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  • Article
  • Open Access
4,126 Views
10 Pages

Chromosomal Instability at Fragile Sites in Blue Foxes, Silver Foxes, and Their Interspecific Hybrids

  • Marta Kuchta-Gładysz,
  • Ewa Wójcik,
  • Anna Grzesiakowska,
  • Katarzyna Rymuza and
  • Olga Szeleszczuk

11 June 2021

A cytogenetic assay based on fragile sites (FS) enables the identification of breaks, chromatid gaps, and deletions. In healthy individuals, the number of these instabilities remains low. Genome stability in these species is affected by Robertsonian...

  • Article
  • Open Access
7 Citations
3,834 Views
16 Pages

Population Genetics of California Gray Foxes Clarify Origins of the Island Fox

  • Benjamin N. Sacks,
  • Mark J. Statham,
  • Laurel E. K. Serieys and
  • Seth P. D. Riley

14 October 2022

We used mitochondrial sequences and nuclear microsatellites to investigate population structure of gray foxes (Urocyon cinereoargenteus) and the evolutionary origins of the endemic island fox (Urocyon littoralis), which first appeared in the northern...

  • Article
  • Open Access
5 Citations
5,814 Views
36 Pages

Foxes in Retrospect—Unraveling Human-Fox Relationships through Fox Tooth Ornaments in the Swabian Jura

  • Flavia Venditti,
  • Madison J. McCartin,
  • Melanie-Larisa Ostermann,
  • Nicholas J. Conard and
  • Sibylle Wolf

21 September 2023

Personal ornaments play an important role in our understanding of human cultural and behavioral change during the Upper Paleolithic, providing insights into intangible aspects of human cultural behavior. Some ornament forms are better studied than ot...

  • Article
  • Open Access
14 Citations
3,490 Views
12 Pages

Canine Circovirus in Foxes from Northern Italy: Where Did It All Begin?

  • Giovanni Franzo,
  • Maria Luisa Menandro,
  • Claudia Maria Tucciarone,
  • Giacomo Barbierato,
  • Lorenzo Crovato,
  • Alessandra Mondin,
  • Martina Libanora,
  • Federica Obber,
  • Riccardo Orusa and
  • Laura Grassi
  • + 2 authors

9 August 2021

Canine circovirus (CanineCV) is a recently identified virus affecting both domestic and wild carnivores, including foxes, sometimes in presence of severe clinical signs. Its circulation in wild animals can thus represent a potential threat for endang...

  • Article
  • Open Access
4 Citations
3,486 Views
16 Pages

25 April 2021

In this study we assessed the level of genetic introgression between red foxes bred on fur farms in Poland and the native wild population. We also evaluated the impact of a geographic barrier and isolation by distance on gene flow between two isolate...

  • Article
  • Open Access
9 Citations
3,123 Views
8 Pages

Mycobacterium microti Infection in Red Foxes in France

  • Lorraine Michelet,
  • Céline Richomme,
  • Edouard Réveillaud,
  • Krystel De Cruz,
  • Jean-Louis Moyen and
  • Maria Laura Boschiroli

Mycobacterium microti, member of the Mycobacterium tuberculosis, complex is known to interfere in the screening and diagnosis of bovine tuberculosis. This pathogen is increasingly detected in the frame of surveillance programs for tuberculosis in liv...

  • Article
  • Open Access
31 Citations
7,589 Views
18 Pages

Application of YOLOv4 for Detection and Motion Monitoring of Red Foxes

  • Anne K. Schütz,
  • Verena Schöler ,
  • E. Tobias Krause ,
  • Mareike Fischer ,
  • Thomas Müller ,
  • Conrad M. Freuling,
  • Franz J. Conraths ,
  • Mario Stanke,
  • Timo Homeier-Bachmann and
  • Hartmut H. K. Lentz

9 June 2021

Animal activity is an indicator for its welfare and manual observation is time and cost intensive. To this end, automatic detection and monitoring of live captive animals is of major importance for assessing animal activity, and, thereby, allowing fo...

