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Journal of Personalized Medicine, Volume 12, Issue 6

June 2022 - 167 articles

Cover Story: Non-obstructive azoospermia (NOA) is a form of male infertility, which is characterized by a complete lack of spermatozoa in the ejaculate due to a severe spermatogenic failure. The most extreme manifestation of NOA leads to a total absence of the germ line known as Sertoli cell-only (SCO) syndrome. Recent advances in the field have shown that idiopathic NOA is a complex disease. Therefore, common genetic variation involved in the control of gene expression during spermatogenesis might have a relevant role in NOA. The PIN1 locus encodes a prolyl isomerase that is essential for the survival of the spermatogonial cell linage and the maintenance of the blood–testis barrier. Cerván-Martín et al. have shown that common non-coding single-nucleotide polymorphisms involved in the gene and isoform expression of PIN1 increase the genetic risk of developing SCO. View this paper
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Articles (167)

  • Editorial
  • Open Access
1 Citations
1,955 Views
2 Pages

20 June 2022

This Special Issue, entitled “Personalized Diagnosis and Therapy for Multiple Sclerosis” encompasses eight publications that we consider relevant, because their reading will help the clinician working regularly with people who suffer from...

  • Article
  • Open Access
5 Citations
4,176 Views
12 Pages

HR-pQCT for the Evaluation of Muscle Quality and Intramuscular Fat Infiltration in Ageing Skeletal Muscle

  • Simon Kwoon-Ho Chow,
  • Marloes van Mourik,
  • Vivian Wing-Yin Hung,
  • Ning Zhang,
  • Michelle Meng-Chen Li,
  • Ronald Man-Yeung Wong,
  • Kwok-Sui Leung and
  • Wing-Hoi Cheung

20 June 2022

Myosteatosis is the infiltration of fat in skeletal muscle during the onset of sarcopenia. The quantification of intramuscular adipose tissue (IMAT) can be a feasible imaging modality for the clinical assessment of myosteatosis, important for the ear...

  • Review
  • Open Access
5 Citations
3,304 Views
9 Pages

20 June 2022

Purpose: The purpose of the study was to review the literature on the shape of the mandibular lingula. Methods: English articles published from 1970 to 2021 in databases (PubMed, Web of Science, and Embase) were selected. Articles meeting the search...

  • Article
  • Open Access
4 Citations
2,575 Views
9 Pages

Multifactorial Analysis of Endodontic Microsurgery Using Finite Element Models

  • Raphael Richert,
  • Jean-Christophe Farges,
  • Jean-Christophe Maurin,
  • Jérôme Molimard,
  • Philippe Boisse and
  • Maxime Ducret

20 June 2022

Background: The present study aimed to classify the relative contributions of four biomechanical factors—the root-end filling material, the apical preparation, the root resection length, and the bone height—on the root stresses of the res...

  • Article
  • Open Access
6 Citations
2,571 Views
9 Pages

Surgical Treatment for Empyema Thoracis: Prognostic Role of Preoperative Transthoracic Echocardiography and Serum Calcium

  • Pei-Yi Chu,
  • Yu-Cheng Wu,
  • Ya-Ling Lin,
  • Hung Chang,
  • Shih-Chun Lee,
  • Tsai-Wang Huang and
  • Yuan-Ming Tsai

20 June 2022

Background: Empyema is a major cause of mortality and hospitalization. Symptoms include difficulty breathing and chest pain. Calcium plays an essential role in the physiology of the cardiovascular system. However, there is little evidence on the role...

  • Article
  • Open Access
13 Citations
4,145 Views
13 Pages

20 June 2022

Intellectual disability (ID) and autism spectrum disorder (ASD) are complex neurodevelopmental disorders with high heritability. To search for the genetic deficits in two siblings affected with ID and ASD in a family, we first performed a genome-wide...

  • Article
  • Open Access
7 Citations
3,119 Views
10 Pages

Ethical and Legal Aspects of Technology-Assisted Care in Neurodegenerative Disease

  • Bjoern Schmitz-Luhn,
  • Jennifer Chandler and
  • on behalf of the iCARE-PD Consortium

20 June 2022

Technological solutions are increasingly seen as a way to respond to the demands of managing complex chronic conditions, especially neurodegenerative diseases such as Parkinson’s Disease. All of these new possibilities provide a variety of chan...

  • Review
  • Open Access
47 Citations
9,904 Views
24 Pages

Role of ABCA1 in Cardiovascular Disease

  • Jing Wang,
  • Qianqian Xiao,
  • Luyun Wang,
  • Yan Wang,
  • Daowen Wang and
  • Hu Ding

20 June 2022

Cholesterol homeostasis plays a significant role in cardiovascular disease. Previous studies have indicated that ATP-binding cassette transporter A1 (ABCA1) is one of the most important proteins that maintains cholesterol homeostasis. ABCA1 mediates...

  • Systematic Review
  • Open Access
12 Citations
6,623 Views
11 Pages

The Role of Hemodynamics through the Circle of Willis in the Development of Intracranial Aneurysm: A Systematic Review of Numerical Models

  • Yuanyuan Shen,
  • Rob Molenberg,
  • Reinoud P. H. Bokkers,
  • Yanji Wei,
  • Maarten Uyttenboogaart and
  • J. Marc C. van Dijk

20 June 2022

Background: The role of regional hemodynamics in the intracranial aneurysmal formation, growth, and rupture has been widely discussed based on numerical models over the past decades. Variation of the circle of Willis (CoW), which results in hemodynam...

  • Commentary
  • Open Access
10 Citations
3,702 Views
13 Pages

Researching Mitigation of Alcohol Binge Drinking in Polydrug Abuse: KCNK13 and RASGRF2 Gene(s) Risk Polymorphisms Coupled with Genetic Addiction Risk Severity (GARS) Guiding Precision Pro-Dopamine Regulation

  • Kenneth Blum,
  • Mark S. Brodie,
  • Subhash C. Pandey,
  • Jean Lud Cadet,
  • Ashim Gupta,
  • Igor Elman,
  • Panayotis K. Thanos,
  • Marjorie C. Gondre-Lewis,
  • David Baron and
  • Shan Kazmi
  • + 6 authors

20 June 2022

Excessive alcohol intake, e.g., binge drinking, is a serious and mounting public health problem in the United States and throughout the world. Hence the need for novel insights into the underlying neurobiology that may help improve prevention and the...

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J. Pers. Med. - ISSN 2075-4426