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Brain Sciences, Volume 13, Issue 5

2023 May - 139 articles

Cover Story: Patients with persistent postural-perceptual dizziness (PPPD) often report having problems with balance control. Artificial systems providing vibro-tactile feedback of trunk sway (VTfbTS) have been used to improve balance control in several patient groups. We examined whether VTfbTS improves balance control during stance and gait phases in PPPD patients and reduces the effects of dizziness on their living circumstances. Two PPPD patient groups with dizziness were studied: those initially with pathological balance control, and those with normal balance control. The results show that providing VTfbTS to PPPD patients yields an improvement in balance control and dizziness. The benefit was greater for the gait trials than it was for the stance trials and benefited the group of PPPD patients with initially pathological balance control most. View this paper
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Articles (139)

  • Article
  • Open Access
50 Citations
5,025 Views
14 Pages

Trimethylamine N-Oxide Exacerbates Neuroinflammation and Motor Dysfunction in an Acute MPTP Mice Model of Parkinson’s Disease

  • Wei Quan,
  • Chen-Meng Qiao,
  • Gu-Yu Niu,
  • Jian Wu and ,
  • Li-Ping Zhao,
  • Chun Cui,
  • Wei-Jiang Zhao and
  • Yan-Qin Shen
  • + 3 authors+ 0 author

Observational studies have shown abnormal changes in trimethylamine N-oxide (TMAO) levels in the peripheral circulatory system of Parkinson’s disease (PD) patients. TMAO is a gut microbiota metabolite that can cross the blood–brain barrie...

(This article belongs to the Section Neurodegenerative Diseases)
  • Review
  • Open Access
22 Citations
5,258 Views
11 Pages

IL-10/β-Endorphin-Mediated Neuroimmune Modulation on Microglia during Antinociception

  • Thiago Caetano Andrade Belo,
  • Gabriela Xavier Santos,
  • Bruno Eduardo Gabriel da Silva,
  • Bruno Lopes Gonçalves Rocha and ,
  • Dennis William Abdala,
  • Larissa Alves Moreira Freire,
  • Fernanda Santos Rocha and
  • Giovane Galdino
  • + 3 authors+ 0 author

Microglia are glial cells centrally related to pathophysiology and neuroimmunological regulation of pain through microglia–neuron crosstalk mechanisms. In contrast, anti-inflammatory mechanisms guided by immunological effectors such as IL-10 tr...

(This article belongs to the Section Molecular and Cellular Neuroscience)
  • Article
  • Open Access
3 Citations
3,306 Views
13 Pages

Advertising uses sounds and dynamic images to provide visual, auditory, and tactile experiences, and to make the audience feel like the protagonist. During COVID-19, companies modified their communication by including pandemic references, but without...

(This article belongs to the Special Issue New Horizons in Multisensory Perception and Processing)
  • Article
  • Open Access
3,334 Views
16 Pages

Semantic Variant of Primary Progressive Aphasia (svPPA) has often been considered as a loss of knowledge stored in semantic memory, but might also be due to a general disruption of mechanisms allowing the acquisition, storage, and retrieval of semant...

(This article belongs to the Section Neurolinguistics)
  • Case Report
  • Open Access
2 Citations
3,115 Views
15 Pages

Meningioangiomatosis Combined with Calcifying Pseudoneoplasms of Neuraxis

  • Xiangyu Sun,
  • Chengshi Xu,
  • Yuxiang Cai,
  • Zhiyong Pan and
  • Zhiqiang Li

Meningioangiomatosis (MA) is a rare hamartomatous or meningovascular lesion involving the central nervous system, and is sometimes associated with intracranial meningiomas. Calcifying pseudoneoplasms of the neuraxis (CAPNON) are rare, slow-growing be...

(This article belongs to the Special Issue Advances in Diagnosis and Treatment of Brain Tumors and Nervous System Tumors)
  • Systematic Review
  • Open Access
32 Citations
14,432 Views
32 Pages

An understanding of the neurocognitive profile underlying the use of social networking sites (SNSs) can help inform decisions about the classification of problematic SNS use as an addictive disorder and elucidate how/when ‘SNS addiction’...

