Search Results (3,720)

Background: Carcinogenic, Mutagenic, and Reprotoxic (CMR) substances are among the most significant occupational health hazards in healthcare and research laboratories. Despite preventive measures and regulations, exposure assessment and risk management remain complex due to varied working practices, mixed exposures, and the lack of harmonized monitoring protocols. This systematic review investigates occupational exposure to CMR substances in laboratory and healthcare environments. Methods: Searches were conducted in PubMed, Scopus, and Web of Science up to February 2025 using tailored keyword strategies. Studies published between 2020 and 2025 reporting exposure assessment, monitoring, and/or risk management of CMR chemicals were included; non-English papers and irrelevant studies were excluded. Titles/abstracts and full texts were screened independently by two reviewers with arbitration by a third. Risk of bias was assessed by three authors who independently evaluated each study. A narrative synthesis with frequency tables was performed; no meta-analysis was conducted. Results: Of 446 screened records, 50 studies were included. Formaldehyde (25 studies) and antineoplastic drugs (18 studies) were most frequently examined. Healthcare settings—e.g., hospital pharmacies, oncology wards, and pathology laboratories—were predominant, while research laboratories were underrepresented. Inhalation was the main exposure route for formaldehyde, whereas dermal uptake and surface contamination predominated for antineoplastic drugs. Monitoring methods included air sampling, surface wipe testing, and biological assays; preventive strategies varied and were inconsistently applied. Most included studies involved environmental monitoring and did not report participant numbers, so a total number of participants cannot be aggregated; for the main outcomes, participant counts were often not available. Limitations of the evidence include marked heterogeneity across settings, matrices, analytical methods, and reporting units, which precluded meta-analysis, as well as imprecision and incomplete reporting in several studies. Conclusions: Findings reveal persistent gaps in harmonized exposure limits, monitoring standards, and long-term health surveillance, underscoring the need for comprehensive prevention strategies. This review was not registered and did not receive any external funding. Full article

Due to their potential to reduce occupational physical strain and enhance human performance, the development of exoskeletons has gained significant attention. This study presents a musculoskeletal simulation pipeline designed to evaluate the biomechanical effects of shoulder-supporting exoskeletons. The focus of the investigation is on the biomechanical tools obtained from musculoskeletal simulations for the evaluation of exoskeletons. Such tools result in many biomechanical values, such as joint kinematics, external joint torques, muscle activation and joint reaction forces. The pipeline was applied to a use case, where electromyography (EMG) signals were collected and compared with simulated muscle activations for validation. The simulated muscle activations had a relative root mean square error (RMSE) of 37% in the area under the curve (AUC) compared to the EMG muscle activation. Joint reaction force analysis revealed altered magnitude and direction of the tangential JRF in the glenohumeral joint during exoskeleton support. This work raises the question of whether the focus in the development of shoulder exoskeletons should be on reducing the load on the subacromial space. By analyzing joint reaction forces and muscle activations, the pipeline can help to identify design parameters that reduce the load on the rotator cuff in the subacromial space. Full article

In healthy ecosystems, large raptors such as the White-tailed Eagle perform the essential roles of predators, bioindicators, and umbrella species. Despite their importance, many species of raptors are globally endangered, and similarly, in the Republic of Moldova, 13 species of diurnal birds of prey went extinct in the last 7 decades. The White-tailed Eagle (Haliaeetus albicilla) is the only example of a raptor that has regionally made a demographic and distributional comeback after decades of absence. Following this comeback, a national monitoring scheme during 2014–2025, including a nest counting survey in 2022–2024, has been implemented to understand what the current national situation of the species is and its ecological preferences and threats, together with the fundamental ecological context that allowed the breeding population to adapt to an ever-changing landscape. Field research conducted over 12 years confirmed the breeding of eight pairs, with data indicating a minimum of 19–23 nesting pairs. Pairs generally avoid human-dominated landscapes, preferring higher coverage of wetlands and forests, but current data suggests frequent occupancy of suboptimal territories and increasing tolerance towards human activity and infrastructure. Although currently small, the breeding population experiences high breeding success with no negative outcomes recorded. However, droughts and forestry activities in the proximity of the nests potentially reduced and delayed breeding success. Current forestry and fish farming practices increase the vulnerability of the few known breeding pairs to habitat degradation, poaching, and deforestation. To improve the conservation status of this endangered raptor in the Republic of Moldova, as close as possible to Least Concern status, it is crucial to implement multi-purpose buffer zones around active nests during the breeding season and to further survey the breeding population and assess any demographic trends. Full article

