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Journal of Clinical Medicine, Volume 10, Issue 16

2021 August-2 - 311 articles

Cover Story: Myeloid-derived suppressor cells (MDSCs) are immature myeloid precursors which emerged as a potent regulator of the immune system, exerting suppressive properties in diverse disease settings. The contribution of MDSCs in immune regulation during hematologic malignancies and particularly in lymphomas is emerging. The figure depicts the main immune cell subsets and malignant cells that circulate in the blood of lymphoma patients (left side). The MDSC subsets and the respective mechanisms that have been described for MDSC-mediated suppression of antitumor immunity in different types of lymphomas are shown (right side). View this paper
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Articles (311)

  • Article
  • Open Access
2 Citations
2,849 Views
8 Pages

Prevalence and Prognostic Value of Myocardial Injury in the Initial Presentation of SARS-CoV-2 Infection among Older Adults

  • Isabel Arnau-Barrés,
  • Ana Pascual-Dapena,
  • Inmaculada López-Montesinos,
  • Silvia Gómez-Zorrilla and ,
  • Luisa Sorlí,
  • Marta Herrero,
  • Xavier Nogués,
  • Mila Montero,
  • Olga Vázquez and
  • Robert Güerri-Fernández
  • + 7 authors+ 2 authors

23 August 2021

Myocardial involvement during SARS-CoV-2 infection has been reported in many prior publications. We aim to study the prevalence and the clinical implications of acute myocardial injury (MIN) during SARS-CoV-2 infection, particularly in older patients...

(This article belongs to the Section Cardiology)
  • Review
  • Open Access
24 Citations
5,361 Views
12 Pages

Recent Advances in Endosonography—Elastography: Literature Review

  • Akira Yamamiya,
  • Atsushi Irisawa,
  • Koki Hoshi,
  • Akane Yamabe and ,
  • Naoya Izawa,
  • Kazunori Nagashima,
  • Takahito Minaguchi,
  • Masamichi Yamaura,
  • Yoshitsugu Yoshida and
  • Kenichi Goda
  • + 10 authors+ 5 authors

23 August 2021

Ultrasonographic elastography is a modality used to visualize the elastic properties of tissues. Technological advances in ultrasound equipment have supported the evaluation of elastography (EG) in endosonography (EUS). Currently, the usefulness of n...

(This article belongs to the Special Issue Clinical Advances of Endoscopy in Pancreaticobiliary Disease)
  • Article
  • Open Access
11 Citations
3,269 Views
12 Pages

Decreased Bone Mineral Density Is a Predictor of Poor Survival in Critically Ill Patients

  • Maximilian F. Schulze-Hagen,
  • Christoph Roderburg,
  • Theresa H. Wirtz,
  • Markus S. Jördens and ,
  • Lukas Bündgens,
  • Samira Abu Jhaisha,
  • Philipp Hohlstein,
  • Jonathan F. Brozat,
  • Philipp Bruners and
  • Alexander Koch
  • + 11 authors+ 6 authors

23 August 2021

Alterations in bone mineral density (BMD) have been suggested as independent predictors of survival for several diseases. However, little is known about the role of BMD in the context of critical illness and intensive care medicine. We therefore eval...

(This article belongs to the Section Intensive Care)
  • Article
  • Open Access
12 Citations
8,850 Views
17 Pages

Hyperthyroidism in Pregnancy: The Delicate Balance between Too Much or Too Little Antithyroid Drug

  • Monica Livia Gheorghiu,
  • Roxana Georgiana Bors,
  • Ancuta-Augustina Gheorghisan-Galateanu,
  • Anca Lucia Pop and ,
  • Dragos Cretoiu and
  • Valentin Nicolae Varlas
  • + 1 author+ 0 author

23 August 2021

Overt hyperthyroidism (HT) during pregnancy is associated with a risk of maternal–fetal complications. Antithyroid drugs (ATD) have a potential risk for teratogenic effects and fetal–neonatal hypothyroidism. This study evaluated ATD treatment and thy...

(This article belongs to the Special Issue New Insights and Clinical Management of Thyroid Diseases)
  • Article
  • Open Access
7 Citations
3,780 Views
8 Pages

Arterial Hypertension and Diabetes Mellitus in COVID-19 Patients: What Is Known by Gender Differences?

  • Tiziana Ciarambino,
  • Filippina Ciaburri,
  • Venere Delli Paoli,
  • Giuseppe Caruso and ,
  • Mauro Giordano and
  • Maria D’Avino
  • + 1 author+ 0 author

23 August 2021

Background. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has infected >160 million people around the world. Hypertension (HT), chronic heart disease (CHD), and diabetes mellitus (DM) increase susceptibility to SARS-CoV-2 infection....

(This article belongs to the Special Issue Unusual Clinical Presentation of COVID-19)
  • Review
  • Open Access
9 Citations
9,880 Views
17 Pages

Diagnosis and Management of Aortic Valve Stenosis: The Role of Non-Invasive Imaging

  • Gloria Santangelo,
  • Andrea Rossi,
  • Filippo Toriello,
  • Luigi Paolo Badano and ,
  • David Messika Zeitoun and
  • Pompilio Faggiano
  • + 1 author+ 0 author

23 August 2021

Aortic stenosis is the most common heart valve disease necessitating surgical or percutaneous intervention. Imaging has a central role for the initial diagnostic work-up, the follow-up and the selection of the optimal timing and type of intervention....

