Article
  • Open Access
3 Citations
3,932 Views
26 Pages

18 August 2021

Chronic widespread pain (CWP), including fibromyalgia (FM), is characterized by generalized musculoskeletal pain. An important clinical feature is widespread increased pain sensitivity such as lowered pain thresholds for different stimuli such as hea...

(This article belongs to the Section Clinical Laboratory Medicine)
  • Review
  • Open Access
12 Citations
4,491 Views
13 Pages

The Relative Merits of Posterior Surgical Treatments for Multi-Level Degenerative Cervical Myelopathy Remain Uncertain: Findings from a Systematic Review

  • Xiaoyu Yang,
  • Aref-Ali Gharooni,
  • Rana S. Dhillon,
  • Edward Goacher and ,
  • Edward W. Dyson,
  • Oliver Mowforth,
  • Alexandru Budu,
  • Guy Wynne-Jones,
  • Jibin Francis and
  • Mark R. N. Kotter
  • + 21 authors+ 16 authors

18 August 2021

Objectives: To assess the reporting of study design and characteristics in multi-level degenerative cervical myelopathy (DCM) treated by posterior surgical approaches, and perform a comparison of clinical and radiographic outcomes between different a...

(This article belongs to the Special Issue Management of Degenerative Cervical Myelopathy and Spinal Cord Injury)
  • Review
  • Open Access
11 Citations
6,448 Views
18 Pages

Optimal Immunosuppression Strategy in the Sensitized Kidney Transplant Recipient

  • Danae Olaso,
  • Miriam Manook,
  • Dimitrios Moris,
  • Stuart Knechtle and
  • Jean Kwun

18 August 2021

Patients with previous sensitization events against anti-human leukocyte antigens (HLA) often have circulating anti-HLA antibodies. Following organ transplantation, sensitized patients have higher rates of antibody-mediated rejection (AMR) compared t...

(This article belongs to the Special Issue Optimizing Drug Therapy and Developing Novel Therapeutic Interventions in Nephrology)
  • Review
  • Open Access
12 Citations
5,724 Views
22 Pages

Post-Stroke Psychiatric and Cognitive Symptoms in West Asia, South Asia and Africa: A Systematic Review and Meta-Analysis

  • Sangeetha Mahadevan,
  • Moon Fai Chan,
  • Marzieh Moghadas,
  • Maithili Shetty and ,
  • David T. Burke,
  • Khalid Al-Rasadi and
  • Samir Al-Adawi
  • + 2 authors+ 0 author

18 August 2021

Recent research has shown that the prevalence of stroke incidents and the number of survivors in developing countries surpass those from developed countries. This study aimed to enumerate the prevalence of post-stroke psychiatric and cognitive sympto...

(This article belongs to the Special Issue Post-stroke Intervention)
  • Article
  • Open Access
3 Citations
2,397 Views
8 Pages

Early Gender Differences in Pain and Functional Recovery Following Thoracolumbar Spinal Arthrodesis

  • Matthew T. Gulbrandsen,
  • Nina Lara,
  • James A. Beauchamp,
  • Andrew Chung and ,
  • Michael Chang and
  • Dennis Crandall
  • + 1 author+ 0 author

18 August 2021

Background: To analyze gender differences regarding the recovery experience (pain, function, complications) after spinal arthrodesis surgery. Methods: Pre-operative and post-operative gender-based differences in patient-reported outcomes for open pos...

(This article belongs to the Special Issue Current Advances in Spinal Diseases of Elderly Patients)
  • Review
  • Open Access
38 Citations
8,062 Views
29 Pages

Clinical Relevance of Immersive Virtual Reality in the Assessment and Treatment of Addictive Disorders: A Systematic Review and Future Perspective

  • Simon Langener,
  • Joanne Van Der Nagel,
  • Jeannette van Manen,
  • Wiebren Markus and ,
  • Boukje Dijkstra,
  • Laura De Fuentes-Merillas,
  • Randy Klaassen,
  • Janika Heitmann,
  • Dirk Heylen and
  • Arnt Schellekens
  • + 5 authors+ 0 author

18 August 2021

(1) Background: Virtual reality (VR) has been investigated in a variety of psychiatric disorders, including addictive disorders (ADs); (2) Objective: This systematic review evaluates the current evidence of immersive VR (using head-mounted displays)...