(This article belongs to the Section Neuropsychology)
  • Review
  • Open Access
114 Citations
13,265 Views
27 Pages

Epilepsy is a central nervous system disorder involving spontaneous and recurring seizures that affects 50 million individuals globally. Because approximately one-third of patients with epilepsy do not respond to drug therapy, the development of new...

(This article belongs to the Special Issue Recent Advances in Pathophysiology and Therapeutic Approaches in Epilepsy)
  • Project Report
  • Open Access
3 Citations
3,261 Views
17 Pages

We assessed the neurocognitive correlates of auditory executive attention in low socioeconomic status 9–12-year-old children—with and without training in a social music program (OrKidstra). Event-related potentials (ERPs) were recorded du...

(This article belongs to the Special Issue The Brain Goes to School)
  • Article
  • Open Access
9 Citations
6,180 Views
18 Pages

Background: Patients with persistent postural-perceptual dizziness (PPPD) frequently report having problems with balance control. Artificial systems providing vibro-tactile feedback (VTfb) of trunk sway to the patient could aid recalibration of &ldqu...

(This article belongs to the Special Issue Vestibular Neurology)
  • Article
  • Open Access
9 Citations
3,802 Views
18 Pages

The brain–computer interface (BCI) provides direct communication between human brains and machines, including robots, drones and wheelchairs, without the involvement of peripheral systems. BCI based on electroencephalography (EEG) has been appl...

(This article belongs to the Special Issue Brain-Computer Interfaces and Their Applications in Rehabilitation, Robotics, and Control of Human Brain States)
  • Article
  • Open Access
1 Citations
2,785 Views
10 Pages

Treatments to restore the balance of the temporomandibular joint (TMJ) are performed in the field of complementary and alternative medicine; however, evidence supporting this approach remains weak. Therefore, this study attempted to establish such ev...

(This article belongs to the Topic Translational Advances in Neurodegenerative Dementias)
  • Article
  • Open Access
27 Citations
8,786 Views
12 Pages

Structural magnetic resonance imaging (sMRI) studies have shown abnormalities in the brain structure of ASD patients, but the relationship between structural changes and social communication problems is still unclear. This study aims to explore the s...

(This article belongs to the Section Behavioral Neuroscience)
  • Article
  • Open Access
4 Citations
5,379 Views
9 Pages

The cerebrospinal fluid (CSF) analysis in ruptured aneurysms can be greatly affected by subarachnoid hemorrhage (SAH), making the diagnosis of intracranial infection more difficult after surgery. This study aimed to identify the reference value range...

(This article belongs to the Section Neurosurgery and Neuroanatomy)
  • Article
  • Open Access
2 Citations
3,827 Views
14 Pages

The somatosensory system is multidimensional and processes important information for survival, including the experience of pain. The brainstem and spinal cord serve pivotal roles in both transmitting and modulating pain signals from the periphery; al...

(This article belongs to the Section Sensory and Motor Neuroscience)
  • Feature Paper
  • Review
  • Open Access
25 Citations
11,881 Views
10 Pages

The rostral ventromedial medulla (RVM) is a brainstem structure critical for the descending pain modulation system involved in both pain facilitation and inhibition through its projection to the spinal cord. Since the RVM is well connected with pain-...

(This article belongs to the Section Behavioral Neuroscience)
  • Article
  • Open Access
2 Citations
2,734 Views
12 Pages

L-DOPA Improves Ventilation but Not the Ventilatory Response to Hypercapnia in a Reserpine Model of Parkinson’s Disease

  • Monika Jampolska,
  • Kryspin Andrzejewski,
  • Paweł M. Boguszewski and
  • Katarzyna Kaczyńska

Parkinson’s disease (PD) is a neurological disorder characterized by progressive degeneration of the substantia nigra that affects mainly movement control. However, pathological changes associated with the development of PD may also alter respi...