(This article belongs to the Special Issue Valvular Heart Disease: A World in Constant Motion)
  • Article
  • Open Access
1 Citations
2,625 Views
11 Pages

Mortality after Use of Paclitaxel-Coated Balloons Correlates with Total Cumulative Dosage of Paclitaxel in Real-World Analysis

  • Seon-Hee Heo,
  • Shin-Young Woo,
  • Seung-Hyuk Choi,
  • Taek-Kyu Park and ,
  • Young-Soo Do,
  • Kwang-Bo Park,
  • Dong-Ik Kim,
  • Young-Wook Kim and
  • Yang-Jin Park
  • + 4 authors+ 0 author

23 August 2021

This study used independent, real-world, patient-level data to examine whether the dosage or frequency of paclitaxel exposure correlated with mortality during follow up. We conducted a retrospective analysis of patients treated with a drug-coated bal...

(This article belongs to the Section Vascular Medicine)
  • Article
  • Open Access
14 Citations
3,745 Views
10 Pages

The Association between Peri-Transplant RBC Transfusion and Graft Failure after Kidney Transplantation: A Nationwide Cohort Study

  • Kyungho Lee,
  • Seohee Lee,
  • Eun Jin Jang,
  • Ga Hee Kim and ,
  • Seokha Yoo,
  • Minkyoo Lee,
  • Hye Ryoun Jang and
  • Ho Geol Ryu
  • + 3 authors+ 0 author

23 August 2021

Background: Patients undergoing kidney transplantation (KT) often receive red blood cell (RBC) transfusion during admission for KT which may increase the risk of allosensitization. The association between peri-transplant RBC transfusion and graft sur...

(This article belongs to the Special Issue Infections, Complications and Management of Kidney Transplantation)
  • Review
  • Open Access
17 Citations
7,687 Views
19 Pages

Hysterolaparoscopy: A Gold Standard for Diagnosing and Treating Infertility and Benign Uterine Pathology

  • Valentin Varlas,
  • Yassin Rhazi,
  • Eliza Cloțea,
  • Roxana Georgiana Borș and ,
  • Radu Mihail Mirică and
  • Nicolae Bacalbașa
  • + 1 author+ 0 author

23 August 2021

Background: Combined hysteroscopy and laparoscopy is a valuable method for diagnosing and treating infertility and benign uterine pathology. Both procedures are minimally invasive, reliable, and safe, with a low complication rate. Aim: In this review...

(This article belongs to the Special Issue Challenges and Controversies in Minimally Invasive Surgery: What Is Really New in Gynecologic Surgery?)
  • Article
  • Open Access
10 Citations
5,770 Views
11 Pages

Comparison of COVID-19 and Non-COVID-19 Pneumonia in Down Syndrome

  • Diego Real de Asua,
  • Miguel A. Mayer,
  • María del Carmen Ortega,
  • Jose M. Borrel and ,
  • Teresa de Jesús Bermejo,
  • Domingo González-Lamuño,
  • Coral Manso,
  • Fernando Moldenhauer,
  • María Carmona-Iragui and
  • Mara Dierssen
  • + 9 authors+ 4 authors

23 August 2021

Whether the increased risk for coronavirus disease 2019 (COVID-19) hospitalization and death observed in Down syndrome (DS) are disease specific or also occur in individuals with DS and non-COVID-19 pneumonias is unknown. This retrospective cohort st...

(This article belongs to the Special Issue COVID-19: Special Populations and Risk Factors)
  • Article
  • Open Access
3 Citations
3,473 Views
10 Pages

23 August 2021

Background and Objectives: Pelvic organ prolapse (POP) and osteoporosis are major disease entities in older women that have the same epidemiology and might also have the same molecular physiology. However, few data have been reported on the relations...

(This article belongs to the Section Obstetrics & Gynecology)
  • Article
  • Open Access
8 Citations
3,957 Views
14 Pages

JAK Inhibition with Ruxolitinib in Patients with COVID-19 and Severe Pneumonia: Multicenter Clinical Experience from a Compassionate Use Program in Italy

  • Alessandro Maria Vannucchi,
  • Andrea Mortara,
  • Andrea D’Alessio,
  • Mara Morelli and ,
  • Alberto Tedeschi,
  • Moreno Benedetto Festuccia,
  • Antonella D’Arminio Monforte,
  • Enrico Capochiani,
  • Carmine Selleri and
  • Giuseppe Saglio
  • + 19 authors+ 14 authors

23 August 2021

Jak inhibitors are potent anti-inflammatory drugs that have the potential to dampen the hyperactive inflammatory response associated with severe COVID-19. We reviewed the clinical outcomes of 218 patients with COVID-19 hospitalized for severe pneumon...

