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35 Results Found

  • Article
  • Open Access
21 Citations
10,849 Views
10 Pages

Identification of 1-Butyl-Lysergic Acid Diethylamide (1B-LSD) in Seized Blotter Paper Using an Integrated Workflow of Analytical Techniques and Chemo-Informatics

  • Emmanouil Tsochatzis,
  • Joao Alberto Lopes,
  • Fabiano Reniero,
  • Margaret Holland,
  • Jenny Åberg and
  • Claude Guillou

7 February 2020

The rapid dispersion of new psychoactive substances (NPS) presents challenges to customs services and analytical laboratories, which are involved in their detection and characterization. When the seized material is limited in quantity or of a complex...

  • Article
  • Open Access
1,027 Views
14 Pages

Background: During the COVID-19 pandemic, a high-volume field clinic was rapidly established in Taichung, Taiwan, to manage patients with mild symptoms and reduce hospital burden. To streamline workflow and support timely care, a tailored medical inf...

  • Article
  • Open Access
23 Citations
6,724 Views
28 Pages

COVID-19 vaccines have been instrumental tools in reducing the impact of SARS-CoV-2 infections around the world by preventing 80% to 90% of hospitalizations and deaths from reinfection, in addition to preventing 40% to 65% of symptomatic illnesses. H...

  • Article
  • Open Access
2 Citations
1,547 Views
29 Pages

14 October 2025

The digitization of healthcare has enabled the application of advanced analytics, such as process mining and machine learning, to electronic health records (EHRs). This study aims to identify workflow inefficiencies, temporal bottlenecks, and risk fa...

  • Article
  • Open Access
2 Citations
1,047 Views
10 Pages

Participatory Workflow Analysis of Newborn Genetic Screening (NBS) to Support Tools for Improved Follow-Up: Comparing the Use Case of Hemoglobinopathy Traits Across U.S. States

  • Peter Taber,
  • Jennifer Baysinger,
  • Sierra Daniels,
  • Natalie Diaz-Kincaid,
  • Amy Gaviglio,
  • Jacob Ginter,
  • Patrice K. Held,
  • Emily Reeves,
  • Virginia Sack and
  • Karen Eilbeck
  • + 1 author

Communication of newborn screening (NBS) results often fails to provide clear explanations of NBS screen results to parents. Understanding existing NBS workflows is vital for improving NBS follow-up. We sought to describe a diverse range of state NBS...

  • Review
  • Open Access
11 Citations
4,183 Views
26 Pages

Cultivating Clinical Clarity through Computer Vision: A Current Perspective on Whole Slide Imaging and Artificial Intelligence

  • Ankush U. Patel,
  • Nada Shaker,
  • Sambit Mohanty,
  • Shivani Sharma,
  • Shivam Gangal,
  • Catarina Eloy and
  • Anil V. Parwani

Diagnostic devices, methodological approaches, and traditional constructs of clinical pathology practice, cultivated throughout centuries, have transformed radically in the wake of explosive technological growth and other, e.g., environmental, cataly...

  • Review
  • Open Access
7 Citations
4,428 Views
20 Pages

Why Do We Need Food Systems Informatics? Introduction to This Special Collection on Smart and Connected Regional Food Systems

  • Thomas P. Tomich,
  • Casey Hoy,
  • Michael R. Dimock,
  • Allan D. Hollander,
  • Patrick R. Huber,
  • Ayaz Hyder,
  • Matthew C. Lange,
  • Courtney M. Riggle,
  • Michael T. Roberts and
  • James F. Quinn

12 April 2023

Public interest in where food comes from and how it is produced, processed, and distributed has increased over the last few decades, with even greater focus emerging during the COVID-19 pandemic. Mounting evidence and experience point to disturbing w...

  • Article
  • Open Access
769 Views
16 Pages

Digital Transformation in Critical Care: Implications for Quality of Care, Infection Control, and Clinical Outcomes

  • Daiana Toma,
  • Laura Andreea Ghenciu,
  • Ovidiu Horea Bedreag,
  • Adelina Băloi,
  • Carmen Alina Gizea,
  • Stelian Adrian Rițiu,
  • Emil Robert Stoicescu,
  • Claudiu Rafael Bârsac,
  • Marius Păpurică and
  • Dorel Săndesc
  • + 1 author

18 December 2025

Background/Objectives: Digitalization of intensive care units (ICUs) aims to enhance patient safety and efficiency through standardized documentation, real-time data integration, and clinical decision support. This study evaluated whether the impleme...

