Permeable concrete is a class of materials that has long been tested and implemented to control water pollution. Its application in low-impact development practices has proved its efficiency in mitigating some of the impacts of urbanization on the en...
In this study, the Bragg resonance of water waves scattered by multiple permeable thin barriers over a series of periodic breakwaters was solved by employing the eigenfunction matching method (EMM). The geometrical configuration was divided into mult...
Sources of contamination in a subsurface environment are petrol, diesel fuel, gasoline at oil refineries, underground storage tanks, transmission pipelines, and different industries. The permeable reactive barrier (PRB) is a promising technology to r...
This work addresses the rehabilitation of water contaminated with atrazine, entrapping it in a permeable and sustainable barrier designed with waste materials (sepiolite) and with biomaterials (cork and pine bark). Atrazine adsorption was assessed by...
Ensuring access to clean water for drinking, agriculture, and recreational activities remains a global challenge. Groundwater, supplying approximately 50% of domestic water and 40% of agricultural irrigation, faces increasing threats from climate cha...
In this study, a bioremediation approach was evaluated for the decontamination of an aquifer affected by the release of organohalides by an industrial landfill. After preliminary physicochemical and microbiological characterization of the landfill gr...
This paper aims to examine the potential of permeable reactive barriers (PRBs) as an in-situ removal approach for phosphate polluted agricultural runoff. Four different reactive materials (RMs) of: autoclaved aerated concrete (AAC), Polonite®, ze...
The technology of using metallic iron (Fe0) for in situ generation of iron oxides for water treatment is a very old one. The Fe0 remediation technology has been re-discovered in the framework of groundwater remediation using permeable reactive barrie...
12 October 2022
The presence of residual Cr(VI) in soils causes groundwater contamination in aquifers, affecting the health of exposed populations. Initially, permeable reactive barriers(PRB) effectively removed Cr(VI) from groundwater. However, as PRB clogging incr...
The intestinal barrier is essential in human health and constitutes the interface between the outside and the internal milieu of the body. A functional intestinal barrier allows absorption of nutrients and fluids but simultaneously prevents harmful s...
Altered intestinal barrier permeability has been associated with obesity and its metabolic and inflammatory complications in animal models. The purpose of this systematic review is to assess the evidence regarding the association between obesity with...
By being an antagonist of glutamate and other receptors, kynurenic acid serves as an endogenous neuroprotectant in several pathologies of the brain. Unfortunately, systemic administration of kynurenic acid is hindered by its low permeability through...
The blood–brain barrier (BBB) plays an important protective role in the central nervous system and maintains its homeostasis. It regulates transport into brain tissue and protects neurons against the toxic effects of substances circulating in the blo...
Lung-on-a-chip (LoC) models hold the potential to rapidly change the landscape for pulmonary drug screening and therapy, giving patients more advanced and less invasive treatment options. Understanding the drug absorption in these microphysiological...
Assessing the human placental barrier permeability of drugs is very important to guarantee drug safety during pregnancy. Quantitative structure–activity relationship (QSAR) method was used as an effective assessing tool for the placental transfer st...
Dietary factors can modify the function of the intestinal barrier, causing permeability changes. This systematic review analyzed evidence on the link between diet or dietary interventions and changes in intestinal barrier permeability (IBP) in health...
Background/Objectives: Alzheimer’s disease (AD) is the most common type of dementia, characterized by complex processes such as neuro-inflammation, oxidative damage, synaptic loss, and neuronal death. Carotenoids are among the potential therape...
Serotonin affects many functions in the body, both in the central nervous system (CNS) and the periphery. However, its effect on the blood–brain barrier (BBB) in separating these two worlds has been scarcely investigated. The aim of this work was to...
Effective prediction of blood–brain barrier (BBB) permeability remains essential for central nervous system drug development. This study evaluates multiple supervised machine learning models using a public dataset of permeable and non-permeable...
Phase-change nanodroplets (PCND;NDs) are emulsions with a perfluorocarbon (PFC) core that undergo acoustic vaporisation as a response to ultrasound (US). Nanodroplets change to microbubbles and cavitate while under the effect of US. This cavitation c...
Palmitic acid (PA), a long-chain saturated fatty acid, might activate innate immune cells. PA plays a role in chronic liver disease, diabetes and Crohn’s disease, all of which are associated with impaired intestinal permeability. We investigate...
Very often, in-situ soil does not meet the requirements for landfill barriers; therefore, it is necessary to purchase the material from quarries. An increasing number of by-products have been proposed as alternative landfill barrier materials. The pr...
Background: High grade gliomas (HGG) are incapacitating and prematurely fatal diseases. To overcome the poor prognosis, novel therapies must overcome the selective and restricted permeability of the blood–brain barrier (BBB). This study critically ev...
Groundwater samples contaminated with potentially toxic elements (PTE), including metals and nitrate ions, were collected at a depth of 8–10 m from the Siberian Chemical Plant multicomponent waste storage. The possibility of developing a permea...
Chronic ultraviolet B (UV-B) irradiation is known to be one of the most important hazards acting on the skin and poses a risk of developing photoaging, skin with cutaneous field cancerization (CFC), actinic keratosis (AKs), and squamous cell carcinom...
