In visual diffuse transmission density measurement, it is hard to measure optical density (OD) up to 6.0 because the signal to noise is more than 10E-06. Thus, there are only two methods to find the measurement. One is using a highly sensitive detect...
This work reviews physical concepts, technologies and applications of time-domain diffuse optics based on time-gated single-photon detection. This particular photon detection strategy is of the utmost importance in the diffuse optics field as it unle...
Optical techniques based on diffuse optics have been around for decades now and are making their way into the day-to-day medical applications. Even though the physics foundations of these techniques have been known for many years, practical implement...
Time-resolved diffuse optical spectroscopy (TR-DOS) is an increasingly used method to determine the optical properties of diffusive media, particularly for medical applications including functional brain, breast and muscle measurements. For medical i...
Silicon photomultipliers (SiPM) are pixelated single-photon detectors combining high sensitivity, good time resolution and high dynamic range. They are emerging in many fields, such as time-domain diffuse optics (TD-DO). This is a promising technique...
Diffuse optical imaging is highly versatile and has a very broad range of applications in biology and medicine. It covers diffuse optical tomography, fluorescence diffuse optical tomography, bioluminescence and a number of other new imaging methods....
Diffuse optical tomography using deep learning is an emerging technology that has found impressive medical diagnostic applications. However, creating an optical imaging system that uses visible and near-infrared (NIR) light is not straightforward due...
A hybrid reflectance-based diffuse optical imaging (DOI) technique combining discrete wavelength frequency-domain (FD) near-infrared spectroscopy (NIRS) with broadband continuous wave NIRS measurements was developed to quantify the broadband optical...
Fiber optic interferometer (FOI) sensors have been fabricated by directly growing pure-silica MFI-type zeolite (i.e., silicalite) films on straight-cut endfaces of single-mode communication optical fibers. The FOI sensor has been demonstrated for det...
Time-resolved diffuse optical tomography is a technique used to recover the optical properties of an unknown diffusive medium by solving an ill-posed inverse problem. In time-domain, reconstructions based on datatypes are used for their computational...
Tunable optical diffusers have attracted attention because of the rapid development of next generation stretchable optoelectronics and optomechanics applications. Flexible wrinkle structures have the potential to change the light path and tune the di...
Diffuse optical imaging (DOI) uses scattered light to non-invasively sense and image highly diffuse media, including biological tissues such as the breast and brain. Despite its clinical potential, widespread adoption remains limited because physical...
Diffuse optical spectroscopy (DOS) and diffuse optical imaging (DOI) are emerging non-invasive imaging modalities that have wide spread potential applications in many fields, particularly for structural and functional imaging in medicine. In this art...
In this work, we use the method of optical coherence elastography (OCE) to enable quantitative, spatially resolved visualization of diffusion-associated deformations in the areas of maximum concentration gradients during diffusion of hyperosmotic sub...
We report on the comparative analysis of self-calibrating and single-slope diffuse reflectance spectroscopy in resistance to different measurement perturbations. We developed an experimental setup for diffuse reflectance spectroscopy (DRS) in a wide...
The characteristics of modern portable spectrometers based on photodetector arrays make it possible to create on their basis a new class of devices for operational control of the optical properties of various media. The introduction into the practice...
Indium tin oxide (ITO) film is one of the ideal candidates for transparent conductive cathode in methylammonium lead halide perovskite solar cells. Thus, the diffusion of methyl group in ITO film is inevitable, which could deteriorate the optical-ele...
Time-domain (TD) diffuse reflectance can be modeled using diffusion theory (DT) to non-invasively estimate optical transport coefficients of biological media, which serve as markers of tissue physiology. We employ an optimized N-layer DT solver in cy...
In this article, we propose a new approach utilizing diffuse optical tomography (DOT) to monitoring the changes in tissues’ optical properties and temperature in high-intensity focused ultrasound (HIFU) therapy. By correlating the tissue reduce...
Time Domain Diffuse Optical Tomography (TD-DOT) enables a full 3D reconstruction of the optical properties of tissue, and could be used for non-invasive and cost-effective in-depth body exploration (e.g., thyroid and breast imaging). Performance quan...
Diffuse optical tomography is emerging as a non-invasive optical modality used to evaluate tissue information by obtaining the optical properties’ distribution. Two procedures are performed to produce reconstructed absorption and reduced scatte...
Diffuse Reflectance Spectroscopy (DRS) can provide tissue feedback for pedicle screw placement in spine surgery, yet the integration of fiber optics into the tip of the pedicle probe, a device used to pierce through bone, is challenging, since the op...
Based on recent developments in both single-photon detectors and timing electronic circuits, we designed a compact and cost effective time-domain diffuse optical tomography system operated at 1 Hz acquisition rate, based on eight silicon photomultipl...
Diffuse optical tomography (DOT) is a biomedical imaging modality that can reconstruct hemoglobin concentration and associated oxygen saturation by using detected light passing through a biological medium. Various clinical applications of DOT such as...
Diffuse reflectance spectroscopy (DRS) and imaging are increasingly being used in surgical guidance for tumor margin detection during endoscopic operations. However, the accuracy of the boundary detection with optical techniques may depend on the acq...
