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  • Article
  • Open Access
22 Citations
12,484 Views
10 Pages

Guided-Mode Resonance Grating with Self-Assembled Silver Nanoparticles for Surface-Enhanced Raman Scattering Spectroscopy

  • Jing Yang,
  • Fanghui Ren,
  • Xinyuan Chong,
  • Donglei Fan,
  • Swapnajit Chakravarty,
  • Zheng Wang,
  • Ray T. Chen and
  • Alan X. Wang

23 October 2014

We designed and fabricated guided-mode resonance (GMR) gratings on indium-tin-oxide (ITO) thin film to generate a significantly enhanced local electric field for surface-enhanced Raman scattering (SERS) spectroscopy. Ag nanoparticles (NPs) were self...

  • Article
  • Open Access
5 Citations
3,642 Views
16 Pages

Shaping in the Third Direction; Synthesis of Patterned Colloidal Crystals by Polyester Fabric-Guided Self-Assembly

  • Ion Sandu,
  • Claudiu Teodor Fleaca,
  • Florian Dumitrache,
  • Bogdan Alexandru Sava,
  • Iuliana Urzica,
  • Iulia Antohe,
  • Simona Brajnicov and
  • Marius Dumitru

24 November 2021

A polyester fabric with rectangular openings was used as a sacrificial template for the guiding of a sub-micron sphere (polystyrene (PS) and silica) aqueous colloid self-assembly process during evaporation as a patterned colloidal crystal (PCC). This...

  • Article
  • Open Access
2 Citations
3,348 Views
17 Pages

DNA-Guided Assembly for Fibril Proteins

  • Alexandru Amărioarei,
  • Frankie Spencer,
  • Gefry Barad,
  • Ana-Maria Gheorghe,
  • Corina Iţcuş,
  • Iris Tuşa,
  • Ana-Maria Prelipcean,
  • Andrei Păun,
  • Mihaela Păun and
  • Eugen Czeizler
  • + 2 authors

19 February 2021

Current advances in computational modelling and simulation have led to the inclusion of computer scientists as partners in the process of engineering of new nanomaterials and nanodevices. This trend is now, more than ever, visible in the field of deo...

  • Article
  • Open Access
1 Citations
2,287 Views
17 Pages

Color Masking Ability of Guided Enamel Regeneration with a Novel Self-Assembling Peptide and Resin Infiltration on Artificial Enamel Lesions Under Various Challenges: An In Vitro Spectrophotometric Analysis

  • Nassreen Albar,
  • Syed Nahid Basheer,
  • Mohammed M. Al Moaleem,
  • Sana Ageel,
  • Rehab Abbas,
  • Rafaa Hakami,
  • Arwa Daghrery,
  • Mohammed Sawady,
  • Syed Wali Peeran and
  • Bassam Zidane
  • + 1 author

16 December 2024

The color masking ability of resin infiltration (RI) and curodont repair fluoride plus–self-assembling peptide (CRFP-SAP) was investigated under various simulated oral challenging conditions. Sixty-four extracted caries-free human canines were...

  • Article
  • Open Access
2 Citations
3,458 Views
17 Pages

Guided Self-Assembly of ES-Derived Lung Progenitors into Biomimetic Tube Structures That Impact Cell Differentiation

  • John P. Soleas,
  • Linwen Huang,
  • Elisa D’Arcangelo,
  • Maria Cristina Nostro,
  • Thomas K. Waddell,
  • Alison P. McGuigan and
  • Golnaz Karoubi

Chemically directed differentiation of pluripotent stem cells (PSCs) into defined cell types is a potent strategy for creating regenerative tissue models and cell therapies. In vitro observations suggest that physical cues can augment directed differ...

  • Article
  • Open Access
5 Citations
2,514 Views
13 Pages

14 January 2023

Ion bombardment (IB) is a promising nanofabrication tool for self-organized nanostructures. When ions bombard a nominally flat solid surface, self-organized nanoripples can be induced on the irradiated target surface, which are called intrinsic nanor...