(This article belongs to the Section Mental Health)
  • Article
  • Open Access
9 Citations
3,682 Views
20 Pages

Changes in the Proteome Profile of People Achieving Remission of Type 2 Diabetes after Bariatric Surgery

  • Zohaib Iqbal,
  • Helene A. Fachim,
  • J. Martin Gibson,
  • Ivona Baricevic-Jones and ,
  • Amy E. Campbell,
  • Bethany Geary,
  • Rachelle P. Donn,
  • Dashne Hamarashid,
  • Akheel Syed and
  • Adrian H. Heald
  • + 7 authors+ 2 authors

18 August 2021

Bariatric surgery (BS) results in metabolic pathway recalibration. We have identified potential biomarkers in plasma of people achieving type 2 diabetes mellitus (T2DM) remission after BS. Longitudinal analysis was performed on plasma from 10 individ...

(This article belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
  • Article
  • Open Access
11 Citations
3,234 Views
15 Pages

GDF-15 Predicts In-Hospital Mortality of Critically Ill Patients with Acute Kidney Injury Requiring Continuous Renal Replacement Therapy: A Multicenter Prospective Study

  • Jeong-Hoon Lim,
  • Yena Jeon,
  • Ji-Sun Ahn,
  • Sejoong Kim and ,
  • Dong Ki Kim,
  • Jung Pyo Lee,
  • Dong-Ryeol Ryu,
  • Eun Young Seong,
  • Shin Young Ahn and
  • Jang-Hee Cho
  • + 11 authors+ 6 authors

18 August 2021

Growth differentiation factor-15 (GDF-15) is a stress-responsive cytokine. This study evaluated the association between GDF-15 and in-hospital mortality among patients with severe acute kidney injury (AKI) requiring continuous renal replacement thera...

(This article belongs to the Special Issue Novel Biomarkers for the Diagnosis, Prognosis and Management of Acute Kidney Injury)
  • Article
  • Open Access
9 Citations
2,899 Views
8 Pages

Melanoma Inhibitory Activity and Melanoma Inhibitory Activity 2 as Novel Immunohistochemical Markers of Oral Epithelial Dysplasia

  • Ryoko Kawai,
  • Yoshihiko Sugita,
  • Toshikatsu Suzumura,
  • Takehiro Hattori and ,
  • Waka Yoshida,
  • Katsutoshi Kubo and
  • Hatsuhiko Maeda
  • + 2 authors+ 0 author

18 August 2021

Oral potentially malignant disorders are associated with the development of oral squamous cell carcinoma (OSCC). Most OSCCs are diagnosed via histopathology as oral epithelial dysplasia (OED), but the histologic diagnostic criteria remain non-uniform...

(This article belongs to the Topic Advances in Dental Biomaterials and Oral Tissues Engineering)
  • Article
  • Open Access
9 Citations
3,846 Views
13 Pages

Usefulness of Easy-to-Use Risk Scoring Systems Rated in the Emergency Department to Predict Major Adverse Outcomes in Hospitalized COVID-19 Patients

  • Julieta González-Flores,
  • Carlos García-Ávila,
  • Rashidi Springall,
  • Malinalli Brianza-Padilla and ,
  • Yaneli Juárez-Vicuña,
  • Ricardo Márquez-Velasco,
  • Fausto Sánchez-Muñoz,
  • Martha A. Ballinas-Verdugo,
  • Edna Basilio-Gálvez and
  • Luis M. Amezcua-Guerra
  • + 14 authors+ 9 authors

18 August 2021

Background: Several easy-to-use risk scoring systems have been built to identify patients at risk of developing complications associated with COVID-19. However, information about the ability of each score to early predict major adverse outcomes durin...