(This article belongs to the Section Infectious Diseases)
  • Article
  • Open Access
5 Citations
3,056 Views
15 Pages

Incidence and Outcomes of Hemorrhagic Stroke among Adults in Spain (2016–2018) According to Sex: A Retrospective, Cohort, Observational, Propensity Score Matched Study

  • Jose M. de Miguel-Yanes,
  • Ana Lopez-de-Andres,
  • Rodrigo Jimenez-Garcia,
  • Valentin Hernandez-Barrera and ,
  • Javier de Miguel-Diez,
  • Manuel Méndez-Bailón,
  • Napoleón Pérez-Farinós,
  • Nuria Muñoz-Rivas,
  • David Carabantes-Alarcon and
  • Marta López-Herranz
  • + 5 authors+ 0 author

23 August 2021

(1) Background: We aim to analyze sex differences in the incidence, clinical characteristics and in-hospital outcomes of hemorrhagic stroke (HS) in Spain (2016–2018) using the National Hospital Discharge Database. (2) Methods: Retrospective, cohort,...

(This article belongs to the Section Clinical Neurology)
  • Review
  • Open Access
23 Citations
6,179 Views
17 Pages

23 August 2021

Patient-reported outcome (PRO) instruments are widely used to assess quality of life in Systemic Lupus Erythematosus (SLE) research, and there is growing evidence for their use in clinical care. In this review, we evaluate the current evidence for th...

(This article belongs to the Special Issue Clinical Features and Long-Term Outcomes of Systemic Lupus Erythematosus)
  • Article
  • Open Access
4 Citations
3,341 Views
15 Pages

A Pharyngoplasty with a Dorsal Palatal Flap Expansion: The Evaluation of a Modified Surgical Treatment Method for Obstructive Sleep Apnea Syndrome—A Preliminary Report

  • Ewa Olszewska,
  • Piotr Fiedorczuk,
  • Adam Stróżyński,
  • Agnieszka Polecka and ,
  • Ewa Roszkowska and
  • B. Tucker Woodson
  • + 1 author+ 0 author

23 August 2021

Surgical techniques for obstructive sleep apnea syndrome (OSAS) constantly evolve. This study aims to assess the effectiveness and safety of a new surgical approach for an OSAS pharyngoplasty with a dorsal palatal flap expansion (PDPFEx). A total of...

(This article belongs to the Special Issue Current Perspectives on the Treatment of Obstructive Sleep Apnea - Part I)
  • Article
  • Open Access
14 Citations
8,414 Views
7 Pages

Effects of Selenium Supplementation on Sperm Parameters and DNA-Fragmentation Rate in Patients with Chronic Autoimmune Thyroiditis

  • Rossella Cannarella,
  • Rosita A. Condorelli,
  • Aldo E. Calogero,
  • Vincenzo Bagnara and ,
  • Antonio Aversa,
  • Emanuela A. Greco,
  • Antonio Brunetti and
  • Sandro La Vignera
  • + 3 authors+ 0 author

23 August 2021

Background: Selenium (Se) is an essential component of selenoenzymes, which have catalytic and antioxidant functions. A low Se status has been reported in patients with chronic autoimmune thyroiditis (AT) who benefit from Se supplementation. The role...

(This article belongs to the Section Endocrinology & Metabolism)
  • Review
  • Open Access
60 Citations
14,850 Views
19 Pages

Criterion-Related Validity of Field-Based Fitness Tests in Adults: A Systematic Review

  • Jose Castro-Piñero,
  • Nuria Marin-Jimenez,
  • Jorge R. Fernandez-Santos,
  • Fatima Martin-Acosta and ,
  • Victor Segura-Jimenez,
  • Rocio Izquierdo-Gomez,
  • Jonatan R. Ruiz and
  • Magdalena Cuenca-Garcia
  • + 3 authors+ 0 author

23 August 2021

We comprehensively assessed the criterion-related validity of existing field-based fitness tests used to indicate adult health (19–64 years, with no known pathologies). The medical electronic databases MEDLINE (via PubMed) and Web of Science (all dat...

(This article belongs to the Special Issue Physical Activity, Exercise Testing and Clinical Assessment in Sports Medicine)
  • Case Report
  • Open Access
6 Citations
3,322 Views
6 Pages

A Rare Case of Patiromer Induced Hypercalcemia

  • Swetha Rani Kanduri,
  • Kathryn J. Suchow and
  • Juan Carlos Q. Velez

23 August 2021

Patiromer is a calcium (Ca)-potassium (K) exchange resin approved for the treatment of hyperkalemia. Disorders of Ca or acid base balance were not reported in pre-approval clinical trials. We present a case of a patient with chronic kidney disease (C...

(This article belongs to the Section Nephrology & Urology)
  • Review
  • Open Access
31 Citations
5,605 Views
23 Pages

Role of the Immune System Elements in Pulmonary Arterial Hypertension

  • Michał Tomaszewski,
  • Dominika Bębnowska,
  • Rafał Hrynkiewicz,
  • Jakub Dworzyński and ,
  • Paulina Niedźwiedzka-Rystwej,
  • Grzegorz Kopeć and
  • Ewelina Grywalska
  • + 2 authors+ 0 author

23 August 2021

Pulmonary arterial hypertension (PAH) is a relatively rare disease, but, today, its incidence tends to increase. The severe course of the disease and poor patient survival rate make PAH a major diagnostic and therapeutic challenge. For this reason, a...