  • Article
  • Open Access
4 Citations
4,590 Views
14 Pages

Experimental Infection of Captive Red Foxes (Vulpes vulpes) with Mycobacterium bovis

  • Céline Richomme,
  • Sandrine Lesellier,
  • Francisco Javier Salguero,
  • Jacques Laurent Barrat,
  • Jean-Marc Boucher,
  • Jennifer Danaidae Reyes-Reyes,
  • Sylvie Hénault,
  • Krystel De Cruz,
  • Jennifer Tambosco and
  • Maria Laura Boschiroli
  • + 6 authors

In Europe, animal tuberculosis (TB) due to Mycobacterium bovis involves multi-host communities that include cattle and wildlife species, such as wild boar (Sus scrofa), badgers (Meles meles) and red deer (Cervus elaphus). Red fox (Vulpes vulpes) infe...

  • Article
  • Open Access
6 Citations
3,156 Views
23 Pages

A Decomposition-Based Multi-Objective Flying Foxes Optimization Algorithm and Its Applications

  • Chen Zhang,
  • Ziyun Song,
  • Yufei Yang,
  • Changsheng Zhang and
  • Ying Guo

The flying foxes optimization (FFO) algorithm stimulated by the strategy used by flying foxes for subsistence in heat wave environments has shown good performance in the single-objective domain. Aiming to explore the effectiveness and benefits of the...

  • Article
  • Open Access
3 Citations
2,629 Views
11 Pages

Tumor and Tumor-like Lesions in Red Foxes (Vulpes vulpes) from Croatia

  • Šimun Naletilić,
  • Ivan-Conrado Šoštarić-Zuckermann and
  • Željko Mihaljević

7 February 2024

The red fox, found on all continents except Antarctica, occupies diverse habitats. In Croatia, it is an indigenous wild species with a population density of 0.7 animals per square kilometer. While tumors in wild animals from the Canidae family are sc...

  • Article
  • Open Access
11 Citations
4,079 Views
9 Pages

Occurrence of Bacterial and Protozoan Pathogens in Red Foxes (Vulpes vulpes) in Central Italy

  • Valentina Virginia Ebani,
  • Chiara Trebino,
  • Lisa Guardone,
  • Fabrizio Bertelloni,
  • Giulia Cagnoli,
  • Simona Nardoni,
  • Emily Sel,
  • Emily Wilde,
  • Alessandro Poli and
  • Francesca Mancianti

21 October 2022

Most surveys of pathogens in red foxes (Vulpes vulpes) have focused on particular agents. The aim of this study was to verify, with bacteriological and molecular analyses, the occurrence of the main bacterial and protozoan pathogens that are able to...

  • Article
  • Open Access
25 Citations
3,855 Views
11 Pages

Mycobacterium bovis Infection in Red Foxes in Four Animal Tuberculosis Endemic Areas in France

  • Céline Richomme,
  • Edouard Réveillaud,
  • Jean-Louis Moyen,
  • Perrine Sabatier,
  • Krystel De Cruz,
  • Lorraine Michelet and
  • Maria Laura Boschiroli

In France, animal tuberculosis (TB) due to Mycobacterium bovis (M. bovis) affects a multi-host community that include cattle and wildlife species such as wild boars (Sus scrofa), badgers (Meles meles), or wild deer (Cervus elaphus, Capreolus capreolu...

  • Article
  • Open Access
2 Citations
2,864 Views
9 Pages

14 October 2022

A 3 × 3 factorial experiment was conducted to investigate the influence of dietary calcium, phosphorus, and vitamin D3 (VD3) supplement levels on the growth performance, nutrient digestibility, and serum biochemical indices of growing-furring b...

  • Feature Paper
  • Article
  • Open Access
1,692 Views
16 Pages

Den Use Patterns of Endangered San Joaquin Kit Foxes in Urban Environments May Facilitate Disease Transmission

  • Brian L. Cypher,
  • Alyse Gabaldon,
  • Erica C. Kelly,
  • Tory L. Westall and
  • Nicole A. Deatherage

16 January 2025

A robust population of endangered San Joaquin kit foxes (Vulpes macrotis mutica; SJKFs) occurs in the city of Bakersfield, CA. In 2013, sarcoptic mange was detected and significantly reduced SJKF abundance. Dens may be a mode of mange mite transmissi...