(This article belongs to the Section Neurodegenerative Diseases)
  • Article
  • Open Access
3 Citations
3,481 Views
25 Pages

Maternal Variability of Amplitudes of Frequency Fluctuations Is Related to the Progressive Self–Other Transposition Group Intervention in Autistic Children

  • Jianxin Zhang,
  • Xiaorong Guo,
  • Weiguo Zhang,
  • Dianzhi Liu and ,
  • Peiqi Chen,
  • Yuqing Zhang and
  • Xiaoyuan Ru
  • + 2 authors+ 0 author

The self-to-other model of empathy (SOME) states that a key reason for the empathic deficiency in autistic individuals is the imbalance of the self–other switch. The existing interventions of theory of mind contain training of self–other...

(This article belongs to the Special Issue Cognitive, Emotional and Social Skills in Typical and Atypical Development: Domain-Specific Abilities and Possible Overlaps for Prevention, Diagnosis and Treatment)
  • Article
  • Open Access
2 Citations
4,611 Views
15 Pages

The Big Five as Predictors of Cognitive Function in Individuals with Bipolar Disorder

  • Eva Fleischmann,
  • Nina Dalkner,
  • Frederike T. Fellendorf,
  • Susanne A. Bengesser and ,
  • Melanie Lenger,
  • Armin Birner,
  • Robert Queissner,
  • Martina Platzer,
  • Adelina Tmava-Berisha and
  • Eva Z. Reininghaus
  • + 11 authors+ 6 authors

The connection between cognitive function and the “Big Five” personality traits (openness, conscientiousness, extraversion, agreeableness, and neuroticism) in the general population is well known; however, studies researching bipolar diso...

(This article belongs to the Special Issue Etiology, Pathogenesis and Treatment of Bipolar Disorder)
  • Article
  • Open Access
3 Citations
4,001 Views
14 Pages

No studies have looked at the effects of cumulative sleep restriction (CSR) on sleep architecture or the power spectrum of sleep EEG (electroencephalogram) in school-age children, as recorded by PSG (polysomnography). This is true for both typically...

(This article belongs to the Special Issue Effects of Sleep Deprivation on Cognition, Emotion, and Behavior)
  • Article
  • Open Access
11 Citations
4,536 Views
20 Pages

Reduced Expression of Very-Long-Chain Acyl-CoA Synthetases SLC27A4 and SLC27A6 in the Glioblastoma Tumor Compared to the Peritumoral Area

  • Jan Korbecki,
  • Klaudyna Kojder,
  • Dariusz Jeżewski,
  • Donata Simińska and ,
  • Patrycja Tomasiak,
  • Maciej Tarnowski,
  • Dariusz Chlubek and
  • Irena Baranowska-Bosiacka
  • + 3 authors+ 0 author

This study aimed to analyze solute carrier family 27 (SLC27) in glioblastoma tumors. The investigation of these proteins will provide insight into how and to what extent fatty acids are taken up from the blood in glioblastoma tumors, as well as the s...

(This article belongs to the Section Neuro-oncology)
  • Article
  • Open Access
13 Citations
5,193 Views
21 Pages

We present a framework for electroencephalography (EEG)-based classification between patients with Alzheimer’s Disease (AD) and robust normal elderly (RNE) via a graph theory approach using visibility graphs (VGs). This EEG VG approach is motiv...

  • Article
  • Open Access
6 Citations
4,379 Views
15 Pages

Joint Contributions of Depression and Insufficient Sleep to Self-Harm Behaviors in Chinese College Students: A Population-Based Study in Jiangsu, China

  • Yiwen Hua,
  • Hui Xue,
  • Xiyan Zhang,
  • Lijun Fan and ,
  • Yong Tian,
  • Xin Wang,
  • Xiaoyan Ni,
  • Wei Du,
  • Fengyun Zhang and
  • Jie Yang
  • + 5 authors+ 0 author

Self-harm in young people is common, and previous studies have shown that insufficient sleep or depression was associated with self-harm. However, the joint association of insufficient sleep and depression with self-harm is unknown. We employed repre...