(This article belongs to the Special Issue Pulmonary Arterial Hypertension and Beyond: Risk Assessment, Prognosis and Emerging Clinical Perspectives)
  • Article
  • Open Access
10 Citations
2,991 Views
8 Pages

Risk of Early Childhood Obesity in Offspring of Women with Preeclampsia: A Population-Based Study

  • Seung-Woo Yang,
  • Min-Jeong Oh,
  • Keon-Vin Park,
  • Sung-Won Han and ,
  • Hee-Sun Kim,
  • In-Sook Sohn,
  • Han-Sung Kwon,
  • Geum-Joon Cho and
  • Han-Sung Hwang
  • + 4 authors+ 0 author

23 August 2021

Preeclampsia (PE) is a major disease of pregnancy, with various short- or long-term complications for both the mother and offspring. We focused on the body mass index (BMI) of offspring and compared the incidence of obesity during early childhood bet...

(This article belongs to the Special Issue The Prevention and Treatment of Preeclampsia and Fetal Growth Restriction)
  • Article
  • Open Access
21 Citations
3,947 Views
13 Pages

Effect of Systemic Steroid Use for Immune-Related Adverse Events in Patients with Non-Small Cell Lung Cancer Receiving PD-1 Blockade Drugs

  • Atsuto Mouri,
  • Kyoichi Kaira,
  • Ou Yamaguchi,
  • Kousuke Hashimoto and ,
  • Yu Miura,
  • Ayako Shiono,
  • Shun Shinomiya,
  • Hisao Imai,
  • Kunihiko Kobayashi and
  • Hiroshi Kagamu
  • + 5 authors+ 0 author

23 August 2021

Objectives: Programmed death-1(PD-1)/programmed death ligand-1 (PD-L1) antibodies have clinical benefits for cancer patients facing immune-related adverse events (irAEs). However, the effect of steroid use on the prognosis of patients with non-small...

(This article belongs to the Section Immunology & Rheumatology)
  • Review
  • Open Access
69 Citations
9,093 Views
21 Pages

Familial Melanoma and Susceptibility Genes: A Review of the Most Common Clinical and Dermoscopic Phenotypic Aspect, Associated Malignancies and Practical Tips for Management

  • Lamberto Zocchi,
  • Alberto Lontano,
  • Martina Merli,
  • Emi Dika and ,
  • Eduardo Nagore,
  • Pietro Quaglino,
  • Susana Puig and
  • Simone Ribero
  • + 3 authors+ 0 author

23 August 2021

A family history of melanoma greatly increases the risk of developing cutaneous melanoma, a highly aggressive skin cancer whose incidence has been steadily increasing worldwide. Familial melanomas account for about 10% of all malignant melanomas and...

(This article belongs to the Section Dermatology)
  • Article
  • Open Access
10 Citations
5,933 Views
7 Pages

Perioperative Management of Pheochromocytoma: From a Dogmatic to a Tailored Approach

  • Salvatore Buscemi,
  • Giuseppe Di Buono,
  • Rocco D’Andrea,
  • Claudio Ricci and ,
  • Laura Alberici,
  • Lorenzo Querci,
  • Saverio Selva,
  • Francesco Minni,
  • Roberto Citarrella and
  • Antonino Agrusa
  • + 6 authors+ 1 author

23 August 2021

Background: Perioperative management of pheochromocytoma (PCC) remains under debate. Methods: A bicentric retrospective study was conducted, including all patients who underwent laparoscopic adrenalectomy for PCC from 2000 to 2017. Patients were divi...

(This article belongs to the Special Issue Outcomes and Therapeutic Management of Thyroid Carcinoma)
  • Article
  • Open Access
7 Citations
6,236 Views
12 Pages

Discriminant Analysis of Main Prognostic Factors Associated with Hemodynamically Significant PDA: Apgar Score, Silverman–Anderson Score, and NT-Pro-BNP Level

  • Anna V. Permyakova,
  • Artem Porodikov,
  • Alex G. Kuchumov,
  • Alexey Biyanov and ,
  • Vagram Arutunyan,
  • Evgeniy G. Furman and
  • Yuriy S. Sinelnkov
  • + 2 authors+ 0 author

22 August 2021

Hemodynamically significant patent ductus arteriosus (hsPDA) in premature newborns is associated with a risk of PDA-related morbidities. Classification into risk groups may have a clinical utility in cases of suspected hsPDA to decrease the need for...