  • Article
  • Open Access
29 Citations
9,594 Views
18 Pages

6 August 2019

Solvent vapor annealing is as an effective and versatile alternative to thermal annealing to equilibrate and control the assembly of polymer chains in thin films. Here, we present scientific and practical aspects of the solvent vapor annealing method...

  • Article
  • Open Access
5 Citations
3,248 Views
11 Pages

Fabrication of a Fish-Bone-Inspired Inorganic–Organic Composite Membrane

  • YuYang Jiao,
  • Masahiro Okada,
  • Bhingaradiya Nutan,
  • Noriyuki Nagaoka,
  • Ahmad Bikharudin,
  • Randa Musa and
  • Takuya Matsumoto

23 October 2023

Biological materials have properties like great strength and flexibility that are not present in synthetic materials. Using the ribs of crucian carp as a reference, we investigated the mechanisms behind the high mechanical properties of this rib bone...

  • Article
  • Open Access
7 Citations
3,920 Views
28 Pages

23 February 2020

This paper presents a new micro additive manufacturing process and initial characterization of its capabilities. The process uses modulated electric fields to manipulate and deposit particles from colloidal solution in a contactless way and is named...

  • Review
  • Open Access
30 Citations
8,615 Views
15 Pages

Role of Entropy in Colloidal Self-Assembly

  • Brunno C. Rocha,
  • Sanjib Paul and
  • Harish Vashisth

10 August 2020

Entropy plays a key role in the self-assembly of colloidal particles. Specifically, in the case of hard particles, which do not interact or overlap with each other during the process of self-assembly, the free energy is minimized due to an increase i...

  • Article
  • Open Access
2 Citations
6,269 Views
14 Pages

Self-Assembly of Human Serum Albumin: A Simplex Phenomenon

  • Garima Thakur,
  • Kovur Prashanthi,
  • Keren Jiang and
  • Thomas Thundat

20 September 2017

Spontaneous self-assemblies of biomolecules can generate geometrical patterns. Our findings provide an insight into the mechanism of self-assembled ring pattern generation by human serum albumin (HSA). The self-assembly is a process guided by kinetic...

  • Review
  • Open Access
12 Citations
4,499 Views
18 Pages

25 August 2022

Self-assembled biomaterials have been widely explored for real-time fluorescence imaging, imaging-guided surgery, and targeted therapy for tumors, etc. In particular, small molecule-based self-assembly has been established as a reliable strategy for...

  • Review
  • Open Access
29 Citations
5,385 Views
17 Pages

22 June 2022

Proteins are functional building blocks of living organisms that exert a wide variety of functions, but their synthesis and industrial production can be cumbersome and expensive. By contrast, short peptides are very convenient to prepare at a low cos...

  • Feature Paper
  • Review
  • Open Access
29 Citations
14,582 Views
14 Pages

3D DNA Crystals and Nanotechnology

  • Paul J. Paukstelis and
  • Nadrian C. Seeman

18 August 2016

DNA’s molecular recognition properties have made it one of the most widely used biomacromolecular construction materials. The programmed assembly of DNA oligonucleotides has been used to create complex 2D and 3D self-assembled architectures and to gu...

  • Review
  • Open Access
38 Citations
11,883 Views
24 Pages

1 December 2017

Nucleobase interactions play a fundamental role in biological functions, including transcription and translation. Natural nucleic acids like DNA are also widely implemented in material realm such as DNA guided self-assembly of nanomaterials. Inspired...

  • Article
  • Open Access
4 Citations
3,809 Views
11 Pages

23 March 2024

We conducted a computational study on the self-assembly behavior of cylinder-forming block copolymers, directed by a guide pattern of hexagonally or tetragonally arrayed pillars, using mesoscale density functional theory simulations. By adjusting the...

  • Article
  • Open Access
13 Citations
6,421 Views
13 Pages

Supramolecular Assembly of pH-Sensitive Triphenylene Derived π-Gelators and Their Application as Molecular Template for the Preparation of Silica Nanotubes

  • Ignacio Muñoz Resta,
  • Verónica E. Manzano,
  • Florencia Cecchi,
  • Carla C. Spagnuolo,
  • Fabio D. Cukiernik and
  • Pablo H. Di Chenna

1 February 2016

The gelation properties and mode of self-assembly of six asymmetrical hexaether triphenylene derivatives mono-functionalized with carboxylic and primary amine groups were investigated. The presence of a carboxylic and amine group attached to the trip...