(This article belongs to the Special Issue Clinical Health Care during the COVID-19 Pandemic: Therapeutic and Management Strategies)
  • Systematic Review
  • Open Access
21 Citations
6,435 Views
41 Pages

Postoperative Analgesia after Open Liver Surgery: Systematic Review of Clinical Evidence

  • Paula Dudek,
  • Mateusz Zawadka,
  • Paweł Andruszkiewicz,
  • Remigiusz Gelo and ,
  • Francesco Pugliese and
  • Federico Bilotta
  • + 1 author+ 0 author

18 August 2021

Background: The existing recommendations for after open liver surgery, published in 2019, contains limited evidence on the use of regional analgesia techniques. The aim of this systematic review is to summarize available clinical evidence, published...

(This article belongs to the Section Anesthesiology)
  • Review
  • Open Access
37 Citations
14,758 Views
21 Pages

Shunt Overdrainage: Reappraisal of the Syndrome and Proposal for an Integrative Model

  • Bienvenido Ros,
  • Sara Iglesias,
  • Jorge Linares,
  • Laura Cerro and ,
  • Julia Casado and
  • Miguel Angel Arráez
  • + 1 author+ 0 author

17 August 2021

Although shunt overdrainage is a well-known complication in hydrocephalus management, the problem has been underestimated. Current literature suggests that the topic requires more examination. An insight into this condition is limited by a lack of un...

(This article belongs to the Special Issue Diagnosis and Treatment of Normal-Pressure Hydrocephalus Syndrome—an Update)
  • Article
  • Open Access
11 Citations
3,300 Views
11 Pages

The Role of Demographics, Social Deprivation and Ethnicity on Anal Squamous Cell Carcinoma Incidence in England

  • Danielle R. L. Brogden,
  • Christos Kontovounisios,
  • Sundhiya Mandalia,
  • Paris Tekkis and
  • Sarah C. Mills

17 August 2021

Anal Squamous Cell Carcinoma (ASCC) is an HPV-related malignancy with increasing incidence in high-income economies. Although ethnicity and social deprivation are known to be risk factors in other malignancies, little is known about socioeconomic sta...

(This article belongs to the Special Issue Colorectal Surgery: Latest Advances and Prospects)
  • Article
  • Open Access
17 Citations
3,489 Views
14 Pages

Comprehensive Use of Routine Clinical Parameters to Identify Patients at Risk of New-Onset Atrial Fibrillation in Acute Myocardial Infarction

  • Monika Raczkowska-Golanko,
  • Grzegorz Raczak,
  • Marcin Gruchała and
  • Ludmiła Daniłowicz-Szymanowicz

17 August 2021

(1) Background: New-onset atrial fibrillation (NOAF) is a significant complication of acute myocardial infarction (AMI). Our study aimed to investigate whether routinely checked clinical parameters aid in NOAF identification in modernly treated AMI p...

(This article belongs to the Section Cardiology)
  • Article
  • Open Access
2 Citations
2,701 Views
12 Pages

Severe Myocardial Dysfunction after Non-Ischemic Cardiac Arrest: Effectiveness of Percutaneous Assist Devices

  • Stéphane Manzo-Silberman,
  • Christoph Nix,
  • Andreas Goetzenich,
  • Pierre Demondion and ,
  • Chantal Kang,
  • Michel Bonneau,
  • Alain Cohen-Solal,
  • Pascal Leprince and
  • Guillaume Lebreton
  • + 4 authors+ 0 author

17 August 2021

Introduction: Despite the improvements in standardized cardiopulmonary resuscitation, survival remains low, mainly due to initial myocardial dysfunction and hemodynamic instability. Our goal was to compare the efficacy of two left ventricular assist...

(This article belongs to the Special Issue Cardiogenic Shock: Updates, Challenges and Opportunities)
  • Article
  • Open Access
6 Citations
4,463 Views
10 Pages

Poor Correction Capacity of Preexisting Ankle Valgus Deformity after Total Knee Arthroplasty

  • Han-Ting Shih,
  • Wei-Jen Liao,
  • Kao-Chang Tu,
  • Cheng-Hung Lee and ,
  • Shih-Chieh Tang and
  • Shun-Ping Wang
  • + 1 author+ 0 author

17 August 2021

This study investigated the differences in ankle alignment changes after TKA in patients with varying preexisting ankle deformities. We retrospectively examined 90 knees with osteoarthritis and varus deformity in 78 patients who underwent TKA. Preope...