(This article belongs to the Special Issue Clinical Research into the Cardiovascular Health of People Born Preterm)
  • Article
  • Open Access
6 Citations
4,027 Views
10 Pages

Serum Amphiregulin and Heparin-Binding Epidermal Growth Factor as Biomarkers in Patients with Idiopathic Inflammatory Myopathy

  • Norio Hanata,
  • Yasuo Nagafuchi,
  • Yusuke Sugimori,
  • Satomi Kobayashi and ,
  • Yumi Tsuchida,
  • Yukiko Iwasaki,
  • Hirofumi Shoda and
  • Keishi Fujio
  • + 3 authors+ 0 author

22 August 2021

Background. The epidermal growth factors amphiregulin (AREG) and heparin-binding epidermal growth factor (HB-EGF) are implicated in the pathogenesis of several autoimmune diseases, but their clinical and pathological roles in idiopathic inflammatory...

(This article belongs to the Section Immunology & Rheumatology)
  • Review
  • Open Access
20 Citations
3,864 Views
10 Pages

22 August 2021

There is insufficient evidence about the cardioprotective effects of statins against chemotherapy-induced cardiomyopathy. The MEDLINE and EMBASE databases were searched from inception to March 2021 for studies that reported the mean left ventricular...

(This article belongs to the Section Cardiology)
  • Article
  • Open Access
6 Citations
4,174 Views
10 Pages

Novel Iron Parameters in Patients with Type 2 Diabetes Mellitus in Relation to Kidney Function

  • Agnieszka Zapora-Kurel,
  • Łukasz Kuźma,
  • Magdalena Zakrzewska,
  • Marcin Żórawski and ,
  • Sławomir Dobrzycki,
  • Małgorzata Twardowska-Kawalec and
  • Jolanta Małyszko
  • + 2 authors+ 0 author

22 August 2021

Background/aims: Anemia of chronic disease is a common feature in diabetes and chronic kidney disease. Hepcidin is the key element involved in iron metabolism; however, studies on new indices of iron status are still ongoing. The aim of the study was...

(This article belongs to the Special Issue Management of the Progression and Complications of CKD)
  • Review
  • Open Access
12 Citations
5,859 Views
11 Pages

22 August 2021

Chronic lymphocytic leukemia (CLL) is highly heterogeneous, with extremely variable clinical course. The clinical heterogeneity of CLL reflects differences in the biology of the disease, including chromosomal alterations, specific immunophenotypic pa...

(This article belongs to the Special Issue Advances in the Treatment of Chronic Lymphocytic Leukemia)
  • Article
  • Open Access
8 Citations
3,210 Views
12 Pages

Value of Left Ventricular Feature Tracking Strain Analysis for Detection of Early Cardiac Involvement in Fabry Disease (FD)

  • Fritz Christian Roller,
  • Alexander Brose,
  • Martin Richter,
  • Armin Schüssler and ,
  • Sebastian Harth,
  • Christian Tanislav and
  • Gabriele Anja Krombach
  • + 2 authors+ 0 author

22 August 2021

Purpose: Detection of cardiac involvement in Fabry disease (FD) is of high importance for treatment management. Native T1 mapping especially showed great potential for detection of early cardiac manifestations. Echocardiographic studies showed strain...

(This article belongs to the Section Cardiology)
  • Review
  • Open Access
24 Citations
6,241 Views
16 Pages

Clinical Implications of Growth Hormone Deficiency for Oral Health in Children: A Systematic Review

  • Natalia Torlińska-Walkowiak,
  • Katarzyna Anna Majewska,
  • Andrzej Kędzia and
  • Justyna Opydo-Szymaczek

22 August 2021

Growth hormone (GH) is involved in the regulation of the postnatal dental and skeletal growth, but its effects on oral health have not been clearly defined. This paper aims to provide a review of current clinical knowledge of dental caries, tooth wea...

(This article belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
  • Review
  • Open Access
15 Citations
4,790 Views
17 Pages

Outcomes of Diabetic Retinopathy Post-Bariatric Surgery in Patients with Type 2 Diabetes Mellitus

  • Ana Maria Dascalu,
  • Anca Pantea Stoian,
  • Alina Popa Cherecheanu,
  • Dragos Serban and ,
  • Daniel Ovidiu Costea,
  • Mihail Silviu Tudosie,
  • Daniela Stana,
  • Denisa Tanasescu,
  • Alexandru Dan Sabau and
  • Catalin Gabriel Smarandache
  • + 8 authors+ 3 authors

22 August 2021

Bariatric surgery is an emerging therapeutic approach for obese type 2 diabetes mellitus (T2DM) patients, with proven benefits for achieving target glucose control and even remission of diabetes. However, the effect of bariatric surgery upon diabetic...

(This article belongs to the Special Issue Chronic Diabetic Complications: Current Challenges and Opportunities)
  • Article
  • Open Access
22 Citations
5,293 Views
14 Pages

High-Resolution 18F-FDG PET/CT for Assessing Three-Dimensional Intraoperative Margins Status in Malignancies of the Head and Neck, a Proof-of-Concept

  • Jens M. Debacker,
  • Vanessa Schelfhout,
  • Lieve Brochez,
  • David Creytens and ,
  • Yves D’Asseler,
  • Philippe Deron,
  • Vincent Keereman,
  • Koen Van de Vijver,
  • Christian Vanhove and
  • Wouter Huvenne
  • + 5 authors+ 0 author

22 August 2021

The surgical treatment of head and neck malignancies relies on the complete removal of tumoral tissue, while inadequate margins necessitate the use of adjuvant therapy. However, most positive margins are identified postoperatively as deep margins, an...