Enclosure space constitutes the fundamental habitat for captive animals, directly influencing domestication success and production performance. Alpine musk deer (Moschus chrysogaster), an endangered ungulate present on the Tibet plateau and surrounding areas, has been commonly farmed in captivity as an essential strategy for the ex situ conservation and sustainable musk production. In captive musk deer farming, understanding spatial selection patterns within enclosures is critical for improving farming practices. To evaluate patterns of space use under captive conditions and the effect of enclosure designing, we studied 70 captive Alpine musk deer housed in 17 enclosures at the Zhuanglang Musk Deer Breeding Farm (Gansu, China) during the summer of 2022 (from July 1st to August 29th). Focal sampling and all-occurrence recording were adopted to collect the behavioral data of the musk deer, and the point occupancy rate was calculated to analyze the enclosure space utilization patterns. The results showed significant differences in activity site selection and shelter use time among captive musk deer (p < 0.05). The central enclosure site (G5), which contains the shelter, exhibited the highest utilization rate (21.21 ± 9.19%). Shelter use was significantly higher in adults (22.09 ± 7.80%) than in subadults (17.27 ± 3.98%) (p < 0.05), and significantly higher in males (29.55 ± 5.65%) than in females (20.86 ± 7.95%) (p < 0.05). However, at equal population density, the shelter use time between all-male and mixed-sex groups was not significant (p > 0.05). These results reveal that captive Alpine musk deer display distinct shelter use patterns, with shelters acting as key spatial resources. Therefore, this study provides practical implications for optimizing enclosure design (e.g., increasing shelter quantity and improving spatial distribution) to enhance the welfare and productivity of captive Alpine musk deer. Full article

Background and Objectives: Emergency physicians practice in high-pressure environments and face occupational stressors that may affect their mental health. This study was designed to evaluate the prevalence of depression among emergency physicians in South Korea and examined environmental, sociolegal, and individual factors associated with depressive symptoms in the post-pandemic period. Materials and Methods: This nationwide cross-sectional study analyzed data from the 2025 Korean Emergency Physician Survey. Screening positive for depressive symptoms was defined as a Patient Health Questionnaire-9 (PHQ-9) score ≥ 10, indicating moderate-to-severe depressive symptom severity. Measures included the PHQ-9, the Korean Epworth Sleepiness Scale (KESS), and the Adult APGAR, a brief self-administered instrument assessing overall wellness. Multivariable logistic regression was performed to identify factors associated with depression after adjusting for demographic, clinical, and work-related variables. Results: Of the 1050 physicians who responded (response rate: 37.5%), 743 emergency physicians completed the PHQ-9 section (completion rate: 70.8%; mean age, 43.2 ± 7.78 years; 86.5% male), and 111 (14.9%) screened positive for depressive symptoms. Objective workload indicators, including total work hours and number of night shifts, did not differ between physicians with and without depression. However, emergency physicians screening positive for depression reported higher perceived burdens related to staffing shortages and patient-related stressors. Protective factors included being married (adjusted odds ratio [AOR], 0.22; 95% confidence interval [CI], 0.08–0.58), longer sleep duration (AOR, 0.65; 95% CI, 0.50–0.86), better sleep quality (AOR, 0.45; 95% CI, 0.27–0.74), fixed mealtimes (AOR, 0.60; 95% CI, 0.39–0.93), and higher Adult APGAR scores (AOR, 0.72; 95% CI, 0.60–0.86). Factors associated with increased odds of depression included a history of cancer (AOR, 14.63, 95% CI, 2.53–84.61), current alcohol consumption (AOR, 2.54, 95% CI, 1.14–5.68), daytime sleepiness (AOR, 1.17; 95% CI, 1.04–1.31), and more frequent verbal abuse during the previous 12 months (AOR, 1.25; 95% CI, 1.08–1.44). Conclusions: Depression was prevalent and was associated with perceived work burden, sleep health, lifestyle regularity, and psychosocial factors. Interventions should address sleep quality, workplace safety, and social support. Full article

