Advances in Gastrointestinal and Liver Disease: From Physiological Mechanisms to Clinical Practice

Dear Colleagues,

Management of gastrointestinal and hepatic diseases is constantly evolving. The greater understanding of pathogenic mechanisms has brought concrete fruits for daily management. This is real translational medicine.

Understanding the mechanisms underlying HCV virus infection has allowed the development of Direct-Acting Antivirals (DAA).

The decrease in the prevalence of Helicobacter pylori (H. pylori) infection, the widespread use of proton pump inhibitors, and the relative ease of access to gastroscopies have reduced the incidence of peptic disease and stomach cancer, once the main gastrointestinal pathology. In many areas of the world, however, H. pylori infection is still widespread and there is still room for improvement in eradication strategies.

Understanding the inflammatory pathways involved in inflammatory bowel disease has allowed the development of target therapies (anti-TNF, anti-IL12/12, anti-JAK).

In the coming decades, NAFLD/NASH will supplant viral hepatitis as the leading cause of chronic liver damage. Growing understanding of the microbiota will lead to applications that will go beyond the confines of the gut, though the COVID-19 pandemic will still affect the management of all diseases.

The objective of this Special Issue is to present the most up-to-date data on the pathogenesis and management of gastrointestinal and hepatological diseases, with a view to an increasingly personalized management of the patient.

Dr. Davide Giuseppe Ribaldone
Dr. Gian Paolo Caviglia
Guest Editors

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