  • Article
  • Open Access
16 Citations
3,698 Views
11 Pages

28 December 2020

The management of geometrical variations throughout the product life cycle strongly relies on the gathering, processing, sharing and dissemination of tolerancing information and knowledge. While today, this is performed with many manual interventions...

  • Article
  • Open Access
29 Citations
6,517 Views
12 Pages

Nanopore Sequencing Resolves Elusive Long Tandem-Repeat Regions in Mitochondrial Genomes

  • Liina Kinkar,
  • Robin B. Gasser,
  • Bonnie L. Webster,
  • David Rollinson,
  • D. Timothy J. Littlewood,
  • Bill C.H. Chang,
  • Andreas J. Stroehlein,
  • Pasi K. Korhonen and
  • Neil D. Young

11 February 2021

Long non-coding, tandem-repetitive regions in mitochondrial (mt) genomes of many metazoans have been notoriously difficult to characterise accurately using conventional sequencing methods. Here, we show how the use of a third-generation (long-read) s...

  • Article
  • Open Access
41 Citations
9,447 Views
15 Pages

Disseminating Metaproteomic Informatics Capabilities and Knowledge Using the Galaxy-P Framework

  • Clemens Blank,
  • Caleb Easterly,
  • Bjoern Gruening,
  • James Johnson,
  • Carolin A. Kolmeder,
  • Praveen Kumar,
  • Damon May,
  • Subina Mehta,
  • Bart Mesuere and
  • Pratik D. Jagtap
  • + 9 authors

The impact of microbial communities, also known as the microbiome, on human health and the environment is receiving increased attention. Studying translated gene products (proteins) and comparing metaproteomic profiles may elucidate how microbiomes r...

  • Feature Paper
  • Article
  • Open Access
1 Citations
3,510 Views
29 Pages

6 August 2021

In this paper, we investigate ontology-supported interfaces for health informatics search tasks involving large document sets. We begin by providing background on health informatics, machine learning, and ontologies. We review leading research on hea...

  • Article
  • Open Access
7 Citations
3,712 Views
15 Pages

The Development of an Infrastructure to Facilitate the Use of Whole Genome Sequencing for Population Health

  • Nephi A. Walton,
  • Brent Hafen,
  • Sara Graceffo,
  • Nykole Sutherland,
  • Melanie Emmerson,
  • Rachel Palmquist,
  • Christine M. Formea,
  • Maricel Purcell,
  • Bret Heale and
  • Howard L. McLeod
  • + 33 authors

8 November 2022

The clinical use of genomic analysis has expanded rapidly resulting in an increased availability and utility of genomic information in clinical care. We have developed an infrastructure utilizing informatics tools and clinical processes to facilitate...

  • Article
  • Open Access
52 Citations
12,093 Views
14 Pages

Predictions of Physicochemical Properties of Ionic Liquids with DFT

  • Karl Karu,
  • Anton Ruzanov,
  • Heigo Ers,
  • Vladislav Ivaništšev,
  • Isabel Lage-Estebanez and
  • José M. García de la Vega

Nowadays, density functional theory (DFT)-based high-throughput computational approach is becoming more efficient and, thus, attractive for finding advanced materials for electrochemical applications. In this work, we illustrate how theoretical model...

  • Article
  • Open Access
6 Citations
3,463 Views
8 Pages

Oriental theileriosis is an economically important tickborne disease of bovines, caused by some members of the Theileria orientalis complex. Currently, 11 distinct operational taxonomic units (OTUs), or genotypes, are recognized based on their major...

  • Article
  • Open Access
2,349 Views
15 Pages

Exploring Canine Picornavirus Diversity in the USA Using Wastewater Surveillance: From High-Throughput Genomic Sequencing to Immuno-Informatics and Capsid Structure Modeling

  • Temitope O. C. Faleye,
  • Peter Skidmore,
  • Amir Elyaderani,
  • Sangeet Adhikari,
  • Nicole Kaiser,
  • Abriana Smith,
  • Allan Yanez,
  • Tyler Perleberg,
  • Erin M. Driver and
  • Matthew Scotch
  • + 2 authors

24 July 2024

The SARS-CoV-2 pandemic resulted in a scale-up of viral genomic surveillance globally. However, the wet lab constraints (economic, infrastructural, and personnel) of translating novel virus variant sequence information to meaningful immunological and...