(This article belongs to the Section Behavioral Neuroscience)
  • Review
  • Open Access
9 Citations
6,827 Views
34 Pages

This position paper offers a perspective on the long-standing debate concerning the role of oromotor, nonverbal gestures in understanding typical and disordered speech motor control secondary to neurological disease. Oromotor nonverbal tasks are empl...

(This article belongs to the Special Issue Profiles of Dysarthria: Clinical Assessment and Treatment)
  • Review
  • Open Access
16 Citations
7,968 Views
11 Pages

Empathy has garnered increasing recognition as a pivotal component of teacher–student interactions and a notable determinant of student achievement. Nevertheless, the exact impact of empathy on teacher–student interactions remains elusive...

(This article belongs to the Section Cognitive, Social and Affective Neuroscience)
  • Article
  • Open Access
17 Citations
5,000 Views
16 Pages

Tactile attention tasks are used in the diagnosis and treatment of neurological and sensory processing disorders, while somatosensory event-related potentials (ERP) measured by electroencephalography (EEG) are used as neural correlates of attention p...

(This article belongs to the Special Issue Emerging Topics in Brain-Computer Interface)
  • Review
  • Open Access
9 Citations
3,907 Views
19 Pages

The concreteness effect (CE), namely a better performance with concrete compared to abstract concepts, is a constant feature in healthy people, and it usually increases in persons with aphasia (PWA). However, a reversal of the CE has been reported in...

(This article belongs to the Section Neurolinguistics)
  • Article
  • Open Access
13 Citations
4,008 Views
12 Pages

Modification of Body-Related Attentional Bias through Virtual Reality and Eye-Tracking in Healthy Participants: Implications for Anorexia Nervosa Treatments

  • Helena Miquel-Nabau,
  • Natalia Briseño-Oloriz,
  • Bruno Porras-Garcia,
  • Mariarca Ascione and ,
  • Franck-Alexandre Meschberger-Annweiler,
  • Marta Ferrer-Garcia,
  • Manuel Moreno-Sanchez,
  • Eduardo Serrano-Troncoso,
  • Marta Carulla-Roig and
  • José Gutiérrez Maldonado
  • + 5 authors+ 0 author

Cognitive biases have a significant impact on the etiology and treatment of eating disorders (EDs). These biases, including selective attentional bias (AB) to disliked body parts, may reinforce concerns about body shape, fear of gaining weight and bo...

(This article belongs to the Special Issue Hedonic, Motivation and Learning Mechanisms of Ingestive Behavior)
  • Article
  • Open Access
4 Citations
3,668 Views
17 Pages

(1) Background: there is an urgent clinical need for rapid and effective antidepressants. (2) Methods: We employed proteomics to profile proteins in two animal models (n = 48) of Chronic Unpredictable Stress and Chronic Social Defeat Stress. Addition...

(This article belongs to the Section Neuropsychiatry)
  • Article
  • Open Access
13 Citations
6,999 Views
17 Pages

Background: Endothelial dysfunction is implicated in various inflammatory diseases such as ischemic stroke, heart attack, organ failure, and COVID-19. Recent studies have shown that endothelial dysfunction in the brain is attributed to excessive infl...

(This article belongs to the Special Issue Identification of Molecular Targets and Anti-cancer Agents in Glioblastoma Multiforme: New Perspectives for Cancer Therapy)
  • Brief Report
  • Open Access
5 Citations
3,145 Views
7 Pages

Sex Differences in Excitatory and Inhibitory Function in the Primary Somatosensory Cortex during the Early Follicular Phase: A Preliminary Study

  • Sayaka Anazawa,
  • Koya Yamashiro,
  • Taiki Makibuchi,
  • Koyuki Ikarashi and ,
  • Tomomi Fujimoto,
  • Genta Ochi and
  • Daisuke Sato
  • + 2 authors+ 0 author

Background and objectives: We examined sex differences in the excitatory and inhibitory functions of the primary somatosensory cortex (S1) between males and females during the early follicular phase, when estradiol hormones are unaffected. Methods: F...