  • Brief Report
  • Open Access
3 Citations
3,338 Views
5 Pages

Broad Range Screening of Vector-Borne Pathogens in Arctic Foxes (Vulpes lagopus) in Iceland

  • Sándor Hornok,
  • Kristin Mühldorfer,
  • Nóra Takács,
  • Regina Hofmann-Lehmann,
  • Marina L. Meli,
  • Miklós Gyuranecz,
  • Ester R. Unnsteinsdóttir,
  • Alex D. Greenwood and
  • Gábor Á. Czirják

4 November 2020

The arctic fox (Vulpes lagopus) is the only native terrestrial mammal in Iceland. While red foxes (V. vulpes) are known to be epidemiologically important carriers of several vector-borne pathogens in Europe, arctic foxes have never been evaluated in...

  • Article
  • Open Access
11 Citations
4,636 Views
13 Pages

Opposing Roles of FoxA1 and FoxA3 in Intrahepatic Cholangiocarcinoma Progression

  • Raynoo Thanan,
  • Waleeporn Kaewlert,
  • Chadamas Sakonsinsiri,
  • Timpika Chaiprasert,
  • Napat Armartmuntree,
  • Duangkamon Muengsaen,
  • Anchalee Techasen,
  • Poramate Klanrit,
  • Worachart Lert-itthiporn and
  • Chawalit Pairojkul
  • + 1 author

Cholangiocarcinoma (CCA), a malignancy of biliary epithelium, is related to liver stem cell deregulation. FoxAs are a group of transcription factors that play critical roles in liver stem cell differentiation. In this study, the expression levels of...

  • Article
  • Open Access
21 Citations
9,788 Views
26 Pages

Exotic Prey Facilitate Coexistence between Pumas and Culpeo Foxes in the Andes of Central Chile

  • Christian Osorio,
  • Ana Muñoz,
  • Nicolás Guarda,
  • Cristian Bonacic and
  • Marcella Kelly

20 August 2020

Coexistence between species with similar ecological niches implies species must segregate along one or more niche axes to survive. Space, time, and trophic resources are regarded as the principal axes upon which species segregate. We examined segrega...

  • Article
  • Open Access
2 Citations
3,802 Views
12 Pages

Wildlife and Bait Density Monitoring to Describe the Effectiveness of a Rabies Vaccination Program in Foxes

  • Paolo Tizzani,
  • Angela Fanelli,
  • Carsten Potzsch,
  • Joerg Henning,
  • Srdjan Šašić,
  • Paolo Viviani and
  • Mevlida Hrapović

Fox rabies has been eliminated from vast areas of West and Central Europe, but cases still occur in the Balkans. Oral vaccination is an effective method for reducing the incidence of the disease in wildlife, but it requires monitoring if bait density...

  • Feature Paper
  • Article
  • Open Access
13 Citations
4,857 Views
13 Pages

9 July 2020

Red foxes are a well-established species of urban ecosystems in the UK and worldwide. Understanding the spatial ecology of foxes in urban landscapes is important for enhancement of urban biodiversity and effective disease management. The Resource Dis...

  • Article
  • Open Access
1 Citations
1,456 Views
16 Pages

Metabolic Bone Disease in Captive Flying Foxes: A Comprehensive Survey Across Zoological Parks

  • Diana Faim,
  • Filipe Silva,
  • Anton Weissenbacher,
  • Iris Starnberger and
  • Isabel Pires

13 March 2025

Metabolic bone disease (MBD) is clinically characterized by bone deformities and is associated with vitamin D3 deficiency in diurnal animals. However, the pathogenesis and etiology of this condition in flying foxes, considered nocturnal animals, are...

  • Article
  • Open Access
7 Citations
3,287 Views
13 Pages

Newlavirus, a Novel, Highly Prevalent, and Highly Diverse Protoparvovirus of Foxes (Vulpes spp.)

  • Marta Canuti,
  • Émilie Bouchard,
  • Bruce Rodrigues,
  • Hugh G. Whitney,
  • Marti Hopson,
  • Cornelia Gilroy,
  • Garry Stenson,
  • Suzanne C. Dufour,
  • Andrew S. Lang and
  • Joost T. P. Verhoeven

30 September 2021

The genus Protoparvovirus (family Parvoviridae) includes several viruses of carnivores. We describe a novel fox protoparvovirus, which we named Newlavirus as it was discovered in samples from Newfoundland and Labrador, Canada. Analysis of the full no...

