Most Recent

Background: We previously established that striatal, but not cortical, dopaminergic activation stimulates movement, indicating that the crucial and original site of dopaminergic stimulation of motor function is the striatum, not the motor cortex. In...

Mental illnesses represent a significant public health challenge on a global scale, contributing substantially to morbidity, mortality, disability, and impaired health-related quality of life, while exacerbating regional health inequities [...]

Multiple Sclerosis (MS) is a chronic, autoimmune neurological disease resulting from the interplay between genetic susceptibility and environmental factors. In recent decades, the rising incidence of MS, particularly pediatric-onset forms, has parall...

Background/Objective: Auditory and vestibular (AV) symptoms can be considered functional neurological disorders (FND) when they do not arise from structural abnormalities. These symptoms can arise as expressions of underlying neuropsychological or ps...

Adolescence and early adulthood are critical developmental periods marked by an increasing vulnerability to emotional dysregulation and social difficulties, highlighting the need for engaging psychosocial interventions. This protocol presents a pilot...

Background/Objectives: The aim of this study was to identify predictors of temporal window failure (TWF) in transcranial color-coded duplex sonography (TCCS) based on demographical and computed tomography (CT)-based parameters such as temporal bone t...

Background/Objectives: Autism Spectrum Disorder (ASD) diagnosis is difficult due to heterogeneity. Current Time-series Transformer (TST) methods cannot capture both dynamic and global brain connectivity simultaneously, which limits ASD classification...

Background/Objectives: Older adults are increasingly exposed to foreign-accented speech in everyday communication, yet such speech is known to increase perceptual and cognitive demands even when intelligibility is preserved. While previous research h...

Mild traumatic brain injury (mTBI) is typically associated with transient cognitive disturbance, particularly involving attention and new learning, with most patients demonstrating full recovery within weeks. Memory impairment in uncomplicated mTBI g...

Background: Persistent cognitive and neuropsychiatric symptoms have been increasingly reported as part of the post-COVID-19 condition. Neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) are circulating biomarkers of neuronal a...

Background/Objectives: Developmental prosopagnosia (DP) is a neurodevelopmental condition characterized by lifelong difficulties in face recognition. Although substantial work has examined identity-processing impairments in DP, less is known about wh...

Background/Objectives: Mild traumatic brain injury (mTBI) is the most common subtype of traumatic brain injury, where patients experience a multitude of symptoms from headaches to memory loss and mood changes. Consequently, there are known poor progn...

Background: Hemorrhagic stroke is a life-threatening cerebrovascular disease, and early identification is crucial for timely clinical intervention. Microwave imaging is non-ionizing, portable, and low-cost, and thus has potential for pre-hospital and...

Background: Spasticity, affecting over 80% of children with cerebral palsy (CP), is a major source of disability. Transcranial photobiomodulation (tPBM) is a promising non-invasive neuromodulatory intervention, but evidence for its use in pediatric C...

Background/Objectives: The perceived-time-based model posits that time perception is a critical factor in intertemporal decision-making; however, the mechanisms underlying this influence remain inadequately explored. Despite growing behavioral and ne...

Background: Sirtuin 3 (SIRT3), a mitochondrial NAD⁺-dependent deacetylase, plays a central role in regulating mitochondrial metabolism, oxidative stress, and cell survival. Although SIRT3 has been implicated in angiogenesis, apoptosis, and inflammati...

Background: Emotion recognition ability (ERA) plays a central role in children’s socio-emotional functioning, supporting early social interactions. This study examined whether ERA shows a pre–post change in a classroom-based training cont...

Introduction: Major depressive disorder (MDD) is a common comorbidity of type 2 diabetes (T2D) with low rates of treatment response to antidepressants. The pathophysiology of these conditions overlaps in N-methyl-d-aspartate receptors (NMDARs), which...

Background/Objectives: Decoding affective states from Electroencephalography (EEG) signals is fundamental to non-invasive Brain–Computer Interfaces. Despite recent advances, accurate recognition is impeded by the inherently non-stationary natur...

Purpose: This study aimed to investigate alterations in brain white matter fiber bundle integrity among older long-term breast cancer survivors treated with chemotherapy, with a focus on identifying potential neural correlates of cancer-related cogni...

Background: Despite recent breakthroughs in pharmacological treatment for Alzheimer’s disease, high costs and the complex procedure to monitor safety have limited access for many patients. Less invasive and more accessible non-pharmacological t...

Background: Although alexithymia is characterized by difficulties in emotional processing, the underlying mechanisms remain uncertain. We hypothesized that specific deficits in activating and using emotion concepts would be associated with impairment...

Objective: Cerebral meningiomas are the most common primary intracranial tumors in adults. Treatment of symptomatic tumors is normally surgical; tumors not suitable for surgery can be irradiated. While there is good data on the effectiveness of acute...

In the Discussion section of the original publication [...]

Emotion formation in older adults may be influenced not only by top-down cognitive strategies such as the positivity bias but also by bottom-up physiological changes. Decreased interoceptive awareness in older adults may alter the traditional emotion...