  • Article
  • Open Access
1,364 Views
12 Pages

4 October 2025

Current medical informatics systems face critical challenges, including limited scalability across distributed institutions, insufficient real-time AI-driven decision support, and lack of standardized interoperability for heterogeneous medical data e...

  • Feature Paper
  • Article
  • Open Access
68 Citations
32,221 Views
15 Pages

15 October 2021

Myocarditis and pericarditis have been linked recently to COVID-19 vaccines without exploring the underlying mechanisms, or compared to cardiac adverse events post-non-COVID-19 vaccines. We introduce an informatics approach to study post-vaccine adve...

  • Article
  • Open Access
18 Citations
3,524 Views
10 Pages

Establishment of a Pharmacogenetics Service Focused on Optimizing Existing Pharmacogenetic Testing at a Large Academic Health Center

  • Amy L. Pasternak,
  • Kristen M. Ward,
  • Mohammad B. Ateya,
  • Hae Mi Choe,
  • Amy N. Thompson,
  • John S. Clark and
  • Vicki Ellingrod

3 October 2020

Multiple groups have described strategies for clinical implementation of pharmacogenetics (PGx) that often include internal laboratory tests that are specifically developed for their implementation needs. However, many institutions are not able to fo...

  • Article
  • Open Access
7 Citations
4,747 Views
14 Pages

Ultraviolet Photodissociation for Non-Target Screening-Based Identification of Organic Micro-Pollutants in Water Samples

  • Christian Panse,
  • Seema Sharma,
  • Romain Huguet,
  • Dennis Vughs,
  • Jonas Grossmann and
  • Andrea Mizzi Brunner

12 September 2020

Non-target screening (NTS) based on the combination of liquid chromatography coupled to high-resolution mass spectrometry has become the key method to identify organic micro-pollutants (OMPs) in water samples. However, a large number of compounds rem...

  • Article
  • Open Access
2 Citations
2,572 Views
11 Pages

Accuracy-Based Glomerular Filtration Rate Assessment by Plasma Iohexol Clearance in Kidney Transplant Donors

  • Zhicheng Jin,
  • Rongrong Huang,
  • Paul Christensen,
  • Roger L. Bertholf and
  • Xin Yi

19 September 2023

Background: An accurate measurement of the glomerular filtration rate (GFR) is essential for detecting renal insufficiency in living kidney donors. Iohexol is a “near-ideal” exogenous filtration marker for GFR measurements that has attrac...

  • Review
  • Open Access
27 Citations
5,841 Views
26 Pages

4 April 2023

This review will focus on advances in electronic and optoelectronic technologies by through the analysis of a full research and industrial application scenario. Starting with the analysis of nanocomposite sensors, and electronic/optoelectronic/mechat...

  • Review
  • Open Access
1,581 Views
32 Pages

A Survey of the Application of Explainable Artificial Intelligence in Biomedical Informatics

  • Hassan Eshkiki,
  • Farinaz Tanhaei,
  • Fabio Caraffini and
  • Benjamin Mora

8 December 2025

This review investigates the application of Explainable Artificial Intelligence (XAI) in biomedical informatics, encompassing domains such as medical imaging, genomics, and electronic health records. Through a systematic analysis of 43 peer-reviewed...

  • Review
  • Open Access
2,205 Views
43 Pages

FC-BENTEN: Synchrotron X-Ray Experimental Database for Polymer-Electrolyte Fuel-Cell Material Analysis

  • Takahiro Matsumoto,
  • Shigeru Yokota,
  • Takuma Kaneko,
  • Mayeesha Marium,
  • Jeheon Kim,
  • Yasuhiro Watanabe,
  • Hiroyuki Iwamoto,
  • Keiji Umetani,
  • Tomoya Uruga and
  • Yoshiharu Sakurai
  • + 8 authors

3 April 2025

This review is focused on FC-BENTEN, an advanced synchrotron X-ray experimental database developed at SPring-8 with support from Japan’s New Energy and Industrial Technology Development Organization (NEDO). Designed to advance polymer electroly...

  • Article
  • Open Access
13 Citations
6,332 Views
20 Pages

23 August 2023

With the rapid advancement of the informatization process of China’s construction industry, the requirements for the integration of engineering design and construction are getting higher and higher. The quality of engineering design and the lev...

