Search Results (2,926)

Power supply for traction substations (TSs) of AC railways has traditionally been provided by 110–220 kV overhead transmission lines (OHL). These OHLs can be damaged during strong winds and ice formation. Furthermore, these lines generate significant electromagnetic fields (EMFs), which adversely affect maintenance personnel, the public, and the environment. Mitigating the resulting damages requires the establishment of protection zones, necessitating significant land allocation. Enhancing the reliability of power supply to traction substations and reducing EMF levels can be achieved through the use of gas-insulated lines (GIL), whose application in the power industry of many countries is continuously increasing. The aim of the research presented in this article was to develop computer models for determining the EMF of a GIL supplying a group of traction substations, taking into account actual traction loads characterized by non-sinusoidal waveforms and asymmetry. To solve this problem, an approach implemented in the Fazonord AC-DC software package, based on the use of phase coordinates, was applied. This allowed for the correct accounting of the skin effect and proximity effect in the massive current-carrying parts of the GIL, as well as the influence of asymmetry and harmonic distortions. The simulation results showed that the use of GIL brings the voltage unbalance factors at the 110 kV busbars of the traction substations within the permissible range, with the maximum values of these coefficients not exceeding 2%. The results of the harmonic distortion assessment demonstrated a significant reduction in harmonic distortion factors in the 110 kV network for the GIL compared to the OHL. The performed electromagnetic field calculations confirmed that the GIL generates magnetic field strengths one order of magnitude lower than those of the OHL. The obtained results lead to the conclusion that the use of gas-insulated lines for powering traction substations is highly effective, ensuring increased reliability, improved power quality, and a reduced negative impact of EMF on personnel, the public, the environment, and electronic equipment. Full article

This study aimed to identify metabolomic biomarkers for diabetes progression and validate their response to lifestyle intervention. A two-phase design was employed: first, untargeted metabolomics distinguished normoglycemic, prediabetic (PDM), and diabetic (DM) individuals, identifying 1,5-anhydroglucitol (1,5-AG) as the most significant biomarker for differentiating PDM from DM (apparent AUC = 0.97, 95% CI: 0.95–1.00; corrected AUC = 0.94, 95% CI: 0.83–1.00; q < 0.001). Second, in a 3-month randomized controlled trial involving 300 adults with PDM, the combined diet and exercise intervention significantly improved fasting blood glucose and glycated hemoglobin levels, while concurrently elevating serum 1,5-AG levels compared with the control group, though it did not yield significant improvements in other cardiovascular disease-related risk factors including body mass index, waist circumference, systolic blood pressure, and diastolic blood pressure. The intervention also showed a trend toward reduced diabetes incidence. Integrated analysis establishes 1,5-AG as a sensitive biomarker of dysglycemia that is responsive to lifestyle modification, supporting its potential as a mechanistic tool for monitoring intervention efficacy in diabetes prevention. Full article

This study aims to investigate the predictive value of pre-treatment multi-phasic contrast-enhanced computed tomography (CECT) radiomic features for treatment resistance in patients with rat sarcoma virus (RAS)-mutated colorectal liver metastases (CRLMs) receiving bevacizumab-based chemotherapy. Seventy-three samples with RAS-mutated CRLMs receiving bevacizumab-combined chemotherapy regimens were evaluated. Radiomic features were extracted from arterial phase (AP), portal venous phase (PVP), AP-PVP subtraction image, and Delta phase (DeltaP, calculated as AP-to-PVP ratio) images. Three groups of radiomics features were extracted for each phase, including peritumor, core tumor, and whole-tumor regions. For each of the four phases, a two-sided independent Mann–Whitney U test with the Bonferroni correction and K-means clustering was applied to the remnant features for each phase. Subsequently, the Least Absolute Shrinkage and Selection Operator (LASSO) algorithm was then applied for further feature selection. Six machine learning algorithms were then used for model development and validated on the independent testing cohort. Results showed peritumoral radiomic features and features derived from Laplacian of Gaussian (LoG) filtered images were dominant in all the compared machine learning algorithms; NB models yielded the best-performing prediction (Avg. training AUC: 0.731, Avg. testing AUC: 0.717) when combining all features from different phases of CECT images. This study demonstrates that peritumoral radiomic features and LoG-filtered pre-treatment multi-phasic CECT images were more predictive of treatment response to bevacizumab-based chemotherapy in RAS-mutated CRLMs compared to core tumor features. Full article