(This article belongs to the Section Oncology)
  • Feature Paper
  • Article
  • Open Access
13 Citations
4,105 Views
19 Pages

Clinical Evaluation of Different Treatment Strategies for Motor Recovery in Poststroke Rehabilitation during the First 90 Days

  • Ekaterina S. Koroleva,
  • Stanislav D. Kazakov,
  • Ivan V. Tolmachev,
  • Anton J. M. Loonen and ,
  • Svetlana A. Ivanova and
  • Valentina M. Alifirova
  • + 1 author+ 0 author

21 August 2021

Background: Motor recovery after stroke is based on neuronal plasticity and the structural reorganization of the brain. Questions are debated about the proper moment to start rehabilitation in the acute period of stroke, the significance of rehabilit...

(This article belongs to the Section Clinical Neurology)
  • Article
  • Open Access
3 Citations
2,851 Views
12 Pages

Predictive Role of Prior Radiotherapy and Immunotherapy-Related Adverse Effects in Advanced NSCLC Patients Receiving Anti-PD-1/L1 Therapy

  • Jeong Uk Lim,
  • Soo Han Kim,
  • Hye Seon Kang,
  • Sung Kyoung Kim and ,
  • Ju Sang Kim,
  • Jin Woo Kim,
  • Seung Joon Kim,
  • Chang Dong Yeo and
  • Chang Min Choi
  • + 4 authors+ 0 author

21 August 2021

The present study evaluated the impact of prior radiotherapy (RT) on patients with advanced non-small cell lung cancer (NSCLC) receiving therapy with immune checkpoint inhibitors (ICIs) and further assessed the prognostic factors in patients receivin...

(This article belongs to the Section Respiratory Medicine)
  • Article
  • Open Access
18 Citations
4,312 Views
9 Pages

Vascular Complications in Patients with Chronic Pancreatitis

  • Miroslav Vujasinovic,
  • Ana Dugic,
  • Amar Nouri,
  • Torkel B Brismar and ,
  • Francisco Baldaque-Silva,
  • Ebba Asplund,
  • Wiktor Rutkowski,
  • Poya Ghorbani,
  • Ernesto Sparrelid and
  • J.-Matthias Löhr
  • + 6 authors+ 1 author

21 August 2021

Introduction: Chronic pancreatitis (CP) is a long-standing progressive inflammation of the pancreas, which can lead to a variety of vascular complications, such as splanchnic venous thrombosis (VT) and arterial pseudoaneurysm (PA). There is a lack of...

(This article belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
  • Article
  • Open Access
17 Citations
4,411 Views
15 Pages

Markers of Inflammation and Vascular Parameters in Selective Progesterone Receptor Modulator (Ulipristal Acetate)-Treated Uterine Fibroids

  • Iwona Szydłowska,
  • Marta Grabowska,
  • Jolanta Nawrocka-Rutkowska,
  • Andrzej Kram and ,
  • Małgorzata Piasecka and
  • Andrzej Starczewski
  • + 1 author+ 0 author

21 August 2021

The exact mechanism of selective progesterone receptor modulator action in leiomyoma still challenges researchers. The aim of the study was to assess the effects of ulipristal acetate (UPA) on immunoexpression of inflammatory markers and vascularizat...

(This article belongs to the Special Issue Diagnosis and Management of Endometriosis and Uterine Fibroids)
  • Article
  • Open Access
4 Citations
3,976 Views
9 Pages

Cytomegalovirus-Associated Autoantibody against TAF9 Protein in Patients with Systemic Lupus Erythematosus

  • Yen-Fu Chen,
  • Ao-Ho Hsieh,
  • Lian-Chin Wang,
  • Kuang-Hui Yu and
  • Chang-Fu Kuo

21 August 2021

Background: Evidence indicates a causal link between cytomegalovirus (CMV) infection and the triggering of systemic lupus erythematosus (SLE). Animal studies have revealed that CMV phosphoprotein 65 (pp65) induces autoantibodies against nuclear mater...

(This article belongs to the Special Issue Systemic Lupus Erythematosus: Pathogenesis, Diagnosis and Treatment)
  • Article
  • Open Access
3 Citations
3,148 Views
14 Pages

Differences between Obese and Non-Obese Children and Adolescents Regarding Their Oral Status and Blood Markers of Kidney Diseases

  • Katarzyna Maćkowiak-Lewandowicz,
  • Danuta Ostalska-Nowicka,
  • Jacek Zachwieja and
  • Elżbieta Paszyńska

21 August 2021

(1) Background: A rarely discussed effect of obesity-related glomerulopathy (ORG) may slowly lead to irreversible glomerular damage and the development of chronic kidney disease. These patients need to undertake medical care, but whether they should...