(This article belongs to the Section Behavioral Neuroscience)
  • Article
  • Open Access
4 Citations
2,893 Views
13 Pages

There are limited treatment options for drug-resistant epilepsy (DRE) in children. We performed a pilot study to investigate the tolerability and effectiveness of cathodal transcranial direct current stimulation (tDCS) in DRE. Twelve children with DR...

(This article belongs to the Section Developmental Neuroscience)
  • Article
  • Open Access
9 Citations
3,628 Views
17 Pages

Electroencephalogram (EEG) connectivity patterns can reflect neural correlates of emotion. However, the necessity of evaluating bulky data for multi-channel measurements increases the computational cost of the EEG network. To date, several approaches...

(This article belongs to the Special Issue Emerging Trends of Biomedical Signal Processing in Intelligent Emotion Recognition)
  • Article
  • Open Access
8 Citations
4,621 Views
14 Pages

The phenomenon of future rewards being devalued as a function of delay is referred to as delay discounting (DD). It is considered a measure of impulsivity, and steep DD characterizes psychiatric problems such as addictive disorders and attention defi...

(This article belongs to the Section Behavioral Neuroscience)
  • Article
  • Open Access
2 Citations
2,990 Views
15 Pages

Hippocampus Parcellation via Discriminative Embedded Clustering of fMRI Functional Connectivity

  • Limin Peng,
  • Chenping Hou,
  • Jianpo Su,
  • Hui Shen and ,
  • Lubin Wang,
  • Dewen Hu and
  • Ling-Li Zeng
  • + 2 authors+ 0 author

Dividing a pre-defined brain region into several heterogenous subregions is crucial for understanding its functional segregation and integration. Due to the high dimensionality of brain functional features, clustering is often postponed until dimensi...

(This article belongs to the Section Neurotechnology and Neuroimaging)
  • Article
  • Open Access
4 Citations
2,638 Views
11 Pages

How Sample Size Impacts Probabilistic Stimulation Maps in Deep Brain Stimulation

  • Teresa Nordin,
  • Patric Blomstedt,
  • Simone Hemm and
  • Karin Wårdell

Probabilistic stimulation maps of deep brain stimulation (DBS) effect based on voxel-wise statistics (p-maps) have increased in literature over the last decade. These p-maps require correction for Type-1 errors due to multiple testing based on the sa...

(This article belongs to the Section Neurotechnology and Neuroimaging)
  • Article
  • Open Access
19 Citations
4,493 Views
12 Pages

Persistent Non-Suicidal Self-Injury and Suicidality in Referred Adolescents: A Longitudinal Study Exploring the Role of Cyclothymic Temperament

  • Gabriele Masi,
  • Simone Pisano,
  • Gianluca Sesso,
  • Cristina Mazzullo and ,
  • Stefano Berloffa,
  • Pamela Fantozzi,
  • Antonio Narzisi,
  • Francesca Placini,
  • Elena Valente and
  • Annarita Milone
  • + 6 authors+ 1 author

Non-suicidal self-injury (NSSI) is deliberate harm to the body surface without suicidal intent, though it may be a predictor of suicide attempts. Our aim was to test the hypothesis that persisting and recovering NSSI may have a different longitudinal...

(This article belongs to the Special Issue Clinical and Biological Correlates of Emotional Dysregulation in Children and Adolescents: A Transdiagnostic Approach to Developmental Psychopathology)
  • Article
  • Open Access
5 Citations
3,768 Views
16 Pages

Surgically Induced Demyelination in Rat Sciatic Nerve

  • Rahul Shankar Rao Rayilla,
  • MUR Naidu and
  • Phanithi Prakash Babu

Demyelination is a common sign of peripheral nerve injuries (PNIs) caused by damage to the myelin sheath surrounding axons in the sciatic nerve. There are not many methods to induce demyelination in the peripheral nervous system (PNS) using animal mo...