  • Article
  • Open Access
4 Citations
2,964 Views
13 Pages

CT Findings and Histological Evaluation of Red Foxes (Vulpes vulpes) with Chronic Head Trauma Injury: A Retrospective Study

  • Luca Lacitignola,
  • Rossella Samarelli,
  • Nicola Zizzo,
  • Elena Circella,
  • Claudia Acquafredda,
  • Marzia Stabile,
  • Roberto Lombardi,
  • Francesco Staffieri and
  • Antonio Camarda

3 April 2021

Large numbers of wild animals are injured every year in road traffic accidents. Scant data are available for rescued wild carnivores, in particular for red foxes. Cases of foxes with head trauma were retrospectively considered for inclusion in this s...

  • Communication
  • Open Access
11 Citations
7,169 Views
11 Pages

17 September 2018

Pteropus griseus (gray flying fox) is a species of Old World fruit bat that is listed by the International Union for Conservation of Nature (IUCN) as Data Deficient. The species is found on small islands in the Lesser Sundas and Sulawesi, and is ende...

  • Article
  • Open Access
17 Citations
3,290 Views
20 Pages

The role of red fox, Vulpes vulpes, and its associated ticks in maintaining Borrelia burgdorferi sensu lato (s.l.) was studied. A total of 1583 ticks were removed from ears of 120 infested animals and were identified as species using a nested PCR tar...

  • Article
  • Open Access
4 Citations
2,774 Views
13 Pages

15 July 2022

Based on the randomized design, a 3 × 3 factorial experiment was designed to examine the effects of dietary calcium (Ca), phosphorus (P), and vitamin D3 (VD3) supplemental levels with a fixed 1.5/1 ratio of Ca to P on the growth performance, nu...

  • Communication
  • Open Access
2,202 Views
13 Pages

Sarcoptic Mange in Reintroduced Red Foxes (Vulpes vulpes) in South Korea: Case Histories, Clinical Assessments, Treatments, and Pathological Findings

  • Sook-Jin Lee,
  • An-Na Lee,
  • Eun-Bin Shin,
  • Min-Sung Kim,
  • Hyoung-Jin Kim,
  • Doo-Hyun Han,
  • Yong-Sik Jo,
  • Jin-Suk Ahn,
  • Seung-Hoon Chea and
  • Jeong-Jin Yang
  • + 3 authors

21 May 2025

Sarcoptic mange is a highly contagious and often lethal parasitic skin disease caused by the mite Sarcoptes scabiei, which is frequently reported in red foxes (Vulpes vulpes). However, there is a lack of documented cases and treatment strategies for...

  • Article
  • Open Access
406 Views
35 Pages

Phenotypic Antimicrobial Resistance of Some Bacterial Strains Isolated from Red Foxes (Vulpes vulpes) in Western Romania

  • Alex-Cristian Moza,
  • Iulia-Maria Bucur,
  • Kalman Imre,
  • Sebastian Alexandru Popa,
  • Alexandra Adriana Grigoreanu,
  • Ana-Maria Plotuna,
  • Andrei Alexandru Ivan,
  • Narcisa Geanina Mederle,
  • Andreea-Talida Tîrziu and
  • Emil Tîrziu

Background/Objectives: Recent investigations point to red foxes (Vulpes vulpes) as a very potent sentinel species for monitoring the dissemination of antimicrobial bacteria in wildlife habitats. Methods: This study investigated antimicrobial resistan...

  • Article
  • Open Access
2 Citations
1,105 Views
14 Pages

29 April 2025

The comparative analysis of the feeding ecology among sympatric small carnivores reveals both differentiation and overlap in resource utilization patterns, which serves as a critical pathway for understanding interspecific interactions and maintainin...

