Special Issue "Spinal Cord Injury and Transcutaneous Spinal Cord Stimulation"
Deadline for manuscript submissions: 1 July 2021.
Interests: human spinal locomotor circuits; multiple sclerosis; neural control of movement; neuromodulation; neurorehabilitation; spinal cord; spinal cord injury; spinal cord stimulation
Interests: catecholaminergic system; central pattern generator; electrophysiology; epidural electrical stimulation; locomotion; neuromodulation; spinal cord physiology; spinal cord injury
Recent research of epidural and transcutaneous electrical spinal cord stimulation has demonstrated unprecedented improvements in motor function thought to be irreversibly lost due to chronic, severe spinal cord injury. Studies in parallel assess these methods for spasticity management as an alternative to medications that are often accompanied by deleterious side effects. As a noninvasive intervention, transcutaneous spinal cord stimulation holds the great potential to find its way into wide clinical application. Its firm establishment and lasting acceptance as clinical practice in spinal cord injury will not only hinge on the demonstration of safety and efficacy, but also on the delineation of a conceptual framework of the underlying physiological mechanisms. This will also require advancing our understanding of immediate and temporary effects of transcutaneous spinal cord on neuronal circuits in the intact and injured spinal cord. The purpose of the present Special Issue is to bring together peers in the field to share—and eventually fuse—their pertinent research into current neurorehabilitation practice by providing a clinical perspective and novel insights into the underlying mechanisms.
Dr. Ursula S. Hofstoetter
Dr. Karen Minassian
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.
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- Spinal cord circuits
- Spinal cord injury
- Spinal reflexes
- Transcutaneous spinal cord stimulation
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Stephen P. Estes1, Anastasia Zarkou1, Jasmine Hope1,2, Edelle C Field-Fote1,2
 Shepherd Center,  Emory University School of Medicine
Locomotor training (LT) aims to improve walking function and can reduce spasticity in persons with motor-incomplete spinal cord injury (MISCI). Likewise, transcutaneous spinal stimulation (TSS) has been shown to influence these same outcomes.
Comparative efficacy of transcutaneous spinal stimulation versus whole body vibration for reducing spasticity in persons with SCI
Kyle Condon1, Evan Sandler1,2, Edelle Field-Fote1,2,3
 Shepherd Center,  Georgia Institute of Technology,  Emory University School of Medicine
In persons with spinal cord injury (SCI), spasticity is a common secondary complication which negatively impacts function and quality of life. Literature indicates antispasmodics have limited value for managing spasticity, prompting interest in non-pharmacological approaches. Both transcutaneous spinal stimulation (TSS) and whole body vibration (WBV) and have been shown to reduce spasticity. We compared immediate, delayed, and persistent single-session effects of TSS and TSS on quadriceps spasticity as measured by the pendulum test.
Tentative Title: Transcutaneous spinal cord stimulation enhances the Quadriceps Motor Evoked Potentials in healthy subjects. A double-blinded randomized controlled study.
Megía-García A; Serrano-Muñoz D; Taylor J; Avendaño-Coy J; Comino-Suarez N; Gómez-Soriano J.
Tentative Abstract: Introduction: transcutaneous electrical spinal cord stimulation (tSCS) is a non-invasive technique purposed to generate a neuromodulatory effect in the central nervous system. It has demonstrated to be a safe and feasible technique with a great therapeutic potential. The main aim of the present study is to quantify the effect of a single session of tSCS over the motor evoked potentials (MEPs) measured in healthy subjects.
Tentative Title: Is the Posterior Muscle Root reflex influenced by the body weight load in spinal cord injury subjects?
Authors: Comino-Sánchez N; Megía-García A; del Ama-Espinosa A; Moreno J; Gómez-Soriano J; Gil-Agudo A; Taylor J; Serrano-Muñoz D.
Tentative Abstract: Introduction: posterior root muscle reflex (PRM) is the muscle response evoked by the direct stimulation of large-diameter afferent fibres (Ia, Ib, II) belong to the posterior root in the spinal cord entrance. Previous studies have been demonstrated that PRM can be modulated by active muscle contraction, posture, and others central components. However, it isn´t knowledge of the modulation of PRM threshold suffered by suspension of body weight. This information is essential due to the combination of the spinal stimulation with gait training using body weight support assistance, that is being used in several protocols for gait rehabilitation in spinal cord injury. Aims: To analyse the variations in threshold of PRM due to body weight discharge in spinal cord injury subjects. Moreover, the peak-to-peak amplitude and latencies of PMR will be also analysed with the objective of exploring the modulations in central nervous system due to body weigh suspension.
Tentative Title: Transcutaneous spinal cord stimulation combined with Lokomat for gait rehabilitation of the spinal cord injury
Authors: Comino-Suárez N; Megía-García A; del Ama-Espinosa A; Moreno J; Gómez-Soriano J; Serrano-Muñoz D; Gil-Agudo A; Avendaño-Coy J; Esclarín-de-Ruz A.
Tentative Abstract: Introduction: Locomotion is affected in most of the patients with spinal cord injury. The use of robotic devices for gait recovery enables an early, high intensity and task-specific stepping therapy inducing neuroplastic changes. Recently, as well as epidural spinal cord stimulation, transcutaneous spinal cord stimulation (tSCS) allows for the stimulation of the dorsal root, evoking a reflex at lower limbs known as posterior root-muscle reflex (PRM). Objective: To analyse the feasibility, the safety and the effectiveness of a combined treatment of tSCS and Lokomat for gait rehabilitation in incomplete spinal cord injury patients.
Characterization of spinal sensorimotor network using transcutaneous spinal stimulation during voluntary movement preparation and performance
Authors：D.A. Atkinson, A.G. Steele, B. Varghese, J. Oh, D.G. Sayenko
Brief Abstract：Transcutaneous electrical spinal cord stimulation (TSS) can be used to differentially activate motor pools based on their anatomical arrangements in the lumbosacral enlargement. These spatial patterns of spinal motor activation may have important clinical implications, especially when there is a need to target specific motor pools. However, our understanding of the net effects and interplay between the motor pools projecting to agonist and antagonist muscles during the preparation and performance of voluntary movements is still limited. The present study was designed to systematically investigate and diﬀerentiate the multi-segmental convergence of supraspinal inputs on lumbosacral neural network before and during the execution of voluntary movements in neurologically intact participants.