The scientific study of affect has been historically characterized by a profound lack of terminological consensus, leading to a state of conceptual fragmentation that persists in psychology, neuroscience and many other fields. This ambiguity is not m...

Objective: The purpose of this research is to examine how motivational music immediately impacts the brain’s functional connectivity patterns in male athletes following a single session of intense endurance exercise, utilizing resting-state ele...

Background: Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by social deficits, repetitive behaviors, and heightened anxiety. Despite extensive research, effective interventions targeting core symptoms remain limited. G...

Objective: To propose that migraine-related symptoms such as dizziness, sudden hearing loss, tinnitus, and vertigo—when occurring without headache—should be recognized as manifestations of central sensitivity syndrome (CSS), and to explor...

Background: Occipital nerve stimulation (ONS) is an effective therapy for patients with refractory chronic cluster headache (rCCH); however, it is not without complications, and to date, there are no conclusive findings regarding factors that would a...

Background: Imaging-transcriptomic analysis, through the integration of multimodal magnetic resonance imaging (MRI) and transcriptomic data, provides complementary structural, functional, and molecular information that is crucial for the early detect...

Background/Objectives: Traumatic brain injury (TBI) is a significant public health concern resulting in physical, cognitive, and behavioral impairments. Emerging evidence highlights a bidirectional relationship between brain injury and gut health, kn...

Background/Objectives: Despite many neurobiological models of semantics and phonology, there is no consensus regarding their functional organization. Specifically, there is considerable debate concerning the precise functional roles of the left infer...

In recent years, we have observed a clear and dramatic increase in mental health difficulties and psychological problems among young people [...]

Objectives: Although behavioral studies suggest that syntactic comprehension is relatively preserved in healthy aging, the underlying neural mechanisms remain a subject of intense debate. This review aims to synthesize neuroimaging and electrophysiol...

Background: Adolescents with neurodevelopmental disorders (NDDs), particularly autism spectrum disorder (ASD) and borderline intellectual functioning/intellectual disability (BIF/ID), represent a clinically complex population in psychiatric emergency...

Background: Sense of Time (SoT) refers to a range of cognitive abilities involved in the time processing (TP) and management (TM) of temporal durations. Impairments in these abilities can impact various domains of daily life, including academic, soci...

Background/Objectives: Tripping is a major cause of falls and necessitates accessible training. This study aimed to fundamentally evaluate the biomechanical fidelity of a simplified simulated obstacle-crossing paradigm using visual height cues. Metho...

Background/Objectives: Deficits in auditory change detection are well-known in psychiatric disorders such as schizophrenia. An abrupt change in sound feature during periodic sounds elicits both evoked potentials and a transient change in neural oscil...

Background/Objectives: This study explored the heterogeneous distribution pattern of translocator protein 18kDa (TSPO)-PET/MRI using radioligand [¹⁸F] DPA-714 in temporal lobe epilepsy patients and identified clinical factors influencing imaging outc...

Background: Dynamic visual acuity (DVA) is functionally distinct from static visual acuity (SVA), though SVA is often used clinically as a reference. Methods: To identify EEG biomarkers for DVA, we presented participants with a high-contrast checkerb...

Background: Exercise is a key component in managing hypertension, yet adherence remains low. Beyond deliberate decision-making, implicit attitudes also play an important role in exercise behavior as automatic and unconscious evaluative processes. Tra...

Background/Objectives: A high-fat diet disrupts metabolic and neuroimmune balance in the brain, making neural tissue more reactive to inflammatory challenges. However, it is not well understood how this vulnerability varies across brain regions or ho...

Background/Objectives: The gut–brain axis and its role in neurological disorders have garnered increasing attention in recent years. However, studies assessing the association between microbiota and Alzheimer’s disease in Japanese cohorts...

Background/Objectives: Multimodal neuroimaging, particularly the integration of electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS), has emerged as a key methodology for investigating brain function and classifying neural a...

Background/Objectives: Response heterogeneity limits the implementation of dry needling for spasticity in multiple sclerosis (MS). This secondary analysis aimed to identify early responders and explore predictors of response. Methods: We conducted a...

Background/Objectives: This study introduces a reproducible and interpretable graph-based framework for resting-state functional near-infrared spectroscopy (fNIRS) that enables network-level biomarker discovery for Alzheimer’s disease (AD). Alt...

Objective: This study investigated the effects of a 10-week dancesport intervention on rhythm perception ability and its multisensory correlates in college students. Methods: Forty students were randomly assigned to an intervention group (dancesport)...

Background/Objectives: Observational learning enables children to acquire new skills by observing others’ actions. Attention is widely recognized as a key supporting process and consists of multiple components that develop substantially during...

Background/Objectives: Clinical reasoning is essential in neurological rehabilitation, in which patient management is complex and multifactorial. However, existing models lack operationalization for neurophysiotherapy practice. This paper proposes th...