  • Brief Report
  • Open Access
15 Citations
3,113 Views
7 Pages

Emergence of Echinococcus multilocularis in Central Continental Croatia: A Human Case Series and Update on Prevalence in Foxes

  • Mirjana Balen Topić,
  • Neven Papić,
  • Klaudija Višković,
  • Mario Sviben,
  • Tajana Filipec Kanižaj,
  • Stipislav Jadrijević,
  • Daria Jurković and
  • Relja Beck

16 June 2023

Human alveolar echinococcosis (HAE), caused by the metacestode stage of Echinococcus multilocularis, has emerged in many European countries over the last two decades. Here, we report the first data on the new HAE focus with increasing incidence in ce...

  • Article
  • Open Access
16 Citations
5,325 Views
12 Pages

Long-Term Immunogenicity and Efficacy of the Oral Rabies Virus Vaccine Strain SPBN GASGAS in Foxes

  • Conrad M. Freuling,
  • Verena te Kamp,
  • Antonia Klein,
  • Maria Günther,
  • Luca Zaeck,
  • Madlin Potratz,
  • Elisa Eggerbauer,
  • Katharina Bobe,
  • Christian Kaiser and
  • Thomas Müller
  • + 5 authors

27 August 2019

To evaluate the long-term immunogenicity of the live-attenuated, oral rabies vaccine SPBN GASGAS in a full good clinical practice (GCP) compliant study, forty-six (46) healthy, seronegative red foxes (Vulpes vulpes) were allocated to two treatment gr...

  • Brief Report
  • Open Access
781 Views
9 Pages

Antimicrobial Resistance and Wildlife: Occurrence of Antimicrobial Resistance Genes in Red Foxes (Vulpes vulpes, Linnaeus, 1758), in Italy

  • Antonietta Di Francesco,
  • Daniela Salvatore,
  • Roberta Taddei,
  • Fabrizio Bertelloni,
  • Caterina Lupini,
  • Giulia Cagnoli and
  • Valentina Virginia Ebani

9 July 2025

Clinically significant antimicrobial-resistant bacteria and resistance genes are increasingly being reported in wildlife. In this study, 127 splenic samples from red foxes (Vulpes vulpes) from northern and central Italy were analysed for the presence...

  • Article
  • Open Access
5 Citations
5,243 Views
14 Pages

Comparable Long-Term Rabies Immunity in Foxes after IntraMuscular and Oral Application Using a Third-Generation Oral Rabies Virus Vaccine

  • Verena te Kamp,
  • Virginia Friedrichs,
  • Conrad M. Freuling,
  • Ad Vos,
  • Madlin Potratz,
  • Antonia Klein,
  • Luca M. Zaeck,
  • Elisa Eggerbauer,
  • Peter Schuster and
  • Thomas Müller
  • + 7 authors

14 January 2021

The live genetically-engineered oral rabies virus (RABV) variant SPBN GASGAS induces long-lasting immunity in foxes and protection against challenge with an otherwise lethal dose of RABV field strains both after experimental oral and parenteral route...

  • Article
  • Open Access
1 Citations
1,978 Views
12 Pages

Syntopy between Endangered San Joaquin Kit Foxes and Potential Competitors in an Urban Environment

  • Brian L. Cypher,
  • Nicole A. Deatherage,
  • Erica C. Kelly and
  • Tory L. Westall

14 October 2023

The endangered San Joaquin kit fox (Vulpes macrotis mutica; SJKF) occurs in the city of Bakersfield, CA, where several putative competitors also occur, including domestic cats (Felis catus), striped skunks (Mephitis mephitis), raccoons (Procyon lotor...

  • Article
  • Open Access
16 Citations
9,522 Views
17 Pages

6 July 2020

Red foxes, European wildcats and domestic cats share cattle pastures for hunting in La Pernía Valley, northern Spain. To understand the mechanisms that allow the coexistence of these mesopredators in a habitat characterized by its anthropogeni...

  • Feature Paper
  • Article
  • Open Access
2 Citations
2,743 Views
14 Pages

6 August 2024

Needed for cosmological and stellar nucleosynthesis, we are studying the closed-form analytic evaluation of thermonuclear reaction rates. In this context, we undertake a comprehensive analysis of three largely distinct velocity distributions, namely...