(This article belongs to the Special Issue Deformity Correction, Bone Lengthening and Correction Osteotomies of the Lower Limb)
  • Review
  • Open Access
57 Citations
12,530 Views
12 Pages

17 August 2021

Degenerative cervical myelopathy (DCM) is a leading cause of spinal cord injury and a major contributor to morbidity resulting from narrowing of the spinal canal due to osteoarthritic changes. This narrowing produces chronic spinal cord compression a...

(This article belongs to the Special Issue Management of Degenerative Cervical Myelopathy and Spinal Cord Injury)
  • Article
  • Open Access
15 Citations
3,460 Views
12 Pages

Age as a Prognostic Factor in Patients with Ewing Sarcoma—The Polish Sarcoma Group Experience

  • Paulina Jagodzińska-Mucha,
  • Anna Raciborska,
  • Hanna Koseła-Paterczyk,
  • Katarzyna Kozak and ,
  • Katarzyna Bilska,
  • Tomasz Świtaj,
  • Sławomir Falkowski,
  • Anna Dawidowska,
  • Piotr Rutkowski and
  • Iwona Ługowska
  • + 5 authors+ 0 author

17 August 2021

Ewing sarcoma (ES) is a rare and aggressive disease that requires multidisciplinary treatment with the use of chemotherapy, radiotherapy, and surgery. Our retrospective study aimed to analyze the prognostic factors and treatment results in different...

(This article belongs to the Section Oncology)
  • Review
  • Open Access
50 Citations
12,083 Views
20 Pages

Clinical Management of Moyamoya Patients

  • Isabella Canavero,
  • Ignazio Gaspare Vetrano,
  • Marialuisa Zedde,
  • Rosario Pascarella and ,
  • Laura Gatti,
  • Francesco Acerbi,
  • Sara Nava,
  • Paolo Ferroli,
  • Eugenio Agostino Parati and
  • Anna Bersano
  • + 5 authors+ 0 author

17 August 2021

Moyamoya angiopathy (MMA) is a peculiar cerebrovascular condition characterized by progressive steno-occlusion of the terminal part of the internal carotid arteries (ICAs) and their proximal branches, associated with the development of a network of f...

(This article belongs to the Section Clinical Neurology)
  • Article
  • Open Access
15 Citations
4,324 Views
11 Pages

Functional Outcomes with Facial Artery Musculo-Mucosal (FAMM) Flap and Dental Implants for Reconstruction of Floor of the Mouth and Tongue Defects in Oncologic Patients

  • Carlos Navarro Cuéllar,
  • Manuel Tousidonis Rial,
  • Raúl Antúnez-Conde,
  • Marc Agea Martínez and ,
  • Ignacio Navarro Cuéllar,
  • José Ignacio Salmerón Escobar and
  • Carlos Navarro Vila
  • + 2 authors+ 0 author

17 August 2021

Optimal functional outcomes in oncologic patients with squamous cell carcinoma (SCCA) of the tongue and floor of the mouth require good lingual mobility, adequate facial competence, the cheek suction effect and dental rehabilitation with osseointegra...

(This article belongs to the Special Issue New Perspectives in Maxillo-Facial Surgery)
  • Article
  • Open Access
12 Citations
4,390 Views
17 Pages

Living in the Southern Hemisphere: Metabolic Syndrome and Its Components in Amazonian Riverine Populations

  • Gabriela P. Arrifano,
  • Jacqueline I. Alvarez-Leite,
  • Barbarella M. Macchi,
  • Núbia F. S. S. Campos and ,
  • Marcus Augusto-Oliveira,
  • Letícia Santos-Sacramento,
  • Amanda Lopes-Araújo,
  • José Rogério Souza-Monteiro,
  • Raquel Alburquerque-Santos and
  • Maria Elena Crespo-Lopez
  • + 9 authors+ 4 authors

17 August 2021

The metabolic syndrome (MetS) epidemic is a global challenge. Although developing countries (including Brazil, India, and South Africa) present a higher proportion of deaths by cardiovascular diseases than developed countries, most of our knowledge i...

