Research on Bone Cells in Health and Disease

Dear Colleagues,

Bone homeostasis is maintained by the dynamic interaction between bone cells, including osteoclasts, osteoblasts and osteocytes. Osteoblast-mediated bone formation and osteoclast-mediated bone resorption are tightly coupled by the extensive cellular network formed by osteocytes. However, under pathological conditions, the fine-tuned balance between bone formation and resorption is altered, such as in osteoporosis, autoimmune disease-associated inflammatory bone loss, periodontitis and tumor-induced osteolysis. For instance, inflammatory lymphocytes and osteotropic tumor cells can produce several growth factors and differentiation inducers, which promote the development and function of osteoclasts directly or indirectly via osteoblasts and osteocytes. Therefore, the development of novel strategies for the treatment of bone diseases is urgently needed, which requires a better understanding of the molecular and cellular mechanisms underlying bone formation and resorption during the process of bone remodeling.

This Special Issue entitled “Research on Bone Cells in Health and Disease” welcomes original research articles and timely reviews on the cellular and molecular mechanisms underlying bone formation and resorption, with a special focus on the activation of osteoclasts, osteoblasts and osteocytes in pathological conditions, such as osteoporosis, inflammatory and tumor-induced bone loss.

Dr. David Gyori
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.