(This article belongs to the Section Neurodegenerative Diseases)
  • Article
  • Open Access
11 Citations
4,383 Views
13 Pages

Prevention of Neurological Sequelae in Preterm Infants

  • Eduardo Gonzalez-Moreira,
  • Thalía Harmony,
  • Manuel Hinojosa-Rodríguez,
  • Cristina Carrillo-Prado and ,
  • María Elena Juárez-Colín,
  • Claudia Calipso Gutiérrez-Hernández,
  • María Elizabeth Mónica Carlier,
  • Lourdes Cubero-Rego,
  • Susana A. Castro-Chavira and
  • Thalía Fernández
  • + 5 authors+ 0 author

Background: Preterm birth is one of the world’s critical health problems, with an incidence of 5% to 18% of living newborns according to various countries. White matter injuries due to preoligodendrocytes deficits cause hypomyelination in child...

(This article belongs to the Section Developmental Neuroscience)
  • Article
  • Open Access
2 Citations
3,121 Views
12 Pages

Introduction: Non-invasive brain stimulation can modulate both neural processing and behavioral performance. Its effects may be influenced by the stimulated area and hemisphere. In this study (EC no. 09083), repetitive transcranial magnetic stimulati...

(This article belongs to the Section Neurorehabilitation)
  • Review
  • Open Access
34 Citations
7,310 Views
16 Pages

Motor-Related Mu/Beta Rhythm in Older Adults: A Comprehensive Review

  • Takashi Inamoto,
  • Masaya Ueda,
  • Keita Ueno,
  • China Shiroma and ,
  • Rin Morita,
  • Yasuo Naito and
  • Ryouhei Ishii
  • + 2 authors+ 0 author

Mu rhythm, also known as the mu wave, occurs on sensorimotor cortex activity at rest, and the frequency range is defined as 8–13Hz, the same frequency as the alpha band. Mu rhythm is a cortical oscillation that can be recorded from the scalp ov...

(This article belongs to the Section Neurorehabilitation)
  • Review
  • Open Access
30 Citations
7,088 Views
21 Pages

Loss of Consciousness and Righting Reflex Following Traumatic Brain Injury: Predictors of Post-Injury Symptom Development (A Narrative Review)

  • Rina Berman,
  • Haley Spencer,
  • Martin Boese,
  • Sharon Kim and ,
  • Kennett Radford and
  • Kwang Choi
  • + 1 author+ 0 author

Identifying predictors for individuals vulnerable to the adverse effects of traumatic brain injury (TBI) remains an ongoing research pursuit. This is especially important for patients with mild TBI (mTBI), whose condition is often overlooked. TBI sev...

(This article belongs to the Topic Brain Injury, Microcirculation and Tissue Perfusion)
  • Article
  • Open Access
8 Citations
4,017 Views
21 Pages

Lumbar degenerative disc disease (LDDD) is widely acknowledged as a significant contributor to low back pain (LBP), which is a prevalent and debilitating health condition affecting millions of individuals worldwide. The pathogenesis of LDDD and assoc...

(This article belongs to the Special Issue Recent Advances in Pain Research)
  • Article
  • Open Access
1 Citations
2,460 Views
11 Pages

Differences in Cortical Area Activity and Motor Imagery Vivid-Ness during Evaluation of Motor Imagery Tasks in Right and Left Hemiplegics

  • Kengo Fujiwara,
  • Masatomo Shibata,
  • Yoshinaga Awano,
  • Naoki Iso and ,
  • Koji Shibayama and
  • Toshio Higashi
  • + 1 author+ 0 author

The ability to develop vivid motor imagery (MI) is important for effective mental practice. Therefore, we aimed to determine differences in the MI clarity and cortical area activity between patients with right hemiplegia and left hemiplegia after str...

(This article belongs to the Special Issue At the Frontiers of Neurorehabilitation: Series II)
  • Case Report
  • Open Access
12 Citations
9,270 Views
12 Pages

Cerebral Amyloid Angiopathy-Related Inflammation (CAA-rI): Three Heterogeneous Case Reports and a Focused Literature Review

  • Ivo Bozovic,
  • Marta Jeremic,
  • Aleksandra Pavlovic,
  • Carna Jovanovic and ,
  • Nikola Kresojevic,
  • Nikola Vojvodic,
  • Dejana Jovanovic,
  • Dragoslav Sokic and
  • Milija Mijajlovic
  • + 4 authors+ 0 author

Cerebral amyloid angiopathy-related inflammation (CAA-rI) is a largely reversible, subacute encephalopathy, which is considered as a rare variant of cerebral amyloid angiopathy (CAA). Although the diagnosis of this inflammatory vasculopathy is genera...