Accurate displacement field measurement by holographic interferometry requires robust analysis of high-density fringe patterns, which is hindered by speckle noise inherent in any interferogram, no matter how perfect. Conventional skeletonization methods, such as edge detection algorithms and active contour models, often fail under these conditions, producing fragmented and unreliable fringe contours. This paper presents a novel skeletonization procedure that simultaneously addresses three fundamental challenges: (1) topology preservation—by representing the fringe family within a physics-informed, finite-dimensional parametric subspace (e.g., Fourier-based contours), ensuring global smoothness, connectivity, and correct nesting of each fringe; (2) extreme noise robustness—through a robust strip integration functional that replaces noisy point sampling with Gaussian-weighted intensity averaging across a narrow strip, effectively suppressing speckle while yielding a smooth objective function suitable for gradient-based optimization; and (3) sub-pixel accuracy without phase extraction—leveraging continuous bicubic interpolation within a recursive quasi-optimization framework that exploits fringe similarity for precise and stable contour localization. The method’s performance is quantitatively validated on synthetic interferograms with controlled noise, demonstrating significantly lower error compared to baseline techniques. Practical utility is confirmed by successful processing of a real interferogram of a bent plate containing over 100 fringes, enabling precise displacement field reconstruction that closely matches independent theoretical modeling. The proposed procedure provides a reliable tool for processing challenging interferograms where traditional methods fail to deliver satisfactory results. Full article

Background: Perceptual decision-making requires transforming sensory inputs into goal-directed actions under uncertainty. Neural oscillations in the theta band (3–7 Hz), particularly within frontal regions, have been implicated in cognitive control and decision confidence. However, whether changes in theta oscillations reflect greater effort during ambiguous decisions or more efficient control during clear conditions remains debated, and theta’s relationship to stimulus clarity is incompletely understood. Purpose: This study’s purpose was to examine how task difficulty modulates theta activity and how theta dynamics evolve across the decision-making process using two complementary analytical approaches. Methods: Electroencephalography (EEG) data were acquired from 26 healthy adults performing a face/house categorization task with images containing three levels of scrambled phase and Gaussian noise: clear (0%), moderate (40%), and high (55%). Theta dynamics were assessed from current source density (CSD) time courses of event-related potentials (ERPs) and single-trials. Statistical comparisons used Wilcoxon signed-rank tests with false discovery rate (FDR) correction for multiple comparisons. Results: Frontal theta power was greater for clear than noisy face stimuli (corrected p < 0.001), suggesting that theta activity reflects cognitive control effectiveness and decision confidence rather than processing difficulty. Connectivity decomposition revealed that frontoparietal theta coupling was modulated by stimulus clarity through both phase-locked (evoked: corrected p = 0.0085, dz = −0.61) and ongoing (induced: corrected p = 0.049, dz = −0.36) synchronization, with phase-locked coordination dominating the effect and showing opposite directionality to the induced components. Conclusions: Theta oscillations support perceptual decision-making through stimulus clarity modulation of both phase-locked and ongoing synchronization, with evoked component dominating. These findings underscore the importance of methodological choices in EEG-based connectivity research, as different analytical approaches capture different aspects of the same neural dynamics. The pattern of stronger theta activity for clear stimuli is consistent with neural processes related to decision confidence, though confidence was not measured behaviorally. Full article

Lightning rods, while essential for protecting weather radars from direct lightning strikes, act as persistent non-meteorological scatterers that can interfere with signal transmission and reception and thereby degrade detection accuracy and product quality. Existing studies have mainly focused on X-band and C-band systems, and robust, measurement-based quantitative assessments for S-band dual-polarization radars remain scarce. In this study, a controllable tilting lightning rod, a high-precision Far-field Antenna Measurement System (FAMS), and an S-band dual-polarization weather radar (SAD radar) are jointly employed to systematically quantify lightning-rod impacts on antenna electromagnetic parameters under different rod elevation angles and azimuth configurations. Typical precipitation events were analyzed to evaluate the influence of the lightning rods on dual-polarization parameters. The results show that the lightning rod substantially elevates sidelobe levels, with a maximum enhancement of 4.55 dB, while producing only limited changes in the antenna main-beam azimuth and beamwidth. Differential reflectivity () is the most sensitive polarimetric parameter, exhibiting a persistent positive bias of about 0.24–0.25 dB in snowfall and mixed-phase precipitation, while no persistent azimuthal anomaly is evident during freezing rain; the co-polar correlation coefficient () is only marginally affected. Collectively, these results provide quantitative, far-field evidence of lightning-rod interference in S-band dual-polarization radars and provide practical guidance for more reasonable lightning-rod placement and configuration, as well as useful references for -oriented polarimetric quality-control and correction strategies. Full article