  • Review
  • Open Access
93 Citations
21,182 Views
42 Pages

Chemical Interactions and Their Role in the Microphase Separation of Block Copolymer Thin Films

  • Richard A. Farrell,
  • Thomas G. Fitzgerald,
  • Dipu Borah,
  • Justin D. Holmes and
  • Michael A. Morris

25 August 2009

The thermodynamics of self-assembling systems are discussed in terms of the chemical interactions and the intermolecular forces between species. It is clear that there are both theoretical and practical limitations on the dimensions and the structura...

  • Review
  • Open Access
22 Citations
13,102 Views
13 Pages

Biomimetic Enamel Regeneration Using Self-Assembling Peptide P11-4

  • Mohammad Alkilzy,
  • Ghalib Qadri,
  • Christian H. Splieth and
  • Ruth M. Santamaría

The recent understanding of the etiology and pathology of dental caries has shifted its treatment from invasive drill and fill conventional strategies to noninvasive and/or minimally invasive approaches. Guided tissue regeneration (GTR) is a well-est...

  • Review
  • Open Access
4 Citations
5,842 Views
19 Pages

Review of Directed Self-Assembly Material, Processing, and Application in Advanced Lithography and Patterning

  • Xiuyan Cheng,
  • Di Liang,
  • Miao Jiang,
  • Yufei Sha,
  • Xiaonan Liu,
  • Jinlai Liu,
  • Qingchen Cao and
  • Jiangliu Shi

Directed self-assembly (DSA) lithography, a cutting-edge technology based on the self-assembly of block copolymers (BCPs), has received significant attention in recent years. Combining DSA with established lithography technologies, such as extreme ul...

  • Review
  • Open Access
29 Citations
8,437 Views
19 Pages

Gold-Nanoparticle-Based Chiral Plasmonic Nanostructures and Their Biomedical Applications

  • Hanbo Li,
  • Xinshuang Gao,
  • Chenqi Zhang,
  • Yinglu Ji,
  • Zhijian Hu and
  • Xiaochun Wu

1 November 2022

As chiral antennas, plasmonic nanoparticles (NPs) can enhance chiral responses of chiral materials by forming hybrid structures and improving their own chirality preference as well. Chirality-dependent properties of plasmonic NPs broaden application...

  • Review
  • Open Access
25 Citations
8,560 Views
30 Pages

Nanostructured Guidance for Peripheral Nerve Injuries: A Review with a Perspective in the Oral and Maxillofacial Area

  • Stefano Sivolella,
  • Giulia Brunello,
  • Nadia Ferrarese,
  • Alessandro Della Puppa,
  • Domenico D'Avella,
  • Eriberto Bressan and
  • Barbara Zavan

20 February 2014

Injury to peripheral nerves can occur as a result of various surgical procedures, including oral and maxillofacial surgery. In the case of nerve transaction, the gold standard treatment is the end-to-end reconnection of the two nerve stumps. When it...

  • Communication
  • Open Access
4 Citations
2,445 Views
14 Pages

Template-Assisted Assembly of Hybrid DNA/RNA Nanostructures Using Branched Oligodeoxy- and Oligoribonucleotides

  • Alesya Fokina,
  • Yulia Poletaeva,
  • Svetlana Dukova,
  • Kristina Klabenkova,
  • Zinaida Rad’kova,
  • Anastasia Bakulina,
  • Timofei Zatsepin,
  • Elena Ryabchikova and
  • Dmitry Stetsenko

5 November 2023

A template-assisted assembly approach to a C24 fullerene-like double-stranded DNA polyhedral shell is proposed. The assembly employed a supramolecular oligonucleotide dendrimer as a 3D template that was obtained via the hybridization of siRNA strands...