Textile fabrics intended for use in protective clothing, workwear, and uniforms are subjected to repeated high-temperature industrial washing and drying processes. It is evident that due to the rigorous nature of the prescribed preservation conditions, textiles that are currently utilised for this purpose do not contain elastomeric yarns: a consequence of their suboptimal thermal stability. However, elastomers enable garments to better fit the wearer’s figure and enhance safety and comfort during occupational activities. Currently, no investigations of EOL (elastolefin) yarn elastic durability under commercial maintenance conditions have been conducted. The publication evaluates the elastic properties and pilling resistance of fabrics with EOL-core weft yarns before and after repeated industrial washing under conditions that are typical of rental use. Additionally, an analysis using SEM, FTIR spectroscopy, thermal and thermogravimetric techniques of core-yarns and the core itself was performed. The tested fabrics retained a high elasticity index, even after 100 industrial washing cycles, as confirmed by instrumental analysis. In conclusion, fabrics with EOL-core yarns can be used for garments that are subjected to intensive maintenance in industrial washing conditions without losing their elastic properties. Full article

Organic solvents are known to affect the nervous system, but neurotoxicity testing is not routinely required for industrial chemicals under current European regulations. Glycol ethers are widely used in consumer and industrial products. They can cross skin and lung barriers, distribute systemically, and penetrate the blood–brain barrier due to their physicochemical properties, while their neurotoxic potential remains poorly characterized. P-series glycol ethers now dominate the European market, making exposure assessment critical for public health. We compiled and integrated data from five authoritative sources to build an inventory of glycol ethers currently used in Europe and performed a structured descriptive analysis of high-volume propylene glycol ether compounds. Six high-volume compounds (≥1000 t/year) were selected for analysis. Production volumes, Swiss product registrations, occupational exposure limits, and product categories were compiled. Propylene glycol methyl ether (PGME) showed the highest tonnage (100,000–1,000,000 t/year) and was present in 9497 registered products, followed by propylene glycol ethyl ether (PGEE) (10,000–100,000 t/year; 1333 products). Paints/coatings and cleaning agents were the most frequent product categories, while additional presence in personal care and indoor-use products was observed. These products may lead to exposure depending on use conditions, such as spraying or inadequate ventilation, which can increase inhalation and skin contact. Their presence in diverse products suggests potential for both occupational and chronic low-level exposures. By providing an integrated overview of market presence, use patterns, and available neurotoxicity evidence for propylene glycol ethers, our findings highlight a critical gap in chemical risk assessment: the absence of neurotoxicity testing despite high production volumes and widespread use. Integrating neurotoxicity endpoints and new approach methodologies into regulatory frameworks is essential to strengthen public health protection. Full article

Objective: Rare-earth elements are extensively employed across diverse industrial sectors, increasingly raising concerns about their potential health hazards in both occupational and environmental contexts. Samarium oxide (Sm₂O₃), a routinely processed rare-earth product, reproducibly precipitates pulmonary fibrosis in experimental models, yet the molecular circuitry that transduces its fibrogenic signal remains almost entirely unmapped. This study aims to elucidate the role of miR-214-3p in Sm₂O₃-induced pulmonary fibrosis and to investigate its regulatory mechanism at the molecular level. Methods: A murine model of pulmonary fibrosis was established via intratracheal instillation of Sm₂O₃, and histopathological changes were assessed using hematoxylin and eosin (H&E) and Masson’s trichrome staining. RNA sequencing was performed on lung tissues to identify differentially expressed mRNAs. Leveraging our previously generated miRNA landscape of Sm₂O₃-exposed lungs, we subjected the dataset to Gene Ontology and KEGG enrichment analyses, which convergently identified miR-214-3p as the top-ranking candidate regulator of the fibrogenic MAPK axis. The direct targeting of MAP2K3 by miR-214-3p was validated using a dual-luciferase reporter assay. Expression levels of fibrotic markers (α-SMA, Collagen I) and key components of the MAPK signaling pathway (MAP2K3, p-MAPK14, MST1) were quantified in both in vivo and in vitro models using qRT-PCR and Western blotting. Gain- and loss-of-function studies, complemented by rescue assays, were performed in human embryonic lung fibroblasts (HELFs) via transient transfection of miR-214-3p mimics, inhibitors, or MAP2K3-overexpression plasmids. Cell proliferation was evaluated using the EdU assay, and TGF-β1 secretion was measured by ELISA. Results: Sm₂O₃ exposure induced significant pulmonary fibrosis in mice, accompanied by marked downregulation of miR-214-3p and upregulation of MAP2K3 in lung tissues. Overexpression of miR-214-3p or silencing of MAP2K3 effectively suppressed Sm₂O₃-induced fibroblast activation, including reduced cell proliferation, decreased expression of α-SMA and Collagen I, and inhibition of p38 MAPK phosphorylation. Notably, ectopic overexpression of MAP2K3 reversed the protective effects conferred by miR-214-3p, confirming a functional rescue. Conclusions: miR-214-3p directly silences MAP2K3, thereby blunting p38 MAPK-driven fibrogenesis after Sm₂O₃ exposure. Our data unveil a miR-214-3p–MAP2K3–p38 MAPK axis that constitutes a readily druggable target for rare-earth-element-induced pulmonary fibrosis. Full article