Satellite attitude is critical for both satellite antenna phase center offset and phase wind-up correction. However, during the eclipse season, the nominal satellite attitude is almost impossible to maintain, and the satellite attitude variability affects the geometric distance correction of GNSS-LEO satellites, which ultimately affects the orbital accuracy of LEO satellites. To explore the impact of neglecting eclipsing attitude models on LEO satellite orbit determination, this study utilizes the attitude quaternion products provided by CNES to analyze the discrepancies between nominal attitude yaw angles and attitude quaternion-derived yaw angles. It also examines the variations in phase center offset and phase wind-up corrections, caused by neglecting eclipsing attitude models. The model is validated through orbit determination tests using onboard GRACE-FO data from days 90 to 109 of 2023. Based on these analyses, a simplified reduced-dynamic orbit determination model for LEO satellites using attitude quaternion is proposed. It is found that the phase residuals of GRACE-C and GRACE-D under the attitude quaternion strategy are reduced by 3.6% and 3.9%, respectively, and the orbital accuracies of GRACE-C and GRACE-D are improved by 7.3% and 4.5%, respectively, compared with the nominal attitude. Full article

This paper reports the findings of the first initiative of developing a year-round streamflow forecasting system using the HBV hydrologic model in a data-scarce Ruvu catchment in Tanzania. Considering the importance of the Ruvu catchment as the main source of water to the fast-growing mega city of Dar es Salaam, the researchers in this study made the most of the available data and their joint previous application experience of the modelling framework for the purpose of setting up a reliable operational model. In addition, the researchers adopted a phased approach of developing the streamflow forecasting system, using HBV as a hydrological model, which resulted in a simplified model structure with minimized complexity. For instance, the snow routine was removed as it is not relevant to the study area, and a few parameters were reduced to improve model efficiency. As a measure to demonstrate model performance, in addition to the Nash–Sutcliffe Efficiency (NSE) parameter used for model calibration and verification, several other error functions and graphical displays were used. The model performance values, as measured by NSE for calibration and verification periods, are 0.85 and 0.82 for Ruvu Roadbridge (1H8A), and 0.80 and 0.82 for Kidunda (1H3), respectively, and all are classified as “Very Good”. In addition, the PBIAS of less than ±5% in calibration indicates excellent water balance simulation. Furthermore, the forecast’s performance in this study is evidenced by an annual forecast R² of 0.933, with operational meteorological forecasts improving to 0.962 with “perfect” precipitation; dry season performance with R² of 0.964, demonstrating high skill in baseflow-dominated periods; and the PBIAS for forecasts of 0.866, indicating a slight systematic under-forecasting correctable by a ~15% precipitation adjustment. Although the Ruvu catchment has been characterized by this study as a data-scarce catchment, the results of the operational hydrological forecasting system vary with season and quality of forecast meteorological data, and the model is already launched for operational use. As evidenced by these study findings, the journey from data scarcity to operational forecast provision in the Ruvu catchment demonstrates that the principal barriers are fundamentally institutional and capacity-related. The authors suggest that any future forecasting initiative should put much emphasis on both the understanding of the modelling framework to be used and adequate data collection and analysis, in a synergetic manner with all relevant agencies. And it is also recommended to be vigilant regarding changes in the catchment characteristics and model performance during its life cycle, as the performance of the developed model is only valid under the condition that it was calibrated and validated. Full article

The first measurements of the magnetic dipole hyperfine structure constants A in singly ionized thulium revealed substantial discrepancies with the corresponding theoretical calculations. Subsequent measurements expanded the very limited available dataset and demonstrated that two of the previously reported experimental A values were incorrect, thereby motivating new theoretical calculations. In this work, we employ the configuration interaction method to calculate the A constants for several low-lying levels in Tm ii, with the random-phase-approximation corrections also taken into account. Our results show good agreement with the new experimental data and provide reliable predictions for additional states where measurements are not yet available. Full article