  • Feature Paper
  • Review
  • Open Access
37 Citations
10,035 Views
15 Pages

Neural Circuits on a Chip

  • Md. Fayad Hasan and
  • Yevgeny Berdichevsky

5 September 2016

Neural circuits are responsible for the brain’s ability to process and store information. Reductionist approaches to understanding the brain include isolation of individual neurons for detailed characterization. When maintained in vitro for several d...

  • Review
  • Open Access
18 Citations
4,644 Views
28 Pages

Nanomedicine employs molecular materials for prevention and treatment of disease. Recently, smart nanoparticle (NP)-based drug delivery systems were developed for the advanced transport of drug molecules. Rationally engineered organic and inorganic N...

  • Article
  • Open Access
3 Citations
3,115 Views
8 Pages

5 August 2021

We report a fabrication route of silica nanoparticles with two, three or six patches with an easily tunable patch-to-particle size ratio. The synthetic pathway includes two main stages: the synthesis of silica/polystyrene multipod-like templates and...

  • Article
  • Open Access
11 Citations
3,042 Views
16 Pages

9 May 2024

MXenes, as emerging 2D sensing materials for next-generation electronics, have attracted tremendous attention owing to their extraordinary electrical conductivity, mechanical strength, and flexibility. However, challenges remain due to the weak stabi...

  • Article
  • Open Access
11 Citations
5,600 Views
18 Pages

2 March 2018

Four-dimensional (4D) biofabrication techniques aim to dynamically produce and control three-dimensional (3D) biological structures that would transform their shapes or functionalities with time, when a stimulus is imposed or cell post-printing self-...

  • Review
  • Open Access
5 Citations
4,811 Views
20 Pages

Scaffold-Free Strategies in Dental Pulp/Dentine Tissue Engineering: Current Status and Implications for Regenerative Biological Processes

  • Mohammad Samiei,
  • Martin Conrad Harmsen,
  • Elaheh Dalir Abdolahinia,
  • Jaleh Barar and
  • Xenos Petridis

Conventionally, root canal treatment is performed when the dental pulp is severely damaged or lost due to dental trauma or bacterial endodontic infections. This treatment involves removing the compromised or infected pulp tissue, disinfecting the roo...

  • Article
  • Open Access
11 Citations
5,211 Views
18 Pages

Designing Imidazolium Poly(amide-amide) and Poly(amide-imide) Ionenes and Their Interactions with Mono- and Tris(imidazolium) Ionic Liquids

  • Kathryn E. O’Harra,
  • Danielle M. Noll,
  • Irshad Kammakakam,
  • Emily M. DeVriese,
  • Gala Solis,
  • Enrique M. Jackson and
  • Jason E. Bara

30 May 2020

Here we introduce the synthesis and thermal properties of a series of sophisticated imidazolium ionenes with alternating amide-amide or amide-imide backbone functionality, and investigate the structural effects of mono(imidazolium) and unprecedented...

  • Article
  • Open Access
2 Citations
2,057 Views
15 Pages

30 December 2024

The demand for flexible automation in manufacturing has increased, incorporating vision-guided systems for object grasping. However, a key challenge is in-hand error, where discrepancies between the actual and estimated positions of an object in the...

  • Article
  • Open Access
4 Citations
4,539 Views
12 Pages

Resist-Free Directed Self-Assembly Chemo-Epitaxy Approach for Line/Space Patterning

  • Tommaso Jacopo Giammaria,
  • Ahmed Gharbi,
  • Anne Paquet,
  • Paul Nealey and
  • Raluca Tiron

7 December 2020

This work reports a novel, simple, and resist-free chemo-epitaxy process permitting the directed self-assembly (DSA) of lamella polystyrene-block-polymethylmethacrylate (PS-b-PMMA) block copolymers (BCPs) on a 300 mm wafer. 193i lithography is used t...

  • Article
  • Open Access
1 Citations
1,827 Views
29 Pages

Car interior design should evoke emotions, offer comfort, convey safety and at the same time project the brand identity of the car manufacturer. Lighting is used to address these functions. Modules required for automotive interior lighting often feat...