Movable guardrail systems are increasingly used in work zones, reversible lanes, and temporary traffic operations; however, evidence on their crashworthiness, material performance, and operational reliability remains dispersed across multiple design typologies and regulatory frameworks. This PRISMA-compliant systematic review synthesizes 78 studies involving full-scale crash tests, validated finite-element simulations, field performance evaluations, and compliance evaluations under MASH, EN 1317, NCHRP 350, and AS/NZS 3845.1. The findings indicate that modular rigid barriers reliably achieve TL-3/TL-4 performance when joint alignment and foundation conditions are properly controlled; semi-rigid steel systems provide a practical balance between containment capacity and redeployability, but remain sensitive to post spacing and connector detailing; and flexible polymer systems are best suited for short-duration, low-speed applications. Material-focused research highlights the advantages of UHPC section refinement, high-strength steels, and hybrid FRP–metal configurations in enhancing energy absorption without exceeding occupant-risk thresholds. Across studies, connection integrity consistently emerges as the dominant factor governing redirection stability and working-width performance. Field evaluations confirm satisfactory operational performance in constrained environments, while life-cycle assessments identify refurbishment intervals and mass-related logistics as major cost contributors. This review provides an integrated, evidence-based synthesis and a structured engineering foundation for advancing next-generation movable barrier designs, testing protocols, and deployment strategies. Full article

Intelligent Transportation Systems (ITS) primarily rely on flow rate and occupancy to estimate traffic states. However, in heterogeneous traffic conditions characterized by weak lane discipline and diverse vehicle classes, these conventional metrics fail to capture the true operational efficiency of signalized intersections. High flow rates can mask underlying inefficiencies, while low flow rates do not necessarily indicate free-flow conditions. This paper introduces a novel computer vision-based metric, the Effective Flow Ratio (EFR), designed to quantify the actual discharge efficiency of mixed traffic. By leveraging Bird’s-Eye View (BEV) vehicle tracking using You Only Look Once version 11 (YOLOv11) and ByteTrack, EFR distinguishes between kinematic movement and effective discharge, resolving the ambiguity of “moving but not clearing” states. We analyze 21 days of continuous footage from a rooftop-mounted camera overlooking a congested intersection in Dhaka, Bangladesh, exhibiting distinct non-linear behaviors compared to raw flow counts. Our results demonstrate that: (i) Flow rate and discharge efficiency are dynamically decoupled, evidenced by significant variance in EFR within identical flow bins; (ii) Temporal rolling correlations reveal transient regimes where traditional signal control logic would misinterpret congestion severity; and (iii) EFR provides a more robust proxy for intersection performance than occupancy or volume alone. The proposed metric offers a granular, physics-informed input for next-generation adaptive traffic signal control in developing urban environments. Full article

Machine learning (ML) models can complement traditional measurement-based approaches by supporting large-scale screening, spatial analysis, and prioritization of buildings for testing of indoor radon, a leading cause of lung cancer among non-smokers. Originating from uranium decay in soil and rock, radon enters homes via foundation cracks and accumulates indoors, influenced by building characteristics, ventilation, urbanization, and geogenic factors. As part of the Zagreb pilot within the “Evidence Driven Indoor Air Quality Improvement” (EDIAQI) project, this is the first ML application for indoor radon analysis in Croatia. This research evaluates residential indoor radon concentrations in Zagreb using ML applied to a dataset of 80 households. Several linear regression and tree-based ensemble methods were tested. The best-performing model (GBR) achieved an R² of 0.99 on the training set and 0.57 on the test set, with an RMSE of 33 Bq/m³ and MAE of 26 Bq/m³. Although predictive performance was moderate and generalization limited, key building characteristics such as construction year, dwelling type, occupancy details, and floor level were identified as relevant variables. The results suggest that machine learning may support radon risk prioritization in urban environments, but cannot replace direct measurements for regulatory purposes. Full article