Multiphase flow in porous media is ubiquitous in physical processes, yet modeling it consistently remains difficult, and sometimes it can be coupled with solid-phase decomposition and phase change, such as in hydrate dissociation or internal erosion processes. Recent code comparison studies have highlighted this difficulty, revealing clear inconsistencies in numerical results across different research groups for the same benchmark problem. This paper presents a new, reliable benchmark test and a hybrid explicit-implicit finite element method adaptable to various scenarios. In our mathematical framework, the solid decomposition is described by a rate equation for porosity that depends on the fluid pressure, and the phase change is modeled via mass source terms. The hybrid explicit-implicit finite element method features a novel three-stage updating strategy, which incorporates an artificial diffusion term and carefully selects the transport equation for the final saturation update. Validation results demonstrate that our proposed method achieves substantial agreement with those of the fully implicit finite volume method, confirming its reliability. Furthermore, our analysis confirms that the saturation update must use the transport equation of the incompressible fluid phase, and that the artificial diffusion term is critical for capturing physically correct saturation profiles, even when advection is not dominant. Overall, this work provides a consistent and effective tool for simulating complex multiphase flow scenarios and serves as a valuable complement to future benchmark studies. Full article

Background/Objectives: This ecological study aimed to investigate changes in the time-varying reproduction number (Rt) of SARS-CoV-2 across six regions of Massachusetts from 2020 to 2022 and to evaluate the impact of various nonpharmaceutical interventions (NPIs) implemented in 2020 by examining associated changes in the Rt. Methods: COVID-19 incident case data from the Johns Hopkins University database were adjusted for reporting delays using deconvolution and for underreporting via a Poisson-distributed multiplier of 4. Negative and zero counts were corrected using imputation. Rt was estimated using R package EpiEstim (Version 2.2-4) with a 7-day sliding window from 2020 to 2022 and with non-overlapping time windows between policy changes in 2020. Results: From 2020 to 2022, Massachusetts experienced five COVID-19 surges, linked to the wild-type strain and emerging variants, with Rt exceeding 1 during each wave and stabilizing at or dropping below 1 during low-incidence phases. School closure and gathering restrictions, the first major intervention, were associated with a 14.7% statewide reduction in Rt (95% credible interval (CrI): −23.6%, −5.6%), with greater reductions in high-density areas such as Boston (−16.9%; 95% CrI: −26.9%, −7.5%). No statistically significant changes in Rt were found to be associated with other NPIs in 2020, including the mask mandate, reopening phases, travel restrictions and quarantine requirements, and curfews. Conclusions: Our findings highlight the different NPIs’ varying impacts on COVID-19 transmission dynamics across regions in Massachusetts in 2020 and underscore the importance of early interventions for future pandemic preparedness. Full article

Purpose: Orthognathic surgery is a cornerstone therapeutic approach for correcting dentofacial deformities; however, its Impact on neuromuscular adaptation remains incompletely understood, particularly regarding different surgical strategies. The aim of this study was to evaluate and compare neuromuscular changes in patients undergoing monomaxillary or bimaxillary orthognathic surgery. Methods: Eighty adult patients treated with combined orthodontic–surgical therapy were included (37 monomaxillary; 43 bimaxillary). A control group of 20 healthy adult subjects with physiological occlusion and no history of orthodontic or orthognathic treatment was included. Surface electromyography (sEMG) of the masseter and anterior temporalis muscles and mandibular kinesiography were performed using standardized protocols at five treatment phases. Electromyographic symmetry indices (Percent Overlapping Coefficient—POC), muscle activity (µV), IMPACT values, and mandibular movement parameters were analyzed. Results: During the presurgical orthodontic phase, both groups showed comparable reductions in neuromuscular activity. Postoperatively, monomaxillary patients exhibited earlier stabilization of sEMG symmetry and a faster increase in IMPACT values, approaching physiological reference ranges at the final follow-up. In contrast, bimaxillary patients showed greater variability and slower functional recovery. Mandibular opening and lateral movements improved in all patients, with more stable kinesiographic patterns observed in the monomaxillary group. Conclusions: Within the limitations of this study, neuromuscular adaptation following orthodontic–surgical treatment appears to be associated with the surgical approach adopted, rather than representing a direct effect of surgical extent. These findings support the role of functional assessment as a complementary component in the management of orthognathic patients. Full article

