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Article

Phase Correction for Absorption Mode Two-Dimensional Mass Spectrometry

1
Institut de Génétique, Biologie Moléculaire et Cellulaire, INSERM U596, UMR 7104, Université de Strasbourg, 1 rue Laurent Fries, 67404 Illkirch-Graffenstaden, France
2
CASC4DE, Pôle API, 300 Bd. Sébastien Grant, 67400 Illkirch-Graffenstaden, France
3
Institute for Organic Chemistry, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria
*
Author to whom correspondence should be addressed.
Academic Editor: Manuel Sergi
Molecules 2021, 26(11), 3388; https://doi.org/10.3390/molecules26113388
Received: 15 April 2021 / Revised: 26 May 2021 / Accepted: 28 May 2021 / Published: 3 June 2021
Two-dimensional mass spectrometry (2D MS) is a tandem mass spectrometry method that relies on manipulating ion motions to correlate precursor and fragment ion signals. 2D mass spectra are obtained by performing a Fourier transform in both the precursor ion mass-to-charge ratio (m/z) dimension and the fragment ion m/z dimension. The phase of the ion signals evolves linearly in the precursor m/z dimension and quadratically in the fragment m/z dimension. This study demonstrates that phase-corrected absorption mode 2D mass spectrometry improves signal-to-noise ratios by a factor of 2 and resolving power by a factor of 2 in each dimension compared to magnitude mode. Furthermore, phase correction leads to an easier differentiation between ion signals and artefacts, and therefore easier data interpretation. View Full-Text
Keywords: mass spectrometry; two-dimensional; tandem mass spectrometry; phase correction; absorption mode; data processing mass spectrometry; two-dimensional; tandem mass spectrometry; phase correction; absorption mode; data processing
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MDPI and ACS Style

Delsuc, M.-A.; Breuker, K.; van Agthoven, M.A. Phase Correction for Absorption Mode Two-Dimensional Mass Spectrometry. Molecules 2021, 26, 3388. https://doi.org/10.3390/molecules26113388

AMA Style

Delsuc M-A, Breuker K, van Agthoven MA. Phase Correction for Absorption Mode Two-Dimensional Mass Spectrometry. Molecules. 2021; 26(11):3388. https://doi.org/10.3390/molecules26113388

Chicago/Turabian Style

Delsuc, Marc-André, Kathrin Breuker, and Maria A. van Agthoven 2021. "Phase Correction for Absorption Mode Two-Dimensional Mass Spectrometry" Molecules 26, no. 11: 3388. https://doi.org/10.3390/molecules26113388

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