Background: Cubital Tunnel Syndrome (CuTS) is the second-most common compressive neuropathy of the upper limb, traditionally associated with prolonged elbow flexion, trauma, or anatomical constraints. With the widespread adoption of smartphones, sustained upper-limb postures have emerged as potential novel risk factors for ulnar nerve compression. This retrospective study aimed to investigate the potential correlation between smartphone use patterns and the development of CuTS. Methods: A retrospective observational study was conducted on 100 subjects recruited between 2021 and 2024, including 50 patients with EMG-confirmed CuTS who underwent surgical decompression and 50 matched controls without clinical or electrophysiological evidence of ulnar neuropathy. Demographic variables, daily smartphone use (h/day), predominant activity type, and habitual posture during device handling were collected through clinical records and questionnaires. Group comparisons were performed using t-tests and Chi-square analyses, with significance set at p < 0.05. Results: Daily smartphone use was higher in the CuTS group compared with controls (4.94 ± 1.8 vs. 4.04 ± 1.5 h/day), although the difference did not reach statistical significance (p = 0.0716). Posture during device use showed a significant association with CuTS: 82% of affected patients reported using smartphones with the elbow flexed, compared with 56% of controls, whereas supportive postures were less frequent among CuTS patients (16% vs. 38%) (p = 0.019). No significant differences were found between groups regarding smartphone activity type (p = 0.858). Conclusions: Smartphone use may contribute to ulnar nerve compression primarily through ergonomically disadvantageous postures, particularly sustained elbow flexion, rather than total usage time. These findings highlight a modifiable behavioral risk factor relevant to the rising prevalence of CuTS in the digital era. Increased clinical attention to device-handling habits and public-health strategies promoting ergonomic posture may support CuTS prevention. Prospective and biomechanically informed studies are warranted to further elucidate causal mechanisms. Unmeasured confounders (e.g., occupational and sleep-related elbow flexion) may influence these associations. Full article

Occupant presence is a primary driver of Heating, Ventilation, and Air Conditioning (HVAC) and lighting energy consumption in office environments. Existing occupancy-sensing solutions often rely on privacy-sensitive modalities or require costly infrastructure, limiting their applicability in Small and Medium Offices (SMOs). To address these limitations, this study proposes a lightweight CSI-based occupancy-sensing framework based on a dual-core ESP32-S3 architecture, enabling concurrent CSI processing, environmental sensing, and cloud communication. A multi-stage signal preprocessing pipeline compresses raw CSI streams into a compact $56\times 8$ statistical feature matrix, achieving 98.86% classification accuracy for multi-level occupancy estimation. Compared with image-based baselines such as DenseNet121, the proposed approach reduces input data size to 24 kB and model parameters to 138 K, yielding over 129× reduction in transmission volume without sacrificing performance. These results demonstrate that the proposed framework provides a practical, privacy-preserving, and edge-deployable solution for occupancy-aware energy management in SMOs. Full article

Ventilation management is a key component of smart building performance, directly affecting indoor air quality, occupant comfort, and energy consumption during operation. The increasing complexity of building systems and variability in occupancy and environmental conditions challenge conventional static or centralised ventilation strategies. This study presents a conceptual and methodological framework for intelligent ventilation management based on the integration of distributed environmental sensorisation, multi-agent systems, and digital twins. The proposed approach focuses on structuring the architecture and decision-making mechanisms that enable adaptive and predictive ventilation strategies, including multi-source air intake selection (6D ventilation). Rather than providing experimental or simulation-based validation, the study defines a coherent framework intended to support future quantitative evaluation and implementation. The expected benefits of the approach, in terms of improved energy efficiency, indoor environmental quality, and life-cycle performance, are discussed in relation to existing research. The framework contributes to the development of smart buildings by providing a structured basis for advanced, adaptive, and sustainable ventilation management. Full article

The large-scale dredging activities in port areas generate substantial quantities of dredged soil, leading to land occupation and disposal challenges, while industrial wastes such as fly ash and desulfurization gypsum remain underutilized. In this study, industrial wastes were employed as a curing agent to stabilize dredged soil, aiming to achieve both mechanical performance improvement and cost-effective recycling. In total, 100 g of curing agent was added to 1 kg of sludge. The optimal strength-maximizing formulation comprised 4.5% activator 1 #, 4.5% fly ash, 4.5% mineral powder, and 0.5% desulfurization gypsum. It achieved an unconfined compressive strength of 0.794 MPa. For enhanced cost-effectiveness, a modified binder blend (1.88% activator 1 #, 4.5% fly ash, 4.5% mineral powder, and 0.5% desulfurization gypsum) delivered 0.63 MPa at 28 days, satisfying mechanical construction specifications. Results demonstrate that unconfined compressive strength increases with solid wastes; however, with the extension of solidification time, the unconfined compressive strength of dredged soil gradually slows down. Full article