You are currently viewing a new version of our website. To view the old version click .

International Journal of Molecular Sciences, Volume 24, Issue 22

November-2 2023 - 530 articles

Cover Story: Predictions were made about how EPI-X4 interacts with CXCR4. Two key requirements emerged. First, the spatial conformation of EPI-X4 must be effectively matched to the CXCR4 receptor protein. Second, the functional groups on the surface of the inhibitor structure must complement the corresponding features of CXCR4 to cause an attraction between the two entities. These prediction results were based on a careful analysis of the conformers performed in a gaseous environment. Ultimately, this rigorous investigation led to a suitable EPI-X4 structure that fulfills the spatial and functional requirements for interaction with CXCR4, potentially opening new avenues for therapeutic development. View this paper
  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (530)

  • Article
  • Open Access
1 Citations
2,219 Views
22 Pages

20 November 2023

Morphine-induced antinociception is partially reduced in interleukin-31 (IL-31) receptor A (IL-31RA)-deficient mice, indicating that IL-31RA is crucial for morphine-induced peripheral antinociception. Herein, we examined the combined effects of IL-31...

  • Review
  • Open Access
5 Citations
2,967 Views
15 Pages

Virus-Encoded Circular RNAs: Role and Significance in Viral Infections

  • Giuseppe Sberna,
  • Fabrizio Maggi and
  • Alessandra Amendola

20 November 2023

Circular RNAs (circRNAs) have been the focus of intense scientific research to understand their biogenesis, mechanisms of action and regulatory functions. CircRNAs are single stranded, covalently closed RNA molecules lacking the 5′-terminal cap...

  • Article
  • Open Access
3 Citations
2,864 Views
17 Pages

Distinct HAND2/HAND2-AS1 Expression Levels May Fine-Tune Mesenchymal and Epithelial Cell Plasticity of Human Mesenchymal Stem Cells

  • Rachel Vazana-Netzarim,
  • Yishay Elmalem,
  • Shachar Sofer,
  • Hod Bruck,
  • Naama Danino and
  • Udi Sarig

20 November 2023

We previously developed several successful decellularization strategies that yielded porcine cardiac extracellular matrices (pcECMs) exhibiting tissue-specific bioactivity and bioinductive capacity when cultured with various pluripotent and multipote...

  • Article
  • Open Access
6 Citations
2,975 Views
15 Pages

Endothelial Glycocalyx of Peritubular Capillaries in Experimental Diabetic Nephropathy: A Target of ACE Inhibitor-Induced Kidney Microvascular Protection

  • Monica Locatelli,
  • Daniela Rottoli,
  • Rayan Mahmoud,
  • Mauro Abbate,
  • Daniela Corna,
  • Domenico Cerullo,
  • Susanna Tomasoni,
  • Giuseppe Remuzzi,
  • Carlamaria Zoja and
  • Ariela Benigni
  • + 1 author

20 November 2023

Peritubular capillary rarefaction is a recurrent aspect of progressive nephropathies. We previously found that peritubular capillary density was reduced in BTBR ob/ob mice with type 2 diabetic nephropathy. In this model, we searched for abnormalities...

  • Article
  • Open Access
4 Citations
2,813 Views
17 Pages

20 November 2023

The insulin resistance caused by impaired glucose metabolism induces ovarian dysfunction due to the central importance of glucose as a source of energy. However, the research on glucose metabolism in the ovaries is still lacking. The objectives of th...

  • Review
  • Open Access
73 Citations
11,931 Views
17 Pages

20 November 2023

Cisplatin is a commonly used chemotherapeutic agent with proven efficacy in treating various malignancies, including testicular, ovarian, cervical, breast, bladder, head and neck, and lung cancer. Cisplatin is also used to treat tumors in children, s...

  • Review
  • Open Access
14 Citations
5,120 Views
30 Pages

Secretome as a Tool to Treat Neurological Conditions: Are We Ready?

  • Andreia Valente da Silva,
  • Inês Serrenho,
  • Beatriz Araújo,
  • Alexandre Martins Carvalho and
  • Graça Baltazar

20 November 2023

Due to their characteristics, mesenchymal stem cells (MSCs) are considered a potential therapy for brain tissue injury or degeneration. Nevertheless, despite the promising results observed, there has been a growing interest in the use of cell-free th...

  • Article
  • Open Access
17 Citations
3,059 Views
14 Pages

20 November 2023

Palmatine, a natural alkaloid found in various plants, has been reported to have diverse pharmacological and biological effects, including anti-inflammatory, antioxidant, and cardiovascular effects. However, the role of palmatine in mitophagy, a fund...

  • Article
  • Open Access
5 Citations
2,273 Views
22 Pages

Effects of Segment Length and Crosslinking via POSS on the Calorimetric and Dynamic Glass Transition of Polyurethanes with Aliphatic Hard Segments

  • Konstantinos N. Raftopoulos,
  • Panagiotis A. Klonos,
  • Patrycja Tworzydło,
  • Jan Ozimek,
  • Edyta Hebda,
  • Apostolos Kyritsis and
  • Krzysztof Pielichowski

20 November 2023

The glass transition in polyurethanes is a complicated phenomenon governed by a multitude of factors, including the microphase separation, which in turn depends strongly on the molar mass of the hard and soft segments, as well as the presence of addi...

  • Article
  • Open Access
2 Citations
2,196 Views
14 Pages

The Feeder Effects of Cultured Rice Cells on the Early Development of Rice Zygotes

  • Yoriko Watanabe,
  • Yuko Nobe,
  • Masato Taoka and
  • Takashi Okamoto

20 November 2023

Feeder cells and the synthetic auxin 2,4-dichlorophenoxyacetic acid (2,4-D) in a culture medium promote mitosis and cell division in cultured cells. These are also added to nutrient medium for the cultivation of highly active in mitosis and dividing...

of 53

Get Alerted

Add your email address to receive forthcoming issues of this journal.

XFacebookLinkedIn
Int. J. Mol. Sci. - ISSN 1422-0067