(This article belongs to the Special Issue Clinical Update on Metabolic Syndrome)
  • Article
  • Open Access
19 Citations
6,915 Views
16 Pages

Lessons Learned from 30 Years of Transverse Myocutaneous Gracilis Flap Breast Reconstruction: Historical Appraisal and Review of the Present Literature and 300 Cases

  • Laurenz Weitgasser,
  • Maximilian Mahrhofer,
  • Karl Schwaiger,
  • Kathrin Bachleitner and ,
  • Elisabeth Russe,
  • Gottfried Wechselberger and
  • Thomas Schoeller
  • + 2 authors+ 0 author

17 August 2021

Background: Happy 30th birthday to the transverse myocutaneous gracilis (TMG) flap. Since 1991 the TMG flap has been used to reconstruct a wide variety of defects and became a workhorse flap and reliable alternative to the deep inferior epigastric pe...

(This article belongs to the Special Issue Challenges and Innovation in Breast Reconstruction)
  • Article
  • Open Access
17 Citations
5,626 Views
13 Pages

Low-Intensity and Short-Duration Continuous Cervical Transcutaneous Spinal Cord Stimulation Intervention Does Not Prime the Corticospinal and Spinal Reflex Pathways in Able-Bodied Subjects

  • Atsushi Sasaki,
  • Roberto M. de Freitas,
  • Dimitry G. Sayenko,
  • Yohei Masugi and ,
  • Taishin Nomura,
  • Kimitaka Nakazawa and
  • Matija Milosevic
  • + 2 authors+ 0 author

17 August 2021

Cervical transcutaneous spinal cord stimulation (tSCS) has been utilized in applications for improving upper-limb sensory and motor function in patients with spinal cord injury. Although therapeutic effects of continuous cervical tSCS interventions h...

(This article belongs to the Special Issue Spinal Cord Injury and Transcutaneous Spinal Cord Stimulation)
  • Article
  • Open Access
3 Citations
3,302 Views
14 Pages

Influence of the Human Development Index on the Maternal–Perinatal Morbidity and Mortality of Pregnant Women with SARS-CoV-2 Infection: Importance for Personalized Medical Care

  • Yolanda Cuñarro-López,
  • Santiago García-Tizón Larroca,
  • Pilar Pintado-Recarte,
  • Concepción Hernández-Martín and ,
  • Pilar Prats-Rodríguez,
  • Óscar Cano-Valderrama,
  • Ignacio Cueto-Hernández,
  • Javier Ruiz-Labarta,
  • María del Mar Muñoz-Chápuli and
  • Juan Antonio De León-Luis
  • + 7 authors+ 2 authors

17 August 2021

Coronavirus disease-19 (COVID-19) is perhaps the most worrisome pandemic in the 21st century, having entailed devastating consequences for the whole society during the last year. Different studies have displayed an existing association between pregna...

(This article belongs to the Special Issue COVID-19 and Pregnancy)
  • Article
  • Open Access
13 Citations
9,453 Views
13 Pages

Clinical Characteristics and Outcomes of Adults with Nephrotic Syndrome Due to Minimal Change Disease

  • Sophia Lionaki,
  • Evangelos Mantios,
  • Ioanna Tsoumbou,
  • Smaragdi Marinaki and ,
  • George Makris,
  • George Liapis,
  • Chrysovalantis Vergandis and
  • Ioannis Boletis
  • + 3 authors+ 0 author

17 August 2021

Purpose: Minimal change disease (MCD) is considered a relatively benign glomerulopathy, as it rarely progresses to end-stage kidney disease. The aim of this study was to describe the characteristics and outcomes of adults with MCD and identify potent...

(This article belongs to the Special Issue Optimizing Drug Therapy and Developing Novel Therapeutic Interventions in Nephrology)
  • Article
  • Open Access
3 Citations
2,324 Views
11 Pages

The Effect of the Timing of Invasive Management on Cardiac Function in Patients with NSTE-ACS, Insights from the OPTIMA-2 Randomized Controlled Trial

  • Nick D. Fagel,
  • Stefan G. J. Leuven,
  • Wouter J. Kikkert,
  • Michelle M. de Leau and ,
  • Loek van Heerebeek and
  • Robert K. Riezebos
  • + 1 author+ 0 author

17 August 2021

The timing of coronary angiography in patients with non-ST-elevation acute coronary syndrome (NSTE-ACS) remains a matter of debate. The relationship between the timing of invasive management and left ventricular function (LVF) is largely unknown. The...