  • Article
  • Open Access
1 Citations
1,943 Views
21 Pages

Systemic and Mucosal Humoral Immune Responses to Lumazine Synthase 60-mer Nanoparticle SARS-CoV-2 Vaccines

  • Cheng Cheng,
  • Jeffrey C. Boyington,
  • Edward K. Sarfo,
  • Cuiping Liu,
  • Danealle K. Parchment,
  • Andrea Biju,
  • Angela R. Corrigan,
  • Lingshu Wang,
  • Wei Shi and
  • Theodore C. Pierson
  • + 11 authors

23 July 2025

Background: Vaccines that stimulate systemic and mucosal immunity to a level required to prevent SARS-CoV-2 infection and transmission are an unmet need. Highly protective hepatitis B and human papillomavirus nanoparticle vaccines highlight the poten...

  • Review
  • Open Access
1,076 Views
26 Pages

The ligand-driven self-assembly of metal clusters offers a powerful strategy for constructing discrete molecular architectures with tunable magnetic and structural properties. By judiciously selecting appropriate multidentate ligands, researchers can...

  • Article
  • Open Access
2 Citations
6,167 Views
11 Pages

1 August 2016

A photo-crosslinked polystyrene (PS) thin film is investigated as a potential guiding sub-layer for polystyrene-block-poly (methyl methacrylate) block copolymer (BCP) cylindrical nanopattern formation via topographic directed self-assembly (DSA). Whe...

  • Review
  • Open Access
9 Citations
6,483 Views
24 Pages

Progress in Polyhedral Oligomeric Silsesquioxane (POSS) Photoresists: A Comprehensive Review across Lithographic Systems

  • Zaoxia Wen,
  • Xingyu Liu,
  • Wenxiu Chen,
  • Ruolin Zhou,
  • Hao Wu,
  • Yongmei Xia and
  • Lianbin Wu

19 March 2024

This paper offers a comprehensive overview of the polyhedral oligomeric silsesquioxane (POSS) and POSS-based composites within the realm of photoresist resin. The study involves a systematic exploration and discussion of the contributions made by POS...

  • Article
  • Open Access
699 Views
15 Pages

13 October 2025

This study presents an enantiomeric-ratio-driven strategy for constructing mechanically robust supramolecular gels using cyclohexane bisurea derivatives. By employing non-equimolar enantiomeric mixtures, we achieved an ultralow critical gelation conc...

  • Article
  • Open Access
27 Citations
5,061 Views
12 Pages

23 October 2019

Plant polyphenols have received considerable attention in recent years due to their ability to undergo oxidation-triggered self-polymerization, forming biocompatible versatile coatings and templated nanoparticles (NPs) that can be leveraged for a var...

  • Review
  • Open Access
20 Citations
5,667 Views
16 Pages

Application of Metal–Organic Frameworks (MOFs) in Environmental Biosystems

  • Lu Zhang,
  • Qingwen Zheng,
  • Zheng Zhang,
  • Huidong Li,
  • Xue Liu,
  • Jinzhi Sun and
  • Ruiwen Wang

21 January 2023

Metal–organic frameworks (MOFs) are crystalline materials that are formed by self-assembling organic linkers and metal ions with large specific areas and pore volumes. Their chemical tunability, structural diversity, and tailor-ability make the...

  • Feature Paper
  • Article
  • Open Access
5 Citations
2,799 Views
15 Pages

Thermal Tunable Tribological Behavior of Shape Memory Biphenyl Epoxy Resin

  • Jing Yang,
  • Pengrui Cao,
  • Ketian Gao,
  • Chang Ding,
  • Shoubing Chen,
  • Xinrui Zhang,
  • Tingmei Wang,
  • Qihua Wang and
  • Yaoming Zhang

12 January 2023

Although polymer-based self-lubricating materials have rapidly developed recently, intelligent lubricating materials with self-adaptable lubrication with external conditions changing are highly demanded, especially for harsh conditions. Herein, a sha...

