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Article

Long-Term Immunogenicity and Efficacy of the Oral Rabies Virus Vaccine Strain SPBN GASGAS in Foxes

1
Institute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut (FLI), WHO Collaborating Centre for Rabies Surveillance and Research, OIE Reference Laboratory for Rabies, 17493 Greifswald-Insel Riems, Germany
2
IDT Biologika GmbH, 06861 Dessau-Rosslau, Germany
*
Author to whom correspondence should be addressed.
Currently affiliated to Thüringer Landesamt für Verbraucherschutz, 99947 Bad Langensalza, Germany.
Currently affiliated to Ceva Innovation Center GmbH, 06861 Dessau-Rosslau, Germany.
§
Currently affiliated to Ceva Santé Animale, 06861 Dessau-Rosslau, Germany.
Viruses 2019, 11(9), 790; https://doi.org/10.3390/v11090790
Received: 12 August 2019 / Revised: 23 August 2019 / Accepted: 26 August 2019 / Published: 27 August 2019
(This article belongs to the Special Issue Rabies Virus: Knowledge Gaps and Challenges to Elimination)
To evaluate the long-term immunogenicity of the live-attenuated, oral rabies vaccine SPBN GASGAS in a full good clinical practice (GCP) compliant study, forty-six (46) healthy, seronegative red foxes (Vulpes vulpes) were allocated to two treatment groups: group 1 (n = 31) received a vaccine bait containing 1.7 ml of the vaccine of minimum potency (106.6 FFU/mL) and group 2 (n = 15) received a placebo-bait. In total, 29 animals of group 1 and 14 animals of group 2 were challenged at 12 months post-vaccination with a fox rabies virus isolate (103.0 MICLD50/mL). While 90% of the animals offered a vaccine bait resisted the challenge, only one animal (7%) of the controls survived. All animals that had seroconverted following vaccination survived the challenge infection at 12 months post-vaccination. Rabies specific antibodies could be detected as early as 14 days post-vaccination. Based on the kinetics of the antibody response to SPBN GASGAS as measured in ELISA and RFFIT, the animals maintained stable antibody titres during the 12-month pre-challenge observation period at a high level. The results indicate that successful vaccination using the oral route with this new rabies virus vaccine strain confers long-term duration of immunity beyond one year, meeting the same requirements as for licensure as laid down by the European Pharmacopoeia. View Full-Text
Keywords: oral rabies vaccines; rabies; genetically engineered vaccine; red foxes; efficacy; long-term immunogenicity; SPBN GASGAGS oral rabies vaccines; rabies; genetically engineered vaccine; red foxes; efficacy; long-term immunogenicity; SPBN GASGAGS
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MDPI and ACS Style

Freuling, C.M.; te Kamp, V.; Klein, A.; Günther, M.; Zaeck, L.; Potratz, M.; Eggerbauer, E.; Bobe, K.; Kaiser, C.; Kretzschmar, A.; Ortmann, S.; Schuster, P.; Vos, A.; Finke, S.; Müller, T. Long-Term Immunogenicity and Efficacy of the Oral Rabies Virus Vaccine Strain SPBN GASGAS in Foxes. Viruses 2019, 11, 790. https://doi.org/10.3390/v11090790

AMA Style

Freuling CM, te Kamp V, Klein A, Günther M, Zaeck L, Potratz M, Eggerbauer E, Bobe K, Kaiser C, Kretzschmar A, Ortmann S, Schuster P, Vos A, Finke S, Müller T. Long-Term Immunogenicity and Efficacy of the Oral Rabies Virus Vaccine Strain SPBN GASGAS in Foxes. Viruses. 2019; 11(9):790. https://doi.org/10.3390/v11090790

Chicago/Turabian Style

Freuling, Conrad M., Verena te Kamp, Antonia Klein, Maria Günther, Luca Zaeck, Madlin Potratz, Elisa Eggerbauer, Katharina Bobe, Christian Kaiser, Antje Kretzschmar, Steffen Ortmann, Peter Schuster, Adriaan Vos, Stefan Finke, and Thomas Müller. 2019. "Long-Term Immunogenicity and Efficacy of the Oral Rabies Virus Vaccine Strain SPBN GASGAS in Foxes" Viruses 11, no. 9: 790. https://doi.org/10.3390/v11090790

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