(This article belongs to the Special Issue Percutaneous Coronary Interventions in Acute Coronary Syndromes)
  • Article
  • Open Access
10 Citations
3,623 Views
14 Pages

Protocol Biopsies on de novo Renal-Transplants at 3 Months after Surgery: Impact on 5-Year Transplant Survival

  • Florian Terrec,
  • Johan Noble,
  • Hamza Naciri-Bennani,
  • Paolo Malvezzi and ,
  • Bénédicte Janbon,
  • Camille Emprou,
  • Diane Giovannini,
  • Lionel Rostaing and
  • Thomas Jouve
  • + 4 authors+ 0 author

17 August 2021

Background: In many centers, a protocol kidney biopsy (PKB) is performed at 3 months post-transplantation (M3), without a demonstrated benefit on death-censored graft survival (DCGS). In this study, we compared DCGS between kidney transplant recipien...

(This article belongs to the Special Issue Infections, Complications and Management of Kidney Transplantation)
  • Article
  • Open Access
7 Citations
2,485 Views
13 Pages

Challenges Associated with Pancreas and Kidney Retransplantation—A Retrospective Analysis

  • Nina Pillokeit,
  • Sascha Grzella,
  • Panagiota Zgoura,
  • Timm Westhoff and ,
  • Richard Viebahn and
  • Peter Schenker
  • + 1 author+ 0 author

17 August 2021

Simultaneous pancreas and kidney transplantation (SPK) is an accepted treatment for diabetic patients with renal failure, and is associated with increased survival and quality of life for recipients. There are only a few publications on the outcomes...

(This article belongs to the Special Issue Recent Advances and Innovations in Kidney and Pancreas-Kidney Transplantation)
  • Article
  • Open Access
15 Citations
3,660 Views
9 Pages

Prognostic Value of Cardiac Troponin and Risk Assessment in Pediatric Supraventricular Tachycardia

  • Chieh-Ching Yen,
  • Shou-Yen Chen,
  • Chung-Hsien Chaou,
  • Chih-Kai Wang and ,
  • Hsin-Tzu Yeh and
  • Chip-Jin Ng
  • + 1 author+ 0 author

17 August 2021

Cardiac troponin I (cTnI) elevation is common in an acute episode of supraventricular tachycardia (SVT). However, there is limited evidence regarding the prognostic value of cTnI and the predictors of SVT recurrence in pediatric patients. We screened...

(This article belongs to the Section Emergency Medicine)
  • Review
  • Open Access
42 Citations
9,082 Views
21 Pages

Blood Biomarkers for Alzheimer’s Disease in Down Syndrome

  • Laia Montoliu-Gaya,
  • Andre Strydom,
  • Kaj Blennow,
  • Henrik Zetterberg and
  • Nicholas James Ashton

17 August 2021

Epidemiological evidence suggests that by the age of 40 years, all individuals with Down syndrome (DS) have Alzheimer’s disease (AD) neuropathology. Clinical diagnosis of dementia by cognitive assessment is complex in these patients due to the pre-ex...

(This article belongs to the Special Issue Aging in Down Syndrome: Latest Clinical Advances and Prospects)
  • Review
  • Open Access
49 Citations
10,557 Views
17 Pages

17 August 2021

In recent years, lipofilling became a popular scar treatment method. Its beneficial outcomes have been partly attributed to the regenerative capacity of adipose-derived stem cells (ADSCs), suspended in an extracellular matrix—the stromal vascular fra...