  • Article
  • Open Access
3 Citations
3,200 Views
11 Pages

Morphometric Characteristics of the Spermatozoa of Blue Fox (Alopex lagopus) and Silver Fox (Vulpes vulpes)

  • Katarzyna Andraszek,
  • Dorota Banaszewska,
  • Olga Szeleszczuk,
  • Marta Kuchta-Gładysz and
  • Anna Grzesiakowska

20 October 2020

The results presented in this study are the first such extensive characterization of the sperm morphometry of the blue fox (Alopex lagopus) and silver fox (Vulpes vulpes), as representatives of the family Canidae. Canine spermatozoa, especially the s...

  • Article
  • Open Access
12 Citations
5,560 Views
9 Pages

18 July 2021

The aim of this study was to identify the nature and cause of foxing spots in a historical manuscript. This manuscript was a Holy Quran from the beginning of the Qajar period and the end of the 18th century. Samples were incubated for 14 days and wer...

  • Article
  • Open Access
5 Citations
2,984 Views
14 Pages

CDI Exerts Anti-Tumor Effects by Blocking the FoxM1-DNA Interaction

  • Woo Dae Jang,
  • Mi Young Lee,
  • Jihye Mun,
  • Gyutae Lim and
  • Kwang-Seok Oh

The Forkhead box protein M1 (FoxM1) is an appealing target for anti-cancer therapeutics as this cell proliferation-associated transcription factor is overexpressed in most human cancers. FoxM1 is involved in tumor invasion, angiogenesis, and metastas...

  • Article
  • Open Access
1,812 Views
12 Pages

Characterization of Inflammasomes and Their Regulation in the Red Fox

  • Huijeong Ahn,
  • Dong-Hyuk Jeong,
  • Gilyoung Lee,
  • Suk-Jin Lee,
  • Jeong-Jin Yang,
  • Yo-Han Kim,
  • Tae-Wook Hahn,
  • Sooyoung Choi and
  • Geun-Shik Lee

13 December 2023

Background: Inflammasomes recognize endogenous and exogenous danger signals, and subsequently induce the secretion of IL-1β. Studying inflammasomes in the red fox (Vulpes vulpes) is crucial for wildlife veterinary medicine, as it can help contro...

  • Review
  • Open Access
1 Citations
3,720 Views
39 Pages

The Role of the Fox Gene in Breast Cancer Progression

  • Shaoxuan Pei,
  • Dechun Zhang,
  • Zhuohan Li,
  • Jinkai Liu,
  • Ziyi Li,
  • Jianrui Chen and
  • Zhenzhen Xie

7 February 2025

Forkhead box (FOX) genes are a family of transcription factors that participate in many biological activities, from early embryogenesis to the formation of organs, and from regulation of glucose metabolism to regulation of longevity. Given the extens...

  • Article
  • Open Access
578 Views
18 Pages

Across the Arctic: Mitogenomic Phylogeny of Arctic Foxes (Vulpes lagopus) Reveals Several New Matrilines and Illuminates the Colonization History of the Icelandic Population

  • Cristóbal Valenzuela-Turner,
  • Vanessa Norden,
  • Martina De Benedetto,
  • Jörns Fickel,
  • Ester R. Unnsteinsdóttir,
  • Gábor Á. Czirják and
  • Daniel W. Förster

10 February 2026

Background/Objectives: Arctic foxes (Vulpes lagopus) exemplify the vulnerability of Arctic species to global warming and anthropogenic impacts, including habitat loss, interspecific competition with temperate species, pollution (chemical and biologic...

  • Article
  • Open Access
1 Citations
4,643 Views
14 Pages

Population Genetics of the Invasive Red Fox, Vulpes vulpes, in South-Eastern Australia

  • Kalynda M.-A. Watson,
  • Katarina M. Mikac and
  • Sibylle G. Schwab

20 May 2021

The use of genetic information in conservation biology has become more widespread with genetic information more readily available for non-model organisms. It has also been recognized that genetic information from invasive species can inform their man...