Several chemicals, such as pesticides and heavy metals, are frequently encountered together in environment matrices, becoming a priority concerning the prevention of their emissions, as well as their removal from the environment. In this sense, this...
Angiostrongylus cantonensis, a zoonotic parasite, can invade the human central nervous system (CNS) and cause acute eosinophilic meningitis or eosinophilic meningoencephalitis. Mice infected with A. cantonensis show elevated levels of pro-inflammator...
In this paper, the performance of a gas barrier that consisted of polyacrylamide (PAM)-modified compacted clayey soil was experimentally explored. The moisture content and water loss characteristics of the tested soils were adopted as indicative indi...
Failure of the blood-brain barrier (BBB) is a critical event in the development and progression of diseases such as acute ischemic stroke, chronic ischemia or small vessels disease that affect the central nervous system. It is not known whether BBB b...
Cannabinoids and their receptors play a significant role in the regulation of gastrointestinal (GIT) peristalsis and intestinal barrier permeability. This review critically evaluates current knowledge about the mechanisms of action and biological eff...
Grape pomace (GP) is a winemaking by-product rich in polyphenols and fibre. Supplementation with GP extracts has shown potential benefits against oxidative stress- and inflammation-related pathologies. As a new nutritional target, this paper explores...
Currently, the mechanisms involved in drug access to the central nervous system (CNS) are not completely elucidated, and research efforts to understand the behaviour of the therapeutic agents to access the blood–brain barrier continue with the...
Angelicae Pubescentis Radix (APR), a widely used traditional Chinese medicine, is reported to have central nervous system activities. The purpose of this study was to characterize the blood-brain barrier permeability of twelve coumarins from APR incl...
The possibility of nanoparticle (NP) uptake to the human central nervous system is a major concern. Recent reports showed that in animal models, nanoparticles (NPs) passed through the blood–brain barrier (BBB). For the safe use of NPs, it is imperati...
The development of drugs targeting the central nervous system (CNS) is challenging because of the presence of the Blood-Brain barrier (BBB). Developing physiologically relevant in vitro BBB models for evaluating drug permeability and predicting the a...
Quantitative structure–activity relationship (QSAR) and quantitative structure–property relationship (QSPR) are established techniques to relate endpoints to molecular features. We present the Alvascience software suite that takes care of...
Permeation through the blood–brain barrier (BBB) is among the most important processes controlling the pharmacokinetic properties of drugs and other bioactive compounds. Using the fragmental (substructural) descriptors representing the occurren...
The recent success of small-molecule kinase inhibitors as anticancer drugs has generated significant interest in their application to other clinical areas, such as disorders of the central nervous system (CNS). However, most kinase inhibitor drug can...
The blood–brain barrier (BBB) is a major obstacle to the development of effective diagnostics and therapeutics for brain cancers and other central nervous system diseases. Peptide agonist analogs of kinin B1 and B2 receptors, acting as BBB perm...
Compromised blood-retinal barrier (BRB) integrity is a significant factor in ocular diseases like uveitis and retinopathies, leading to pathological vascular permeability and retinal edema. Adherens and tight junction (AJ and TJ) dysregulation due to...
Lichen secondary metabolites are characterized by huge pharmacological potential. Our research focused on assessing the anticancer and neuroprotective activity of Hypogymnia physodes acetone extract (HP extract) and physodic acid, its major component...
Psoriasis is a chronic inflammatory disease with unmet medical needs. To clarify potential therapeutic targets, different animal models have been developed. In the current study, imiquimod-induced psoriasiform dermatitis was used for monitoring the c...
The permeation of the blood-brain barrier is a very important consideration for new drug candidate molecules. In this research, the reversed-phase liquid chromatography with different columns (Purosphere RP-18e, IAM.PC.DD2 and Cosmosil Cholester) was...
Uncariae Ramulus Cum Uncis (URCU) is a widely used traditional Chinese medicine, and is reported to have various central nervous system effects. Alkaloids have been demonstrated to be the predominant pharmacological active components of URCU. In orde...
This paper proposes an eco-efficient treatment technology for removing phenanthrene (PHE) from kaolinite soil, incorporating a permeable reactive barrier (PRB) in an electrokinetic (EK) remediation system, which was made by modifying the granulated c...
Nitrate contamination in groundwater is a global concern due to its widespread presence and consequential social, environmental, and economic ramifications. This study investigates the efficacy of biological denitrification in a humid tropical settin...
Arsenic (As) can be naturally present in the native aquifer materials and can be released to groundwater through reduction dissolution of iron oxides containing As. While granular iron permeable reactive barriers (PRBs) can be effective for the treat...
Background: Previous studies have suggested that electromagnetic pulse (EMP) can induce openings in the blood–brain barrier (BBB). However, the temporal variation and spatial distribution of BBB permeability after EMP radiation are difficult to...
A permeable reactive barrier (PRB) containing zero-valent iron (ZVI) is an in situ groundwater remediation technology that passively intercepts and treats contaminated groundwater plumes. Over time, secondary mineral precipitation within the PRB dimi...
Traditional electrokinetic (EK) technology can remove contaminants from soil, but the efficiency is generally low. This study reports on the combination of enhanced EK and a waste ferric hydroxide (Fe(OH)3) permeable reactive barrier (PRB) for the re...
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