(This article belongs to the Special Issue Pediatric and Adolescent Nephrology Facing the Future: Diagnostic Advances and Prognostic Biomarkers in Everyday Practice)
  • Article
  • Open Access
7 Citations
3,244 Views
10 Pages

COVID-19 in Pregnancy—Perinatal Outcomes and Vertical Transmission Preventative Strategies, When Considering More Transmissible SARS-CoV-2 Variants

  • Marcin Januszewski,
  • Laura Ziuzia-Januszewska,
  • Malgorzata Santor-Zaczynska,
  • Alicja A. Jakimiuk and ,
  • Tomasz Oleksik,
  • Marek Pokulniewicz,
  • Kamil Pluta,
  • Waldemar Wierzba and
  • Artur J. Jakimiuk
  • + 4 authors+ 0 author

21 August 2021

The COVID-19 pandemic affected the physical and mental health of people around the world and left unprepared health care systems struggling to mount an adequate response. Understanding the impact of COVID-19 on pregnancy in terms of perinatal and fet...

(This article belongs to the Section Obstetrics & Gynecology)
  • Article
  • Open Access
8 Citations
3,178 Views
13 Pages

New Insights in Microbial Species Predicting Lung Function Decline in CF: Lessons from the MucoFong Project

  • Florence Francis,
  • Raphael Enaud,
  • Perrine Soret,
  • Florian Lussac-Sorton and ,
  • Marta Avalos-Fernandez,
  • MucoFong Investigation Group,
  • Stéphanie Bui,
  • Michael Fayon,
  • Rodolphe Thiébaut and
  • Laurence Delhaes
  • + 5 authors+ 0 author

21 August 2021

Several predictive models have been proposed to understand the microbial risk factors associated with cystic fibrosis (CF) progression. Very few have integrated fungal airways colonisation, which is increasingly recognized as a key player regarding C...

(This article belongs to the Section Respiratory Medicine)
  • Article
  • Open Access
7 Citations
6,934 Views
11 Pages

The Impact of Suture Button Removal in Syndesmosis Fixation

  • Jaeyoung Kim,
  • Minsoo Kwon,
  • Jonathan Day,
  • Jesse Seilern und Aspang and ,
  • Jaehoon Shim and
  • Jaeho Cho
  • + 1 author+ 0 author

21 August 2021

The suture button (SB) device was introduced to negate the need for routine hardware removal in the treatment of syndesmosis injuries. However, a considerable SB removal rate has been reported, and the impact of removal is unknown. This study aimed t...

(This article belongs to the Special Issue Foot & Ankle Pathology: Emerging Approaches)
  • Article
  • Open Access
8 Citations
2,914 Views
11 Pages

Comparison of the Prognostic Value of Ki-67 and Programmed Cell Death Ligand-1 in Patients with Upper Tract Urothelial Carcinoma

  • Mu-Yao Tsai,
  • Ping-Chia Chiang,
  • Chien-Hsu Chen,
  • Ming-Tse Sung and ,
  • Shun-Chen Huang,
  • Jau-Ling Suen,
  • Eing-Mei Tsai and
  • Po-Hui Chiang
  • + 3 authors+ 0 author

21 August 2021

We retrospectively enrolled 102 patients with upper tract urothelial carcinoma (UTUC) who underwent radical nephroureterectomy to examine the prognostic value of Ki-67 and programmed cell death ligand-1 (PD-L1). Then, we performed PD-L1 and Ki-67 imm...

(This article belongs to the Section Nephrology & Urology)
  • Article
  • Open Access
9 Citations
6,038 Views
13 Pages

Beneficial Effects of Opioid Rotation to Buprenorphine/Naloxone on Opioid Misuse, Craving, Mental Health, and Pain Control in Chronic Non-Cancer Pain Patients with Opioid Use Disorder

  • Arnt F. A. Schellekens,
  • Stijn E. Veldman,
  • Eka S. D. Suranto,
  • Steffie M. van Rijswijk and ,
  • Selina E. I. van der Wal,
  • Aart H. Schene and
  • Marleen H. C. T. van Beek
  • + 2 authors+ 0 author

21 August 2021

Patients with chronic non-cancer pain (CNCP) often use opioids for long periods of time. This may lead to opioid use disorder (OUD) and psychiatric symptoms: mainly depression and anxiety. The current study investigated the effect of buprenorphine/na...

(This article belongs to the Section Mental Health)
  • Article
  • Open Access
23 Citations
4,586 Views
11 Pages

Hepatic Hydrothorax—An Independent Decompensating Event Associated with Long-Term Mortality in Patients with Cirrhosis

  • Daniela Matei,
  • Rares Craciun,
  • Dana Crisan,
  • Bogdan Procopet and ,
  • Tudor Mocan,
  • Sergiu Pasca,
  • Roxana Zaharie,
  • Bogdan Popovici and
  • Zeno Sparchez
  • + 4 authors+ 0 author

20 August 2021

Background: Hepatic hydrothorax (HH) is an understudied complication of decompensated cirrhosis. We aimed to evaluate the long-term prognosis of patients with HH by comparing them with a matched non-HH group. Methods: This retrospective study include...