  • Article
  • Open Access
18 Citations
7,852 Views
12 Pages

Preparation and Properties of RDX@FOX-7 Composites by Microfluidic Technology

  • Jin Yu,
  • Hanyu Jiang,
  • Siyu Xu,
  • Heng Li,
  • Yiping Wang,
  • Ergang Yao,
  • Qing Pei,
  • Meng Li,
  • Yang Zhang and
  • Fengqi Zhao

18 January 2023

1,3,5-trinitro-1,3,5-triazacyclohexane (RDX) is a type of high energy explosive, its application in weapon systems is limited by its high mechanical sensitivity. At the same time, 1,1-diamino-2,2-dinitroethylene (FOX-7) is a famous insensitive explos...

  • Review
  • Open Access
73 Citations
10,941 Views
16 Pages

Role of FoxO Proteins in Cellular Response to Antitumor Agents

  • Giovanni Luca Beretta,
  • Cristina Corno,
  • Nadia Zaffaroni and
  • Paola Perego

14 January 2019

FoxO proteins (FoxOs) are transcription factors with a common DNA binding domain that confers selectivity for DNA interaction. In human cells, four proteins (FoxO1, FoxO3, FoxO4 and FoxO6), with redundant activity, exhibit mainly a positive effect on...

  • Article
  • Open Access
21 Citations
2,969 Views
24 Pages

19 April 2023

Nowadays, the world is encountering multiple challenges of energy security, economic recovery, and the effect of global warming. Investing in new fossil fuels only locks in uneconomic practices, sustains existing risks and increases the threats of cl...

  • Article
  • Open Access
6 Citations
2,630 Views
11 Pages

Deletion of the foxO4 Gene Increases Hypoxia Tolerance in Zebrafish

  • Linlin Shi,
  • Axin Zhang,
  • Hong Liu and
  • Huanling Wang

Oxygen homeostasis is an important organizing principle for understanding development, physiology, disease, and evolution. Under various physiological and pathological states, organisms experience oxygen deficiency or hypoxia. FoxO4 has been recogniz...

  • Article
  • Open Access
1 Citations
1,419 Views
23 Pages

Red Foxes (Vulpes vulpes) and European Badgers (Meles meles) as Overlooked Wildlife Hosts of Canine Parvovirus in Slovakia: First Evidence by Molecular Characterization and Virus Isolation

  • Patrícia Petroušková,
  • Andrea Pelegrinová,
  • Jozef Lazár,
  • Jakub Lipinský,
  • Monika Drážovská,
  • Marián Prokeš,
  • Ľuboš Korytár,
  • Boris Vojtek,
  • Maroš Kostičák and
  • Anna Ondrejková
  • + 2 authors

Wild carnivores are increasingly recognized as hosts or reservoirs of canine parvovirus (CPV), a major pathogen of dogs. To investigate CPV circulation in Central Europe, we examined 221 red foxes (Vulpes vulpes) and 53 European badgers (Meles meles)...

  • Article
  • Open Access
7 Citations
2,674 Views
15 Pages

FoxO3 Modulates Circadian Rhythms in Neural Stem Cells

  • Swip Draijer,
  • Raissa Timmerman,
  • Jesse Pannekeet,
  • Alexandra van Harten,
  • Elham Aida Farshadi,
  • Julius Kemmer,
  • Demy van Gilst,
  • Inês Chaves and
  • Marco F. M. Hoekman

4 September 2023

Both FoxO transcription factors and the circadian clock act on the interface of metabolism and cell cycle regulation and are important regulators of cellular stress and stem cell homeostasis. Importantly, FoxO3 preserves the adult neural stem cell po...

  • Article
  • Open Access
1,749 Views
14 Pages

27 May 2025

This study evaluated the effects of dietary lysine supplementation in low-protein diets on nutrient digestibility, nitrogen metabolism, growth performance, serum biomarkers, and pelt quality in female blue foxes (Alopex lagopus) during the fur-growin...

  • Article
  • Open Access
1,936 Views
21 Pages

Comparison of Intestinal Microbiota of Blue Fox before and after Weaning

  • Hang Su,
  • Xinshuai Jiang,
  • Hanyu Liu,
  • Huixin Bai,
  • Xiujuan Bai,
  • Yuan Xu and
  • Zhiheng Du

8 January 2024

Intestinal flora plays an important role in maintaining the internal stability and health of the intestine. Currently, intestinal microbes are considered an important “organ” but are mostly ignored by people. This study evaluated the flor...

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