Diffuse Optical Tomography (DOT) is a non-invasive medical imaging technique that makes use of Near-Infrared (NIR) light to recover the spatial distribution of optical coefficients in biological tissues for diagnostic purposes. Due to the intense sca...
In this work, we put forward and demonstrate a bi-direction free-space visible light communication (VLC) system supporting multiple moveable receivers (Rxs) using a light-diffusing optical fiber (LDOF). The downlink (DL) signal is launched from a hea...
In this study, time-resolved optical coherence tomography (OCT) scanning images of the process of water diffusion in the skin that illustrate the enhancement in the backscattered intensities due to the increased water concentration are presented. In...
This review presents recent developments and a wide overview of broadband time domain diffuse optical spectroscopy (TD-DOS). Various topics including physics of photon migration, advanced instrumentation, methods of analysis, applications covering mu...
Worldwide, breast cancer is the most common type of cancer that mainly affects women. Several diagnosis techniques based on optical instrumentation and image analysis have been developed, and these are commonly used in conjunction with conventional d...
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Tractography based on multishell diffusion-weighted magnetic resonance imaging (DWI) can be used to estimate the course of myelinated white matter tracts and nerves, yielding valuable information regarding normal anatomy and variability. DWI is sensi...
Near infrared diffuse optical tomography (DOT) is a potential tool for diagnosing cancer by image reconstruction of tissue optical properties. A variety of image reconstruction methods for DOT have been attempted, in general, based on the diffusion e...
The present work describes noninvasive diffuse optical tomography (DOT), a technology for measuring hemodynamic changes in the brain. These changes provide relevant information that helps us to understand the basis of neurophysiology in the human bra...
In order to elucidate the effect of wall temperature on a diffusion flame–wall interaction, an acetylene diffusion flame in a head-on quenching type was investigated. Direct photography, two-color thermometry, soot-LII (laser-induced incandesce...
Diffuse reflectance spectroscopy (DRS) is a powerful tool for quantifying optical and physiological tissue properties such as hemoglobin oxygen saturation and vascularity. DRS is increasingly used clinically for distinguishing cancerous lesions from...
This work describes a sapphire cryo-applicator with the ability to sense tissue freezing depth during cryosurgery by illumination of tissue and analyzing diffuse optical signals in a steady-state regime. The applicator was manufactured by the crystal...
Cardiopulmonary bypass (CPB) provides cerebral oxygenation and blood flow (CBF) during neonatal congenital heart surgery, but the impacts of CPB on brain oxygen supply and metabolic demands are generally unknown. To elucidate this physiology, we used...
Skin consists of epidermis and dermis layers that have distinct optical properties. The quantification of skin optical properties is commonly achieved by modeling photon propagation in tissue using Monte Carlo (MC) simulations and iteratively fitting...
Glass Fibre Reinforced Polymer (GRFP) composites are increasingly being used as new materials for civil and petrochemical engineering infrastructures, owing to the combination of relatively high specific strength and stiffness and cost-competitivenes...
Diffuse optical tomography (DOT) has been studied for use in the detection of breast cancer, cerebral oxygenation, and cognitive brain signals. As optical imaging studies have increased significantly, acquiring imaging data in real time has become in...
Near-infrared diffuse optical tomography is a non-invasive photonics-based imaging technology suited to functional brain imaging applications. Recent developments have proved that it is possible to build a compact time-domain diffuse optical tomograp...
Background: The development and initial testing of an optomechatronic system for the reconstruction of three-dimensional (3D) images to identify abnormalities in breast tissue and assist in the diagnosis of breast cancer is presented. Methods: This s...
This contribution presents the development of an optical spectroscopy device, called SpectroLive, that allows spatially-resolved multiply-excited autofluorescence and diffuse reflectance measurements. Besides describing the device, this study aims at...
Functional neuroimaging studies of neuropsychiatric disorders and cognitive impairment are commonly conducted in the clinic setting but less so in the acutely medically ill while hospitalized. This is largely due to technical and logistical limitatio...
The detection of cancer at its earliest stage is crucial in order to increase the probability of a successful treatment. Optical techniques, specifically diffuse reflectance and fluorescence, may considerably improve the ability to detect pre-cancero...
Imaging tasks today are being increasingly shifted toward deep learning-based solutions. Biomedical imaging problems are no exception toward this tendency. It is appealing to consider deep learning as an alternative to such a complex imaging task. Al...
Diffuse optical tomography (DOT) is an emerging modality that reconstructs the optical properties in a highly scattering medium from measured boundary data. One way to solve DOT and recover the quantities of interest is by an inverse problem approach...
Diffuse optical tomography (DOT) is a non-invasive method for detecting breast cancer; however, it struggles to produce high-quality images due to the complexity of scattered light and the limitations of traditional image reconstruction algorithms. T...
The increasing demand for energy in the building sector is mostly due to heat, ventilation and air conditioning (HVAC) systems. In the absence of the clear sky beam optical depth (CSBOD) and clear sky diffuse optical depth (CSDOD), there is a challen...
Continuous wave-diffuse optical tomography (CW-DOT) has emerged as a promising non-invasive neuroimaging technique for assessing brain function. Its ability to provide brain mapping with high spatial resolution over traditional functional near-infrar...
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