(This article belongs to the Special Issue The Clinical Management of Liver Cirrhosis: Current Concepts, Recent Advances and Future Trends)
  • Article
  • Open Access
4 Citations
2,742 Views
9 Pages

Social Distancing during COVID-19 Pandemic among Inflammatory Bowel Disease Patients

  • Michał Łodyga,
  • Katarzyna Maciejewska,
  • Piotr Eder,
  • Katarzyna Waszak and ,
  • Kamila Stawczyk-Eder,
  • Agnieszka Dobrowolska,
  • Aleksandra Kaczka,
  • Anita Gąsiorowska,
  • Beata Stępień-Wrochna and
  • Grażyna Rydzewska
  • + 6 authors+ 1 author

20 August 2021

(1) Background: Social distancing rules have been widely introduced in the fight against the coronavirus disease 2019 (COVID-19) pandemic. So far, the effectiveness of these methods has not been assessed in the group of inflammatory bowel disease (IB...

(This article belongs to the Special Issue Advances in Inflammatory Bowel Disease)
  • Article
  • Open Access
12 Citations
5,040 Views
15 Pages

Application of a Global Multiparameter Scoring System for the Prenatal Prediction of Coarctation of the Aorta

  • Enery Gómez-Montes,
  • Ignacio Herraiz García,
  • David Escribano Abad,
  • Jesús Rodríguez Calvo and ,
  • Cecilia Villalaín González and
  • Alberto Galindo Izquierdo
  • + 1 author+ 0 author

20 August 2021

To assess prospectively the capability of our previously reported global multiparameter scoring system to predict coarctation of the aorta (CoAo) in fetuses with cardiac asymmetry, we applied and analyzed the performance of our scoring system in pred...

(This article belongs to the Section Obstetrics & Gynecology)
  • Review
  • Open Access
11 Citations
3,791 Views
11 Pages

The Impact of ABO Blood Type on Developing Venous Thromboembolism in Cancer Patients: Systematic Review and Meta-Analysis

  • Fumihiko Urabe,
  • Shoji Kimura,
  • Kosuke Iwatani,
  • Keiji Yasue and ,
  • Yuhei Koike,
  • Kojiro Tashiro,
  • Shunsuke Tsuzuki,
  • Hiroshi Sasaki,
  • Takahiro Kimura and
  • Shin Egawa
  • + 5 authors+ 0 author

20 August 2021

The impact of ABO blood type in the development of venous thromboembolism in cancer patients remains controversial. To develop a sense of the current opinion in this area, we conducted a systematic review and meta-analysis. In March 2021, we performe...

(This article belongs to the Section Vascular Medicine)
  • Article
  • Open Access
5 Citations
3,560 Views
11 Pages

Risk Factors and Outcomes Following Septostomy during Fetoscopic Surgery for Twin-to-Twin Transfusion Syndrome

  • Clifton O. Brock,
  • Eric P. Bergh,
  • Edgar A. Hernandez-Andrade,
  • Rodrigo Ruano and ,
  • Anthony Johnson and
  • Ramesha Papanna
  • + 1 author+ 0 author

20 August 2021

Fetoscopic laser photocoagulation (FLP) of placental anastomoses is the preferred treatment for twin-to-twin transfusion syndrome (TTTS). Iatrogenic septostomy (IOS) during FLP is associated with increased risk of neonatal morbidity and mortality. We...

(This article belongs to the Section Obstetrics & Gynecology)
  • Article
  • Open Access
8 Citations
3,608 Views
9 Pages

Analysis of Gender Differences in the Rotational Alignment of the Distal Femur in Kinematically Aligned and Mechanically Aligned Total Knee Arthroplasty

  • Byung-Woo Cho,
  • Hyoung-Taek Hong,
  • Yong-Gon Koh,
  • Jeehoon Choi and ,
  • Kwan-Kyu Park and
  • Kyoung-Tak Kang
  • + 1 author+ 0 author

20 August 2021

To compare the angle between the external rotation references of the femoral components in the axial plane by gender and lower limb alignment in Korean patients with osteoarthritis (OA). Magnetic resonance (MR) images of 1273 patients were imported i...

(This article belongs to the Section Orthopedics)
  • Article
  • Open Access
34 Citations
8,754 Views
17 Pages

Acupuncture Relieved Chemotherapy-Induced Peripheral Neuropathy in Patients with Breast Cancer: A Pilot Randomized Sham-Controlled Trial

  • Chien-Chen Huang,
  • Tsung-Jung Ho,
  • Hsin-Yueh Ho,
  • Pei-Yu Chen and ,
  • Cheng-Hao Tu,
  • Yu-Chuen Huang,
  • Yu-Chen Lee,
  • Mao-Feng Sun and
  • Yi-Hung Chen
  • + 4 authors+ 0 author

20 August 2021

Chemotherapy-induced peripheral neuropathy (CIPN) is a disabling side effect caused by neurotoxic chemotherapy. This randomized controlled trial aimed to evaluate the effect of manual acupuncture on CIPN. Twenty eligible breast cancer patients receiv...

(This article belongs to the Special Issue State-of-the-Art Research on Acupuncture Treatment)

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J. Clin. Med. - ISSN 2077-0383