(This article belongs to the Section Neuropathology)
  • Article
  • Open Access
5 Citations
3,712 Views
11 Pages

Surgical Treatment of Pediatric Incidentally Found Brain Tumors: A Single-Center Experience

  • Lukasz Antkowiak,
  • Mikolaj Zimny,
  • Krzysztof Starszak,
  • Ryszard Sordyl and
  • Marek Mandera

There remains much debate about the correct management of incidentally found brain tumors in the pediatric population. This study aimed to evaluate the efficacy and safety of surgical treatment of incidentally found pediatric brain tumors. A retrospe...

(This article belongs to the Section Neurosurgery and Neuroanatomy)
  • Article
  • Open Access
10 Citations
3,536 Views
14 Pages

DEAD-Box Helicase 17 Promotes Amyloidogenesis by Regulating BACE1 Translation

  • Yue Liu,
  • Guifeng Zhou,
  • Li Song,
  • Qixin Wen and ,
  • Shiqi Xie,
  • Long Chen,
  • Lu Wang,
  • Xiaoyong Xie,
  • Xue Chen and
  • Guojun Chen
  • + 6 authors+ 1 author

Amyloidogenesis is one of the key pathophysiological changes in Alzheimer’s disease (AD). Accumulation of the toxic Aβ results from the catalytic processing of β-amyloid precursor protein (APP) associated β-amyloid converting enz...

(This article belongs to the Collection Collection on Molecular and Cellular Neuroscience)
  • Article
  • Open Access
3 Citations
2,457 Views
12 Pages

Neural Responses to a Working Memory Task in Acute Depressed and Remitted Phases in Bipolar Patients

  • Juliane Kopf,
  • Stefan Glöckner,
  • Heike Althen,
  • Thais Cevada and ,
  • Martin Schecklmann,
  • Thomas Dresler,
  • Sarah Kittel-Schneider and
  • Andreas Reif
  • + 3 authors+ 0 author

(1) Cognitive impairments such as working memory (WM) deficits are amongst the most common dysfunctions characterizing bipolar disorder (BD) patients, severely contributing to functional impairment. We aimed to investigate WM performance and associat...

(This article belongs to the Special Issue Etiology, Pathogenesis and Treatment of Bipolar Disorder)
  • Article
  • Open Access
7 Citations
2,541 Views
16 Pages

Emergence of Treadmill Running Ability and Quantitative Assessment of Gait Dynamics in Young Ts65Dn Mice: A Mouse Model for Down Syndrome

  • Jonah J. Scott-McKean,
  • Ryan Jones,
  • Mark W. Johnson,
  • Joyce Mier and ,
  • Ines A. Basten,
  • Melissa R. Stasko and
  • Alberto C. S. Costa
  • + 2 authors+ 0 author

Down syndrome (DS), which results from the complete or partial trisomy of chromosome 21 (trisomy-21), is the most common genetically defined cause of intellectual disability. Trisomy-21 also produces, or is associated with, many neurodevelopmental ph...

(This article belongs to the Section Developmental Neuroscience)
  • Article
  • Open Access
5 Citations
2,500 Views
14 Pages

It is essential to assess the condition of moyamoya disease (MMD) patients accurately and promptly to prevent MMD from endangering their lives. A Pseudo-Three-Dimensional Residual Network (P3D ResNet) was proposed to process spatial and temporal info...

(This article belongs to the Section Computational Neuroscience, Neuroinformatics, and Neurocomputing)
  • Review
  • Open Access
28 Citations
11,358 Views
15 Pages

The topic of this narrative review is mood stabilizers. First, the author’s definition of mood-stabilizing drugs is provided. Second, mood-stabilizing drugs meeting this definition that have been employed until now are described. They can be cl...

(This article belongs to the Special Issue Neuropsychopharmacology in Mood Disorders)

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