(This article belongs to the Special Issue Therapies Based on Mesenchymal Stem Cells (MSCs) and MSC-Derived Exosomes)
  • Article
  • Open Access
14 Citations
3,624 Views
8 Pages

Relationship between Psoriasis and Prevalence of Cardiovascular Disease in 88 Japanese Patients

  • Fumikazu Yamazaki,
  • Kazuya Takehana,
  • Akihiro Tanaka,
  • Yonsu Son and ,
  • Yoshio Ozaki and
  • Hideaki Tanizaki
  • + 1 author+ 0 author

17 August 2021

Psoriasis is a systemic inflammatory disease known to affect survival in the presence of cerebral or cardiovascular comorbidities. However, no clear guidelines have been defined regarding the extent of vascular lesion testing that should be performed...

(This article belongs to the Special Issue Skin Disease and Comorbidities)
  • Article
  • Open Access
51 Citations
13,266 Views
36 Pages

Stress Echo 2030: The Novel ABCDE-(FGLPR) Protocol to Define the Future of Imaging

  • Eugenio Picano,
  • Quirino Ciampi,
  • Lauro Cortigiani,
  • Adelaide M. Arruda-Olson and ,
  • Clarissa Borguezan-Daros,
  • José Luis de Castro e Silva Pretto,
  • Rosangela Cocchia,
  • Eduardo Bossone,
  • Elisa Merli and
  • The Stress Echo 2030 Study Group of the Italian Society of Echocardiography and Cardiovascular Imaging (SIECVI)
  • + 88 authors+ 83 authors

17 August 2021

With stress echo (SE) 2020 study, a new standard of practice in stress imaging was developed and disseminated: the ABCDE protocol for functional testing within and beyond CAD. ABCDE protocol was the fruit of SE 2020, and is the seed of SE 2030, which...

(This article belongs to the Special Issue Imaging Research in Cardiovascular Diseases)
  • Article
  • Open Access
11 Citations
5,897 Views
15 Pages

Risks of Recurrent Cardiovascular Events and Mortality in 1-Year Survivors of Acute Myocardial Infarction Implanted with Newer-Generation Drug-Eluting Stents

  • Sungmin Lim,
  • Eun Ho Choo,
  • Ik Jun Choi,
  • Kwan Yong Lee and ,
  • Su Nam Lee,
  • Byung-Hee Hwang,
  • Chan Joon Kim,
  • Mahn-Won Park,
  • Jong-Min Lee and
  • Kiyuk Chang
  • + 15 authors+ 10 authors

17 August 2021

Current treatments for acute myocardial infarction (AMI) have dramatically improved clinical outcomes during the first year after AMI. Less is known, however, about the subsequent risks of recurrent cardiovascular events and mortality in patients who...

(This article belongs to the Section Cardiology)
  • Review
  • Open Access
12 Citations
4,240 Views
7 Pages

16 August 2021

The thermal grill illusion (TGI) is a paradoxical perception of burning heat and pain resulting from the simultaneous application of interlaced warm and cold stimuli to the skin. The TGI is considered a type of chronic centralized pain and has been u...

(This article belongs to the Section Dermatology)
  • Article
  • Open Access
4 Citations
3,111 Views
10 Pages

Factors Associated with Occurrence of Atelectasis during Sedation for Imaging in Pediatric Patients: A Retrospective Single Center Cohort Study

  • Pyeong Hwa Kim,
  • Yong-Seok Park,
  • Hee-Mang Yoon,
  • Ah Young Jung and ,
  • Eun-Young Joo,
  • In-Cheol Choi and
  • Myung-Hee Song
  • + 2 authors+ 0 author

16 August 2021

Sedation can induce atelectasis which may cause suboptimal image quality. This study aimed to identify factors associated with the occurrence of atelectasis during sedation for imaging in pediatric patients. Patients < 18 years who had undergone w...

(This article belongs to the Section Respiratory Medicine)
  • Article
  • Open Access
9 Citations
3,616 Views
18 Pages

16 August 2021

The treatment efficacy of immune checkpoint inhibitors (ICIs) in colorectal cancer (CRC) has been reported heterogeneously across clinical trials. We conducted a systematic review and meta-analysis to evaluate the efficacy of ICIs in patients with ad...