  • Article
  • Open Access
1,917 Views
15 Pages

Iodine-Doped Hollow Carbon Nanocages without Templates Strategy for Boosting Zinc-Ion Storage by Nucleophilicity

  • Ruiting Niu,
  • Huailin Fan,
  • Qingfu Ban,
  • Dezhi Zhou,
  • Lekang Zhao,
  • Jiayuan Yu,
  • Qifeng Chen and
  • Xun Hu

9 February 2024

Zn-ion hybrid supercapacitors (ZHCs) combining merits of battery-type and capacitive electrodes are considered to be a prospective candidate in energy storage systems. Tailor-made carbon cathodes with high zincophilicity and abundant physi/chemisorpt...

  • Review
  • Open Access
1,280 Views
37 Pages

Peptide-based biomaterials have emerged as versatile tools for pharmaceutical drug delivery due to their biocompatibility and tunable sequences, yet a comprehensive overview of their categories, mechanisms, and optimization strategies remains lacking...

  • Review
  • Open Access
23 Citations
7,888 Views
36 Pages

Organic Thermoelectric Materials for Wearable Electronic Devices

  • Runfeng Xiao,
  • Xiaoyan Zhou,
  • Chan Zhang,
  • Xi Liu,
  • Shaobo Han and
  • Canyan Che

16 July 2024

Wearable electronic devices have emerged as a pivotal technology in healthcare and artificial intelligence robots. Among the materials that are employed in wearable electronic devices, organic thermoelectric materials possess great application potent...

  • Review
  • Open Access
3 Citations
2,425 Views
20 Pages

Nanovaccines: Innovative Advances from Design Strategies to Clinical Translation

  • Jiuxiang He,
  • Wen Xiao,
  • Dong Hua,
  • Minchi Liu,
  • Hongxia Guo,
  • Li Xu,
  • Meiling Xiao,
  • Yunsha Du and
  • Jintao Li

25 August 2025

Nanovaccines have emerged as a transformative platform in immunotherapy, distinguished by their capabilities in targeted antigen delivery, enhanced immunogenicity, and multifunctional integration. By leveraging nanocarriers, these vaccines achieve pr...

  • Review
  • Open Access
75 Citations
9,349 Views
25 Pages

Direct and Reverse Pluronic Micelles: Design and Characterization of Promising Drug Delivery Nanosystems

  • Almudena Naharros-Molinero,
  • María Ángela Caballo-González,
  • Francisco Javier de la Mata and
  • Sandra García-Gallego

Pluronics are a family of amphiphilic block copolymers broadly explored in the pharmaceutical field. Under certain conditions, Pluronics self-assemble in different structures including nanosized direct and reverse micelles. This review provides an ov...

  • Review
  • Open Access
3 Citations
4,935 Views
22 Pages

7 December 2024

Over the past few years, significant progress has been made in DNA origami technology due to the unrivaled self-assembly properties of DNA molecules. As a highly programmable, addressable, and biocompatible nanomaterial, DNA origami has found widespr...

  • Article
  • Open Access
18 Citations
4,108 Views
12 Pages

5 February 2021

Indocyanine green (ICG) is a near infrared fluorescent tracer used in image-guided surgery to assist surgeons during resection. Despite appearing as a very promising tool for surgical oncology, its employment in this area is limited to lymph node map...

  • Review
  • Open Access
32 Citations
10,038 Views
29 Pages

Unlocking Neural Function with 3D In Vitro Models: A Technical Review of Self-Assembled, Guided, and Bioprinted Brain Organoids and Their Applications in the Study of Neurodevelopmental and Neurodegenerative Disorders

  • Chiara D’Antoni,
  • Lorenza Mautone,
  • Caterina Sanchini,
  • Lucrezia Tondo,
  • Greta Grassmann,
  • Gianluca Cidonio,
  • Paola Bezzi,
  • Federica Cordella and
  • Silvia Di Angelantonio

Understanding the complexities of the human brain and its associated disorders poses a significant challenge in neuroscience. Traditional research methods have limitations in replicating its intricacies, necessitating the development of in vitro mode...

  • Review
  • Open Access
5 Citations
5,348 Views
48 Pages

1 May 2024

Block copolymer (BCP) surfaces permit an exquisite level of nanoscale control in biomolecular assemblies solely based on self-assembly. Owing to this, BCP-based biomolecular assembly represents a much-needed, new paradigm for creating nanobiosensors...

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