The photovoltaic (PV) bands on the mid-wave and long-wave infrared (MWIR and LWIR) cold focal plane assemblies of Terra and Aqua MODIS have suffered from gradually increasing electronic crosstalk contamination as both instruments have continued to operate in their extended missions, respectively. This contamination has considerable impact, particularly for the PV LWIR bands, which includes image striping and radiometric bias in the Level-1B (L1B)-calibrated radiance products as well as higher level (and mostly atmospheric but also land and oceanic) products (e.g., cloud phase particle, cloud mask, land and sea surface temperatures). The crosstalk was characterized early in the mission, and test corrections were developed then. Ultimately, the groundwork for a robust electronic crosstalk correction algorithm was developed in 2016 and implemented in MODIS Collection 6.1 (C6.1) back in 2017 for the Terra MODIS PV LWIR bands. It was later introduced in Aqua MODIS C6.1 for the same group of bands in April 2022. Additional improvements were made in MODIS Collection 7 (C7) to better characterize the electronic crosstalk in the PV LWIR bands, and the electronic crosstalk correction algorithm was also extended to select detectors in the MODIS MWIR bands. This work will describe the electronic crosstalk correction algorithm and its application on the MODIS L1B product, the differences in application between C6.1 and C7, as well as additional improvements made to enhance the contamination correction and improve image quality for the Aqua MODIS PV LWIR bands. The electronic crosstalk correction coefficient time series for the MODIS PV bands will be discussed, and some cases will be presented to illustrate how image quality improves on the L1B and Level 2 products after the correction is applied. Lastly, experiences gained regarding the PV bands electronic crosstalk and the strategy used to correct it will be discussed to provide future data users and scientists with an insight as to how to improve on the legacy record that the Terra and Aqua MODIS sensors will leave behind after both spacecrafts are decommissioned. Full article

Cholesterol plays a fundamental role in the human body—it stabilizes cell membranes, modulates gene expression, and is a precursor to steroid hormones, vitamin D, and bile salts. Its correct level is crucial for homeostasis, while both excess and deficiency are associated with serious metabolic and health consequences. Excessive accumulation of cholesterol leads to the development of atherosclerosis, while its deficiency disrupts the transport of fat-soluble vitamins. Magnetic resonance spectroscopy (MRS) enables the detection of cholesterol esters and the differentiation between their liquid and crystalline phases, but the technical limitations of clinical MRI systems require the use of dedicated coils and sequence modifications. This study demonstrates the feasibility of using MRS to identify cholesterol-specific spectral signatures in atherosclerotic plaque through ex vivo analysis. Using a custom-designed experimental coil adapted for small-volume samples, we successfully detected characteristic cholesterol peaks from plaque material dissolved in chloroform, with spectral signatures corresponding to established NMR databases. To further enhance spectral quality, a deep-learning denoising framework based on a 1D U-Net architecture was implemented, enabling the recovery of low-intensity cholesterol peaks that would otherwise be obscured by noise. The trained U-Net was applied to experimental MRS data from atherosclerotic plaques, where it significantly outperformed traditional denoising methods (Gaussian, Savitzky–Golay, wavelet, median) across six quantitative metrics (SNR, PSNR, SSIM, RMSE, MAE, correlation), enhancing low-amplitude cholesteryl ester detection. This approach substantially improved signal clarity and the interpretability of cholesterol-related resonances, supporting more accurate downstream spectral assessment. The integration of MRS with NMR-based lipidomic analysis, which allows the identification of lipid signatures associated with plaque progression and destabilization, is becoming increasingly important. At the same time, the development of high-resolution techniques such as μOCT provides evidence for the presence of cholesterol crystals and their potential involvement in the destabilization of atherosclerotic lesions. In summary, nanotechnology-assisted MRI has the potential to become an advanced tool in the proof-of-concept of atherosclerosis, enabling not only the identification of cholesterol and its derivatives, but also the monitoring of treatment efficacy. However, further clinical studies are necessary to confirm the practical usefulness of these solutions and their prognostic value in assessing cardiovascular risk. Full article