  • Article
  • Open Access
27 Citations
6,347 Views
30 Pages

31 August 2024

The incorporation of Artificial Intelligence (AI) models into various optimization systems is on the rise. However, addressing complex urban and environmental management challenges often demands deep expertise in domain science and informatics. This...

  • Review
  • Open Access
6 Citations
5,974 Views
31 Pages

Advances and Challenges in Respiratory Sound Analysis: A Technique Review Based on the ICBHI2017 Database

  • Shaode Yu,
  • Jieyang Yu,
  • Lijun Chen,
  • Bing Zhu,
  • Xiaokun Liang,
  • Yaoqin Xie and
  • Qiurui Sun

Respiratory diseases present significant global health challenges. Recent advances in respiratory sound analysis (RSA) have shown great potential for automated disease diagnosis and patient management. The International Conference on Biomedical and H...

  • Systematic Review
  • Open Access
2,109 Views
38 Pages

19 November 2025

Virtual exhibitions of cultural heritage (CH) have become a key means for preservation, education, and global dissemination in the digital era. This study provides a comprehensive systematic review and bibliometric analysis of CH virtual exhibition r...

  • Article
  • Open Access
5 Citations
2,211 Views
23 Pages

Using Machine Learning and Feature Importance to Identify Risk Factors for Mortality in Pediatric Heart Surgery

  • Lorenz A. Kapsner,
  • Manuel Feißt,
  • Ariawan Purbojo,
  • Hans-Ulrich Prokosch,
  • Thomas Ganslandt,
  • Sven Dittrich,
  • Jonathan M. Mang and
  • Wolfgang Wällisch

18 November 2024

Background: The objective of this IRB-approved retrospective monocentric study was to identify risk factors for mortality after surgery for congenital heart defects (CHDs) in pediatric patients using machine learning (ML). CHD belongs to the most com...

  • Review
  • Open Access
326 Views
47 Pages

26 February 2026

This paper is a focused, standards-aligned survey of where autoregressive (AR) large language models (LLMs) tend to break down when deployed inside industrial informatics workflows that must satisfy long-horizon objectives, hard constraints, traceabi...

  • Article
  • Open Access
1 Citations
2,411 Views
16 Pages

1 July 2024

Next Generation Sequencing Technologies (NGS), particularly metabarcoding, are valuable tools for authenticating foodstuffs and detecting eventual fraudulent practices such as species substitution. This technique, mostly used for the analysis of prok...

  • Article
  • Open Access
489 Views
33 Pages

20 December 2025

Nominally weakly coordinating anions are useful for modulating the solubility and chemical properties of metal complexes, but identification and analysis of the systematics of the interactions of anions with cationic metal complexes has not received...

  • Article
  • Open Access
7 Citations
5,190 Views
17 Pages

12 October 2022

Recent advances and lower costs in rapid high-throughput sequencing have engendered hope that whole genome sequencing (WGS) might afford complete resistome characterization in bacterial isolates. WGS is particularly useful for the clinical characteri...

  • Systematic Review
  • Open Access
1,109 Views
40 Pages

A Systematic Review of Diffusion Models for Medical Image-Based Diagnosis: Methods, Taxonomies, Clinical Integration, Explainability, and Future Directions

  • Mohammad Azad,
  • Nur Mohammad Fahad,
  • Mohaimenul Azam Khan Raiaan,
  • Tanvir Rahman Anik,
  • Md Faraz Kabir Khan,
  • Habib Mahamadou Kélé Toyé and
  • Ghulam Muhammad

Background and Objectives: Diffusion models, as a recent advancement in generative modeling, have become central to high-resolution image synthesis and reconstruction. Their rapid progress has notably shaped computer vision and health informatics, pa...

  • Article
  • Open Access
1,664 Views
15 Pages

Canine Parvovirus and Vaccine-Origin Feline Panleukopenia Virus in Wastewater, Arizona, USA: July 2022–June 2023

  • Jacqueline Vargas,
  • Brenda Bermudez-Rivera,
  • Izabella Block,
  • Gray Shaffer,
  • Lesley Estrada,
  • Tegan Dadd,
  • Tanner Dickerson,
  • Courtney Curtis,
  • Craig Woods and
  • Temitope O. C. Faleye
  • + 4 authors

Canine parvovirus (CPV) is a virus of veterinary health significance and a member of the Parvoviridae family. Despite its clinical significance and global distribution, surveillance is often limited to cases serious enough to result in veterinary vis...