(This article belongs to the Section Oncology)
  • Article
  • Open Access
18 Citations
5,973 Views
14 Pages

16 August 2021

The use of new devices for the rehabilitation of the severely atrophic maxillae needs validation. We aimed to report the short-term outcome of severely atrophic jaws rehabilitated with zygomatic implants with no implant head angulation placed extrama...

(This article belongs to the Special Issue Implant Dentistry—Trends, Challenges and Innovations)
  • Article
  • Open Access
8 Citations
3,223 Views
11 Pages

Robot-Assisted Intracorporeal Orthotopic Ileal Neobladder: Description of the “Shell” Technique

  • Roberto Bianchi,
  • Francesco Alessandro Mistretta,
  • Gennaro Musi,
  • Stefano Luzzago and ,
  • Michele Morelli,
  • Vito Lorusso,
  • Michele Catellani,
  • Ettore Di Trapani,
  • Gabriele Cozzi and
  • Ottavio de Cobelli
  • + 8 authors+ 3 authors

16 August 2021

Background: Robot-assisted radical cystectomy (RARC) with intracorporeal neobladder (ICNB) remains a very complicated, technically demanding and time-consuming surgical procedure. In the current study we describe our robot-assisted intracorporeal “Sh...

(This article belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
  • Article
  • Open Access
9 Citations
6,666 Views
17 Pages

Health, Wellbeing, and Prognosis of Australian Adolescents with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Case-Controlled Follow-Up Study

  • Elisha K. Josev,
  • Rebecca C. Cole,
  • Adam Scheinberg,
  • Katherine Rowe and ,
  • Lionel Lubitz and
  • Sarah J. Knight
  • + 1 author+ 0 author

16 August 2021

Background: The purpose of this study was to follow-up an Australian cohort of adolescents newly-diagnosed with ME/CFS at a tertiary paediatric ME/CFS clinic and healthy controls over a mean period of two years (range 1–5 years) from diagnosis. Objec...

(This article belongs to the Special Issue Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: Diagnosis and Treatment)
  • Article
  • Open Access
15 Citations
3,808 Views
10 Pages

Association among Autistic Traits, Treatment Intensity and Outcomes in Adolescents with Anorexia Nervosa: Preliminary Results

  • Jacopo Pruccoli,
  • Simone Rosa,
  • Carlo Alberto Cesaroni,
  • Elisabetta Malaspina and
  • Antonia Parmeggiani

16 August 2021

The present study investigates the impact of Autism Spectrum Disorder (ASD) traits on the treatment intensity and outcomes (psychopathology and weight) of 22 adolescent inpatients with Anorexia Nervosa (AN), who were selected on the basis of suspecte...

(This article belongs to the Special Issue Feature Papers in Clinical Psychology)
  • Review
  • Open Access
14 Citations
5,037 Views
14 Pages

The Use of Titanium 3D Mini-Plates in the Surgical Treatment of Fractures of the Mandibular Condyle: A Systematic Review and Meta-Analysis of Clinical Trials

  • Maciej Sikora,
  • Maciej Chęciński,
  • Zuzanna Nowak,
  • Kamila Chęcińska and ,
  • Tomasz Olszowski and
  • Dariusz Chlubek
  • + 1 author+ 0 author

16 August 2021

Introduction: Fixing fractures of the base and neck of mandibular condyles is demanding due to the difficulties in surgical access and the various shapes of bone fragments. Classic fixation techniques assume the use of straight mini-plates, utilized...

(This article belongs to the Special Issue New Perspectives in Maxillo-Facial Surgery)
  • Review
  • Open Access
20 Citations
11,216 Views
11 Pages

Diagnosis and Management of Achalasia: Updates of the Last Two Years

  • Amir Mari,
  • Fadi Abu Baker,
  • Rinaldo Pellicano and
  • Tawfik Khoury

16 August 2021

Achalasia is a rare neurodegenerative disorder causing dysphagia and is characterized by abnormal esophageal motor function as well as the loss of lower esophageal sphincter (LES) relaxation. The assessment and management of achalasia has significant...

(This article belongs to the Special Issue Advances in Gastrointestinal and Liver Disease: From Physiological Mechanisms to Clinical Practice)

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J. Clin. Med. - ISSN 2077-0383